Cytarabine (hydrochloride)_C-33 A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cytarabine (hydrochloride) perturbation in C-33 A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cytarabine (hydrochloride)_C-33 A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
JMJD1C jumonji domain containing 1C 0.0906931
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0863562
ADGRG6 adhesion G protein-coupled receptor G6 0.0847993
USP9X ubiquitin specific peptidase 9, X-linked 0.0726064
COL5A2 collagen, type V, alpha 2 0.0670072
TOX thymocyte selection-associated high mobility group box 0.0650913
NUP58 nucleoporin 58 0.0635073
DST dystonin 0.0611936
PIAS2 protein inhibitor of activated STAT, 2 0.0611457
ZNF292 zinc finger protein 292 0.0576414
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0574201
KMT2C lysine (K)-specific methyltransferase 2C 0.0555177
HELZ helicase with zinc finger 0.0551081
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0536366
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 0.053457
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0524974
TPD52 tumor protein D52 0.0515938
UBA6 ubiquitin-like modifier activating enzyme 6 0.0512818
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0501626
CDC73 cell division cycle 73 0.0491562
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0483585
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0480128
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.047765
KDM6A lysine (K)-specific demethylase 6A 0.0475806
PCBP2 poly(rC) binding protein 2 0.0471262
ATRN attractin 0.046027
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.04602
RTN4 reticulon 4 0.0458647
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0449024
PUM2 pumilio RNA-binding family member 2 0.0447933
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0447223
OGA O-GlcNAcase 0.0441269
ZFAND3 zinc finger, AN1-type domain 3 0.0435107
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.043198
QKI QKI, KH domain containing, RNA binding 0.0429744
SETD5 SET domain containing 5 0.042549
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0422186
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0415338
PDS5B PDS5 cohesin associated factor B 0.0413153
SMYD3 SET and MYND domain containing 3 0.0402829
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 0.0402497
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0400962
TJP1 tight junction protein 1 0.0383692
NGLY1 N-glycanase 1 0.0381404
FNBP1L formin binding protein 1-like 0.0376198
MAP3K14 mitogen-activated protein kinase kinase kinase 14 0.0375395
ARFGEF3 ARFGEF family member 3 0.0370241
CHD7 chromodomain helicase DNA binding protein 7 0.0370084
SRPK2 SRSF protein kinase 2 0.036865
MIMS1 mitochondrial inner membrane scaffold 1 0.0367176
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0366297
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0364085
PHIP pleckstrin homology domain interacting protein 0.0362488
MEF2A myocyte enhancer factor 2A 0.0358281
ADAM9 ADAM metallopeptidase domain 9 0.0357932
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0357551
FAR1 fatty acyl CoA reductase 1 0.035666
RBM33 RNA binding motif protein 33 0.0353537
SSBP2 single-stranded DNA binding protein 2 0.0350719
LCOR ligand dependent nuclear receptor corepressor 0.0348206
SRSF4 serine/arginine-rich splicing factor 4 0.0347855
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0347717
KMT2E lysine (K)-specific methyltransferase 2E 0.0347521
ADAR adenosine deaminase, RNA-specific 0.0346062
KDM1A lysine (K)-specific demethylase 1A 0.0345496
YAP1 Yes-associated protein 1 0.0341358
SPRED1 sprouty-related, EVH1 domain containing 1 0.0338474
YEATS2 YEATS domain containing 2 0.0331257
KDM3A lysine (K)-specific demethylase 3A 0.0328533
WDR45B WD repeat domain 45B 0.0328054
SLF1 SMC5-SMC6 complex localization factor 1 0.0327439
EIF4B eukaryotic translation initiation factor 4B 0.0326995
CHSY1 chondroitin sulfate synthase 1 0.032596
HACE1 HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1 0.0325586
TMEM41B transmembrane protein 41B 0.0325223
ZMYM2 zinc finger, MYM-type 2 0.032496
WDFY3 WD repeat and FYVE domain containing 3 0.0324659
RLF rearranged L-myc fusion 0.0324229
CABIN1 calcineurin binding protein 1 0.0322299
MATR3 matrin 3 0.0318878
GRID2 glutamate receptor, ionotropic, delta 2 0.0317178
WWC2 WW and C2 domain containing 2 0.0316217
BIRC6 baculoviral IAP repeat containing 6 0.0313133
IPO7 importin 7 0.0311727
USP3 ubiquitin specific peptidase 3 0.0311661
DOCK3 dedicator of cytokinesis 3 0.031078
CCNY cyclin Y 0.0308563
PARD3 par-3 family cell polarity regulator 0.030562
RNF145 ring finger protein 145 0.0303529
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0302736
TM9SF3 transmembrane 9 superfamily member 3 0.0300634
DENND5A DENN/MADD domain containing 5A 0.0299578
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0296011
APP amyloid beta (A4) precursor protein 0.0295121
STRN3 striatin, calmodulin binding protein 3 0.0294509
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0294128
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0293004
PCNX1 pecanex 1 0.0291592
MYO6 myosin VI 0.029041
TBK1 TANK-binding kinase 1 0.0290198

decreased expression

Symbol Name Standardized Value
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.123059
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.118266
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.106061
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.104441
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0992238
SLIT2 slit homolog 2 (Drosophila) -0.0850407
PTMA prothymosin, alpha -0.0843027
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0697246
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.0522875
SOX4 SRY (sex determining region Y)-box 4 -0.0509892
RPS8 ribosomal protein S8 -0.0507891
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0507846
RPS12 ribosomal protein S12 -0.0495442
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0482719
NEBL nebulette -0.0480192
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0439989
CENPF centromere protein F, 350/400kDa -0.0435711
RAD51B RAD51 paralog B -0.0413462
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0410804
RPL26 ribosomal protein L26 -0.0407038
TPT1 tumor protein, translationally-controlled 1 -0.039132
RPLP1 ribosomal protein, large, P1 -0.0389382
IFI6 interferon, alpha-inducible protein 6 -0.0384596
RPL35A ribosomal protein L35a -0.037642
RPL34 ribosomal protein L34 -0.0370907
RCC1 regulator of chromosome condensation 1 -0.036411
NR2F1 nuclear receptor subfamily 2, group F, member 1 -0.0363642
CADM2 cell adhesion molecule 2 -0.0353369
RPLP2 ribosomal protein, large, P2 -0.0352208
CDH18 cadherin 18, type 2 -0.0346366
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 -0.0332954
CANX calnexin -0.0327954
RPL38 ribosomal protein L38 -0.0321696
RPS24 ribosomal protein S24 -0.0320076
RPL36 ribosomal protein L36 -0.0317566
NPAS3 neuronal PAS domain protein 3 -0.0315442
RPL12 ribosomal protein L12 -0.0315416
MKI67 marker of proliferation Ki-67 -0.0309028
RPL37A ribosomal protein L37a -0.030825
TMSB10 thymosin beta 10 -0.0296817
HDAC4 histone deacetylase 4 -0.0296752
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0284152
DENND1A DENN/MADD domain containing 1A -0.0281917
RPL13A ribosomal protein L13a -0.0281595
HMGB1 high mobility group box 1 -0.027786
INTS6 integrator complex subunit 6 -0.0277848
RPS3 ribosomal protein S3 -0.0273378
RPL11 ribosomal protein L11 -0.0271791
AEBP2 AE binding protein 2 -0.0268971
SLC38A2 solute carrier family 38, member 2 -0.0266566
RSL1D1 ribosomal L1 domain containing 1 -0.0264807
RPS29 ribosomal protein S29 -0.0263674
RPS25 ribosomal protein S25 -0.0259056
TBCA tubulin folding cofactor A -0.0258572
RPS16 ribosomal protein S16 -0.0253895
UBAP2 ubiquitin associated protein 2 -0.0251412
RPL18 ribosomal protein L18 -0.0250771
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0249568
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.0248058
RPL28 ribosomal protein L28 -0.0247694
RPLP0 ribosomal protein, large, P0 -0.0246327
SOX2 SRY (sex determining region Y)-box 2 -0.0238457
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0237251
LARP1B La ribonucleoprotein domain family, member 1B -0.0236832
MSH4 mutS homolog 4 -0.0236173
ARHGAP32 Rho GTPase activating protein 32 -0.0232171
NACA nascent polypeptide-associated complex alpha subunit -0.0229856
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0227739
RACK1 receptor for activated C kinase 1 -0.0225455
VDAC1 voltage-dependent anion channel 1 -0.022526
RPS27A ribosomal protein S27a -0.0223747
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa -0.0220266
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta -0.0219352
E2F3 E2F transcription factor 3 -0.0215775
RPL23 ribosomal protein L23 -0.0214175
RPL9 ribosomal protein L9 -0.0212144
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) -0.0201118
R3HDM2 R3H domain containing 2 -0.0198145
WLS wntless Wnt ligand secretion mediator -0.0197885
SNX14 sorting nexin 14 -0.0195906
RPS20 ribosomal protein S20 -0.0194844
CRK v-crk avian sarcoma virus CT10 oncogene homolog -0.019462
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) -0.0194602
HMGA1 high mobility group AT-hook 1 -0.0193051
BPTF bromodomain PHD finger transcription factor -0.0192797
NR6A1 nuclear receptor subfamily 6, group A, member 1 -0.0191773
LARS1 leucyl-tRNA synthetase 1 -0.0191719
CALR calreticulin -0.0191368
RPL35 ribosomal protein L35 -0.0191228
TRNAU1AP tRNA selenocysteine 1 associated protein 1 -0.0190397
MLIP muscular LMNA-interacting protein -0.0189735
CCDC138 coiled-coil domain containing 138 -0.0188638
RPS13 ribosomal protein S13 -0.0185769
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0185667
RPL19 ribosomal protein L19 -0.0184785
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0183962
EIF1 eukaryotic translation initiation factor 1 -0.0181099
TOM1L2 target of myb1-like 2 (chicken) -0.017818
SRRM2 serine/arginine repetitive matrix 2 -0.017772
APOLD1 apolipoprotein L domain containing 1 -0.0176275