Cytarabine (hydrochloride)_C32 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cytarabine (hydrochloride) perturbation in C32 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cytarabine (hydrochloride)_C32 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.178008
NAMPT nicotinamide phosphoribosyltransferase 0.157652
CD109 CD109 molecule 0.0999
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0866722
NDRG1 N-myc downstream regulated 1 0.0817507
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0717648
ESYT2 extended synaptotagmin-like protein 2 0.0697984
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0637578
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0625085
VGF VGF nerve growth factor inducible 0.0601317
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0592606
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0550641
FMNL2 formin-like 2 0.0536642
GPC6 glypican 6 0.0523102
CDC73 cell division cycle 73 0.0520927
KIRREL1 kirre like nephrin family adhesion molecule 1 0.051729
NUP58 nucleoporin 58 0.0501211
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 0.0465919
WDR45B WD repeat domain 45B 0.0452088
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0451902
SMAD3 SMAD family member 3 0.0430217
TMEM178B transmembrane protein 178B 0.0411508
FRMD6 FERM domain containing 6 0.0411466
HILPDA hypoxia inducible lipid droplet-associated 0.0409866
EXT1 exostosin glycosyltransferase 1 0.0399078
CLMN calmin (calponin-like, transmembrane) 0.0397753
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.0395136
BHLHE40 basic helix-loop-helix family, member e40 0.0392142
KMT2C lysine (K)-specific methyltransferase 2C 0.0387399
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0383275
GDF15 growth differentiation factor 15 0.037966
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0374389
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0373074
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 0.0369251
CHSY1 chondroitin sulfate synthase 1 0.036713
SPRED1 sprouty-related, EVH1 domain containing 1 0.0366983
ZNF292 zinc finger protein 292 0.0365385
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.0361189
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0357537
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 0.0352993
FBXO7 F-box protein 7 0.034509
RYBP RING1 and YY1 binding protein 0.0344166
PDIA4 protein disulfide isomerase family A, member 4 0.0331072
FYN FYN proto-oncogene, Src family tyrosine kinase 0.0330106
PGK1 phosphoglycerate kinase 1 0.0326072
E2F7 E2F transcription factor 7 0.0324151
SSBP2 single-stranded DNA binding protein 2 0.0322612
RRM2B ribonucleotide reductase M2 B (TP53 inducible) 0.0322348
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0322094
IFRD1 interferon-related developmental regulator 1 0.0313624
TXNIP thioredoxin interacting protein 0.0310276
KMT2E lysine (K)-specific methyltransferase 2E 0.0307401
PPME1 protein phosphatase methylesterase 1 0.0307238
ANXA2 annexin A2 0.0305742
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.030181
ADAM19 ADAM metallopeptidase domain 19 0.0301701
EIF4H eukaryotic translation initiation factor 4H 0.0288796
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein 0.0288025
ARRDC3 arrestin domain containing 3 0.0285245
IGF1R insulin-like growth factor 1 receptor 0.0273384
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0270549
LRMDA leucine rich melanocyte differentiation associated 0.0270537
RAB1A RAB1A, member RAS oncogene family 0.0269628
C1ORF21 chromosome 1 open reading frame 21 0.0268459
CENPP centromere protein P 0.0265568
INSIG1 insulin induced gene 1 0.0265393
FRMD5 FERM domain containing 5 0.0264582
ZFAND3 zinc finger, AN1-type domain 3 0.026053
RNF150 ring finger protein 150 0.0259376
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0258165
SSBP3 single stranded DNA binding protein 3 0.0254225
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0254131
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0.0252153
TM7SF3 transmembrane 7 superfamily member 3 0.025035
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0250159
LHFPL2 lipoma HMGIC fusion partner-like 2 0.024822
USP3 ubiquitin specific peptidase 3 0.0248009
TMEM123 transmembrane protein 123 0.0243976
UBASH3B ubiquitin associated and SH3 domain containing B 0.0243597
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0241848
PTCHD4 patched domain containing 4 0.0237173
YBX3 Y box binding protein 3 0.0235804
MXI1 MAX interactor 1, dimerization protein 0.0232807
MRTFA myocardin related transcription factor A 0.0231779
CALR calreticulin 0.023175
HOOK2 hook microtubule-tethering protein 2 0.0231556
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.0230869
PYGB phosphorylase, glycogen; brain 0.022951
FNDC3B fibronectin type III domain containing 3B 0.0229465
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 0.022925
HELZ helicase with zinc finger 0.0229199
STXBP1 syntaxin binding protein 1 0.022879
OGA O-GlcNAcase 0.0226677
KDM5B lysine (K)-specific demethylase 5B 0.0224252
ZC3H7A zinc finger CCCH-type containing 7A 0.0223496
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0223485
CNOT2 CCR4-NOT transcription complex, subunit 2 0.022199
PLXNB2 plexin B2 0.022193
NT5C3A 5'-nucleotidase, cytosolic IIIA 0.0221084
XPO6 exportin 6 0.0219012

decreased expression

Symbol Name Standardized Value
FMN1 formin 1 -0.122518
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.120901
FN1 fibronectin 1 -0.11948
MT2A metallothionein 2A -0.0967547
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0963859
IGFBP5 insulin-like growth factor binding protein 5 -0.0867356
EGR1 early growth response 1 -0.0844888
NLGN1 neuroligin 1 -0.0794153
COL19A1 collagen, type XIX, alpha 1 -0.078798
NPAS2 neuronal PAS domain protein 2 -0.0725217
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0710892
VCL vinculin -0.0684124
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0680568
NAV2 neuron navigator 2 -0.0654788
EHBP1 EH domain binding protein 1 -0.0617648
POTEF POTE ankyrin domain family, member F -0.0585063
NPC1 Niemann-Pick disease, type C1 -0.0554814
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0543301
CENPF centromere protein F, 350/400kDa -0.0541044
ASPH aspartate beta-hydroxylase -0.0538384
FRMD4A FERM domain containing 4A -0.0519018
IGFBP3 insulin-like growth factor binding protein 3 -0.0512066
WWTR1 WW domain containing transcription regulator 1 -0.0485662
OXR1 oxidation resistance 1 -0.0456551
S100A6 S100 calcium binding protein A6 -0.0441342
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.04212
PHC2 polyhomeotic homolog 2 (Drosophila) -0.0418518
IFI16 interferon, gamma-inducible protein 16 -0.0398714
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0389237
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0377825
RTN4 reticulon 4 -0.0377135
ACTN1 actinin, alpha 1 -0.0363656
TMSB10 thymosin beta 10 -0.0356753
TNNC1 troponin C type 1 (slow) -0.0356744
PAX3 paired box 3 -0.0354988
RPLP1 ribosomal protein, large, P1 -0.0352586
ACTG1 actin gamma 1 -0.033327
PTMA prothymosin, alpha -0.0320054
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0306465
TBC1D22A TBC1 domain family, member 22A -0.030247
GHR growth hormone receptor -0.0299989
ZSWIM5 zinc finger, SWIM-type containing 5 -0.0289471
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0287521
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0285254
PRRC2C proline-rich coiled-coil 2C -0.0276874
TAGLN2 transgelin 2 -0.0276048
BPTF bromodomain PHD finger transcription factor -0.0274708
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0272143
S100A9 S100 calcium binding protein A9 -0.027164
SBF2 SET binding factor 2 -0.0268368
MYO1E myosin IE -0.0267946
TPM4 tropomyosin 4 -0.0267517
AKAP9 A kinase (PRKA) anchor protein 9 -0.0266917
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0266734
TPI1 triosephosphate isomerase 1 -0.0264977
NAV1 neuron navigator 1 -0.026199
SRSF11 serine/arginine-rich splicing factor 11 -0.0259798
RHOBTB3 Rho-related BTB domain containing 3 -0.025693
ZNF644 zinc finger protein 644 -0.0255853
IFI6 interferon, alpha-inducible protein 6 -0.0254964
ARHGAP5 Rho GTPase activating protein 5 -0.0252755
ZBTB20 zinc finger and BTB domain containing 20 -0.025211
SLC38A2 solute carrier family 38, member 2 -0.0251897
HLA-B major histocompatibility complex, class I, B -0.025134
ANKRD28 ankyrin repeat domain 28 -0.0250328
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0248171
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0248001
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.024642
LIMA1 LIM domain and actin binding 1 -0.0245144
ANKRD12 ankyrin repeat domain 12 -0.0242089
AHCYL2 adenosylhomocysteinase-like 2 -0.0241484
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0238165
STAU2 staufen double-stranded RNA binding protein 2 -0.0235379
TMEM87A transmembrane protein 87A -0.0234061
TNRC6B trinucleotide repeat containing 6B -0.0233766
MT1X metallothionein 1X -0.0233129
SON SON DNA binding protein -0.0231481
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.022987
RBM25 RNA binding motif protein 25 -0.0229511
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0227069
NIPBL Nipped-B homolog (Drosophila) -0.022609
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0224576
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0224496
ADNP activity-dependent neuroprotector homeobox -0.0223724
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0223282
SDC2 syndecan 2 -0.0222152
ANKRD17 ankyrin repeat domain 17 -0.0221876
DSTN destrin (actin depolymerizing factor) -0.0221858
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0218411
NCOA7 nuclear receptor coactivator 7 -0.0217807
CYTH3 cytohesin 3 -0.0215154
MBNL1 muscleblind-like splicing regulator 1 -0.0214368
MBNL2 muscleblind-like splicing regulator 2 -0.0213955
RAD51B RAD51 paralog B -0.02125
ETV6 ets variant 6 -0.0211652
CTTNBP2 cortactin binding protein 2 -0.0210319
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0210112
PDLIM5 PDZ and LIM domain 5 -0.0208767
SCAPER S-phase cyclin A-associated protein in the ER -0.0208009
MMP14 matrix metallopeptidase 14 (membrane-inserted) -0.0206852