Cytarabine (hydrochloride)_CFPAC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cytarabine (hydrochloride) perturbation in CFPAC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cytarabine (hydrochloride)_CFPAC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LAMB3 laminin, beta 3 0.126491
TSC22D2 TSC22 domain family, member 2 0.117756
PLAU plasminogen activator, urokinase 0.11593
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.112792
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.09612
SPAG9 sperm associated antigen 9 0.0912478
ACTG1 actin gamma 1 0.089669
CXCL8 chemokine (C-X-C motif) ligand 8 0.0860552
FAM13A family with sequence similarity 13, member A 0.0828801
CCNY cyclin Y 0.0816927
ADAM9 ADAM metallopeptidase domain 9 0.081554
DTNA dystrobrevin, alpha 0.0799508
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0799073
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0773516
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0769747
PCBP2 poly(rC) binding protein 2 0.0764237
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.07576
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0729683
CCNL1 cyclin L1 0.0715122
MYH9 myosin, heavy chain 9, non-muscle 0.0669445
ENO1 enolase 1, (alpha) 0.0658288
ANKRD11 ankyrin repeat domain 11 0.0655775
BIRC3 baculoviral IAP repeat containing 3 0.0624789
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0616413
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0613665
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0594221
SDC4 syndecan 4 0.0593357
KRT8 keratin 8, type II 0.0578993
ELL2 elongation factor, RNA polymerase II, 2 0.0555889
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0543764
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0537929
OGA O-GlcNAcase 0.0533328
UBA6 ubiquitin-like modifier activating enzyme 6 0.0526519
AHNAK AHNAK nucleoprotein 0.0514415
YTHDC1 YTH domain containing 1 0.0506575
BZW1 basic leucine zipper and W2 domains 1 0.0504963
UGCG UDP-glucose ceramide glucosyltransferase 0.0498045
BCAT1 branched chain amino-acid transaminase 1, cytosolic 0.0497677
AKAP13 A kinase (PRKA) anchor protein 13 0.0494062
EREG epiregulin 0.0485924
RBM39 RNA binding motif protein 39 0.0484949
APP amyloid beta (A4) precursor protein 0.0483102
HELZ helicase with zinc finger 0.0480428
TPM3 tropomyosin 3 0.0475809
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0473761
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0462749
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0451336
FNBP1L formin binding protein 1-like 0.0444248
PGK1 phosphoglycerate kinase 1 0.0436306
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.043581
MCTP1 multiple C2 domains, transmembrane 1 0.0433162
HILPDA hypoxia inducible lipid droplet-associated 0.0432213
RAB8B RAB8B, member RAS oncogene family 0.043141
CDC73 cell division cycle 73 0.0423431
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0423209
ARRDC3 arrestin domain containing 3 0.0422205
GRB10 growth factor receptor-bound protein 10 0.0422126
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0414499
ZFAND3 zinc finger, AN1-type domain 3 0.0409115
PICALM phosphatidylinositol binding clathrin assembly protein 0.0407801
ZNF292 zinc finger protein 292 0.040631
POTEF POTE ankyrin domain family, member F 0.0402486
QKI QKI, KH domain containing, RNA binding 0.0390491
NUP58 nucleoporin 58 0.0386591
DST dystonin 0.0382503
USP3 ubiquitin specific peptidase 3 0.0379686
MACC1 metastasis associated in colon cancer 1 0.0378184
KMT2E lysine (K)-specific methyltransferase 2E 0.0374388
SEC23A Sec23 homolog A (S. cerevisiae) 0.037355
FXR1 fragile X mental retardation, autosomal homolog 1 0.0372889
KMT2C lysine (K)-specific methyltransferase 2C 0.0372588
HLA-C major histocompatibility complex, class I, C 0.0370324
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0368618
EIF4A2 eukaryotic translation initiation factor 4A2 0.0365377
DDX52 DEAD (Asp-Glu-Ala-Asp) box polypeptide 52 0.035766
SLMAP sarcolemma associated protein 0.0357622
B2M beta-2-microglobulin 0.0350744
MACF1 microtubule-actin crosslinking factor 1 0.0347471
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0347429
RAB6A RAB6A, member RAS oncogene family 0.03459
PRRC2C proline-rich coiled-coil 2C 0.0345544
VEGFA vascular endothelial growth factor A 0.0341373
VEZT vezatin, adherens junctions transmembrane protein 0.033709
WAC WW domain containing adaptor with coiled-coil 0.0332968
MYO1B myosin IB 0.0330926
EIF5 eukaryotic translation initiation factor 5 0.0330315
G0S2 G0/G1 switch 2 0.0327599
ATP13A3 ATPase type 13A3 0.0327518
RLF rearranged L-myc fusion 0.0326685
WSB1 WD repeat and SOCS box containing 1 0.0326391
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.032439
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0323656
TFG TRK-fused gene 0.0321894
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0321814
STC2 stanniocalcin 2 0.0318258
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0317758
HOOK2 hook microtubule-tethering protein 2 0.0315762
ABI1 abl-interactor 1 0.0310075
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0308719
NPTN neuroplastin 0.0303438

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.173909
MT2A metallothionein 2A -0.164318
TMSB10 thymosin beta 10 -0.135073
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.125145
NDRG1 N-myc downstream regulated 1 -0.111727
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0963544
APOL1 apolipoprotein L, 1 -0.0850064
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0660282
KRT19 keratin 19, type I -0.0622264
EFNA5 ephrin-A5 -0.0591819
FTL ferritin, light polypeptide -0.0560573
BICC1 BicC family RNA binding protein 1 -0.051068
OSMR oncostatin M receptor -0.0507064
MT1X metallothionein 1X -0.0495927
S100A10 S100 calcium binding protein A10 -0.0447766
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0435619
CDCP1 CUB domain containing protein 1 -0.0428908
ALCAM activated leukocyte cell adhesion molecule -0.0404296
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0395967
RRBP1 ribosome binding protein 1 -0.0383793
CP ceruloplasmin (ferroxidase) -0.0367103
ARHGAP5 Rho GTPase activating protein 5 -0.036629
DOCK5 dedicator of cytokinesis 5 -0.0363955
VIM vimentin -0.0362062
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0360112
PATJ PATJ crumbs cell polarity complex component -0.0355392
BACE2 beta-site APP-cleaving enzyme 2 -0.035344
FNDC3B fibronectin type III domain containing 3B -0.034622
C15ORF48 chromosome 15 open reading frame 48 -0.0345912
EHBP1 EH domain binding protein 1 -0.0345835
RPS24 ribosomal protein S24 -0.0335402
TPT1 tumor protein, translationally-controlled 1 -0.0329261
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0325972
RPS2 ribosomal protein S2 -0.0322243
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0314067
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0306827
IFI27 interferon, alpha-inducible protein 27 -0.0304999
RPLP1 ribosomal protein, large, P1 -0.029429
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0287219
PHF3 PHD finger protein 3 -0.0280282
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0278967
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0277325
H1-0 H1.0 linker histone -0.026184
MBD5 methyl-CpG binding domain protein 5 -0.0257162
PRELID2 PRELI domain containing 2 -0.0256904
TM4SF1 transmembrane 4 L six family member 1 -0.0256759
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0256166
KIF13B kinesin family member 13B -0.0253087
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0250524
BPTF bromodomain PHD finger transcription factor -0.0247103
TMC5 transmembrane channel-like 5 -0.0245578
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0242235
CSTB cystatin B (stefin B) -0.0241613
ST8SIA6 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 -0.0239092
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) -0.0238035
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.023595
NLGN1 neuroligin 1 -0.0233143
ANXA4 annexin A4 -0.0233002
BABAM2 BRISC and BRCA1 A complex member 2 -0.0229777
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.02257
GCC2 GRIP and coiled-coil domain containing 2 -0.0221232
SLC38A2 solute carrier family 38, member 2 -0.0219852
HMGA1 high mobility group AT-hook 1 -0.0219692
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0217421
RPL31 ribosomal protein L31 -0.0215162
SMAD3 SMAD family member 3 -0.0212957
MYO9A myosin IXA -0.0211283
EIF1 eukaryotic translation initiation factor 1 -0.0209307
MMP7 matrix metallopeptidase 7 -0.0208021
CLMN calmin (calponin-like, transmembrane) -0.0206675
ITGA1 integrin, alpha 1 -0.020595
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0205676
SLC38A1 solute carrier family 38, member 1 -0.0205521
ANXA2 annexin A2 -0.0204722
MX2 MX dynamin-like GTPase 2 -0.0204544
ADAM28 ADAM metallopeptidase domain 28 -0.0197313
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0195509
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.019511
MKNK2 MAP kinase interacting serine/threonine kinase 2 -0.0192461
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -0.0189938
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0189704
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0189132
RPS23 ribosomal protein S23 -0.018755
RPS29 ribosomal protein S29 -0.018539
ZBTB20 zinc finger and BTB domain containing 20 -0.0184686
MKI67 marker of proliferation Ki-67 -0.0182814
ANTXR2 anthrax toxin receptor 2 -0.0182593
FOXP1 forkhead box P1 -0.0181963
TMEM45B transmembrane protein 45B -0.018087
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0177621
FAM3C family with sequence similarity 3, member C -0.0176992
MYO1E myosin IE -0.0175252
CLTC clathrin, heavy chain (Hc) -0.0175044
CSNK1A1 casein kinase 1, alpha 1 -0.0174717
UGDH UDP-glucose 6-dehydrogenase -0.0174231
LY6E lymphocyte antigen 6 complex, locus E -0.0173858
ATXN1 ataxin 1 -0.0172936
RPL9 ribosomal protein L9 -0.0171725
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.0170155
HLA-B major histocompatibility complex, class I, B -0.0169948