Cytarabine (hydrochloride)_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cytarabine (hydrochloride) perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cytarabine (hydrochloride)_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LPIN1 lipin 1 0.108648
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.107722
ACTG1 actin gamma 1 0.0960491
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0912061
WDR45B WD repeat domain 45B 0.0775758
PTMA prothymosin, alpha 0.0694156
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0673593
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 0.0643173
HELZ helicase with zinc finger 0.0612429
P4HB prolyl 4-hydroxylase, beta polypeptide 0.05907
FAM13A family with sequence similarity 13, member A 0.0580682
RPL23 ribosomal protein L23 0.0553308
POTEF POTE ankyrin domain family, member F 0.0550562
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0549168
COL3A1 collagen, type III, alpha 1 0.0548139
RPS6 ribosomal protein S6 0.0544638
DDIT4 DNA-damage-inducible transcript 4 0.0521801
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0514972
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0462696
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0458941
CANX calnexin 0.0454115
LMNA lamin A/C 0.0434579
GDF15 growth differentiation factor 15 0.0433207
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0430075
PCBP2 poly(rC) binding protein 2 0.0419612
FDXR ferredoxin reductase 0.041689
RPS12 ribosomal protein S12 0.0416441
B2M beta-2-microglobulin 0.0396791
MEF2A myocyte enhancer factor 2A 0.0390649
WAC WW domain containing adaptor with coiled-coil 0.0386836
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0376028
KPNB1 karyopherin (importin) beta 1 0.0365878
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0358503
SSBP2 single-stranded DNA binding protein 2 0.0355204
RPL35A ribosomal protein L35a 0.0353175
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0347996
PTK2 protein tyrosine kinase 2 0.034615
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0344993
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.034147
CSNK1G1 casein kinase 1, gamma 1 0.0337615
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0337094
CSDE1 cold shock domain containing E1, RNA-binding 0.0330325
AHNAK AHNAK nucleoprotein 0.0328205
SEPTIN9 septin 9 0.032464
MSI2 musashi RNA-binding protein 2 0.0322954
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0321962
RPL13A ribosomal protein L13a 0.0321357
RPL34 ribosomal protein L34 0.032086
RPL27 ribosomal protein L27 0.0318471
STARD4 StAR-related lipid transfer (START) domain containing 4 0.0315669
ZMAT3 zinc finger, matrin-type 3 0.0315086
SET SET nuclear proto-oncogene 0.0312826
MATR3 matrin 3 0.0307956
UBA6 ubiquitin-like modifier activating enzyme 6 0.0307598
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0304898
COPA coatomer protein complex, subunit alpha 0.0304843
NPEPPS aminopeptidase puromycin sensitive 0.0303895
GOLGA4 golgin A4 0.0300106
SEPTIN7 septin 7 0.0299007
CALR calreticulin 0.0297816
RHOA ras homolog family member A 0.0292516
WDR43 WD repeat domain 43 0.0291273
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0287825
RAB6A RAB6A, member RAS oncogene family 0.0285616
LDHA lactate dehydrogenase A 0.0282773
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0279003
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0278464
RIOK3 RIO kinase 3 0.0276598
RPL19 ribosomal protein L19 0.0275663
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0275294
FAM168A family with sequence similarity 168, member A 0.0273955
EIF4B eukaryotic translation initiation factor 4B 0.0273257
BIRC6 baculoviral IAP repeat containing 6 0.0272679
COL1A1 collagen, type I, alpha 1 0.0270225
KDM3A lysine (K)-specific demethylase 3A 0.0269883
S100A6 S100 calcium binding protein A6 0.0269759
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0269064
QKI QKI, KH domain containing, RNA binding 0.0268715
FRMD4A FERM domain containing 4A 0.0268692
NUP58 nucleoporin 58 0.026786
WSB1 WD repeat and SOCS box containing 1 0.026651
USP3 ubiquitin specific peptidase 3 0.0266174
RNF145 ring finger protein 145 0.0265571
TPM3 tropomyosin 3 0.0265276
RPL4 ribosomal protein L4 0.0263938
OGA O-GlcNAcase 0.0263181
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.0262621
SETD5 SET domain containing 5 0.0261758
ZNF292 zinc finger protein 292 0.0259045
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0254945
CD46 CD46 molecule, complement regulatory protein 0.0253259
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0252187
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0251935
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0250238
SEPTIN2 septin 2 0.0246354
IGFBP3 insulin-like growth factor binding protein 3 0.0246052
RPLP1 ribosomal protein, large, P1 0.0244321
MSMO1 methylsterol monooxygenase 1 0.0243306
SPAG9 sperm associated antigen 9 0.0241891
SOX9 SRY (sex determining region Y)-box 9 0.0241714

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.283735
FMN1 formin 1 -0.115354
TRIO trio Rho guanine nucleotide exchange factor -0.0933738
SYT1 synaptotagmin I -0.0869408
MEIS2 Meis homeobox 2 -0.078381
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0732671
LSAMP limbic system-associated membrane protein -0.0728131
BPTF bromodomain PHD finger transcription factor -0.0639819
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -0.0638789
PLAT plasminogen activator, tissue -0.0631229
ZBTB20 zinc finger and BTB domain containing 20 -0.0535033
ITPRID2 ITPR interacting domain containing 2 -0.0514472
PTPRD protein tyrosine phosphatase, receptor type, D -0.0493207
NALF1 NALCN channel auxiliary factor 1 -0.0478521
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0476311
PDE4D phosphodiesterase 4D, cAMP-specific -0.0472807
KLHL13 kelch-like family member 13 -0.0469489
NCAM2 neural cell adhesion molecule 2 -0.0440923
BCAS3 breast carcinoma amplified sequence 3 -0.0436929
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0427649
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0419849
THSD4 thrombospondin, type I, domain containing 4 -0.0412392
SOS1 son of sevenless homolog 1 (Drosophila) -0.0412313
CLTC clathrin, heavy chain (Hc) -0.040877
PCDH9 protocadherin 9 -0.0407526
TPST1 tyrosylprotein sulfotransferase 1 -0.0401895
SLIT2 slit homolog 2 (Drosophila) -0.0385561
SLC38A2 solute carrier family 38, member 2 -0.0385252
UNC5C unc-5 homolog C (C. elegans) -0.037838
ARID5B AT rich interactive domain 5B (MRF1-like) -0.0370983
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0345148
CENPF centromere protein F, 350/400kDa -0.0344827
HAND2 heart and neural crest derivatives expressed 2 -0.0344063
PRKCA protein kinase C, alpha -0.0342701
NREP neuronal regeneration related protein -0.0327399
RPS2 ribosomal protein S2 -0.0318569
TLE4 transducin-like enhancer of split 4 -0.031838
PSD3 pleckstrin and Sec7 domain containing 3 -0.0311523
LPP LIM domain containing preferred translocation partner in lipoma -0.0309455
DST dystonin -0.0297142
MYO9A myosin IXA -0.0290569
TAS2R14 taste receptor, type 2, member 14 -0.0290474
CSNK1A1 casein kinase 1, alpha 1 -0.0279238
VCL vinculin -0.0277094
BICD1 bicaudal D homolog 1 (Drosophila) -0.0276511
CENPE centromere protein E, 312kDa -0.0276239
RUNX1 runt-related transcription factor 1 -0.0276134
DGKH diacylglycerol kinase, eta -0.0275843
PTPRK protein tyrosine phosphatase, receptor type, K -0.0270695
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0270294
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.026895
MKI67 marker of proliferation Ki-67 -0.0268147
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0267725
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0266638
ARPP19 cAMP-regulated phosphoprotein, 19kDa -0.0263283
SBF2 SET binding factor 2 -0.0260905
ANTXR1 anthrax toxin receptor 1 -0.0256497
PCNX4 pecanex 4 -0.0248648
AOPEP aminopeptidase O (putative) -0.0241337
ZNF638 zinc finger protein 638 -0.0239652
CEP350 centrosomal protein 350kDa -0.0238379
RPTOR regulatory associated protein of MTOR, complex 1 -0.0235749
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.023459
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0233166
PTPRM protein tyrosine phosphatase, receptor type, M -0.0232264
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0229241
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0224858
TPM1 tropomyosin 1 (alpha) -0.022383
SDK1 sidekick cell adhesion molecule 1 -0.0223803
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) -0.0221924
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.0221847
MTDH metadherin -0.0220829
RAB30 RAB30, member RAS oncogene family -0.021892
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0218799
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.021621
ZNF804A zinc finger protein 804A -0.0215152
CACNB2 calcium channel, voltage-dependent, beta 2 subunit -0.0214042
ADGRG6 adhesion G protein-coupled receptor G6 -0.0213963
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0212694
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.021083
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.02105
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0207812
PIBF1 progesterone immunomodulatory binding factor 1 -0.0207676
DIAPH2 diaphanous-related formin 2 -0.0205374
PCTP phosphatidylcholine transfer protein -0.0204701
PCDH7 protocadherin 7 -0.0204533
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0202209
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0202067
PDZRN3 PDZ domain containing ring finger 3 -0.0200708
EDEM3 ER degradation enhancer, mannosidase alpha-like 3 -0.0200631
TRPS1 trichorhinophalangeal syndrome I -0.0197767
DNAH14 dynein, axonemal, heavy chain 14 -0.0197321
ETV1 ets variant 1 -0.0193038
RBM20 RNA binding motif protein 20 -0.0192297
PHOX2B paired-like homeobox 2b -0.0190605
ACBD6 acyl-CoA binding domain containing 6 -0.0186372
RBBP6 retinoblastoma binding protein 6 -0.0185711
EXT1 exostosin glycosyltransferase 1 -0.0185676
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0185359
HDAC8 histone deacetylase 8 -0.0184804