Cytarabine (hydrochloride)_HCT15 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cytarabine (hydrochloride) perturbation in HCT15 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cytarabine (hydrochloride)_HCT15 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
P4HB prolyl 4-hydroxylase, beta polypeptide 0.126243
GOLGA4 golgin A4 0.0980687
PCBP2 poly(rC) binding protein 2 0.0947675
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0898903
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.081611
DSCAM Down syndrome cell adhesion molecule 0.0727884
CANX calnexin 0.0699057
MYH9 myosin, heavy chain 9, non-muscle 0.0675321
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0661885
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0642945
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0640724
ZNF292 zinc finger protein 292 0.0622161
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0600873
TXNRD1 thioredoxin reductase 1 0.0595885
RAD51B RAD51 paralog B 0.0594976
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0583837
TM9SF3 transmembrane 9 superfamily member 3 0.0577561
TTC3 tetratricopeptide repeat domain 3 0.0565584
ANKRD11 ankyrin repeat domain 11 0.0549399
CSDE1 cold shock domain containing E1, RNA-binding 0.0549218
DIAPH3 diaphanous-related formin 3 0.0548127
RRM2 ribonucleotide reductase M2 0.0547759
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.054756
TMF1 TATA element modulatory factor 1 0.0545478
ZFAND3 zinc finger, AN1-type domain 3 0.054306
NUP58 nucleoporin 58 0.0531072
AKAP9 A kinase (PRKA) anchor protein 9 0.0523144
OGA O-GlcNAcase 0.0522899
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0500195
YEATS2 YEATS domain containing 2 0.0498014
ZNF638 zinc finger protein 638 0.049334
HELZ helicase with zinc finger 0.0486783
SETD5 SET domain containing 5 0.0483691
MAP2K1 mitogen-activated protein kinase kinase 1 0.048131
SEC31A SEC31 homolog A (S. cerevisiae) 0.0479374
UBA6 ubiquitin-like modifier activating enzyme 6 0.0478684
COPB1 coatomer protein complex, subunit beta 1 0.0474769
TPM3 tropomyosin 3 0.0469353
EEF2 eukaryotic translation elongation factor 2 0.0468924
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0457963
KDM2A lysine (K)-specific demethylase 2A 0.0457183
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0454209
COPA coatomer protein complex, subunit alpha 0.0434839
EIF4B eukaryotic translation initiation factor 4B 0.0430655
RLF rearranged L-myc fusion 0.0428921
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0427122
YME1L1 YME1-like 1 ATPase 0.0426798
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.04246
WDR26 WD repeat domain 26 0.042365
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0423169
KMT2C lysine (K)-specific methyltransferase 2C 0.0422987
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0422093
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0421323
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0418148
NBAS neuroblastoma amplified sequence 0.0417
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0415851
ATAD2 ATPase family, AAA domain containing 2 0.0414693
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0412867
SRP54 signal recognition particle 54kDa 0.0411523
BIRC6 baculoviral IAP repeat containing 6 0.0398967
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0398095
SPAG9 sperm associated antigen 9 0.0394146
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0393687
CALU calumenin 0.0393033
SUCO SUN domain containing ossification factor 0.0391514
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0390519
SDC4 syndecan 4 0.0382206
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.038138
APLP2 amyloid beta (A4) precursor-like protein 2 0.038094
SRSF11 serine/arginine-rich splicing factor 11 0.0380774
RNMT RNA (guanine-7-) methyltransferase 0.0376925
TRIP12 thyroid hormone receptor interactor 12 0.0370825
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 0.0368174
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0364524
GARS1 glycyl-tRNA synthetase 1 0.0363895
RBM5 RNA binding motif protein 5 0.0362526
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0359429
YTHDC1 YTH domain containing 1 0.0358839
TRA2A transformer 2 alpha homolog (Drosophila) 0.0358353
AFF4 AF4/FMR2 family, member 4 0.0358265
MON2 MON2 homolog (S. cerevisiae) 0.0357173
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0355979
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0354962
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0354702
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0354319
FANCI Fanconi anemia, complementation group I 0.0353749
SEC24D SEC24 family member D 0.0352608
FAF1 Fas (TNFRSF6) associated factor 1 0.0350936
KIAA1217 KIAA1217 0.0349999
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.034884
N4BP2L2 NEDD4 binding protein 2-like 2 0.034824
OLA1 Obg-like ATPase 1 0.0348166
MATR3 matrin 3 0.0346832
RBM39 RNA binding motif protein 39 0.0345878
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0343173
WAC WW domain containing adaptor with coiled-coil 0.034316
TMEM41B transmembrane protein 41B 0.0340167
GIGYF2 GRB10 interacting GYF protein 2 0.0340136
DIAPH1 diaphanous-related formin 1 0.0339115
IARS1 isoleucyl-tRNA synthetase 1 0.0336687

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.278017
FAT1 FAT atypical cadherin 1 -0.169102
PTMA prothymosin, alpha -0.118291
NDRG1 N-myc downstream regulated 1 -0.116403
TMSB10 thymosin beta 10 -0.0953155
AHNAK AHNAK nucleoprotein -0.0727321
TPT1 tumor protein, translationally-controlled 1 -0.0639217
S100A10 S100 calcium binding protein A10 -0.0505058
RPS24 ribosomal protein S24 -0.0463806
KRT19 keratin 19, type I -0.0412264
FHIT fragile histidine triad -0.0388902
EGR1 early growth response 1 -0.0373422
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0365542
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0362768
CENPF centromere protein F, 350/400kDa -0.0362697
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0336709
PKM pyruvate kinase, muscle -0.0326519
INTS6 integrator complex subunit 6 -0.031436
H1-0 H1.0 linker histone -0.0301927
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0293965
TXNIP thioredoxin interacting protein -0.0290407
CCND1 cyclin D1 -0.0290183
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0289566
FTL ferritin, light polypeptide -0.028788
SLC38A2 solute carrier family 38, member 2 -0.028542
MT2A metallothionein 2A -0.027499
CADPS Ca++-dependent secretion activator -0.0267649
TUBB tubulin, beta class I -0.0257437
MKI67 marker of proliferation Ki-67 -0.0253013
ZBTB20 zinc finger and BTB domain containing 20 -0.0250298
SERINC5 serine incorporator 5 -0.0249524
RPL31 ribosomal protein L31 -0.0241677
SUMF1 sulfatase modifying factor 1 -0.0234481
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0230982
PNRC1 proline-rich nuclear receptor coactivator 1 -0.023086
KRT18 keratin 18, type I -0.0221002
RPS25 ribosomal protein S25 -0.021976
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0217888
RPL12 ribosomal protein L12 -0.0214422
RPL34 ribosomal protein L34 -0.020208
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0194227
LMNA lamin A/C -0.0191083
HMGA2 high mobility group AT-hook 2 -0.0189942
RPL6 ribosomal protein L6 -0.018846
LRRC23 leucine rich repeat containing 23 -0.0188109
S100A9 S100 calcium binding protein A9 -0.0187408
LOC112694756 uncharaterized LOC112694756 -0.0185891
RPS13 ribosomal protein S13 -0.0185571
TUBB4B tubulin, beta 4B class IVb -0.0184441
RPL35A ribosomal protein L35a -0.0180717
EPCAM epithelial cell adhesion molecule -0.0178315
RPS15 ribosomal protein S15 -0.0174873
FRMD5 FERM domain containing 5 -0.0173906
RPS27A ribosomal protein S27a -0.0172297
TBCA tubulin folding cofactor A -0.0171277
SCLT1 sodium channel and clathrin linker 1 -0.0167692
RPL38 ribosomal protein L38 -0.0167249
FRAS1 Fraser extracellular matrix complex subunit 1 -0.0167235
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.016561
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0162651
RHOBTB3 Rho-related BTB domain containing 3 -0.0162166
SH3BP4 SH3-domain binding protein 4 -0.0160367
RPS19 ribosomal protein S19 -0.0159252
PDE4D phosphodiesterase 4D, cAMP-specific -0.0158862
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0158157
GAS2L3 growth arrest-specific 2 like 3 -0.0156544
RGS6 regulator of G-protein signaling 6 -0.0156474
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0154779
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0152453
ZBTB7A zinc finger and BTB domain containing 7A -0.0148219
RACK1 receptor for activated C kinase 1 -0.0146817
FN1 fibronectin 1 -0.0145398
H1-4 H1.4 linker histone, cluster member -0.0141265
RPL28 ribosomal protein L28 -0.0140307
HMGB1 high mobility group box 1 -0.013876
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0137701
GPC5 glypican 5 -0.0131408
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0129918
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0128855
CCDC146 coiled-coil domain containing 146 -0.0127064
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B -0.0126327
HMGA1 high mobility group AT-hook 1 -0.0124373
BACE2 beta-site APP-cleaving enzyme 2 -0.0122655
TKT transketolase -0.0122447
RPS11 ribosomal protein S11 -0.0122139
TNRC6B trinucleotide repeat containing 6B -0.0121276
PATJ PATJ crumbs cell polarity complex component -0.0120624
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0119275
TPI1 triosephosphate isomerase 1 -0.0118407
RPS23 ribosomal protein S23 -0.0116894
TUBA1B tubulin, alpha 1b -0.0116728
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0116719
IRS1 insulin receptor substrate 1 -0.0116615
ZFHX3 zinc finger homeobox 3 -0.0116608
RPLP1 ribosomal protein, large, P1 -0.0116545
NFIA nuclear factor I/A -0.0115486
RPL36AL ribosomal protein L36a-like -0.0115069
ZNRF3 zinc and ring finger 3 -0.0112837
SHISA5 shisa family member 5 -0.0112488
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.0111628