Cytarabine (hydrochloride)_HEC-1-A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cytarabine (hydrochloride) perturbation in HEC-1-A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cytarabine (hydrochloride)_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FNDC3B fibronectin type III domain containing 3B 0.170579
ACTG1 actin gamma 1 0.149143
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.144766
AHNAK AHNAK nucleoprotein 0.107797
ENO1 enolase 1, (alpha) 0.100573
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0978598
APP amyloid beta (A4) precursor protein 0.0964404
TMSB4X thymosin beta 4, X-linked 0.0855388
LAMB3 laminin, beta 3 0.0845788
SDC4 syndecan 4 0.0766066
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0723166
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0708518
LPP LIM domain containing preferred translocation partner in lipoma 0.0704905
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0676432
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0671623
IGFBP3 insulin-like growth factor binding protein 3 0.0658959
LDHA lactate dehydrogenase A 0.0638557
RBMS3 RNA binding motif, single stranded interacting protein 3 0.062432
ZNF292 zinc finger protein 292 0.0600969
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.058142
PCBP2 poly(rC) binding protein 2 0.0563394
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0561938
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0549102
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0543678
RAD51B RAD51 paralog B 0.0533052
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0527317
B2M beta-2-microglobulin 0.0521622
UGCG UDP-glucose ceramide glucosyltransferase 0.0519876
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0516448
FXR1 fragile X mental retardation, autosomal homolog 1 0.0500165
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0494955
NAMPT nicotinamide phosphoribosyltransferase 0.0489716
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0488728
ADAM9 ADAM metallopeptidase domain 9 0.0483388
CCNL1 cyclin L1 0.048278
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0480038
RAD23B RAD23 homolog B (S. cerevisiae) 0.0478327
GARS1 glycyl-tRNA synthetase 1 0.0476901
CANX calnexin 0.0476748
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 0.0473187
PGK1 phosphoglycerate kinase 1 0.0471734
KRT7 keratin 7, type II 0.0462553
PARD3 par-3 family cell polarity regulator 0.0460232
CALR calreticulin 0.045901
HELZ helicase with zinc finger 0.045897
EIF4A2 eukaryotic translation initiation factor 4A2 0.0457684
EEF2 eukaryotic translation elongation factor 2 0.045581
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0455002
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0452006
SOD2 superoxide dismutase 2, mitochondrial 0.0445983
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0445161
ARHGAP26 Rho GTPase activating protein 26 0.0444021
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0442083
LIMCH1 LIM and calponin homology domains 1 0.043846
CSDE1 cold shock domain containing E1, RNA-binding 0.0428643
SLMAP sarcolemma associated protein 0.0422311
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0420395
FNBP1L formin binding protein 1-like 0.0419806
OSBPL10 oxysterol binding protein-like 10 0.0413255
FMNL2 formin-like 2 0.0412851
ANKRD11 ankyrin repeat domain 11 0.041043
ANXA1 annexin A1 0.0409575
MARCHF6 membrane associated ring-CH-type finger 6 0.0403947
TPM3 tropomyosin 3 0.0402535
EGFR epidermal growth factor receptor 0.0401122
WDR45B WD repeat domain 45B 0.0398289
YTHDC1 YTH domain containing 1 0.0397588
UBE2H ubiquitin-conjugating enzyme E2H 0.0390188
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0389594
ADAM10 ADAM metallopeptidase domain 10 0.0375144
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0373813
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0372947
RPL23 ribosomal protein L23 0.036888
PTMA prothymosin, alpha 0.0368625
ZFAND3 zinc finger, AN1-type domain 3 0.0368602
BIRC3 baculoviral IAP repeat containing 3 0.0368122
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0365892
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0365812
PTK2 protein tyrosine kinase 2 0.0362922
RASA2 RAS p21 protein activator 2 0.0360318
ANXA2 annexin A2 0.036024
IARS1 isoleucyl-tRNA synthetase 1 0.0359554
BHLHE40 basic helix-loop-helix family, member e40 0.0355835
KMT2E lysine (K)-specific methyltransferase 2E 0.0355311
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0353431
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0352503
USP9X ubiquitin specific peptidase 9, X-linked 0.0348782
FAM168A family with sequence similarity 168, member A 0.0346424
TXNRD1 thioredoxin reductase 1 0.0345312
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0341089
EREG epiregulin 0.0340453
WAC WW domain containing adaptor with coiled-coil 0.0340086
PDIA6 protein disulfide isomerase family A, member 6 0.0339201
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0337982
GOLGA4 golgin A4 0.0337919
AFDN afadin, adherens junction formation factor 0.0330104
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0328901
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0328281
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.032771
FBL fibrillarin 0.0327121

decreased expression

Symbol Name Standardized Value
CCND1 cyclin D1 -0.0957565
TOP2A topoisomerase (DNA) II alpha 170kDa -0.090942
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0806931
MKI67 marker of proliferation Ki-67 -0.0750222
H1-0 H1.0 linker histone -0.0619261
RPS2 ribosomal protein S2 -0.0585505
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0547005
FTL ferritin, light polypeptide -0.0543562
CENPF centromere protein F, 350/400kDa -0.0524106
MT2A metallothionein 2A -0.0514391
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0436881
PCLO piccolo presynaptic cytomatrix protein -0.0424956
ZBTB20 zinc finger and BTB domain containing 20 -0.0397341
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0390975
CDCP1 CUB domain containing protein 1 -0.0359496
PKM pyruvate kinase, muscle -0.0335682
RPL31 ribosomal protein L31 -0.032826
RPL32 ribosomal protein L32 -0.0325302
H1-4 H1.4 linker histone, cluster member -0.0319834
RFC3 replication factor C (activator 1) 3, 38kDa -0.0315102
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0310317
CENPE centromere protein E, 312kDa -0.0292145
HMGA1 high mobility group AT-hook 1 -0.0286921
DHRS2 dehydrogenase/reductase (SDR family) member 2 -0.0281125
PCNX4 pecanex 4 -0.0272633
HMGA2 high mobility group AT-hook 2 -0.0271521
ADARB1 adenosine deaminase, RNA-specific, B1 -0.0263145
PRR11 proline rich 11 -0.0261255
PATJ PATJ crumbs cell polarity complex component -0.0259479
BPTF bromodomain PHD finger transcription factor -0.0257967
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0255717
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0253748
TUBB4B tubulin, beta 4B class IVb -0.0251307
KIF18B kinesin family member 18B -0.0248913
SCLT1 sodium channel and clathrin linker 1 -0.0248254
RPS5 ribosomal protein S5 -0.0246953
GOLGB1 golgin B1 -0.0242994
SPATA13 spermatogenesis associated 13 -0.0242321
R3HDM1 R3H domain containing 1 -0.024095
CBX3 chromobox homolog 3 -0.0240361
UBXN4 UBX domain protein 4 -0.023999
TMSB10 thymosin beta 10 -0.0238372
CKAP5 cytoskeleton associated protein 5 -0.02332
ATM ATM serine/threonine kinase -0.0230635
TPX2 TPX2, microtubule-associated -0.0230137
RPL9 ribosomal protein L9 -0.0229151
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0228032
PDE4D phosphodiesterase 4D, cAMP-specific -0.022735
KIAA1328 KIAA1328 -0.0220574
GPATCH8 G patch domain containing 8 -0.0219734
ASPH aspartate beta-hydroxylase -0.0218301
ARPP19 cAMP-regulated phosphoprotein, 19kDa -0.0216529
CLTC clathrin, heavy chain (Hc) -0.0215716
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0215612
S100A10 S100 calcium binding protein A10 -0.0214576
GCC2 GRIP and coiled-coil domain containing 2 -0.0213685
RPS6 ribosomal protein S6 -0.0212386
PKP4 plakophilin 4 -0.0211842
RPL28 ribosomal protein L28 -0.0208406
FLNA filamin A, alpha -0.0207799
MPRIP myosin phosphatase Rho interacting protein -0.0207734
ZDHHC20 zinc finger, DHHC-type containing 20 -0.0204855
H1-10 H1.10 linker histone -0.0203868
TNRC6C trinucleotide repeat containing 6C -0.0203075
FNIP1 folliculin interacting protein 1 -0.0199577
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0194375
SUMF1 sulfatase modifying factor 1 -0.0192538
KIF14 kinesin family member 14 -0.0191956
MACROD2 MACRO domain containing 2 -0.0190301
BBS9 Bardet-Biedl syndrome 9 -0.0189639
DCAF7 DDB1 and CUL4 associated factor 7 -0.0188681
FBXL20 F-box and leucine-rich repeat protein 20 -0.0185277
SOS1 son of sevenless homolog 1 (Drosophila) -0.0185081
CKAP2 cytoskeleton associated protein 2 -0.0180043
EIF1 eukaryotic translation initiation factor 1 -0.0179681
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 -0.0179021
LAMA5 laminin, alpha 5 -0.0175227
KIF4A kinesin family member 4A -0.0172758
SCAPER S-phase cyclin A-associated protein in the ER -0.0171579
NSUN6 NOP2/Sun domain family, member 6 -0.0170222
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0168994
H3-3B H3.3 histone B -0.0168811
NIPBL Nipped-B homolog (Drosophila) -0.0168704
TASOR transcription activation suppressor -0.0168646
EGR1 early growth response 1 -0.0168136
ATXN1 ataxin 1 -0.0167975
NSRP1 nuclear speckle splicing regulatory protein 1 -0.0163979
RPS23 ribosomal protein S23 -0.0163824
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0161838
RPS15 ribosomal protein S15 -0.0160373
KIF18A kinesin family member 18A -0.0160282
XPO1 exportin 1 -0.0159352
FIGN fidgetin -0.0159068
ZFC3H1 zinc finger, C3H1-type containing -0.0158705
RPS24 ribosomal protein S24 -0.0158687
SPAG16 sperm associated antigen 16 -0.0158174
SMAD5 SMAD family member 5 -0.0157186
REST RE1-silencing transcription factor -0.0156893
TUG1 taurine up-regulated 1 (non-protein coding) -0.0155473
MPHOSPH8 M-phase phosphoprotein 8 -0.0155091