Cytarabine (hydrochloride)_HOP62 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cytarabine (hydrochloride) perturbation in HOP62 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cytarabine (hydrochloride)_HOP62 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.139501
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.095011
CDH13 cadherin 13 0.080945
LAMB3 laminin, beta 3 0.0705558
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0605722
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0567335
FAM13A family with sequence similarity 13, member A 0.0542539
JARID2 jumonji, AT rich interactive domain 2 0.0518797
PTMA prothymosin, alpha 0.0513726
ACTG1 actin gamma 1 0.0473608
RRM2 ribonucleotide reductase M2 0.0468437
AKAP12 A kinase (PRKA) anchor protein 12 0.0454871
STC1 stanniocalcin 1 0.0438737
TRIO trio Rho guanine nucleotide exchange factor 0.0411679
EGR1 early growth response 1 0.0381827
RPL35A ribosomal protein L35a 0.0376341
CXCL8 chemokine (C-X-C motif) ligand 8 0.0339047
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0319252
COL6A2 collagen, type VI, alpha 2 0.0318778
SEPTIN9 septin 9 0.0312732
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0312604
AFF3 AF4/FMR2 family, member 3 0.0305808
FNDC3B fibronectin type III domain containing 3B 0.0299276
MAML3 mastermind-like 3 (Drosophila) 0.0292682
RPS6 ribosomal protein S6 0.0288889
ANKRD11 ankyrin repeat domain 11 0.0286745
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.027762
FRMD4A FERM domain containing 4A 0.0274785
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0264152
SDC4 syndecan 4 0.0259856
EFNA5 ephrin-A5 0.0258837
SDK1 sidekick cell adhesion molecule 1 0.0256109
RAI14 retinoic acid induced 14 0.0253851
CLMP CXADR-like membrane protein 0.0251078
RUNX1 runt-related transcription factor 1 0.0248647
IGFBP3 insulin-like growth factor binding protein 3 0.0245533
RAD51B RAD51 paralog B 0.0240813
GRB10 growth factor receptor-bound protein 10 0.0239916
VEGFA vascular endothelial growth factor A 0.0236415
UBA6 ubiquitin-like modifier activating enzyme 6 0.0233249
COL7A1 collagen, type VII, alpha 1 0.0232295
PCBP3 poly(rC) binding protein 3 0.0230993
ADM adrenomedullin 0.0229618
TNS1 tensin 1 0.0228949
ZMYND8 zinc finger, MYND-type containing 8 0.0227322
HPCAL1 hippocalcin-like 1 0.0216353
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.021503
PDE10A phosphodiesterase 10A 0.0214628
COL6A3 collagen, type VI, alpha 3 0.0213405
BASP1 brain abundant, membrane attached signal protein 1 0.0211459
RNMT RNA (guanine-7-) methyltransferase 0.021139
DUSP6 dual specificity phosphatase 6 0.0208319
G0S2 G0/G1 switch 2 0.0203566
INHBA inhibin, beta A 0.0203427
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0203338
MAP1B microtubule-associated protein 1B 0.0202585
CALD1 caldesmon 1 0.0200193
RPL30 ribosomal protein L30 0.0199495
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0197468
NALF1 NALCN channel auxiliary factor 1 0.019535
MYO10 myosin X 0.0194546
RPS12 ribosomal protein S12 0.0193905
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0193468
FMN1 formin 1 0.0192626
WDFY2 WD repeat and FYVE domain containing 2 0.0192009
MTSS1 metastasis suppressor 1 0.0191419
LIMS1 LIM and senescent cell antigen-like domains 1 0.0191292
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0191234
TPM3 tropomyosin 3 0.0189509
GLIS3 GLIS family zinc finger 3 0.0188861
TGFBI transforming growth factor, beta-induced, 68kDa 0.018854
DIAPH2 diaphanous-related formin 2 0.0183876
FLNB filamin B, beta 0.0181157
MSN moesin 0.0181089
DTNA dystrobrevin, alpha 0.0179538
MTCL1 microtubule crosslinking factor 1 0.0177417
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0175123
RASA3 RAS p21 protein activator 3 0.017497
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0173142
CD109 CD109 molecule 0.0173039
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0171452
COL5A1 collagen, type V, alpha 1 0.0170952
MRPS6 mitochondrial ribosomal protein S6 0.017071
MARCHF3 membrane associated ring-CH-type finger 3 0.0170543
DDIT4 DNA-damage-inducible transcript 4 0.0170228
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.0168867
TTC3 tetratricopeptide repeat domain 3 0.0166521
RPL37A ribosomal protein L37a 0.016529
ETV6 ets variant 6 0.0164477
CSNK1E casein kinase 1, epsilon 0.0163228
LPP LIM domain containing preferred translocation partner in lipoma 0.0163033
ABLIM3 actin binding LIM protein family, member 3 0.0162858
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0162339
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0161718
RPS19 ribosomal protein S19 0.0161222
AKAP9 A kinase (PRKA) anchor protein 9 0.0159621
HM13 histocompatibility (minor) 13 0.0158494
CFAP20DC CFAP20 domain containing 0.0158406
SEC23A Sec23 homolog A (S. cerevisiae) 0.0156824
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0156453

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.348108
VIM vimentin -0.281757
TMSB10 thymosin beta 10 -0.107747
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.107559
UBC ubiquitin C -0.0966712
CD44 CD44 molecule (Indian blood group) -0.094281
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0915756
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0627807
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0573433
PKM pyruvate kinase, muscle -0.0509493
RPS27A ribosomal protein S27a -0.050018
ENO1 enolase 1, (alpha) -0.0481946
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0433339
HMGA2 high mobility group AT-hook 2 -0.0431312
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0401783
AHNAK AHNAK nucleoprotein -0.0398751
PDIA3 protein disulfide isomerase family A, member 3 -0.0371218
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0353839
ANKRD28 ankyrin repeat domain 28 -0.0341481
TXNIP thioredoxin interacting protein -0.0333849
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0329577
NDRG1 N-myc downstream regulated 1 -0.0300677
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0295496
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0293193
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0292965
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0290969
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0282462
EEF2 eukaryotic translation elongation factor 2 -0.0271887
FLNA filamin A, alpha -0.0270795
LDHA lactate dehydrogenase A -0.0269405
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.026886
BICD1 bicaudal D homolog 1 (Drosophila) -0.026778
TXNRD1 thioredoxin reductase 1 -0.0263459
MLPH melanophilin -0.0260826
JUN jun proto-oncogene -0.0260231
ACTN4 actinin, alpha 4 -0.0258606
THBS1 thrombospondin 1 -0.024611
PDIA6 protein disulfide isomerase family A, member 6 -0.0245047
CENPF centromere protein F, 350/400kDa -0.0241526
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0232147
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0227968
CANX calnexin -0.0220318
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0217127
ZFAND3 zinc finger, AN1-type domain 3 -0.020734
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0204451
CCND1 cyclin D1 -0.020346
FTL ferritin, light polypeptide -0.0202651
SFPQ splicing factor proline/glutamine-rich -0.0202064
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0201209
CKAP5 cytoskeleton associated protein 5 -0.0200014
PDIA4 protein disulfide isomerase family A, member 4 -0.0193027
CENPE centromere protein E, 312kDa -0.0191926
TPX2 TPX2, microtubule-associated -0.0177699
LOC112694756 uncharaterized LOC112694756 -0.01751
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0173407
TM4SF1 transmembrane 4 L six family member 1 -0.0167263
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0167021
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.016646
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0162715
VMP1 vacuole membrane protein 1 -0.0161746
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.016166
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0155731
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0154306
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.015402
KDM3A lysine (K)-specific demethylase 3A -0.015325
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0150485
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.0150255
PLEC plectin -0.0143965
RAD21 RAD21 homolog (S. pombe) -0.0143549
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0143273
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0142701
GRAMD1B GRAM domain containing 1B -0.0141221
MKI67 marker of proliferation Ki-67 -0.0141151
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.013571
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0135088
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0133893
SLC38A2 solute carrier family 38, member 2 -0.013244
IPO7 importin 7 -0.0131959
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0131603
HDLBP high density lipoprotein binding protein -0.0131521
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0129146
CCNI cyclin I -0.0128646
MED13 mediator complex subunit 13 -0.0126876
TPM1 tropomyosin 1 (alpha) -0.0123182
PCNX1 pecanex 1 -0.0122682
GLG1 golgi glycoprotein 1 -0.0119667
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0119457
PGK1 phosphoglycerate kinase 1 -0.0118982
OSMR oncostatin M receptor -0.0117131
SCLT1 sodium channel and clathrin linker 1 -0.0116767
EPAS1 endothelial PAS domain protein 1 -0.0115571
TOP2B topoisomerase (DNA) II beta 180kDa -0.0114423
RPS24 ribosomal protein S24 -0.011364
HSPA8 heat shock 70kDa protein 8 -0.0111634
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 -0.0111275
SPTAN1 spectrin, alpha, non-erythrocytic 1 -0.0111175
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -0.0110904
GNS glucosamine (N-acetyl)-6-sulfatase -0.0110856
NUP98 nucleoporin 98kDa -0.0110621
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme -0.0109429