Cytarabine (hydrochloride)_HT-29 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cytarabine (hydrochloride) perturbation in HT-29 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cytarabine (hydrochloride)_HT-29 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ATAD2 ATPase family, AAA domain containing 2 0.141858
EXT1 exostosin glycosyltransferase 1 0.113805
KMT2C lysine (K)-specific methyltransferase 2C 0.0989739
MBNL2 muscleblind-like splicing regulator 2 0.0844124
DSCAM Down syndrome cell adhesion molecule 0.0815329
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0813827
GOLGA4 golgin A4 0.0762473
KDM2A lysine (K)-specific demethylase 2A 0.0748444
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0734295
FNDC3B fibronectin type III domain containing 3B 0.0732386
PCBP2 poly(rC) binding protein 2 0.0722735
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0677037
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0665609
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0639006
KDM6A lysine (K)-specific demethylase 6A 0.0633522
TSC22D2 TSC22 domain family, member 2 0.0621992
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.06206
LDHA lactate dehydrogenase A 0.059379
APLP2 amyloid beta (A4) precursor-like protein 2 0.0589428
CCNY cyclin Y 0.0582276
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0576169
PDIA3 protein disulfide isomerase family A, member 3 0.0567938
PTK2 protein tyrosine kinase 2 0.054099
ANKRD11 ankyrin repeat domain 11 0.0537047
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0531894
DIAPH3 diaphanous-related formin 3 0.0527812
NDRG1 N-myc downstream regulated 1 0.0523856
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0505683
NUP58 nucleoporin 58 0.0504189
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0493949
FAM13A family with sequence similarity 13, member A 0.0491447
HYOU1 hypoxia up-regulated 1 0.0485298
FAM91A1 family with sequence similarity 91, member A1 0.0484907
IARS1 isoleucyl-tRNA synthetase 1 0.0480365
B2M beta-2-microglobulin 0.0453918
AKAP9 A kinase (PRKA) anchor protein 9 0.0449504
SPAG9 sperm associated antigen 9 0.044797
RTN3 reticulon 3 0.044127
HELZ helicase with zinc finger 0.0437897
ZFAND3 zinc finger, AN1-type domain 3 0.0428691
KMT2E lysine (K)-specific methyltransferase 2E 0.0417933
PAWR PRKC, apoptosis, WT1, regulator 0.0412356
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0411906
SUCO SUN domain containing ossification factor 0.0400552
BRD2 bromodomain containing 2 0.0398505
EEF2 eukaryotic translation elongation factor 2 0.0390715
DIAPH1 diaphanous-related formin 1 0.0389176
PDS5B PDS5 cohesin associated factor B 0.0387291
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 0.0384687
FBXO32 F-box protein 32 0.0380474
PELI1 pellino E3 ubiquitin protein ligase 1 0.0378905
CCNL1 cyclin L1 0.0374799
BIRC6 baculoviral IAP repeat containing 6 0.037328
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0369847
PTEN phosphatase and tensin homolog 0.0369082
OGA O-GlcNAcase 0.0368098
IFRD1 interferon-related developmental regulator 1 0.0366216
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0365612
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0359646
TMEM65 transmembrane protein 65 0.0359324
RPL21 ribosomal protein L21 0.0357752
PDIA6 protein disulfide isomerase family A, member 6 0.0353669
ARHGAP26 Rho GTPase activating protein 26 0.0353367
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.0344973
NCKAP1 NCK-associated protein 1 0.0344781
USP3 ubiquitin specific peptidase 3 0.0343891
PUM2 pumilio RNA-binding family member 2 0.0343749
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0343641
CDK8 cyclin-dependent kinase 8 0.0340767
YME1L1 YME1-like 1 ATPase 0.0339807
SND1 staphylococcal nuclease and tudor domain containing 1 0.0338446
SPINT2 serine peptidase inhibitor, Kunitz type, 2 0.033793
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0337591
COPA coatomer protein complex, subunit alpha 0.0337518
NBAS neuroblastoma amplified sequence 0.0335144
VEGFA vascular endothelial growth factor A 0.0332756
FXR1 fragile X mental retardation, autosomal homolog 1 0.0329742
KRT8 keratin 8, type II 0.0328677
RBM33 RNA binding motif protein 33 0.032846
ZNF292 zinc finger protein 292 0.0328303
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0324864
XPO1 exportin 1 0.0322754
TPM3 tropomyosin 3 0.0321996
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0318009
EIF4B eukaryotic translation initiation factor 4B 0.0317745
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0317349
RTN4 reticulon 4 0.0316919
RREB1 ras responsive element binding protein 1 0.031605
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0315768
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0313811
NCAPG2 non-SMC condensin II complex, subunit G2 0.0313258
PHF20L1 PHD finger protein 20-like 1 0.0312836
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0312302
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.03109
ZNF638 zinc finger protein 638 0.030777
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0307751
EIF3H eukaryotic translation initiation factor 3, subunit H 0.0307118
TTC3 tetratricopeptide repeat domain 3 0.0306683
CALU calumenin 0.0306536
SUZ12 SUZ12 polycomb repressive complex 2 subunit 0.0305923

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.146485
LAMA4 laminin, alpha 4 -0.0912589
PTMA prothymosin, alpha -0.0749913
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0748368
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 -0.0712289
TMSB10 thymosin beta 10 -0.0638303
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0619154
ACTN4 actinin, alpha 4 -0.0599486
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0580793
EGR1 early growth response 1 -0.0577458
RPS24 ribosomal protein S24 -0.0562895
PLAUR plasminogen activator, urokinase receptor -0.0556378
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0547442
TRIB1 tribbles pseudokinase 1 -0.0536781
SLC45A4 solute carrier family 45, member 4 -0.0536612
MAML3 mastermind-like 3 (Drosophila) -0.050324
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0466932
KLF3 Kruppel-like factor 3 (basic) -0.0444375
ZBTB20 zinc finger and BTB domain containing 20 -0.0427618
KRT20 keratin 20, type I -0.0422113
H1-0 H1.0 linker histone -0.0414101
CENPF centromere protein F, 350/400kDa -0.0413231
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -0.040415
NECTIN2 nectin cell adhesion molecule 2 -0.0386231
PRKN parkin RBR E3 ubiquitin protein ligase -0.0373796
LOC102724023 ES1 protein homolog, mitochondrial -0.0372995
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0370945
TMEM123 transmembrane protein 123 -0.0370903
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0359804
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.0355829
C6ORF132 chromosome 6 open reading frame 132 -0.0354994
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0337897
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0333533
POF1B premature ovarian failure, 1B -0.0330785
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.0329322
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0323305
SMAD3 SMAD family member 3 -0.0321228
TM4SF1 transmembrane 4 L six family member 1 -0.0319354
EZR ezrin -0.0319292
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0317984
MKI67 marker of proliferation Ki-67 -0.0313052
WNT2B wingless-type MMTV integration site family, member 2B -0.0308038
CENPE centromere protein E, 312kDa -0.0306502
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.0303519
KLF10 Kruppel-like factor 10 -0.0301267
ZMYND8 zinc finger, MYND-type containing 8 -0.0300632
ETV6 ets variant 6 -0.0297932
STK24 serine/threonine kinase 24 -0.029528
PTPRK protein tyrosine phosphatase, receptor type, K -0.0290332
RPS6 ribosomal protein S6 -0.0289461
SULF2 sulfatase 2 -0.0289385
AREG amphiregulin -0.0286412
CD2AP CD2-associated protein -0.028441
KLF6 Kruppel-like factor 6 -0.0281137
PYGB phosphorylase, glycogen; brain -0.0280735
LMO7 LIM domain 7 -0.0273516
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0269678
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0269427
RPL35A ribosomal protein L35a -0.0265755
ASPH aspartate beta-hydroxylase -0.0263146
SLC38A1 solute carrier family 38, member 1 -0.0260394
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0257969
RPL12 ribosomal protein L12 -0.0256311
TRAPPC9 trafficking protein particle complex 9 -0.0254234
TUBB4B tubulin, beta 4B class IVb -0.0251905
RPL34 ribosomal protein L34 -0.0250496
DIAPH2 diaphanous-related formin 2 -0.0249539
HMGB1 high mobility group box 1 -0.0244224
VIM vimentin -0.0243399
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0240956
SEPTIN9 septin 9 -0.0231302
BPTF bromodomain PHD finger transcription factor -0.0230986
STAU1 staufen double-stranded RNA binding protein 1 -0.0230983
S100A10 S100 calcium binding protein A10 -0.0230482
ZBTB7A zinc finger and BTB domain containing 7A -0.022991
RHPN2 rhophilin, Rho GTPase binding protein 2 -0.0228749
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0227876
RPL6 ribosomal protein L6 -0.0226847
NTSR1 neurotensin receptor 1 (high affinity) -0.0225178
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.022249
CCSER1 coiled-coil serine-rich protein 1 -0.0219271
MIDN midnolin -0.0218975
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0217329
GSN gelsolin -0.0212823
ABLIM1 actin binding LIM protein 1 -0.0207617
LMNA lamin A/C -0.0207276
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0204448
RAD21 RAD21 homolog (S. pombe) -0.0203727
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0202738
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 -0.0201296
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0199401
IER3 immediate early response 3 -0.0196646
MLLT6 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 -0.0195423
ITGA1 integrin, alpha 1 -0.0194149
B4GALNT3 beta-1,4-N-acetyl-galactosaminyl transferase 3 -0.0192779
RPS25 ribosomal protein S25 -0.0192226
SLC38A2 solute carrier family 38, member 2 -0.0190679
FOXP1 forkhead box P1 -0.018853
POMP proteasome maturation protein -0.0187522
KLF13 Kruppel-like factor 13 -0.0187305