Cytarabine (hydrochloride)_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cytarabine (hydrochloride) perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cytarabine (hydrochloride)_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MEF2A myocyte enhancer factor 2A 0.175368
TRIO trio Rho guanine nucleotide exchange factor 0.137561
KIAA1217 KIAA1217 0.116491
MTSS1 metastasis suppressor 1 0.11227
CEMIP cell migration inducing protein, hyaluronan binding 0.110151
AHNAK AHNAK nucleoprotein 0.0964238
CLU clusterin 0.0943005
MSN moesin 0.0919554
MYH9 myosin, heavy chain 9, non-muscle 0.0817984
FLNB filamin B, beta 0.0805513
ENO1 enolase 1, (alpha) 0.0779939
ITCH itchy E3 ubiquitin protein ligase 0.0779618
RICTOR RPTOR independent companion of MTOR, complex 2 0.0758125
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0718822
ITGA6 integrin, alpha 6 0.0716925
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0687154
OGA O-GlcNAcase 0.0667003
TPM3 tropomyosin 3 0.0639868
SLC35F3 solute carrier family 35, member F3 0.0638737
PLEC plectin 0.0637063
SMAD3 SMAD family member 3 0.0636332
SULF1 sulfatase 1 0.0627592
MYO10 myosin X 0.0618235
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.061583
RAI14 retinoic acid induced 14 0.0613726
FNIP1 folliculin interacting protein 1 0.0612125
NAMPT nicotinamide phosphoribosyltransferase 0.0584095
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 0.0579478
MYOF myoferlin 0.056854
PTK2 protein tyrosine kinase 2 0.0553866
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0547215
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0536068
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0535114
ESYT2 extended synaptotagmin-like protein 2 0.0527299
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0526948
BLCAP bladder cancer associated protein 0.0524822
MACF1 microtubule-actin crosslinking factor 1 0.051869
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0513202
KDM6A lysine (K)-specific demethylase 6A 0.0509865
KMT2E lysine (K)-specific methyltransferase 2E 0.0508547
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0507409
RIN2 Ras and Rab interactor 2 0.0502458
ARRDC3 arrestin domain containing 3 0.0499515
ZNF292 zinc finger protein 292 0.0498722
GRB10 growth factor receptor-bound protein 10 0.04973
SLK STE20-like kinase 0.0494729
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0490889
ASPH aspartate beta-hydroxylase 0.0482814
SH3PXD2A SH3 and PX domains 2A 0.0477845
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0472369
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0468349
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0464632
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0455267
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0451326
SERINC3 serine incorporator 3 0.0447942
TGM2 transglutaminase 2 0.0445487
LAMC2 laminin, gamma 2 0.0439494
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.0436991
UBA6 ubiquitin-like modifier activating enzyme 6 0.043313
AKAP13 A kinase (PRKA) anchor protein 13 0.0431769
ARHGAP29 Rho GTPase activating protein 29 0.0430618
RAD51B RAD51 paralog B 0.0430275
NCOR2 nuclear receptor corepressor 2 0.0429327
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0423636
TIMP3 TIMP metallopeptidase inhibitor 3 0.0421294
PODXL podocalyxin-like 0.0418518
BZW1 basic leucine zipper and W2 domains 1 0.0413984
YEATS2 YEATS domain containing 2 0.0409088
JAG1 jagged 1 0.0409014
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0407852
ZEB1 zinc finger E-box binding homeobox 1 0.0406078
PRELID2 PRELI domain containing 2 0.0403073
KRT17 keratin 17, type I 0.0396856
MBNL2 muscleblind-like splicing regulator 2 0.0394434
PSD3 pleckstrin and Sec7 domain containing 3 0.0393565
TNIP1 TNFAIP3 interacting protein 1 0.0390706
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 0.0389981
ANKH ANKH inorganic pyrophosphate transport regulator 0.0388251
GOLGA4 golgin A4 0.0388208
SDC4 syndecan 4 0.0385235
DOK5 docking protein 5 0.0379005
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0376499
STC1 stanniocalcin 1 0.0375983
CANX calnexin 0.0370611
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 0.0370058
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.036866
ADAM10 ADAM metallopeptidase domain 10 0.0368659
LNPEP leucyl/cystinyl aminopeptidase 0.0366118
MCL1 myeloid cell leukemia 1 0.0364108
DIDO1 death inducer-obliterator 1 0.036313
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0362186
AKAP9 A kinase (PRKA) anchor protein 9 0.0359832
CUL4B cullin 4B 0.0357905
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0356284
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0355731
NBAS neuroblastoma amplified sequence 0.0355672
PGK1 phosphoglycerate kinase 1 0.0355271
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0352181
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0352118
APLP2 amyloid beta (A4) precursor-like protein 2 0.0350148

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.213727
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.108584
TMSB10 thymosin beta 10 -0.0833611
MT2A metallothionein 2A -0.0674345
H1-0 H1.0 linker histone -0.0663287
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0624254
S100A10 S100 calcium binding protein A10 -0.0602216
INTS6 integrator complex subunit 6 -0.055855
PDLIM5 PDZ and LIM domain 5 -0.0524815
ALCAM activated leukocyte cell adhesion molecule -0.0495542
RASAL2 RAS protein activator like 2 -0.0458044
IFITM3 interferon induced transmembrane protein 3 -0.0445434
PALLD palladin, cytoskeletal associated protein -0.0432135
CD44 CD44 molecule (Indian blood group) -0.0417601
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0400802
EGR1 early growth response 1 -0.0397765
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0393645
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0393208
LMO7 LIM domain 7 -0.0391998
MBNL1 muscleblind-like splicing regulator 1 -0.0377406
MT1X metallothionein 1X -0.0362631
TPT1 tumor protein, translationally-controlled 1 -0.0355399
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0350744
SLC38A2 solute carrier family 38, member 2 -0.0339746
MKI67 marker of proliferation Ki-67 -0.0337032
LAMA5 laminin, alpha 5 -0.0335615
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.03218
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0317653
RPLP2 ribosomal protein, large, P2 -0.031435
CNTNAP3 contactin associated protein-like 3 -0.0307718
PTMA prothymosin, alpha -0.0301116
IFITM1 interferon induced transmembrane protein 1 -0.029198
HLA-B major histocompatibility complex, class I, B -0.0290814
RPLP1 ribosomal protein, large, P1 -0.0279348
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0276493
OSMR oncostatin M receptor -0.0274193
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0274167
RRBP1 ribosome binding protein 1 -0.0273843
HMGA2 high mobility group AT-hook 2 -0.0270497
IGF2 insulin-like growth factor 2 -0.0270076
LOC112694756 uncharaterized LOC112694756 -0.0269501
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0266244
FTL ferritin, light polypeptide -0.0264124
FTH1 ferritin, heavy polypeptide 1 -0.0263967
MORF4L2 mortality factor 4 like 2 -0.0262981
RPL12 ribosomal protein L12 -0.0257707
CENPF centromere protein F, 350/400kDa -0.0256884
ACTN4 actinin, alpha 4 -0.0256637
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A -0.0249649
CAPZB capping protein (actin filament) muscle Z-line, beta -0.0246308
CNRIP1 cannabinoid receptor interacting protein 1 -0.0244402
GNAS GNAS complex locus -0.0242277
CORO2A coronin, actin binding protein, 2A -0.0242073
RPS13 ribosomal protein S13 -0.0240495
DUSP6 dual specificity phosphatase 6 -0.0236131
RPL35A ribosomal protein L35a -0.0234812
RAP1B RAP1B, member of RAS oncogene family -0.0234393
AOPEP aminopeptidase O (putative) -0.022968
WNT2B wingless-type MMTV integration site family, member 2B -0.0226724
FBXO11 F-box protein 11 -0.0221013
LMNA lamin A/C -0.0220963
HSPG2 heparan sulfate proteoglycan 2 -0.0220175
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0219731
S100A9 S100 calcium binding protein A9 -0.0219108
RPS6 ribosomal protein S6 -0.0212529
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0202286
S100A4 S100 calcium binding protein A4 -0.0202001
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0198935
SULF2 sulfatase 2 -0.0198584
EIF1 eukaryotic translation initiation factor 1 -0.0196962
TJP1 tight junction protein 1 -0.019685
NDRG1 N-myc downstream regulated 1 -0.0196834
RPL32 ribosomal protein L32 -0.0196183
RPS21 ribosomal protein S21 -0.0191476
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0191269
RPL34 ribosomal protein L34 -0.0189184
SLC38A1 solute carrier family 38, member 1 -0.0188883
IER3 immediate early response 3 -0.0186219
FSCN1 fascin actin-bundling protein 1 -0.018591
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0185569
IGFBP4 insulin-like growth factor binding protein 4 -0.0184835
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0184783
RPL8 ribosomal protein L8 -0.0183912
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0179826
AGO2 argonaute RISC catalytic component 2 -0.0178311
ITSN1 intersectin 1 (SH3 domain protein) -0.0177693
DACH1 dachshund family transcription factor 1 -0.0176551
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.0175371
IFI6 interferon, alpha-inducible protein 6 -0.0173925
REEP3 receptor accessory protein 3 -0.0173612
S100A11 S100 calcium binding protein A11 -0.0172308
RPS24 ribosomal protein S24 -0.017114
FUS FUS RNA binding protein -0.0170613
IFI27 interferon, alpha-inducible protein 27 -0.0169701
S100A2 S100 calcium binding protein A2 -0.0169636
CTBP2 C-terminal binding protein 2 -0.0168746
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0167087
HLA-A major histocompatibility complex, class I, A -0.01659
RCOR1 REST corepressor 1 -0.0165443
VCL vinculin -0.0165175