Cytarabine (hydrochloride)_J82 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cytarabine (hydrochloride) perturbation in J82 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cytarabine (hydrochloride)_J82 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TRIO trio Rho guanine nucleotide exchange factor 0.133738
NALF1 NALCN channel auxiliary factor 1 0.102342
FNDC3B fibronectin type III domain containing 3B 0.0765428
EXT1 exostosin glycosyltransferase 1 0.0740966
ATP13A3 ATPase type 13A3 0.0698824
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0561679
ZNF841 zinc finger protein 841 0.043883
DIAPH3 diaphanous-related formin 3 0.0423098
AKAP12 A kinase (PRKA) anchor protein 12 0.0394853
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0393779
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0392141
DST dystonin 0.038987
ATAD2 ATPase family, AAA domain containing 2 0.0386012
SDK1 sidekick cell adhesion molecule 1 0.037534
RAI14 retinoic acid induced 14 0.0361359
COL5A1 collagen, type V, alpha 1 0.035623
PHACTR1 phosphatase and actin regulator 1 0.0344793
FLNB filamin B, beta 0.0328997
SDC4 syndecan 4 0.032889
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0315855
SLC12A8 solute carrier family 12, member 8 0.0310871
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0310476
NAV2 neuron navigator 2 0.0307556
PICALM phosphatidylinositol binding clathrin assembly protein 0.0306455
TMEM178B transmembrane protein 178B 0.0303188
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0295331
UBA6 ubiquitin-like modifier activating enzyme 6 0.0291153
HLA-C major histocompatibility complex, class I, C 0.0280417
TGFB2 transforming growth factor, beta 2 0.0270675
GLIS3 GLIS family zinc finger 3 0.026441
TPM3 tropomyosin 3 0.0263576
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0258352
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0255633
SULF1 sulfatase 1 0.0249774
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 0.0247288
MYH9 myosin, heavy chain 9, non-muscle 0.0247085
SMAD3 SMAD family member 3 0.0246813
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0239994
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.023859
ZEB2 zinc finger E-box binding homeobox 2 0.0236763
SPAG9 sperm associated antigen 9 0.0225959
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.0224772
CCDC14 coiled-coil domain containing 14 0.0224398
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0222765
TRPC4 transient receptor potential cation channel, subfamily C, member 4 0.0218975
NUP153 nucleoporin 153kDa 0.0209987
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0208876
SOD2 superoxide dismutase 2, mitochondrial 0.0206128
ELL2 elongation factor, RNA polymerase II, 2 0.0204461
MACF1 microtubule-actin crosslinking factor 1 0.0201815
LPP LIM domain containing preferred translocation partner in lipoma 0.0198168
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit 0.0198051
DENND5A DENN/MADD domain containing 5A 0.0195959
BZW1 basic leucine zipper and W2 domains 1 0.0195417
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.019525
DLG1 discs, large homolog 1 (Drosophila) 0.0193528
SUCO SUN domain containing ossification factor 0.0189998
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.018895
COL7A1 collagen, type VII, alpha 1 0.0188782
COL4A2 collagen, type IV, alpha 2 0.0185912
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0185427
STK4 serine/threonine kinase 4 0.0185289
ITCH itchy E3 ubiquitin protein ligase 0.0183735
SAMD4A sterile alpha motif domain containing 4A 0.0182637
EGFR epidermal growth factor receptor 0.0182239
ANKRD36 ankyrin repeat domain 36 0.0181928
RNF144B ring finger protein 144B 0.0179483
CEP250 centrosomal protein 250kDa 0.0179407
COL5A2 collagen, type V, alpha 2 0.0177071
SETX senataxin 0.0176028
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0175876
FSTL1 follistatin-like 1 0.0175049
ANKRD10 ankyrin repeat domain 10 0.0173998
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0173531
AGTPBP1 ATP/GTP binding protein 1 0.0171728
MAML2 mastermind-like 2 (Drosophila) 0.0169434
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0169009
ANO6 anoctamin 6 0.0168985
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0168648
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 0.0167506
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0167489
RRM2 ribonucleotide reductase M2 0.0167064
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae) 0.0166902
BCL2L1 BCL2-like 1 0.0166823
HEG1 heart development protein with EGF-like domains 1 0.016646
DRAM1 DNA-damage regulated autophagy modulator 1 0.0166195
YME1L1 YME1-like 1 ATPase 0.0163537
STARD13 StAR-related lipid transfer (START) domain containing 13 0.0163062
NAMPT nicotinamide phosphoribosyltransferase 0.0162822
YEATS2 YEATS domain containing 2 0.0162676
GRAMD2B GRAM domain containing 2B 0.0159265
DSCAM Down syndrome cell adhesion molecule 0.0157423
TMEM41B transmembrane protein 41B 0.0154789
LIMCH1 LIM and calponin homology domains 1 0.0153701
GOLGA2 golgin A2 0.0153398
PIAS2 protein inhibitor of activated STAT, 2 0.0153304
FAF1 Fas (TNFRSF6) associated factor 1 0.0153291
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0152423
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0152256
MARCHF6 membrane associated ring-CH-type finger 6 0.0151905

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.285434
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.232539
MT2A metallothionein 2A -0.219984
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.210893
HLA-B major histocompatibility complex, class I, B -0.140417
TMSB10 thymosin beta 10 -0.0881399
MT1X metallothionein 1X -0.0799513
RPS6 ribosomal protein S6 -0.0632356
NDRG1 N-myc downstream regulated 1 -0.0611729
B2M beta-2-microglobulin -0.0602096
VIM vimentin -0.0561242
FTH1 ferritin, heavy polypeptide 1 -0.053775
DEK DEK proto-oncogene -0.0499673
MARCKS myristoylated alanine-rich protein kinase C substrate -0.049118
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0462899
RPLP2 ribosomal protein, large, P2 -0.0455974
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0453718
RPL35A ribosomal protein L35a -0.0448289
PTMA prothymosin, alpha -0.0434819
S100A10 S100 calcium binding protein A10 -0.0420357
PKM pyruvate kinase, muscle -0.0418632
ENO1 enolase 1, (alpha) -0.0411478
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0402369
TXNRD1 thioredoxin reductase 1 -0.0399412
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0368074
TPT1 tumor protein, translationally-controlled 1 -0.0367403
POTEF POTE ankyrin domain family, member F -0.0366875
RPS8 ribosomal protein S8 -0.0360433
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0354164
PFN1 profilin 1 -0.0352277
UBC ubiquitin C -0.0351975
CENPF centromere protein F, 350/400kDa -0.033921
IFITM3 interferon induced transmembrane protein 3 -0.0333965
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0326629
IFI6 interferon, alpha-inducible protein 6 -0.0321371
IGFBP3 insulin-like growth factor binding protein 3 -0.032001
PDIA3 protein disulfide isomerase family A, member 3 -0.030647
RPL23 ribosomal protein L23 -0.0303326
RPL12 ribosomal protein L12 -0.0303195
TUBB4B tubulin, beta 4B class IVb -0.0301279
RPS19 ribosomal protein S19 -0.0300545
FOSL1 FOS-like antigen 1 -0.0299679
HLA-A major histocompatibility complex, class I, A -0.0295262
RPLP1 ribosomal protein, large, P1 -0.0294543
EIF1 eukaryotic translation initiation factor 1 -0.0294207
LDHA lactate dehydrogenase A -0.0293861
TUBB tubulin, beta class I -0.029272
ANXA2 annexin A2 -0.0286578
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0279541
RPL8 ribosomal protein L8 -0.0276062
F3 coagulation factor III (thromboplastin, tissue factor) -0.027603
TPI1 triosephosphate isomerase 1 -0.0269094
RPS13 ribosomal protein S13 -0.0268702
HMGB1 high mobility group box 1 -0.0265955
CCND1 cyclin D1 -0.0260369
RPS23 ribosomal protein S23 -0.025441
RPL32 ribosomal protein L32 -0.0249777
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0249434
RPL19 ribosomal protein L19 -0.0248659
SQSTM1 sequestosome 1 -0.0244975
RPL31 ribosomal protein L31 -0.0244695
RPL5 ribosomal protein L5 -0.0244034
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0243673
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0239653
RPL37 ribosomal protein L37 -0.0239142
FN1 fibronectin 1 -0.0237979
RPL28 ribosomal protein L28 -0.0236915
RPL11 ribosomal protein L11 -0.0236404
HMGA1 high mobility group AT-hook 1 -0.0235804
MKI67 marker of proliferation Ki-67 -0.0234717
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0234555
MAP1B microtubule-associated protein 1B -0.0230991
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0230498
LOC112694756 uncharaterized LOC112694756 -0.0230439
ACTG1 actin gamma 1 -0.0227548
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0224642
RPL35 ribosomal protein L35 -0.0224513
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0224294
GNAS GNAS complex locus -0.0222241
BASP1 brain abundant, membrane attached signal protein 1 -0.0221647
KRT7 keratin 7, type II -0.0217038
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0213997
RPS24 ribosomal protein S24 -0.0212634
VDAC1 voltage-dependent anion channel 1 -0.0208498
LMNA lamin A/C -0.0202285
CTSD cathepsin D -0.0198557
S100A11 S100 calcium binding protein A11 -0.0197454
RPL34 ribosomal protein L34 -0.0195806
RPL36 ribosomal protein L36 -0.0193306
SLC38A2 solute carrier family 38, member 2 -0.0189148
TPM1 tropomyosin 1 (alpha) -0.0188443
RPL27A ribosomal protein L27a -0.0186929
PRRC2C proline-rich coiled-coil 2C -0.0184946
YBX1 Y box binding protein 1 -0.0184065
NOL7 nucleolar protein 7, 27kDa -0.0183726
CD44 CD44 molecule (Indian blood group) -0.0183059
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.018213
RPL7A ribosomal protein L7a -0.0182009
CBX3 chromobox homolog 3 -0.018164
ATP5F1E ATP synthase F1 subunit epsilon -0.0180821