Cytarabine (hydrochloride)_LOX-IMVI Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cytarabine (hydrochloride) perturbation in LOX-IMVI cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cytarabine (hydrochloride)_LOX-IMVI drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.173179
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.093567
DTNA dystrobrevin, alpha 0.0927694
ENKUR enkurin, TRPC channel interacting protein 0.0751543
DST dystonin 0.0669775
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0632829
LSAMP limbic system-associated membrane protein 0.0630547
RUNX1 runt-related transcription factor 1 0.0589674
TRIO trio Rho guanine nucleotide exchange factor 0.0586097
MMP12 matrix metallopeptidase 12 0.0571205
CD109 CD109 molecule 0.0541973
ZNF292 zinc finger protein 292 0.0527907
NUP58 nucleoporin 58 0.0525488
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0505773
KDM3A lysine (K)-specific demethylase 3A 0.0485196
SPAG9 sperm associated antigen 9 0.0443595
TLE4 transducin-like enhancer of split 4 0.0442186
PTCHD4 patched domain containing 4 0.0439696
EFNA5 ephrin-A5 0.0433639
MCTP1 multiple C2 domains, transmembrane 1 0.0428367
PICALM phosphatidylinositol binding clathrin assembly protein 0.0411952
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0409413
ASCC3 activating signal cointegrator 1 complex subunit 3 0.040731
SAMD4A sterile alpha motif domain containing 4A 0.0406455
ADAM9 ADAM metallopeptidase domain 9 0.039919
GLS2 glutaminase 2 (liver, mitochondrial) 0.0385851
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0374285
APP amyloid beta (A4) precursor protein 0.0371537
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.03712
MARCHF6 membrane associated ring-CH-type finger 6 0.0369478
FNDC3B fibronectin type III domain containing 3B 0.0368755
ELL2 elongation factor, RNA polymerase II, 2 0.0366135
MAPKAP1 mitogen-activated protein kinase associated protein 1 0.0359528
ETNK1 ethanolamine kinase 1 0.0357816
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0356532
MYO6 myosin VI 0.0345946
MED13L mediator complex subunit 13-like 0.0342289
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0341304
AHNAK AHNAK nucleoprotein 0.0340532
HDAC9 histone deacetylase 9 0.0331331
NCKAP1 NCK-associated protein 1 0.0326459
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0323472
ZFAND3 zinc finger, AN1-type domain 3 0.0319181
CSMD3 CUB and Sushi multiple domains 3 0.0319151
WDR43 WD repeat domain 43 0.0318731
MYO10 myosin X 0.0317271
WDR45B WD repeat domain 45B 0.0317041
HOOK2 hook microtubule-tethering protein 2 0.0315263
KIAA1217 KIAA1217 0.0313842
EIF4B eukaryotic translation initiation factor 4B 0.0307893
PUM2 pumilio RNA-binding family member 2 0.030773
RBM39 RNA binding motif protein 39 0.0307116
DDB2 damage-specific DNA binding protein 2, 48kDa 0.0300829
HELZ helicase with zinc finger 0.0297667
CDC73 cell division cycle 73 0.0296298
YBX3 Y box binding protein 3 0.0290144
FGFR1 fibroblast growth factor receptor 1 0.0289964
WSB1 WD repeat and SOCS box containing 1 0.0288319
RTTN rotatin 0.0280443
MAST4 microtubule associated serine/threonine kinase family member 4 0.0274179
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.027276
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.027206
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0265261
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0263897
ZMYM2 zinc finger, MYM-type 2 0.0262873
GPC6 glypican 6 0.026196
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0261129
CORO1C coronin, actin binding protein, 1C 0.0260965
PDE4D phosphodiesterase 4D, cAMP-specific 0.0260046
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.025985
FMN1 formin 1 0.025856
OGA O-GlcNAcase 0.0257323
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0251188
PLK2 polo-like kinase 2 0.0249072
ZEB1 zinc finger E-box binding homeobox 1 0.0246205
MSR1 macrophage scavenger receptor 1 0.0245358
PGK1 phosphoglycerate kinase 1 0.0245031
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0244216
APLP2 amyloid beta (A4) precursor-like protein 2 0.0244017
RLF rearranged L-myc fusion 0.0243081
GSK3B glycogen synthase kinase 3 beta 0.0242468
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0239441
NAV3 neuron navigator 3 0.0238237
MON2 MON2 homolog (S. cerevisiae) 0.0237963
ATP13A3 ATPase type 13A3 0.0237662
CFAP251 cilia and flagella associated protein 251 0.0234281
GPHN gephyrin 0.0233321
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.023109
NGLY1 N-glycanase 1 0.0230778
RNF145 ring finger protein 145 0.022956
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0228941
RBMS3 RNA binding motif, single stranded interacting protein 3 0.022787
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0225202
BIRC6 baculoviral IAP repeat containing 6 0.0221851
TMPRSS15 transmembrane protease, serine 15 0.0221023
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 0.0220229
DIAPH3 diaphanous-related formin 3 0.0219859
ZFC3H1 zinc finger, C3H1-type containing 0.0218662
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0214476
NALF1 NALCN channel auxiliary factor 1 0.0213676

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.41558
VIM vimentin -0.19204
TMSB10 thymosin beta 10 -0.133964
RPS6 ribosomal protein S6 -0.10296
MT2A metallothionein 2A -0.102465
FTL ferritin, light polypeptide -0.0873566
PTMA prothymosin, alpha -0.0817205
AKAP12 A kinase (PRKA) anchor protein 12 -0.0660791
EGR1 early growth response 1 -0.0633944
RPL35A ribosomal protein L35a -0.0545386
RPLP1 ribosomal protein, large, P1 -0.0544176
TPT1 tumor protein, translationally-controlled 1 -0.0528182
RPLP2 ribosomal protein, large, P2 -0.0506388
RPS19 ribosomal protein S19 -0.0505376
RPS12 ribosomal protein S12 -0.0499227
RPL23 ribosomal protein L23 -0.0477278
RPL37A ribosomal protein L37a -0.0465584
RPS8 ribosomal protein S8 -0.0427615
RPS3 ribosomal protein S3 -0.041879
POTEF POTE ankyrin domain family, member F -0.0412578
VCL vinculin -0.0409923
RPL12 ribosomal protein L12 -0.0407673
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0403169
RPS13 ribosomal protein S13 -0.0381453
HMGA1 high mobility group AT-hook 1 -0.0372175
KIAA1549L KIAA1549-like -0.0349197
RPL19 ribosomal protein L19 -0.0348505
EIF1 eukaryotic translation initiation factor 1 -0.0344306
RPL36 ribosomal protein L36 -0.0336381
RPL8 ribosomal protein L8 -0.0332542
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.033029
RPS25 ribosomal protein S25 -0.032576
PFN1 profilin 1 -0.031867
RPS23 ribosomal protein S23 -0.0312875
PKM pyruvate kinase, muscle -0.0308068
RPLP0 ribosomal protein, large, P0 -0.0299244
RPL31 ribosomal protein L31 -0.029588
NDRG1 N-myc downstream regulated 1 -0.0291309
RPL26 ribosomal protein L26 -0.0290322
RACK1 receptor for activated C kinase 1 -0.0289156
RPS27A ribosomal protein S27a -0.0285165
RPL9 ribosomal protein L9 -0.0284487
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0258636
NTM neurotrimin -0.0256958
RPL28 ribosomal protein L28 -0.0255622
SLC38A2 solute carrier family 38, member 2 -0.0254685
RPS14 ribosomal protein S14 -0.0252961
RPS17 ribosomal protein S17 -0.0252477
RPS29 ribosomal protein S29 -0.0245883
RPL11 ribosomal protein L11 -0.0241463
RPL5 ribosomal protein L5 -0.024146
RPL35 ribosomal protein L35 -0.0237127
LOC112694756 uncharaterized LOC112694756 -0.02369
LOC102724023 ES1 protein homolog, mitochondrial -0.0229267
RPL36A ribosomal protein L36a -0.0228414
RPL34 ribosomal protein L34 -0.02221
RPL18 ribosomal protein L18 -0.0221651
RPL27A ribosomal protein L27a -0.0219341
LDHA lactate dehydrogenase A -0.0215231
RPL13A ribosomal protein L13a -0.0211155
NAV1 neuron navigator 1 -0.0209094
HMGA2 high mobility group AT-hook 2 -0.0208199
TPM4 tropomyosin 4 -0.0207166
ZBTB20 zinc finger and BTB domain containing 20 -0.0205196
RPL7A ribosomal protein L7a -0.0200898
RPS2 ribosomal protein S2 -0.0200294
CSTB cystatin B (stefin B) -0.019906
RPL37 ribosomal protein L37 -0.0198887
RPS27 ribosomal protein S27 -0.019695
RPS16 ribosomal protein S16 -0.0195458
RPS24 ribosomal protein S24 -0.0192944
RPL30 ribosomal protein L30 -0.0190336
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0190155
FOXP1 forkhead box P1 -0.0189401
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0185821
TPI1 triosephosphate isomerase 1 -0.0182718
ADAM19 ADAM metallopeptidase domain 19 -0.0181271
RPS21 ribosomal protein S21 -0.0181237
RPS20 ribosomal protein S20 -0.0179037
RPS10 ribosomal protein S10 -0.0177714
RPL32 ribosomal protein L32 -0.0175804
TXNRD1 thioredoxin reductase 1 -0.0174732
RPL10A ribosomal protein L10a -0.017152
MCL1 myeloid cell leukemia 1 -0.0171427
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0171361
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0170638
BRD2 bromodomain containing 2 -0.0169717
CCN2 cellular communication network factor 2 -0.0167659
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0167587
RPL27 ribosomal protein L27 -0.0165479
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0163661
RPL15 ribosomal protein L15 -0.0163342
MT1E metallothionein 1E -0.0156564
RPS5 ribosomal protein S5 -0.0154531
GNAS GNAS complex locus -0.0153753
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0152422
MT1X metallothionein 1X -0.0151914
RPS11 ribosomal protein S11 -0.015031
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0149435
NACA nascent polypeptide-associated complex alpha subunit -0.0148564