Cytarabine (hydrochloride)_LoVo Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cytarabine (hydrochloride) perturbation in LoVo cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cytarabine (hydrochloride)_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.126795
GOLGA4 golgin A4 0.103545
EPS8 epidermal growth factor receptor pathway substrate 8 0.0826988
TTC3 tetratricopeptide repeat domain 3 0.0777967
CANX calnexin 0.0738326
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0730745
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0678435
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0656874
EEF2 eukaryotic translation elongation factor 2 0.0655949
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0640955
ESYT2 extended synaptotagmin-like protein 2 0.0612693
AKAP9 A kinase (PRKA) anchor protein 9 0.056854
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0561464
ZCCHC7 zinc finger, CCHC domain containing 7 0.0550944
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0535965
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0527664
FAT1 FAT atypical cadherin 1 0.052071
MLEC malectin 0.0505764
LRRC1 leucine rich repeat containing 1 0.0486256
LDHA lactate dehydrogenase A 0.0477296
PCBP2 poly(rC) binding protein 2 0.0475427
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0474454
DSPP dentin sialophosphoprotein 0.0472224
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0466898
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0460401
GOLGB1 golgin B1 0.0416249
KMT2C lysine (K)-specific methyltransferase 2C 0.0415612
BIRC6 baculoviral IAP repeat containing 6 0.0411222
CDK13 cyclin-dependent kinase 13 0.0395871
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.03938
GMDS GDP-mannose 4,6-dehydratase 0.038648
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0384247
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.037469
TMF1 TATA element modulatory factor 1 0.0367273
DSCAM Down syndrome cell adhesion molecule 0.0361494
MSI2 musashi RNA-binding protein 2 0.0361454
BRD2 bromodomain containing 2 0.0360119
CCPG1 cell cycle progression 1 0.0359436
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0359329
SEC31A SEC31 homolog A (S. cerevisiae) 0.0356085
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0349548
SPAG9 sperm associated antigen 9 0.0344401
KDM3A lysine (K)-specific demethylase 3A 0.0339942
LMO7 LIM domain 7 0.0333644
MON2 MON2 homolog (S. cerevisiae) 0.0330978
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0328729
COPB1 coatomer protein complex, subunit beta 1 0.0318117
IARS1 isoleucyl-tRNA synthetase 1 0.031732
ZFAND3 zinc finger, AN1-type domain 3 0.0314525
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0310593
SMAD3 SMAD family member 3 0.030791
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0305649
USP3 ubiquitin specific peptidase 3 0.0303916
PARD3 par-3 family cell polarity regulator 0.030309
HDLBP high density lipoprotein binding protein 0.0302737
MORF4L2 mortality factor 4 like 2 0.0300518
MARCHF6 membrane associated ring-CH-type finger 6 0.0298587
CALB1 calbindin 1, 28kDa 0.0291777
COPA coatomer protein complex, subunit alpha 0.0291589
RNMT RNA (guanine-7-) methyltransferase 0.0290625
DDIT4 DNA-damage-inducible transcript 4 0.0290545
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0290542
JMY junction mediating and regulatory protein, p53 cofactor 0.0287179
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 0.0286813
SRRM2 serine/arginine repetitive matrix 2 0.0286439
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0284566
NFIA nuclear factor I/A 0.0282256
ZC3H11A zinc finger CCCH-type containing 11A 0.0280777
BBX bobby sox homolog (Drosophila) 0.0274795
WAC WW domain containing adaptor with coiled-coil 0.0274782
UBA6 ubiquitin-like modifier activating enzyme 6 0.0273954
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.0272625
DIAPH3 diaphanous-related formin 3 0.0272471
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.026899
MED13L mediator complex subunit 13-like 0.0266326
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0265372
UST uronyl-2-sulfotransferase 0.0265366
KMT2E lysine (K)-specific methyltransferase 2E 0.0263287
ATXN2 ataxin 2 0.026302
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.0262966
SRP54 signal recognition particle 54kDa 0.0262962
EXT1 exostosin glycosyltransferase 1 0.0262709
CSNK1G1 casein kinase 1, gamma 1 0.0261565
FXR1 fragile X mental retardation, autosomal homolog 1 0.0261448
SEC24D SEC24 family member D 0.0260845
BRWD1 bromodomain and WD repeat domain containing 1 0.0260676
MYH14 myosin, heavy chain 14, non-muscle 0.0256283
FAM13A family with sequence similarity 13, member A 0.0255643
ZNF638 zinc finger protein 638 0.0255289
BTBD9 BTB (POZ) domain containing 9 0.025481
PICALM phosphatidylinositol binding clathrin assembly protein 0.0254146
COPB2 coatomer protein complex, subunit beta 2 (beta prime) 0.0250311
SUCO SUN domain containing ossification factor 0.0250188
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0249909
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0249056
CDK19 cyclin-dependent kinase 19 0.0248897
IQGAP1 IQ motif containing GTPase activating protein 1 0.0248096
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0247299
BAZ2A bromodomain adjacent to zinc finger domain, 2A 0.0247058
GCC2 GRIP and coiled-coil domain containing 2 0.0246425

decreased expression

Symbol Name Standardized Value
RPLP1 ribosomal protein, large, P1 -0.149148
TPT1 tumor protein, translationally-controlled 1 -0.147469
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.138621
RPS19 ribosomal protein S19 -0.0844922
RPLP2 ribosomal protein, large, P2 -0.0756405
RPL35A ribosomal protein L35a -0.0665309
RPS12 ribosomal protein S12 -0.0643371
RPS24 ribosomal protein S24 -0.0630344
MYO1E myosin IE -0.0627369
FLNB filamin B, beta -0.0611671
RPL12 ribosomal protein L12 -0.0599479
RPS6 ribosomal protein S6 -0.0591033
RPLP0 ribosomal protein, large, P0 -0.0578339
RPS29 ribosomal protein S29 -0.0572682
PKP2 plakophilin 2 -0.0570877
RPS25 ribosomal protein S25 -0.0553962
RPS23 ribosomal protein S23 -0.0546834
RPL37A ribosomal protein L37a -0.054446
RPL26 ribosomal protein L26 -0.0540896
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0530682
PDE4D phosphodiesterase 4D, cAMP-specific -0.0520026
PRSS3 protease, serine, 3 -0.0499097
ANXA2 annexin A2 -0.0490057
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0476593
RPS8 ribosomal protein S8 -0.0468284
RPL9 ribosomal protein L9 -0.0440145
RPL36 ribosomal protein L36 -0.0436052
RPL31 ribosomal protein L31 -0.0425041
KLF6 Kruppel-like factor 6 -0.0420464
RPS27A ribosomal protein S27a -0.0416345
RPL34 ribosomal protein L34 -0.0414754
WWC1 WW and C2 domain containing 1 -0.0414054
RPS21 ribosomal protein S21 -0.0407458
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0405999
VCL vinculin -0.0398479
KLF3 Kruppel-like factor 3 (basic) -0.0389379
ABHD17C abhydrolase domain containing 17C -0.0383032
TXNRD1 thioredoxin reductase 1 -0.0376171
MX1 MX dynamin-like GTPase 1 -0.0375591
C6ORF132 chromosome 6 open reading frame 132 -0.035534
RPL32 ribosomal protein L32 -0.0354001
AKAP13 A kinase (PRKA) anchor protein 13 -0.0351156
RPL23 ribosomal protein L23 -0.0350733
RPL28 ribosomal protein L28 -0.0347659
KRT8 keratin 8, type II -0.0345038
IER3 immediate early response 3 -0.0342251
TSPAN8 tetraspanin 8 -0.0332795
RPL11 ribosomal protein L11 -0.0330405
NT5C2 5'-nucleotidase, cytosolic II -0.0330341
RPS13 ribosomal protein S13 -0.032418
RHPN2 rhophilin, Rho GTPase binding protein 2 -0.0323525
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0316782
RPL5 ribosomal protein L5 -0.0314178
SH3RF2 SH3 domain containing ring finger 2 -0.0313187
RIGI RNA sensor RIG-I -0.0310489
RPL13A ribosomal protein L13a -0.0303959
EGR1 early growth response 1 -0.030361
RPS3 ribosomal protein S3 -0.0297496
RPS17 ribosomal protein S17 -0.0297221
SPON1 spondin 1, extracellular matrix protein -0.029589
FOXP1 forkhead box P1 -0.0294209
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0290041
RPL38 ribosomal protein L38 -0.0289326
RPL19 ribosomal protein L19 -0.0289148
RPS27 ribosomal protein S27 -0.0286572
ACTN4 actinin, alpha 4 -0.0285312
S100A9 S100 calcium binding protein A9 -0.0276886
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0273523
RPL37 ribosomal protein L37 -0.0272663
MX2 MX dynamin-like GTPase 2 -0.0269651
RPS16 ribosomal protein S16 -0.0269293
TNRC18 trinucleotide repeat containing 18 -0.0268366
P3H2 prolyl 3-hydroxylase 2 -0.0267332
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0264617
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0261022
EXOC4 exocyst complex component 4 -0.0259175
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 -0.0258611
TMEM45B transmembrane protein 45B -0.0252768
CENPF centromere protein F, 350/400kDa -0.025137
NDUFA4 NDUFA4, mitochondrial complex associated -0.024493
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -0.0243832
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.023998
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.0238499
RPS20 ribosomal protein S20 -0.0238358
FOXO1 forkhead box O1 -0.0233932
EPHA2 EPH receptor A2 -0.023304
PLSCR1 phospholipid scramblase 1 -0.0231906
ATP10B ATPase, class V, type 10B -0.0230334
RPS14 ribosomal protein S14 -0.0229938
RPL36A ribosomal protein L36a -0.0229355
COX6C cytochrome c oxidase subunit VIc -0.0226318
RPS15 ribosomal protein S15 -0.0224585
RPL35 ribosomal protein L35 -0.0224255
RPL30 ribosomal protein L30 -0.0221624
OASL 2'-5'-oligoadenylate synthetase-like -0.0219996
DUSP4 dual specificity phosphatase 4 -0.0217856
IFI6 interferon, alpha-inducible protein 6 -0.0217785
RPL27A ribosomal protein L27a -0.0217462
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.021706
CLDN4 claudin 4 -0.0215828