Cytarabine (hydrochloride)_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cytarabine (hydrochloride) perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cytarabine (hydrochloride)_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha 0.10368
RPL35A ribosomal protein L35a 0.0592263
TMSB4X thymosin beta 4, X-linked 0.0510331
POTEF POTE ankyrin domain family, member F 0.0494653
ACTG1 actin gamma 1 0.0452747
GOLGA4 golgin A4 0.0355831
RPS6 ribosomal protein S6 0.0331983
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) 0.0327203
SPAG9 sperm associated antigen 9 0.0316665
CCNL1 cyclin L1 0.0303621
SLK STE20-like kinase 0.0296535
KPNB1 karyopherin (importin) beta 1 0.0291649
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0288976
ZNF292 zinc finger protein 292 0.0280194
AKAP9 A kinase (PRKA) anchor protein 9 0.0277434
DLG1 discs, large homolog 1 (Drosophila) 0.0257275
WSB1 WD repeat and SOCS box containing 1 0.0244399
LOXL2 lysyl oxidase-like 2 0.0240005
RAD51B RAD51 paralog B 0.0222674
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.022243
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0217678
KMT2C lysine (K)-specific methyltransferase 2C 0.02168
RPS19 ribosomal protein S19 0.0211143
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0210136
MBNL2 muscleblind-like splicing regulator 2 0.0206844
BZW1 basic leucine zipper and W2 domains 1 0.0206703
SDC4 syndecan 4 0.0203395
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.0201711
HELZ helicase with zinc finger 0.0200803
EIF3A eukaryotic translation initiation factor 3, subunit A 0.020055
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 0.0197092
MEF2A myocyte enhancer factor 2A 0.0196509
RAB7A RAB7A, member RAS oncogene family 0.019594
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0195314
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0194955
RAB6A RAB6A, member RAS oncogene family 0.0191065
GARS1 glycyl-tRNA synthetase 1 0.0188165
SETD5 SET domain containing 5 0.0186148
CD109 CD109 molecule 0.0185722
UBA6 ubiquitin-like modifier activating enzyme 6 0.0185552
RPS12 ribosomal protein S12 0.0183047
TPR translocated promoter region, nuclear basket protein 0.0182931
TPM3 tropomyosin 3 0.0177257
DDIT4 DNA-damage-inducible transcript 4 0.0176875
LGALS3 lectin, galactoside-binding, soluble, 3 0.0176284
SEC23A Sec23 homolog A (S. cerevisiae) 0.0175232
RPL11 ribosomal protein L11 0.017356
ADGRG6 adhesion G protein-coupled receptor G6 0.0170465
CDK19 cyclin-dependent kinase 19 0.0169639
QKI QKI, KH domain containing, RNA binding 0.0169495
YEATS2 YEATS domain containing 2 0.0168687
SRP54 signal recognition particle 54kDa 0.0168392
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0168381
TTC3 tetratricopeptide repeat domain 3 0.0167281
FXR1 fragile X mental retardation, autosomal homolog 1 0.0166983
F2R coagulation factor II (thrombin) receptor 0.0165305
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0164853
SET SET nuclear proto-oncogene 0.0162769
ARRDC3 arrestin domain containing 3 0.0162303
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.016147
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0160983
PCBP2 poly(rC) binding protein 2 0.0159939
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0159711
RLF rearranged L-myc fusion 0.0159098
BIRC6 baculoviral IAP repeat containing 6 0.0158536
AMBRA1 autophagy/beclin-1 regulator 1 0.0157753
OGA O-GlcNAcase 0.015738
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0156271
ANXA1 annexin A1 0.015621
RPS3 ribosomal protein S3 0.0156104
RPL37A ribosomal protein L37a 0.0155608
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0155051
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0154414
RPL23 ribosomal protein L23 0.0151985
AFF4 AF4/FMR2 family, member 4 0.015131
UBE4B ubiquitination factor E4B 0.0150926
FNBP1L formin binding protein 1-like 0.0150574
PUM2 pumilio RNA-binding family member 2 0.0149246
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0149194
ENO2 enolase 2 (gamma, neuronal) 0.01485
SNX3 sorting nexin 3 0.0146844
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.014656
RBM25 RNA binding motif protein 25 0.014606
MIS18BP1 MIS18 binding protein 1 0.0143886
PLIN2 perilipin 2 0.0143382
RPL13A ribosomal protein L13a 0.0142053
FAM162A family with sequence similarity 162, member A 0.0141358
MSN moesin 0.0141143
MTF2 metal response element binding transcription factor 2 0.0140924
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0139339
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0137864
KDM2A lysine (K)-specific demethylase 2A 0.0137665
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0137456
SEPTIN7 septin 7 0.0136302
CCDC88A coiled-coil domain containing 88A 0.0135915
TRA2A transformer 2 alpha homolog (Drosophila) 0.0135574
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0135568
ADAM17 ADAM metallopeptidase domain 17 0.013494
DSTN destrin (actin depolymerizing factor) 0.0133217
THOC2 THO complex 2 0.0132745

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.364373
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.255072
TM4SF1 transmembrane 4 L six family member 1 -0.170626
TMSB10 thymosin beta 10 -0.144641
UBC ubiquitin C -0.14011
PSD3 pleckstrin and Sec7 domain containing 3 -0.129775
CD44 CD44 molecule (Indian blood group) -0.124483
TP63 tumor protein p63 -0.0954376
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0859158
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0844739
TXNRD1 thioredoxin reductase 1 -0.0722545
EEF2 eukaryotic translation elongation factor 2 -0.0690898
AHNAK AHNAK nucleoprotein -0.0683305
RPS27A ribosomal protein S27a -0.0641781
JUN jun proto-oncogene -0.0639426
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0625304
BCAR3 breast cancer anti-estrogen resistance 3 -0.057358
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0571943
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0516595
SLC38A2 solute carrier family 38, member 2 -0.0463678
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0455154
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0445349
EMP1 epithelial membrane protein 1 -0.0424102
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0416053
ENO1 enolase 1, (alpha) -0.0405095
NPAS2 neuronal PAS domain protein 2 -0.038102
CMIP c-Maf inducing protein -0.0350653
CADM2 cell adhesion molecule 2 -0.0349289
ARHGAP5 Rho GTPase activating protein 5 -0.0348627
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0340374
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -0.0329691
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0322378
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0321357
EHBP1 EH domain binding protein 1 -0.0317965
MKI67 marker of proliferation Ki-67 -0.0296949
MT1X metallothionein 1X -0.0292832
ZDHHC14 zinc finger, DHHC-type containing 14 -0.0290986
WARS1 tryptophanyl-tRNA synthetase 1 -0.0285203
CFLAR CASP8 and FADD-like apoptosis regulator -0.0284112
LOC112694756 uncharaterized LOC112694756 -0.0279968
FMNL2 formin-like 2 -0.0278453
HMGA1 high mobility group AT-hook 1 -0.0276708
WWTR1 WW domain containing transcription regulator 1 -0.0276563
APP amyloid beta (A4) precursor protein -0.0273
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -0.0272272
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0270174
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0267019
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0266673
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0266365
CAPN2 calpain 2, (m/II) large subunit -0.0262205
RAB27B RAB27B, member RAS oncogene family -0.0261975
BICD1 bicaudal D homolog 1 (Drosophila) -0.0260421
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0257776
BIRC3 baculoviral IAP repeat containing 3 -0.0252853
CAPRIN2 caprin family member 2 -0.0248449
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0246844
SP100 SP100 nuclear antigen -0.0241772
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 -0.0238314
PKM pyruvate kinase, muscle -0.0238068
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0235412
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0229288
NT5E 5'-nucleotidase, ecto (CD73) -0.0227955
UPP1 uridine phosphorylase 1 -0.0224452
EZR ezrin -0.0223868
ZMYND8 zinc finger, MYND-type containing 8 -0.0221068
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0220023
ADARB1 adenosine deaminase, RNA-specific, B1 -0.0219747
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0216914
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0215903
PLSCR1 phospholipid scramblase 1 -0.0215872
VMP1 vacuole membrane protein 1 -0.0214255
MCL1 myeloid cell leukemia 1 -0.0213513
FTL ferritin, light polypeptide -0.0213466
TSC22D1 TSC22 domain family, member 1 -0.0212004
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0211133
ZEB1 zinc finger E-box binding homeobox 1 -0.0210874
SPRY4 sprouty homolog 4 (Drosophila) -0.0206525
RIGI RNA sensor RIG-I -0.0203729
DNTTIP1 deoxynucleotidyltransferase, terminal, interacting protein 1 -0.0200669
SFPQ splicing factor proline/glutamine-rich -0.0196551
MACF1 microtubule-actin crosslinking factor 1 -0.0194681
SDCCAG8 serologically defined colon cancer antigen 8 -0.0193992
USP34 ubiquitin specific peptidase 34 -0.019289
RPS24 ribosomal protein S24 -0.0192865
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0191523
SCGB1D1 secretoglobin, family 1D, member 1 -0.0186758
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0186371
OSMR oncostatin M receptor -0.0186163
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0185968
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0185477
DNER delta/notch-like EGF repeat containing -0.0185428
GCLM glutamate-cysteine ligase, modifier subunit -0.0184527
PDIA4 protein disulfide isomerase family A, member 4 -0.018443
H1-0 H1.0 linker histone -0.0183575
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0183249
TGM2 transglutaminase 2 -0.0182361
ZBTB38 zinc finger and BTB domain containing 38 -0.0181532
BLTP2 bridge-like lipid transfer protein family member 2 -0.0181388
MLPH melanophilin -0.0178999
NEK10 NIMA-related kinase 10 -0.0178639