Cytarabine (hydrochloride)_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cytarabine (hydrochloride) perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cytarabine (hydrochloride)_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0753125
FAM13A family with sequence similarity 13, member A 0.0715254
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.071108
FNDC3B fibronectin type III domain containing 3B 0.0667088
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0657127
ARRDC3 arrestin domain containing 3 0.0652842
SLTM SAFB-like, transcription modulator 0.0645894
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0643357
RUNX1 runt-related transcription factor 1 0.0635727
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0596086
ANKRD10 ankyrin repeat domain 10 0.059321
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0581093
CES1 carboxylesterase 1 0.056285
TBC1D22A TBC1 domain family, member 22A 0.0545362
KMT2E lysine (K)-specific methyltransferase 2E 0.0541497
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0540835
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0523121
GSK3B glycogen synthase kinase 3 beta 0.0518396
DENND4A DENN/MADD domain containing 4A 0.0485181
MYH9 myosin, heavy chain 9, non-muscle 0.048219
DSCAM Down syndrome cell adhesion molecule 0.0477359
GLS2 glutaminase 2 (liver, mitochondrial) 0.047263
SMAD3 SMAD family member 3 0.0462298
PGK1 phosphoglycerate kinase 1 0.0455821
NGLY1 N-glycanase 1 0.0452539
KDM2A lysine (K)-specific demethylase 2A 0.0443801
AGO2 argonaute RISC catalytic component 2 0.0436145
FNIP1 folliculin interacting protein 1 0.0417927
KIAA1217 KIAA1217 0.0416793
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.041621
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0415028
ATP13A3 ATPase type 13A3 0.0414838
ENO1 enolase 1, (alpha) 0.0413108
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0405285
ZNF292 zinc finger protein 292 0.0396093
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0391698
HOOK2 hook microtubule-tethering protein 2 0.0383541
SLC35F5 solute carrier family 35, member F5 0.0379129
ADAM17 ADAM metallopeptidase domain 17 0.0379109
HELZ helicase with zinc finger 0.0376906
KDM6A lysine (K)-specific demethylase 6A 0.0372391
ELL2 elongation factor, RNA polymerase II, 2 0.0367178
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0364986
EIF4B eukaryotic translation initiation factor 4B 0.0360167
RAB7A RAB7A, member RAS oncogene family 0.0358444
YEATS2 YEATS domain containing 2 0.0356836
SOD2 superoxide dismutase 2, mitochondrial 0.0355672
UBE2O ubiquitin-conjugating enzyme E2O 0.0354468
NAMPT nicotinamide phosphoribosyltransferase 0.035436
RPL4 ribosomal protein L4 0.0353534
DTNA dystrobrevin, alpha 0.0351704
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0348866
CXCL8 chemokine (C-X-C motif) ligand 8 0.0346008
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.034414
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0339957
PCBP2 poly(rC) binding protein 2 0.0339231
PLEC plectin 0.033834
EIF4A2 eukaryotic translation initiation factor 4A2 0.0332574
OGA O-GlcNAcase 0.0329685
BIRC3 baculoviral IAP repeat containing 3 0.0326168
SAMD4A sterile alpha motif domain containing 4A 0.0325091
LOC112694756 uncharaterized LOC112694756 0.0322963
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 0.0320183
SUCO SUN domain containing ossification factor 0.0315037
RAD51B RAD51 paralog B 0.0314066
NPTN neuroplastin 0.0310381
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0310183
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0308264
HAPSTR1 HUWE1 associated protein modifying stress responses 0.030716
CAMTA1 calmodulin binding transcription activator 1 0.0299776
APLP2 amyloid beta (A4) precursor-like protein 2 0.0299491
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0298666
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0298493
GPHN gephyrin 0.0297152
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0294354
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0294231
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0293936
EP300 E1A binding protein p300 0.0292659
CLTC clathrin, heavy chain (Hc) 0.029068
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0289868
ANKRD11 ankyrin repeat domain 11 0.0288222
RYBP RING1 and YY1 binding protein 0.028703
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.0284836
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0283019
TMEM165 transmembrane protein 165 0.0279627
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.0279116
SRRM2 serine/arginine repetitive matrix 2 0.0273202
GPATCH2L G patch domain containing 2-like 0.027172
GPC6 glypican 6 0.0271317
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0270145
HYOU1 hypoxia up-regulated 1 0.0270126
AP1S3 adaptor-related protein complex 1, sigma 3 subunit 0.0268323
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.02666
CNOT1 CCR4-NOT transcription complex, subunit 1 0.026612
PPP1R15B protein phosphatase 1, regulatory subunit 15B 0.0265485
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 0.0264911
CEMIP cell migration inducing protein, hyaluronan binding 0.0263217
YTHDC1 YTH domain containing 1 0.0261565
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0260693
NBAS neuroblastoma amplified sequence 0.0259057

decreased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 -0.119231
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.115216
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.111767
MT2A metallothionein 2A -0.111752
LMO7 LIM domain 7 -0.0922867
LAMA4 laminin, alpha 4 -0.0816741
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0736938
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0713444
MKI67 marker of proliferation Ki-67 -0.0692818
MAML3 mastermind-like 3 (Drosophila) -0.0674142
FTL ferritin, light polypeptide -0.0613507
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0590601
PTMA prothymosin, alpha -0.0551156
ANXA2 annexin A2 -0.0535421
H1-0 H1.0 linker histone -0.052353
LAMC2 laminin, gamma 2 -0.049171
TPT1 tumor protein, translationally-controlled 1 -0.0488218
TMSB10 thymosin beta 10 -0.04685
OSMR oncostatin M receptor -0.0468302
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0467033
MT1X metallothionein 1X -0.0452454
PATJ PATJ crumbs cell polarity complex component -0.0433096
SCEL sciellin -0.0400596
SLC38A2 solute carrier family 38, member 2 -0.0381061
EGR1 early growth response 1 -0.0363636
DSPP dentin sialophosphoprotein -0.0356267
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0356246
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0355387
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0353366
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 -0.0345876
DOCK5 dedicator of cytokinesis 5 -0.0343747
RIMS2 regulating synaptic membrane exocytosis 2 -0.0341104
EGFR epidermal growth factor receptor -0.0336963
CAV1 caveolin 1, caveolae protein, 22kDa -0.0333821
GRAMD1B GRAM domain containing 1B -0.0330312
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0326457
EMP1 epithelial membrane protein 1 -0.0318131
S100P S100 calcium binding protein P -0.0305266
GM2A GM2 ganglioside activator -0.0297701
DOCK9 dedicator of cytokinesis 9 -0.0295912
S100A11 S100 calcium binding protein A11 -0.0288277
FOXP1 forkhead box P1 -0.028403
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0279813
ANXA1 annexin A1 -0.0279585
CUX1 cut-like homeobox 1 -0.0274307
RIN2 Ras and Rab interactor 2 -0.0267685
LGALS12 lectin, galactoside-binding, soluble, 12 -0.0266208
AHNAK AHNAK nucleoprotein -0.0264533
CSTB cystatin B (stefin B) -0.0264017
RAB27B RAB27B, member RAS oncogene family -0.0263434
LIPH lipase, member H -0.0262747
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0261766
ARHGAP32 Rho GTPase activating protein 32 -0.026082
SLC38A1 solute carrier family 38, member 1 -0.0260303
MGAT4C MGAT4 family, member C -0.0260274
EHBP1 EH domain binding protein 1 -0.0257931
MRTFB myocardin related transcription factor B -0.0257673
EIF1 eukaryotic translation initiation factor 1 -0.0257645
S100A6 S100 calcium binding protein A6 -0.0257248
NDRG1 N-myc downstream regulated 1 -0.0256402
S100A10 S100 calcium binding protein A10 -0.0254415
PTPRM protein tyrosine phosphatase, receptor type, M -0.0241401
RAB10 RAB10, member RAS oncogene family -0.0239741
PERP PERP, TP53 apoptosis effector -0.023837
SYAP1 synapse associated protein 1 -0.0238293
STAU2 staufen double-stranded RNA binding protein 2 -0.0237901
NTN4 netrin 4 -0.0225957
TBC1D5 TBC1 domain family, member 5 -0.0224585
TRAPPC9 trafficking protein particle complex 9 -0.0221211
RPL35A ribosomal protein L35a -0.0217987
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0212187
KLF3 Kruppel-like factor 3 (basic) -0.0211818
RABGAP1L RAB GTPase activating protein 1-like -0.0206347
THSD4 thrombospondin, type I, domain containing 4 -0.0202785
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0200805
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.019854
ZBTB20 zinc finger and BTB domain containing 20 -0.0197546
IGFBP3 insulin-like growth factor binding protein 3 -0.0195835
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0195821
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0195729
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0194202
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) -0.0193769
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.0193382
SMIM14 small integral membrane protein 14 -0.0193326
ETV6 ets variant 6 -0.0190766
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0190217
CXADR coxsackie virus and adenovirus receptor -0.0189224
SPTSSA serine palmitoyltransferase, small subunit A -0.0188445
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0186894
NEBL nebulette -0.0186035
NT5C2 5'-nucleotidase, cytosolic II -0.0185512
ACTG1 actin gamma 1 -0.0184429
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0183638
SIPA1L2 signal-induced proliferation-associated 1 like 2 -0.018281
ATP11A ATPase, class VI, type 11A -0.0182515
PCED1B PC-esterase domain containing 1B -0.018231
PARD3 par-3 family cell polarity regulator -0.0179216
NR4A1 nuclear receptor subfamily 4, group A, member 1 -0.017795
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase -0.0176484
NCOA3 nuclear receptor coactivator 3 -0.0175312