Cytarabine (hydrochloride)_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cytarabine (hydrochloride) perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cytarabine (hydrochloride)_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.170515
SDC4 syndecan 4 0.125086
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0973665
PTK2 protein tyrosine kinase 2 0.0942136
GRB10 growth factor receptor-bound protein 10 0.0818757
KRT17 keratin 17, type I 0.0718452
RPS16 ribosomal protein S16 0.0708137
TSC22D2 TSC22 domain family, member 2 0.0695764
RPS12 ribosomal protein S12 0.0683747
RPL23 ribosomal protein L23 0.0670985
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.065847
RPL34 ribosomal protein L34 0.0657164
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0652582
FN1 fibronectin 1 0.0626007
EIF1 eukaryotic translation initiation factor 1 0.0617117
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0615418
NAP1L1 nucleosome assembly protein 1-like 1 0.0600375
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.058775
KMT2E lysine (K)-specific methyltransferase 2E 0.058108
RPS3 ribosomal protein S3 0.0561516
ZFAND3 zinc finger, AN1-type domain 3 0.053336
RPS8 ribosomal protein S8 0.0522398
ZC3H11A zinc finger CCCH-type containing 11A 0.0518923
COPB1 coatomer protein complex, subunit beta 1 0.0511891
RPS19 ribosomal protein S19 0.0509654
ANKRD11 ankyrin repeat domain 11 0.0504203
SLTM SAFB-like, transcription modulator 0.0502548
FLNB filamin B, beta 0.0502013
CCNH cyclin H 0.0497679
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0493423
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0492601
APLP2 amyloid beta (A4) precursor-like protein 2 0.0487912
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.048467
NCKAP1 NCK-associated protein 1 0.0472788
SET SET nuclear proto-oncogene 0.0470085
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0467451
RPS6 ribosomal protein S6 0.0467135
DSPP dentin sialophosphoprotein 0.0456908
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.0456561
NKTR natural killer cell triggering receptor 0.0453593
TPT1 tumor protein, translationally-controlled 1 0.0451533
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0446101
NDRG1 N-myc downstream regulated 1 0.0445877
ANXA1 annexin A1 0.0443906
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.044327
PDE10A phosphodiesterase 10A 0.0441615
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0440959
SSBP2 single-stranded DNA binding protein 2 0.0440687
LDHA lactate dehydrogenase A 0.0437425
RACK1 receptor for activated C kinase 1 0.043716
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0431476
KMT2C lysine (K)-specific methyltransferase 2C 0.0431184
PCBP2 poly(rC) binding protein 2 0.0431021
ZBTB43 zinc finger and BTB domain containing 43 0.0429556
EGLN3 egl-9 family hypoxia-inducible factor 3 0.0424955
CD46 CD46 molecule, complement regulatory protein 0.042405
KDM2A lysine (K)-specific demethylase 2A 0.041757
ELL2 elongation factor, RNA polymerase II, 2 0.0415807
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0413435
LOC112694756 uncharaterized LOC112694756 0.0405092
PUM2 pumilio RNA-binding family member 2 0.040429
B2M beta-2-microglobulin 0.0402373
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0397891
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0394466
XRN1 5'-3' exoribonuclease 1 0.038941
CREB5 cAMP responsive element binding protein 5 0.038939
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa 0.0379572
ARB2A ARB2 cotranscriptional regulator A 0.0377275
SETD5 SET domain containing 5 0.0376945
CAMTA1 calmodulin binding transcription activator 1 0.0374846
RPLP1 ribosomal protein, large, P1 0.0374637
RHOBTB3 Rho-related BTB domain containing 3 0.0373482
CXCL8 chemokine (C-X-C motif) ligand 8 0.0368122
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.036421
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0364107
CCNL1 cyclin L1 0.0363116
CALR calreticulin 0.0362266
ZCCHC7 zinc finger, CCHC domain containing 7 0.035527
JPT1 Jupiter microtubule associated homolog 1 0.0353712
TPM3 tropomyosin 3 0.0351363
USP32 ubiquitin specific peptidase 32 0.0350758
P4HB prolyl 4-hydroxylase, beta polypeptide 0.034822
RPL37 ribosomal protein L37 0.0348205
SEC24A SEC24 family member A 0.0347936
WDR45B WD repeat domain 45B 0.0341467
RYBP RING1 and YY1 binding protein 0.0338599
MAST4 microtubule associated serine/threonine kinase family member 4 0.0337415
PDIA3 protein disulfide isomerase family A, member 3 0.0335965
IGFBP5 insulin-like growth factor binding protein 5 0.0333475
YTHDF3 YTH N(6)-methyladenosine RNA binding protein 3 0.0332228
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0331933
ATP13A3 ATPase type 13A3 0.0330771
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0325236
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0324067
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0322827
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0321081
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0317458
EEF2 eukaryotic translation elongation factor 2 0.0317235
PTGES2 prostaglandin E synthase 2 0.0317111
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0316489

decreased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 -0.175944
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.136897
TXNRD1 thioredoxin reductase 1 -0.128282
PARD3 par-3 family cell polarity regulator -0.124037
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.121292
ATOSA atos homolog A -0.114528
TJP1 tight junction protein 1 -0.105625
ANXA2 annexin A2 -0.0921219
VIM vimentin -0.0907673
MAML3 mastermind-like 3 (Drosophila) -0.0888239
STC1 stanniocalcin 1 -0.0888201
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.086873
SVIL supervillin -0.0751622
LAMC2 laminin, gamma 2 -0.0710247
LAMB3 laminin, beta 3 -0.0708155
BACE2 beta-site APP-cleaving enzyme 2 -0.0697943
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0694086
AHNAK AHNAK nucleoprotein -0.0686747
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6 -0.0665568
MUC16 mucin 16, cell surface associated -0.0665184
F3 coagulation factor III (thromboplastin, tissue factor) -0.0661034
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0657452
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0656871
JMJD1C jumonji domain containing 1C -0.06531
USP3 ubiquitin specific peptidase 3 -0.0621253
LSAMP limbic system-associated membrane protein -0.0616142
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0610688
KATNBL1 katanin p80 subunit B-like 1 -0.0603575
BRWD1 bromodomain and WD repeat domain containing 1 -0.0591097
INHBA inhibin, beta A -0.0590639
RBM47 RNA binding motif protein 47 -0.0590094
EGR1 early growth response 1 -0.0588243
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0585957
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 -0.0581527
ASPH aspartate beta-hydroxylase -0.0569746
PTPRM protein tyrosine phosphatase, receptor type, M -0.0562736
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0555523
SQSTM1 sequestosome 1 -0.0542341
SLC38A1 solute carrier family 38, member 1 -0.0538346
CAPN2 calpain 2, (m/II) large subunit -0.0536179
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0534794
NPEPPS aminopeptidase puromycin sensitive -0.0534463
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.052928
CEMIP cell migration inducing protein, hyaluronan binding -0.0527764
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0523675
EZR ezrin -0.0523087
PRKCA protein kinase C, alpha -0.0520347
KDM5B lysine (K)-specific demethylase 5B -0.0516881
COL6A3 collagen, type VI, alpha 3 -0.0514908
NCOA2 nuclear receptor coactivator 2 -0.0514349
FOXP1 forkhead box P1 -0.0508813
MAN2A1 mannosidase, alpha, class 2A, member 1 -0.0507052
CUX1 cut-like homeobox 1 -0.0505773
AKAP12 A kinase (PRKA) anchor protein 12 -0.0504
PPP2R2C protein phosphatase 2, regulatory subunit B, gamma -0.0496998
NHSL1 NHS-like 1 -0.0496298
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0477597
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0474201
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 -0.0471972
TRIP12 thyroid hormone receptor interactor 12 -0.0469821
MED13 mediator complex subunit 13 -0.0468847
DOCK5 dedicator of cytokinesis 5 -0.0467856
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0466881
KCNH8 potassium channel, voltage gated eag related subfamily H, member 8 -0.0460104
RRBP1 ribosome binding protein 1 -0.0454439
SAMD12 sterile alpha motif domain containing 12 -0.0451919
ERBIN erbb2 interacting protein -0.0426912
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0424327
AHNAK2 AHNAK nucleoprotein 2 -0.0420387
FAM13A family with sequence similarity 13, member A -0.0420176
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0419322
HMGA2 high mobility group AT-hook 2 -0.0417457
CPEB4 cytoplasmic polyadenylation element binding protein 4 -0.0416967
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0410904
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0409847
FMNL2 formin-like 2 -0.0408334
OSMR oncostatin M receptor -0.0405249
MACC1 metastasis associated in colon cancer 1 -0.039915
CDK13 cyclin-dependent kinase 13 -0.0395571
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0390906
MED13L mediator complex subunit 13-like -0.0390868
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0390444
GLS2 glutaminase 2 (liver, mitochondrial) -0.0389529
BCL2L1 BCL2-like 1 -0.0386616
PTPRK protein tyrosine phosphatase, receptor type, K -0.0380244
LIMCH1 LIM and calponin homology domains 1 -0.0377303
EHBP1 EH domain binding protein 1 -0.0369717
CLIP1 CAP-GLY domain containing linker protein 1 -0.0368574
SEPTIN9 septin 9 -0.0368128
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0365583
ZBTB20 zinc finger and BTB domain containing 20 -0.0363816
SNX9 sorting nexin 9 -0.036306
TCF12 transcription factor 12 -0.0360671
ABHD17C abhydrolase domain containing 17C -0.0358496
MYO5C myosin VC -0.0357619
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0356256
TXNIP thioredoxin interacting protein -0.0351784
TM4SF1 transmembrane 4 L six family member 1 -0.0346339
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.034591
USP34 ubiquitin specific peptidase 34 -0.0339807