Cytarabine (hydrochloride)_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cytarabine (hydrochloride) perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cytarabine (hydrochloride)_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SYNE2 spectrin repeat containing, nuclear envelope 2 0.149111
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0908
DIAPH3 diaphanous-related formin 3 0.0799773
GRAMD1B GRAM domain containing 1B 0.0755032
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0663852
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0586743
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0562761
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0553264
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0551625
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0545374
MELK maternal embryonic leucine zipper kinase 0.0533744
PDE4D phosphodiesterase 4D, cAMP-specific 0.052112
SSH2 slingshot protein phosphatase 2 0.0520559
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.050908
AFF3 AF4/FMR2 family, member 3 0.0501475
RRM2 ribonucleotide reductase M2 0.0499788
SMAD3 SMAD family member 3 0.0498166
ANKRD36 ankyrin repeat domain 36 0.0496852
DST dystonin 0.0487688
CSDE1 cold shock domain containing E1, RNA-binding 0.0483107
NCAPG2 non-SMC condensin II complex, subunit G2 0.048117
MACF1 microtubule-actin crosslinking factor 1 0.0459953
SPIDR scaffolding protein involved in DNA repair 0.0445522
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.043471
FAF1 Fas (TNFRSF6) associated factor 1 0.0433408
FMNL2 formin-like 2 0.0431387
PRIM2 primase, DNA, polypeptide 2 (58kDa) 0.0429933
TM4SF1 transmembrane 4 L six family member 1 0.0429673
ATXN1 ataxin 1 0.0426191
CPNE8 copine VIII 0.042066
ANKRD36C ankyrin repeat domain 36C 0.0418566
BRCA1 breast cancer 1, early onset 0.0416536
ATAD2 ATPase family, AAA domain containing 2 0.0410297
CAMTA1 calmodulin binding transcription activator 1 0.040827
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0404794
PRKCE protein kinase C, epsilon 0.0397701
RIMS2 regulating synaptic membrane exocytosis 2 0.0394446
ADGRG6 adhesion G protein-coupled receptor G6 0.0391881
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.039088
WWOX WW domain containing oxidoreductase 0.0389405
CEP192 centrosomal protein 192kDa 0.0386065
AHNAK AHNAK nucleoprotein 0.0383373
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0382183
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.03804
ENO1 enolase 1, (alpha) 0.0378187
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0376863
BASP1 brain abundant, membrane attached signal protein 1 0.0370732
PUM2 pumilio RNA-binding family member 2 0.0361688
APP amyloid beta (A4) precursor protein 0.035805
RAD51B RAD51 paralog B 0.0356348
IGF1R insulin-like growth factor 1 receptor 0.0355408
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0355249
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0353434
ADAR adenosine deaminase, RNA-specific 0.0351115
BMAL2 basic helix-loop-helix ARNT like 2 0.0347624
PHIP pleckstrin homology domain interacting protein 0.0346958
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.0343682
ZNF638 zinc finger protein 638 0.0341815
HLA-B major histocompatibility complex, class I, B 0.0340765
TLK1 tousled-like kinase 1 0.0339258
OGA O-GlcNAcase 0.0335882
FNDC3B fibronectin type III domain containing 3B 0.0331911
RYR3 ryanodine receptor 3 0.0331796
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0329807
CLSPN claspin 0.032941
CCT4 chaperonin containing TCP1, subunit 4 (delta) 0.0327099
WDHD1 WD repeat and HMG-box DNA binding protein 1 0.0326369
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0322856
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0322518
SAMD4A sterile alpha motif domain containing 4A 0.0317435
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0317411
TPM3 tropomyosin 3 0.03134
NUP153 nucleoporin 153kDa 0.0312362
CD2AP CD2-associated protein 0.0309721
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0303824
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 0.0300761
FANCI Fanconi anemia, complementation group I 0.0300539
FANCL Fanconi anemia, complementation group L 0.029858
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0297397
FUS FUS RNA binding protein 0.0293647
PRELID2 PRELI domain containing 2 0.0290851
SDK1 sidekick cell adhesion molecule 1 0.0289216
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.0286742
NCOA7 nuclear receptor coactivator 7 0.0285775
CAVIN1 caveolae associated protein 1 0.0284391
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0283624
DENND1A DENN/MADD domain containing 1A 0.0281854
CSE1L CSE1 chromosome segregation 1-like (yeast) 0.0280946
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0279523
PFKP phosphofructokinase, platelet 0.0278114
ANLN anillin, actin binding protein 0.027684
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0276522
PTK2 protein tyrosine kinase 2 0.0275954
EIF4B eukaryotic translation initiation factor 4B 0.0274961
ZNF217 zinc finger protein 217 0.0274346
KRT8 keratin 8, type II 0.0273725
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) 0.0273169
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.0271615
ERRFI1 ERBB receptor feedback inhibitor 1 0.0271397
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.0270129

decreased expression

Symbol Name Standardized Value
EGR1 early growth response 1 -0.166423
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.14526
MCL1 myeloid cell leukemia 1 -0.0672978
KTN1 kinectin 1 (kinesin receptor) -0.0553689
POTEF POTE ankyrin domain family, member F -0.0523244
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0481656
NABP1 nucleic acid binding protein 1 -0.0457602
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0451364
SLC38A2 solute carrier family 38, member 2 -0.0440129
TXNRD1 thioredoxin reductase 1 -0.0424163
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0404321
MT2A metallothionein 2A -0.0395523
RPS27 ribosomal protein S27 -0.0391552
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0384052
BRD2 bromodomain containing 2 -0.037584
ELL2 elongation factor, RNA polymerase II, 2 -0.0364919
PFN1 profilin 1 -0.0361367
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0356575
RPS12 ribosomal protein S12 -0.0348175
RPLP1 ribosomal protein, large, P1 -0.0338687
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.03264
GATAD2B GATA zinc finger domain containing 2B -0.0326233
RPL28 ribosomal protein L28 -0.0325886
ZBTB20 zinc finger and BTB domain containing 20 -0.0323152
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 -0.0323034
RPL35A ribosomal protein L35a -0.0320046
MEF2D myocyte enhancer factor 2D -0.0317604
RPL26 ribosomal protein L26 -0.0309893
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0305713
WSB1 WD repeat and SOCS box containing 1 -0.0305419
PCBP2 poly(rC) binding protein 2 -0.0297589
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0288245
EEF2 eukaryotic translation elongation factor 2 -0.0281938
RAB7A RAB7A, member RAS oncogene family -0.0281365
LOC102724023 ES1 protein homolog, mitochondrial -0.0278893
EIF1 eukaryotic translation initiation factor 1 -0.0276266
RPL12 ribosomal protein L12 -0.0275363
YBX1 Y box binding protein 1 -0.0274255
FBXO11 F-box protein 11 -0.0269812
HMGA1 high mobility group AT-hook 1 -0.0259723
KDM6B lysine (K)-specific demethylase 6B -0.025231
RPLP2 ribosomal protein, large, P2 -0.0244542
RPS19 ribosomal protein S19 -0.0244459
RPL37A ribosomal protein L37a -0.0243757
NTSR1 neurotensin receptor 1 (high affinity) -0.0240133
RPS8 ribosomal protein S8 -0.0239253
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.023899
RPL36 ribosomal protein L36 -0.023823
SPRED2 sprouty-related, EVH1 domain containing 2 -0.023758
KMT2D lysine (K)-specific methyltransferase 2D -0.0235776
EEF1G eukaryotic translation elongation factor 1 gamma -0.0234734
EIF5B eukaryotic translation initiation factor 5B -0.0231893
RPL18 ribosomal protein L18 -0.0222587
RPS29 ribosomal protein S29 -0.0221154
PER1 period circadian clock 1 -0.0219696
CSNK1A1 casein kinase 1, alpha 1 -0.0218566
RPL35 ribosomal protein L35 -0.0213932
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0212751
WNT2B wingless-type MMTV integration site family, member 2B -0.0210765
WASF2 WAS protein family, member 2 -0.0207753
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0206443
CCNL1 cyclin L1 -0.0203649
H1-0 H1.0 linker histone -0.0203649
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.020177
RPS3 ribosomal protein S3 -0.019967
NACA nascent polypeptide-associated complex alpha subunit -0.0199544
KCMF1 potassium channel modulatory factor 1 -0.0199319
DLC1 DLC1 Rho GTPase activating protein -0.0198908
RPS6 ribosomal protein S6 -0.0194779
FTL ferritin, light polypeptide -0.0192187
RPS25 ribosomal protein S25 -0.0190436
BPTF bromodomain PHD finger transcription factor -0.0189312
STC1 stanniocalcin 1 -0.0188558
INTS6 integrator complex subunit 6 -0.0188008
RPL5 ribosomal protein L5 -0.0187766
NR4A1 nuclear receptor subfamily 4, group A, member 1 -0.0186175
MYPN myopalladin -0.0184806
RPL23 ribosomal protein L23 -0.0183335
RPL13A ribosomal protein L13a -0.0182411
SETD5 SET domain containing 5 -0.0181471
BRD4 bromodomain containing 4 -0.0175818
RPS23 ribosomal protein S23 -0.0175687
RBM25 RNA binding motif protein 25 -0.0174293
TMBIM6 transmembrane BAX inhibitor motif containing 6 -0.0172757
BSG basigin (Ok blood group) -0.0172428
BAG6 BCL2-associated athanogene 6 -0.0171749
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0169803
SON SON DNA binding protein -0.0167813
CDK2AP2 cyclin-dependent kinase 2 associated protein 2 -0.0165118
RPS2 ribosomal protein S2 -0.0163664
TIPARP TCDD-inducible poly(ADP-ribose) polymerase -0.0160648
RACK1 receptor for activated C kinase 1 -0.016
ZCCHC7 zinc finger, CCHC domain containing 7 -0.015931
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0158616
RPS20 ribosomal protein S20 -0.0158312
CCT2 chaperonin containing TCP1, subunit 2 (beta) -0.0158288
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0157294
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 -0.015416
MAGEA4 melanoma antigen family A4 -0.0153728
RPL34 ribosomal protein L34 -0.0152711