Cytarabine (hydrochloride)_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cytarabine (hydrochloride) perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cytarabine (hydrochloride)_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.160841
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.149604
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.107572
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0942361
NAMPT nicotinamide phosphoribosyltransferase 0.0914587
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0690354
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.061317
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.06071
FXR1 fragile X mental retardation, autosomal homolog 1 0.0489809
MYH9 myosin, heavy chain 9, non-muscle 0.0458555
CCNL1 cyclin L1 0.0440205
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0432342
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0428591
ASPH aspartate beta-hydroxylase 0.0427249
HSPA8 heat shock 70kDa protein 8 0.0396322
RPL4 ribosomal protein L4 0.0394712
BHLHE40 basic helix-loop-helix family, member e40 0.0393765
CANX calnexin 0.0365951
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0365793
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0361159
PCBP2 poly(rC) binding protein 2 0.0357259
NCKAP1 NCK-associated protein 1 0.0356994
MATR3 matrin 3 0.0343029
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0342886
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0336768
ARRDC3 arrestin domain containing 3 0.0336764
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0336367
USP3 ubiquitin specific peptidase 3 0.032537
FAM13A family with sequence similarity 13, member A 0.0323485
EEF2 eukaryotic translation elongation factor 2 0.0317026
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0309136
AHNAK AHNAK nucleoprotein 0.0303821
TPM3 tropomyosin 3 0.0300652
UBA6 ubiquitin-like modifier activating enzyme 6 0.0295188
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.028899
SDC4 syndecan 4 0.0281883
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0279815
CPNE8 copine VIII 0.0278845
BIRC3 baculoviral IAP repeat containing 3 0.027745
CD83 CD83 molecule 0.0274353
TFG TRK-fused gene 0.0272124
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0268479
ELL2 elongation factor, RNA polymerase II, 2 0.0265849
ZNF292 zinc finger protein 292 0.0265816
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0262395
TNIP1 TNFAIP3 interacting protein 1 0.0259185
PLEC plectin 0.0258455
PEG10 paternally expressed 10 0.0252993
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0252457
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.025223
PAPOLA poly(A) polymerase alpha 0.0252162
EIF4A2 eukaryotic translation initiation factor 4A2 0.0249657
RAD23B RAD23 homolog B (S. cerevisiae) 0.0245403
MSMO1 methylsterol monooxygenase 1 0.0245344
GARS1 glycyl-tRNA synthetase 1 0.0245039
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0241978
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.024086
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0238906
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0237183
CDC73 cell division cycle 73 0.0236773
NUP58 nucleoporin 58 0.0234627
MSN moesin 0.0229209
TXNRD1 thioredoxin reductase 1 0.0227493
DSPP dentin sialophosphoprotein 0.0226278
APP amyloid beta (A4) precursor protein 0.0223286
RBM33 RNA binding motif protein 33 0.0222159
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0222032
RYBP RING1 and YY1 binding protein 0.0218981
MEF2A myocyte enhancer factor 2A 0.0213375
YTHDC1 YTH domain containing 1 0.0212993
ADAM9 ADAM metallopeptidase domain 9 0.0210622
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0209891
PDIA6 protein disulfide isomerase family A, member 6 0.0209511
QKI QKI, KH domain containing, RNA binding 0.0207575
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0206645
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0205222
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.020451
TMEM131L transmembrane 131 like 0.019841
IPO7 importin 7 0.0197254
PPP1R15B protein phosphatase 1, regulatory subunit 15B 0.0195776
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0195732
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0195679
FAR1 fatty acyl CoA reductase 1 0.0193326
IRF6 interferon regulatory factor 6 0.019233
LRRC1 leucine rich repeat containing 1 0.0191415
NAP1L1 nucleosome assembly protein 1-like 1 0.0189843
NPTN neuroplastin 0.018903
MTMR3 myotubularin related protein 3 0.0188438
CD46 CD46 molecule, complement regulatory protein 0.0188218
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0184986
SET SET nuclear proto-oncogene 0.0184394
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0184203
LYN LYN proto-oncogene, Src family tyrosine kinase 0.0184094
EIF4B eukaryotic translation initiation factor 4B 0.0183658
TFRC transferrin receptor 0.0183156
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0180103
DSCAM Down syndrome cell adhesion molecule 0.01792
GLS2 glutaminase 2 (liver, mitochondrial) 0.0179083
USP12 ubiquitin specific peptidase 12 0.0178744
USP9X ubiquitin specific peptidase 9, X-linked 0.0178706

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.228989
TMSB10 thymosin beta 10 -0.190362
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.172329
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.163482
PTMA prothymosin, alpha -0.155982
IFI27 interferon, alpha-inducible protein 27 -0.0850627
LIMCH1 LIM and calponin homology domains 1 -0.0798734
FBXO32 F-box protein 32 -0.0759935
S100A6 S100 calcium binding protein A6 -0.0753846
CSTB cystatin B (stefin B) -0.0742926
IFI6 interferon, alpha-inducible protein 6 -0.0693227
SOX4 SRY (sex determining region Y)-box 4 -0.0672089
EIF1 eukaryotic translation initiation factor 1 -0.0655836
EXT1 exostosin glycosyltransferase 1 -0.0636767
LMO7 LIM domain 7 -0.0631272
IGFBP3 insulin-like growth factor binding protein 3 -0.0629592
SAMD4A sterile alpha motif domain containing 4A -0.061663
TM4SF1 transmembrane 4 L six family member 1 -0.0612137
S100A10 S100 calcium binding protein A10 -0.0603386
TPT1 tumor protein, translationally-controlled 1 -0.0592199
IFITM1 interferon induced transmembrane protein 1 -0.0574515
ACTG1 actin gamma 1 -0.0567602
IFITM3 interferon induced transmembrane protein 3 -0.0564412
WSB1 WD repeat and SOCS box containing 1 -0.0559197
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0556573
LPP LIM domain containing preferred translocation partner in lipoma -0.0549415
RPL35A ribosomal protein L35a -0.0541164
ISG15 ISG15 ubiquitin-like modifier -0.0529832
BASP1 brain abundant, membrane attached signal protein 1 -0.0525381
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0517695
POTEF POTE ankyrin domain family, member F -0.051616
MT2A metallothionein 2A -0.0506741
HLA-A major histocompatibility complex, class I, A -0.05053
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.050286
ERBIN erbb2 interacting protein -0.0486317
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0476413
LAMB3 laminin, beta 3 -0.046585
NPEPPS aminopeptidase puromycin sensitive -0.0453917
TPM4 tropomyosin 4 -0.0451155
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 -0.0437328
TMEM165 transmembrane protein 165 -0.042907
GNAS GNAS complex locus -0.0428462
ACBD3 acyl-CoA binding domain containing 3 -0.042187
RPL34 ribosomal protein L34 -0.0419054
MYO1E myosin IE -0.0406713
HLA-B major histocompatibility complex, class I, B -0.0396011
CCND1 cyclin D1 -0.0389037
MDK midkine (neurite growth-promoting factor 2) -0.0388823
S100A9 S100 calcium binding protein A9 -0.0388085
RAB7A RAB7A, member RAS oncogene family -0.0386512
KDM5B lysine (K)-specific demethylase 5B -0.038435
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0381841
ALCAM activated leukocyte cell adhesion molecule -0.0378262
LY6E lymphocyte antigen 6 complex, locus E -0.0369692
VIM vimentin -0.0369132
SACK1A scaffolding CK1 anchoring protein A -0.0369074
RRBP1 ribosome binding protein 1 -0.0367966
HMGA1 high mobility group AT-hook 1 -0.0361678
UBE2H ubiquitin-conjugating enzyme E2H -0.0355332
RPLP1 ribosomal protein, large, P1 -0.0354576
RPLP2 ribosomal protein, large, P2 -0.0354408
EFNA5 ephrin-A5 -0.0352316
RPS29 ribosomal protein S29 -0.0352311
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0349184
HSPB1 heat shock 27kDa protein 1 -0.0348834
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0347746
TMSB4X thymosin beta 4, X-linked -0.0342676
TMEM263 transmembrane protein 263 -0.034069
ITCH itchy E3 ubiquitin protein ligase -0.0339907
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0339584
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0337903
UBC ubiquitin C -0.0336404
MYO6 myosin VI -0.0335253
LMNA lamin A/C -0.0333161
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0332293
TXNIP thioredoxin interacting protein -0.0328511
CD2AP CD2-associated protein -0.0326649
SEC31A SEC31 homolog A (S. cerevisiae) -0.0324972
RPS13 ribosomal protein S13 -0.0323569
RASAL2 RAS protein activator like 2 -0.0323254
SH3KBP1 SH3-domain kinase binding protein 1 -0.0317127
RPS19 ribosomal protein S19 -0.0315576
F3 coagulation factor III (thromboplastin, tissue factor) -0.031545
RAI14 retinoic acid induced 14 -0.0313341
TPI1 triosephosphate isomerase 1 -0.0310334
RPS23 ribosomal protein S23 -0.0309579
RPL8 ribosomal protein L8 -0.030791
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0304011
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0303546
ARHGAP5 Rho GTPase activating protein 5 -0.0303356
CD63 CD63 molecule -0.0302991
RPS24 ribosomal protein S24 -0.0300761
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0297776
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.029751
MX2 MX dynamin-like GTPase 2 -0.0296818
F11R F11 receptor -0.02958
CDCP1 CUB domain containing protein 1 -0.0295434
NIPBL Nipped-B homolog (Drosophila) -0.0295313
GOLGB1 golgin B1 -0.0291941
RBM47 RNA binding motif protein 47 -0.0290522