Cytarabine (hydrochloride)_PANC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cytarabine (hydrochloride) perturbation in PANC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cytarabine (hydrochloride)_PANC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FBL fibrillarin 0.172157
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.138305
ACTG1 actin gamma 1 0.0835495
AHNAK AHNAK nucleoprotein 0.0640456
ATP13A3 ATPase type 13A3 0.0525303
SPAG9 sperm associated antigen 9 0.0506516
OGA O-GlcNAcase 0.0491147
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0488437
PCBP2 poly(rC) binding protein 2 0.0442692
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.041849
ADAM17 ADAM metallopeptidase domain 17 0.0390057
HELLS helicase, lymphoid-specific 0.0389804
ENO1 enolase 1, (alpha) 0.0386352
FMNL2 formin-like 2 0.037452
EIF4B eukaryotic translation initiation factor 4B 0.0366356
PUM2 pumilio RNA-binding family member 2 0.0366067
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0362641
NUP153 nucleoporin 153kDa 0.0353236
USP3 ubiquitin specific peptidase 3 0.0352315
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0350499
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0340876
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0333596
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1 0.0320733
RRM2 ribonucleotide reductase M2 0.031664
AFDN afadin, adherens junction formation factor 0.031287
NAP1L4 nucleosome assembly protein 1-like 4 0.0309642
NUP58 nucleoporin 58 0.0303892
SUCO SUN domain containing ossification factor 0.0303875
TPM3 tropomyosin 3 0.0303371
PICALM phosphatidylinositol binding clathrin assembly protein 0.0301675
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0300227
ELOVL5 ELOVL fatty acid elongase 5 0.0291897
WDR45B WD repeat domain 45B 0.0291728
CCNL1 cyclin L1 0.0290435
DGKD diacylglycerol kinase, delta 130kDa 0.0288238
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0288028
UBA2 ubiquitin-like modifier activating enzyme 2 0.0282541
TFG TRK-fused gene 0.0281467
BIRC6 baculoviral IAP repeat containing 6 0.0277628
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 0.0276423
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0270974
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila) 0.0268575
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0268159
RPL4 ribosomal protein L4 0.026613
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0266035
MARCHF6 membrane associated ring-CH-type finger 6 0.026342
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0258446
IPO7 importin 7 0.0255596
TRIO trio Rho guanine nucleotide exchange factor 0.0255532
QKI QKI, KH domain containing, RNA binding 0.025428
LRRC49 leucine rich repeat containing 49 0.0254236
OLA1 Obg-like ATPase 1 0.0252561
KRT8 keratin 8, type II 0.0249551
DENND5A DENN/MADD domain containing 5A 0.0240977
FANCI Fanconi anemia, complementation group I 0.0240603
ATAD2 ATPase family, AAA domain containing 2 0.0238669
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 0.0237509
RLF rearranged L-myc fusion 0.0237434
WDR43 WD repeat domain 43 0.0235528
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0235317
PLAU plasminogen activator, urokinase 0.0234162
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0234094
KPNB1 karyopherin (importin) beta 1 0.0227657
UBE2O ubiquitin-conjugating enzyme E2O 0.0226213
YAP1 Yes-associated protein 1 0.0224419
COPA coatomer protein complex, subunit alpha 0.0224351
SDC4 syndecan 4 0.0223914
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0223379
ARRDC3 arrestin domain containing 3 0.0222027
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0220995
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0220038
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0216717
DENND4A DENN/MADD domain containing 4A 0.0215765
FAR1 fatty acyl CoA reductase 1 0.0214692
APP amyloid beta (A4) precursor protein 0.0214563
PHIP pleckstrin homology domain interacting protein 0.0210724
ITGAV integrin, alpha V 0.021054
GOLGA4 golgin A4 0.0208866
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0208789
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0208462
POTEF POTE ankyrin domain family, member F 0.0207773
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0207495
MYH9 myosin, heavy chain 9, non-muscle 0.0206059
CPNE8 copine VIII 0.0201813
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0200944
NAV2 neuron navigator 2 0.0200772
MATR3 matrin 3 0.0200539
TMEM41B transmembrane protein 41B 0.0200472
MED13L mediator complex subunit 13-like 0.0199658
RRM1 ribonucleotide reductase M1 0.0198631
TBK1 TANK-binding kinase 1 0.0198178
YBX1 Y box binding protein 1 0.0197021
SNX13 sorting nexin 13 0.0196276
UVRAG UV radiation resistance associated 0.0195022
KDM6A lysine (K)-specific demethylase 6A 0.0194571
BZW1 basic leucine zipper and W2 domains 1 0.0191851
EIF4A2 eukaryotic translation initiation factor 4A2 0.0191346
ZCCHC7 zinc finger, CCHC domain containing 7 0.019056
PAWR PRKC, apoptosis, WT1, regulator 0.0190132
CCDC14 coiled-coil domain containing 14 0.0186461

decreased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 -0.323435
ERRFI1 ERBB receptor feedback inhibitor 1 -0.193394
VIM vimentin -0.182633
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.143411
VCL vinculin -0.0925901
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0782993
CENPF centromere protein F, 350/400kDa -0.0748248
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0684504
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0640791
CD44 CD44 molecule (Indian blood group) -0.0619096
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0572775
TMSB10 thymosin beta 10 -0.0566825
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0542054
MT2A metallothionein 2A -0.0475435
SAMD4B sterile alpha motif domain containing 4B -0.0455191
MKI67 marker of proliferation Ki-67 -0.0434029
ZNF780B zinc finger protein 780B -0.0431179
SLC35F3 solute carrier family 35, member F3 -0.0424919
ZFP36 ZFP36 ring finger protein -0.042246
PTMA prothymosin, alpha -0.0421662
RPS16 ribosomal protein S16 -0.0417131
SLC38A2 solute carrier family 38, member 2 -0.0415663
ASPH aspartate beta-hydroxylase -0.0414206
MCL1 myeloid cell leukemia 1 -0.0407615
EGR1 early growth response 1 -0.0405617
RPS2 ribosomal protein S2 -0.0400396
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0393102
CSNK1A1 casein kinase 1, alpha 1 -0.0374811
KTN1 kinectin 1 (kinesin receptor) -0.037286
ANGPTL4 angiopoietin-like 4 -0.0344751
EGFR epidermal growth factor receptor -0.0344465
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0342772
RNF220 ring finger protein 220 -0.0337918
THSD4 thrombospondin, type I, domain containing 4 -0.033271
AFAP1 actin filament associated protein 1 -0.0331811
FTL ferritin, light polypeptide -0.0329852
ZBTB20 zinc finger and BTB domain containing 20 -0.0328199
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0327252
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.0326168
RPS24 ribosomal protein S24 -0.0323507
MAML3 mastermind-like 3 (Drosophila) -0.0322149
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0320069
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0316651
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0309804
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0303111
USP34 ubiquitin specific peptidase 34 -0.0300384
CENPE centromere protein E, 312kDa -0.0299968
ACTN4 actinin, alpha 4 -0.0296797
ATM ATM serine/threonine kinase -0.0296264
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0294995
RPLP2 ribosomal protein, large, P2 -0.0289785
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0289629
ATXN1 ataxin 1 -0.0288704
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.028599
MAP1B microtubule-associated protein 1B -0.0285599
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0282626
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) -0.0280962
INTS6 integrator complex subunit 6 -0.0277846
FBXO17 F-box protein 17 -0.0268973
SDK1 sidekick cell adhesion molecule 1 -0.0268342
UBASH3B ubiquitin associated and SH3 domain containing B -0.0266792
MYO9A myosin IXA -0.0266369
TM4SF1 transmembrane 4 L six family member 1 -0.0265702
BRD2 bromodomain containing 2 -0.0263198
RPL28 ribosomal protein L28 -0.0261463
NT5E 5'-nucleotidase, ecto (CD73) -0.0259065
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0257978
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0257603
OSMR oncostatin M receptor -0.0257399
MBD5 methyl-CpG binding domain protein 5 -0.0253723
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0248434
GOLGB1 golgin B1 -0.0248053
NUP98 nucleoporin 98kDa -0.0246122
TAS2R14 taste receptor, type 2, member 14 -0.0245697
MYADM myeloid-associated differentiation marker -0.0245167
TPX2 TPX2, microtubule-associated -0.0243482
PLEKHG2 pleckstrin homology domain containing, family G (with RhoGef domain) member 2 -0.0241993
FHL2 four and a half LIM domains 2 -0.0239782
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0239238
SRRM2 serine/arginine repetitive matrix 2 -0.0237733
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0237036
H1-0 H1.0 linker histone -0.0236427
TPM1 tropomyosin 1 (alpha) -0.0232883
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0231259
ANO6 anoctamin 6 -0.0230854
EXT1 exostosin glycosyltransferase 1 -0.0230827
BPTF bromodomain PHD finger transcription factor -0.0228679
FBXL17 F-box and leucine-rich repeat protein 17 -0.0228485
MYO1E myosin IE -0.0225128
RPL37A ribosomal protein L37a -0.0224525
GLCCI1 glucocorticoid induced 1 -0.0224094
ATG7 autophagy related 7 -0.0221355
SMYD3 SET and MYND domain containing 3 -0.0221011
WSB1 WD repeat and SOCS box containing 1 -0.021814
ANKRD12 ankyrin repeat domain 12 -0.0218113
DOCK1 dedicator of cytokinesis 1 -0.0217617
PRELID2 PRELI domain containing 2 -0.0214424
PDIA3 protein disulfide isomerase family A, member 3 -0.0213847
CTSD cathepsin D -0.0212037
MACF1 microtubule-actin crosslinking factor 1 -0.0211012