Cytarabine (hydrochloride)_Panc 03.27 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cytarabine (hydrochloride) perturbation in Panc 03.27 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cytarabine (hydrochloride)_Panc 03.27 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LAMB3 laminin, beta 3 0.144913
FNDC3B fibronectin type III domain containing 3B 0.0927757
NAV2 neuron navigator 2 0.0866771
MYO6 myosin VI 0.0851572
UGCG UDP-glucose ceramide glucosyltransferase 0.0807018
CCNL1 cyclin L1 0.0762973
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0756338
MACF1 microtubule-actin crosslinking factor 1 0.0733026
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.068933
SDC4 syndecan 4 0.0678883
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0663618
TSC22D2 TSC22 domain family, member 2 0.0640571
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0628305
AFDN afadin, adherens junction formation factor 0.0605154
POTEF POTE ankyrin domain family, member F 0.0604976
VEGFA vascular endothelial growth factor A 0.0569435
CD47 CD47 molecule 0.0559957
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0559287
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0554354
PCBP2 poly(rC) binding protein 2 0.0553043
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0547333
GOLGA4 golgin A4 0.0534809
NRIP1 nuclear receptor interacting protein 1 0.052331
DDIT4 DNA-damage-inducible transcript 4 0.0519769
LPP LIM domain containing preferred translocation partner in lipoma 0.0506322
ARRDC3 arrestin domain containing 3 0.0503013
ARHGAP29 Rho GTPase activating protein 29 0.0501015
SAMD4A sterile alpha motif domain containing 4A 0.0491196
UBA6 ubiquitin-like modifier activating enzyme 6 0.04822
PLAU plasminogen activator, urokinase 0.0481661
OGA O-GlcNAcase 0.0479123
DLG1 discs, large homolog 1 (Drosophila) 0.047453
SLMAP sarcolemma associated protein 0.0455045
TMF1 TATA element modulatory factor 1 0.0452677
FAM3C family with sequence similarity 3, member C 0.0447844
TPM3 tropomyosin 3 0.0440714
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.043836
TRIO trio Rho guanine nucleotide exchange factor 0.0433447
DSPP dentin sialophosphoprotein 0.0429588
MEF2A myocyte enhancer factor 2A 0.0426617
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0421107
PABPC1 poly(A) binding protein, cytoplasmic 1 0.041809
PDE8A phosphodiesterase 8A 0.0396729
MBNL2 muscleblind-like splicing regulator 2 0.0388421
PARD3 par-3 family cell polarity regulator 0.0387344
UBE2H ubiquitin-conjugating enzyme E2H 0.0385943
NPEPPS aminopeptidase puromycin sensitive 0.0385161
RPS12 ribosomal protein S12 0.0384128
RAB6A RAB6A, member RAS oncogene family 0.0382627
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0372276
ITCH itchy E3 ubiquitin protein ligase 0.0370858
TMOD3 tropomodulin 3 (ubiquitous) 0.0363565
KMT2E lysine (K)-specific methyltransferase 2E 0.0359784
FGD4 FYVE, RhoGEF and PH domain containing 4 0.0355483
FXR1 fragile X mental retardation, autosomal homolog 1 0.0351801
FOSL1 FOS-like antigen 1 0.0351653
RUNX1 runt-related transcription factor 1 0.0351651
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0348101
ZNF292 zinc finger protein 292 0.0342716
XPO1 exportin 1 0.0341107
PLPP6 phospholipid phosphatase 6 0.0336217
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like 0.0335444
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0334732
TNIP1 TNFAIP3 interacting protein 1 0.033419
KDM6A lysine (K)-specific demethylase 6A 0.0330271
ANLN anillin, actin binding protein 0.032929
KIAA1671 KIAA1671 0.0324459
PICALM phosphatidylinositol binding clathrin assembly protein 0.0322687
SMAD3 SMAD family member 3 0.032249
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0321616
RTN4 reticulon 4 0.0318155
DST dystonin 0.0313729
YAP1 Yes-associated protein 1 0.0312678
AKAP9 A kinase (PRKA) anchor protein 9 0.0307696
PNN pinin, desmosome associated protein 0.0306629
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.030114
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0298446
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0296271
SEC23A Sec23 homolog A (S. cerevisiae) 0.0296024
KIAA1217 KIAA1217 0.0295703
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 0.0295664
RLF rearranged L-myc fusion 0.0292569
ATP11B ATPase, class VI, type 11B 0.0291239
FAM13A family with sequence similarity 13, member A 0.0291009
PRRC2C proline-rich coiled-coil 2C 0.0290798
PTBP3 polypyrimidine tract binding protein 3 0.029065
CCNY cyclin Y 0.0288022
ERBIN erbb2 interacting protein 0.028703
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0284824
KPNB1 karyopherin (importin) beta 1 0.0284092
RBM25 RNA binding motif protein 25 0.0281182
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0278652
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 0.0275915
BHLHE40 basic helix-loop-helix family, member e40 0.0275736
NDRG1 N-myc downstream regulated 1 0.0275485
BZW1 basic leucine zipper and W2 domains 1 0.0273697
EIF4A2 eukaryotic translation initiation factor 4A2 0.0273196
GRB10 growth factor receptor-bound protein 10 0.0272744
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0268898
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0266231

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.363149
TMSB10 thymosin beta 10 -0.145334
UBC ubiquitin C -0.103317
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0936381
LAMA4 laminin, alpha 4 -0.0891637
TPT1 tumor protein, translationally-controlled 1 -0.0799949
RPS27A ribosomal protein S27a -0.060744
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0571655
OSMR oncostatin M receptor -0.0562242
ZBTB20 zinc finger and BTB domain containing 20 -0.0558805
PLSCR1 phospholipid scramblase 1 -0.0505478
RPLP1 ribosomal protein, large, P1 -0.0487167
KRT19 keratin 19, type I -0.0479767
RPL31 ribosomal protein L31 -0.0468174
RPS24 ribosomal protein S24 -0.0465614
TM4SF1 transmembrane 4 L six family member 1 -0.0446252
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0439804
SLC38A2 solute carrier family 38, member 2 -0.0426466
FTL ferritin, light polypeptide -0.0422244
RPS5 ribosomal protein S5 -0.0411657
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0402966
H1-0 H1.0 linker histone -0.0402142
LOC102724023 ES1 protein homolog, mitochondrial -0.0391168
S100A10 S100 calcium binding protein A10 -0.0374517
INTS6 integrator complex subunit 6 -0.0373754
RPL32 ribosomal protein L32 -0.0373497
NF1 neurofibromin 1 -0.0366541
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0361332
HLA-E major histocompatibility complex, class I, E -0.0360027
RPL8 ribosomal protein L8 -0.0358811
H3-3B H3.3 histone B -0.0358403
EIF1 eukaryotic translation initiation factor 1 -0.0355595
EFNA5 ephrin-A5 -0.0350214
ACTN4 actinin, alpha 4 -0.0344412
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0339341
AHNAK AHNAK nucleoprotein -0.0337176
RPS23 ribosomal protein S23 -0.0328595
ANXA2 annexin A2 -0.0322419
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.031888
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0314428
THBS1 thrombospondin 1 -0.0313358
TXNIP thioredoxin interacting protein -0.0313302
RPS15 ribosomal protein S15 -0.0311973
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0309248
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0307832
KRT7 keratin 7, type II -0.0301984
BPTF bromodomain PHD finger transcription factor -0.0297823
SENP5 SUMO1/sentrin specific peptidase 5 -0.0297039
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0296308
RPL34 ribosomal protein L34 -0.0293279
CDK12 cyclin-dependent kinase 12 -0.0288148
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0286199
ETV6 ets variant 6 -0.0285456
IFI27 interferon, alpha-inducible protein 27 -0.0279016
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0274383
F3 coagulation factor III (thromboplastin, tissue factor) -0.0269133
RACK1 receptor for activated C kinase 1 -0.0267458
CLDN1 claudin 1 -0.0265417
PCLO piccolo presynaptic cytomatrix protein -0.0265343
MYO1E myosin IE -0.025448
JUN jun proto-oncogene -0.0251646
EZR ezrin -0.0251559
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0251162
RPL36AL ribosomal protein L36a-like -0.0248535
EHF ets homologous factor -0.0247437
EMP1 epithelial membrane protein 1 -0.0244179
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0240768
REEP3 receptor accessory protein 3 -0.0240654
TUBB tubulin, beta class I -0.0240101
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0238542
SP100 SP100 nuclear antigen -0.023674
WWC1 WW and C2 domain containing 1 -0.0233549
EPCAM epithelial cell adhesion molecule -0.0229228
MX2 MX dynamin-like GTPase 2 -0.0227236
RPL23 ribosomal protein L23 -0.0227075
RPS13 ribosomal protein S13 -0.0225253
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0224744
HLA-C major histocompatibility complex, class I, C -0.0223417
LY6E lymphocyte antigen 6 complex, locus E -0.0222947
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0222376
CD44 CD44 molecule (Indian blood group) -0.0219515
FHIT fragile histidine triad -0.021512
LMO7 LIM domain 7 -0.0213295
ARHGAP5 Rho GTPase activating protein 5 -0.0212887
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0211607
SLC38A1 solute carrier family 38, member 1 -0.0210043
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.020674
RPL28 ribosomal protein L28 -0.0204916
TAS2R14 taste receptor, type 2, member 14 -0.0204795
IL1RAP interleukin 1 receptor accessory protein -0.0204233
NCOA7 nuclear receptor coactivator 7 -0.0203788
FBXL17 F-box and leucine-rich repeat protein 17 -0.0203334
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0201325
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0200822
ST14 suppression of tumorigenicity 14 (colon carcinoma) -0.0200394
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0199229
VMP1 vacuole membrane protein 1 -0.0198997
SCLT1 sodium channel and clathrin linker 1 -0.0195498
UBASH3B ubiquitin associated and SH3 domain containing B -0.0194265
C15ORF48 chromosome 15 open reading frame 48 -0.019354