Cytarabine (hydrochloride)_SHP-77 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cytarabine (hydrochloride) perturbation in SHP-77 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cytarabine (hydrochloride)_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NALF1 NALCN channel auxiliary factor 1 0.109764
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0905671
DTNA dystrobrevin, alpha 0.0897253
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0859281
CHD7 chromodomain helicase DNA binding protein 7 0.0837746
ENO1 enolase 1, (alpha) 0.0830034
SMOC1 SPARC related modular calcium binding 1 0.0776252
PTMA prothymosin, alpha 0.0773451
ZNF292 zinc finger protein 292 0.0757599
PEG10 paternally expressed 10 0.0753554
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0739477
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0677743
MAP1B microtubule-associated protein 1B 0.0663457
SASH1 SAM and SH3 domain containing 1 0.0626589
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0605701
PELI2 pellino E3 ubiquitin protein ligase family member 2 0.0598254
SINHCAF SIN3-HDAC complex associated factor 0.0597596
TPM3 tropomyosin 3 0.0586736
CPE carboxypeptidase E 0.0580397
MATR3 matrin 3 0.0573317
FAM13A family with sequence similarity 13, member A 0.0566269
PUM2 pumilio RNA-binding family member 2 0.0548749
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0540488
CAMTA1 calmodulin binding transcription activator 1 0.0532696
NCOR1 nuclear receptor corepressor 1 0.052988
NBAS neuroblastoma amplified sequence 0.0528788
NCAM1 neural cell adhesion molecule 1 0.0523275
TRIO trio Rho guanine nucleotide exchange factor 0.0522214
MACF1 microtubule-actin crosslinking factor 1 0.0520309
PRKD1 protein kinase D1 0.0520266
MED13L mediator complex subunit 13-like 0.0517737
DGKB diacylglycerol kinase, beta 90kDa 0.0510826
MARCHF6 membrane associated ring-CH-type finger 6 0.0510437
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0503602
NFIA nuclear factor I/A 0.0501075
DPYSL3 dihydropyrimidinase-like 3 0.0498573
PGK1 phosphoglycerate kinase 1 0.0474802
MBNL2 muscleblind-like splicing regulator 2 0.047373
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0471831
LIFR leukemia inhibitory factor receptor alpha 0.0470885
FAF1 Fas (TNFRSF6) associated factor 1 0.0462669
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.045498
RTN4 reticulon 4 0.0452066
WRN Werner syndrome, RecQ helicase-like 0.0451543
PITPNM2 phosphatidylinositol transfer protein, membrane-associated 2 0.0447715
ATAD2 ATPase family, AAA domain containing 2 0.0444669
SSBP2 single-stranded DNA binding protein 2 0.0431946
KPNB1 karyopherin (importin) beta 1 0.0431261
XPO1 exportin 1 0.0431034
GRB10 growth factor receptor-bound protein 10 0.042888
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0427008
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0426036
CCNY cyclin Y 0.0423093
CA8 carbonic anhydrase VIII 0.0422232
WDR45B WD repeat domain 45B 0.0420887
MYH9 myosin, heavy chain 9, non-muscle 0.0420664
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5 0.0418134
RPL4 ribosomal protein L4 0.0411471
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0410181
PPME1 protein phosphatase methylesterase 1 0.0405734
MSI2 musashi RNA-binding protein 2 0.0397604
NCKAP1 NCK-associated protein 1 0.039693
GPHN gephyrin 0.0392969
ADAM17 ADAM metallopeptidase domain 17 0.0391049
PTK2 protein tyrosine kinase 2 0.039027
DGKD diacylglycerol kinase, delta 130kDa 0.0389889
RIT2 Ras-like without CAAX 2 0.0387284
CHGB chromogranin B 0.038655
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0384791
TSPYL2 TSPY-like 2 0.0383638
SET SET nuclear proto-oncogene 0.0383124
NUP58 nucleoporin 58 0.0381043
BCLAF1 BCL2-associated transcription factor 1 0.0376671
ADGRL2 adhesion G protein-coupled receptor L2 0.0373825
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit 0.0373217
HELLS helicase, lymphoid-specific 0.0372131
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0370983
XRN2 5'-3' exoribonuclease 2 0.0368786
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0368774
PCBP3 poly(rC) binding protein 3 0.0368301
CDK5RAP2 CDK5 regulatory subunit associated protein 2 0.0367951
TPD52 tumor protein D52 0.0365488
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0361493
FANCI Fanconi anemia, complementation group I 0.0359255
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0356368
AFF1 AF4/FMR2 family, member 1 0.0354657
KTN1 kinectin 1 (kinesin receptor) 0.0354353
CYRIB CYFIP related Rac1 interactor B 0.0354021
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0353218
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0352944
DST dystonin 0.035074
RAD21 RAD21 homolog (S. pombe) 0.0348024
ZNF395 zinc finger protein 395 0.0343793
UBA6 ubiquitin-like modifier activating enzyme 6 0.0341672
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0338454
RRM2 ribonucleotide reductase M2 0.0338147
PCM1 pericentriolar material 1 0.0337422
LOC112694756 uncharaterized LOC112694756 0.0336238
HDAC9 histone deacetylase 9 0.0333894
ARB2A ARB2 cotranscriptional regulator A 0.0333836

decreased expression

Symbol Name Standardized Value
TENM1 teneurin transmembrane protein 1 -0.178649
SNTG1 syntrophin, gamma 1 -0.101822
MT2A metallothionein 2A -0.0852288
FTL ferritin, light polypeptide -0.0639049
RIMS2 regulating synaptic membrane exocytosis 2 -0.0498529
GDAP1 ganglioside induced differentiation associated protein 1 -0.0424249
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0418644
MCTP1 multiple C2 domains, transmembrane 1 -0.0409523
GPC5 glypican 5 -0.0401032
EGR1 early growth response 1 -0.0399843
ESRRG estrogen-related receptor gamma -0.0394934
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0378433
TSHZ2 teashirt zinc finger homeobox 2 -0.0375658
ZBTB20 zinc finger and BTB domain containing 20 -0.0364702
KCNMB3 potassium channel subfamily M regulatory beta subunit 3 -0.0334916
KCNB2 potassium channel, voltage gated Shab related subfamily B, member 2 -0.0327459
RNF213 ring finger protein 213 -0.0326805
ST18 suppression of tumorigenicity 18, zinc finger -0.0309679
KIF26B kinesin family member 26B -0.0303841
SLC38A2 solute carrier family 38, member 2 -0.030045
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6 -0.0292263
SP100 SP100 nuclear antigen -0.0290427
NLGN1 neuroligin 1 -0.0284649
TMSB10 thymosin beta 10 -0.0273036
CENPF centromere protein F, 350/400kDa -0.0271928
MCL1 myeloid cell leukemia 1 -0.027101
PTCHD4 patched domain containing 4 -0.0268476
BPTF bromodomain PHD finger transcription factor -0.0266865
H1-0 H1.0 linker histone -0.0261178
PDE4D phosphodiesterase 4D, cAMP-specific -0.0254708
CSNK1A1 casein kinase 1, alpha 1 -0.0253474
ZNF804A zinc finger protein 804A -0.0250781
RPLP1 ribosomal protein, large, P1 -0.0247617
MYT1L myelin transcription factor 1-like -0.0246825
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0246224
ANKRD36C ankyrin repeat domain 36C -0.0245995
SIK2 salt-inducible kinase 2 -0.0244443
ERRFI1 ERBB receptor feedback inhibitor 1 -0.024097
RIGI RNA sensor RIG-I -0.0240213
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0237427
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0218862
AKAP12 A kinase (PRKA) anchor protein 12 -0.0215065
RPS19 ribosomal protein S19 -0.0213166
ASIC2 acid sensing (proton gated) ion channel 2 -0.020631
MKI67 marker of proliferation Ki-67 -0.0198666
FBXL17 F-box and leucine-rich repeat protein 17 -0.0198094
PCF11 PCF11 cleavage and polyadenylation factor subunit -0.0197257
CNTNAP5 contactin associated protein-like 5 -0.0194284
INTS6 integrator complex subunit 6 -0.0193952
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0193837
UNC5D unc-5 homolog D (C. elegans) -0.0193651
PPP4R3B protein phosphatase 4 regulatory subunit 3B -0.0190509
SGO2 shugoshin 2 -0.0190096
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0188735
ZDHHC14 zinc finger, DHHC-type containing 14 -0.0188554
STAU2 staufen double-stranded RNA binding protein 2 -0.0185363
GPATCH8 G patch domain containing 8 -0.0184855
CNTNAP2 contactin associated protein-like 2 -0.0183177
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.018305
HELZ2 helicase with zinc finger 2, transcriptional coactivator -0.0182932
CRK v-crk avian sarcoma virus CT10 oncogene homolog -0.0180671
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0177868
GLCCI1 glucocorticoid induced 1 -0.0177687
SON SON DNA binding protein -0.0177407
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0177269
MT1X metallothionein 1X -0.0176971
AHI1 Abelson helper integration site 1 -0.0175651
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.0174581
IGFBP5 insulin-like growth factor binding protein 5 -0.0174474
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0172058
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0171361
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0170317
RPS11 ribosomal protein S11 -0.0169477
MACROD2 MACRO domain containing 2 -0.0169283
TXNRD1 thioredoxin reductase 1 -0.0168318
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0167737
PHF14 PHD finger protein 14 -0.016754
LRFN2 leucine rich repeat and fibronectin type III domain containing 2 -0.0166466
STPG2 sperm-tail PG-rich repeat containing 2 -0.0165783
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0164969
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) -0.0164908
PRELID2 PRELI domain containing 2 -0.0163184
NCKAP5 NCK-associated protein 5 -0.0162955
ZNF638 zinc finger protein 638 -0.0162359
FGF14 fibroblast growth factor 14 -0.0161065
NKAIN2 Na+/K+ transporting ATPase interacting 2 -0.0160982
PMP22 peripheral myelin protein 22 -0.0160351
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.016032
LARP1B La ribonucleoprotein domain family, member 1B -0.0160013
HOMER1 homer scaffolding protein 1 -0.0158385
BACE2 beta-site APP-cleaving enzyme 2 -0.0158293
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0157796
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.0157535
KANSL1L KAT8 regulatory NSL complex subunit 1-like -0.0155798
CDK13 cyclin-dependent kinase 13 -0.0155699
TBCA tubulin folding cofactor A -0.0154004
GOLGA3 golgin A3 -0.0153743
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0153101
PPP1R10 protein phosphatase 1, regulatory subunit 10 -0.0152576
SCG2 secretogranin II -0.0152278