Cytarabine (hydrochloride)_SK-MEL-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cytarabine (hydrochloride) perturbation in SK-MEL-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cytarabine (hydrochloride)_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FNDC3B fibronectin type III domain containing 3B 0.159398
LSAMP limbic system-associated membrane protein 0.159178
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.100736
NRG3 neuregulin 3 0.098884
SLC39A11 solute carrier family 39, member 11 0.098378
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0825307
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0787686
MSI2 musashi RNA-binding protein 2 0.0773008
SPAG9 sperm associated antigen 9 0.0715233
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0704617
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0646425
CXCL8 chemokine (C-X-C motif) ligand 8 0.0645852
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0626754
RAD51B RAD51 paralog B 0.0622287
KAZN kazrin, periplakin interacting protein 0.0576838
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0553693
KMT2E lysine (K)-specific methyltransferase 2E 0.0549342
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0548603
ADAM17 ADAM metallopeptidase domain 17 0.0537621
AKAP12 A kinase (PRKA) anchor protein 12 0.0526879
NOTCH2 notch 2 0.0514548
PRELID2 PRELI domain containing 2 0.050827
MSN moesin 0.0504908
SPTBN1 spectrin, beta, non-erythrocytic 1 0.048764
ZFAND3 zinc finger, AN1-type domain 3 0.0481611
FMNL2 formin-like 2 0.0481015
NLGN1 neuroligin 1 0.0479173
LINGO2 leucine rich repeat and Ig domain containing 2 0.047844
SMAD3 SMAD family member 3 0.0476662
GOLGA4 golgin A4 0.0474834
LRMDA leucine rich melanocyte differentiation associated 0.0470249
PCBP2 poly(rC) binding protein 2 0.0470174
TPM3 tropomyosin 3 0.0464491
CFAP20DC CFAP20 domain containing 0.0464249
SETD5 SET domain containing 5 0.0461534
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0456692
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0456358
ZNF292 zinc finger protein 292 0.0453544
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0446038
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0441166
BBX bobby sox homolog (Drosophila) 0.0438523
YEATS2 YEATS domain containing 2 0.0436924
PTK2 protein tyrosine kinase 2 0.0431866
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0430287
SREBF2 sterol regulatory element binding transcription factor 2 0.0415706
CHD1 chromodomain helicase DNA binding protein 1 0.0414521
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0409036
NAMPT nicotinamide phosphoribosyltransferase 0.0406226
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0405892
UBA6 ubiquitin-like modifier activating enzyme 6 0.0404907
SEPTIN9 septin 9 0.0401407
PTPRM protein tyrosine phosphatase, receptor type, M 0.0401321
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0397317
PHF21A PHD finger protein 21A 0.0392786
HELZ helicase with zinc finger 0.039257
NGLY1 N-glycanase 1 0.0392396
NBAS neuroblastoma amplified sequence 0.0389936
ELL2 elongation factor, RNA polymerase II, 2 0.0386523
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0386334
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0383872
MEF2A myocyte enhancer factor 2A 0.0379473
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0376451
OGA O-GlcNAcase 0.0372259
MAP2K1 mitogen-activated protein kinase kinase 1 0.037149
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.037094
FAM13A family with sequence similarity 13, member A 0.0366825
MMP12 matrix metallopeptidase 12 0.0364268
ANKRD11 ankyrin repeat domain 11 0.0360511
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0355011
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0354668
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0354492
SFTPA2 surfactant protein A2 0.0349609
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0347317
USP3 ubiquitin specific peptidase 3 0.0345453
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0342489
NAV2 neuron navigator 2 0.0341835
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 0.0341765
PDE4D phosphodiesterase 4D, cAMP-specific 0.0337741
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0337347
DSCAM Down syndrome cell adhesion molecule 0.0336586
CA8 carbonic anhydrase VIII 0.0336099
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0334571
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0333041
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.033166
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.033013
FYN FYN proto-oncogene, Src family tyrosine kinase 0.0327537
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 0.0325807
ATP13A3 ATPase type 13A3 0.0321566
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0320445
TRIM33 tripartite motif containing 33 0.0319196
MYH9 myosin, heavy chain 9, non-muscle 0.0318907
CSDE1 cold shock domain containing E1, RNA-binding 0.031877
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 0.031731
AFF3 AF4/FMR2 family, member 3 0.031491
CCNL1 cyclin L1 0.0313594
NFE2L1 nuclear factor, erythroid 2-like 1 0.0309914
PRRC2C proline-rich coiled-coil 2C 0.030972
FHIT fragile histidine triad 0.0309624
FLNB filamin B, beta 0.0308964
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0306762

decreased expression

Symbol Name Standardized Value
FMN1 formin 1 -0.186592
VIM vimentin -0.162152
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.159521
FN1 fibronectin 1 -0.118084
MT2A metallothionein 2A -0.102999
FRMD5 FERM domain containing 5 -0.0838946
CCND1 cyclin D1 -0.0644004
FTL ferritin, light polypeptide -0.0639059
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0635508
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0611864
TMSB10 thymosin beta 10 -0.0498678
SQSTM1 sequestosome 1 -0.0457659
TP63 tumor protein p63 -0.0441637
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -0.0439303
RPLP1 ribosomal protein, large, P1 -0.0394017
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0361066
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0355195
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0354044
EIF1 eukaryotic translation initiation factor 1 -0.0350125
TM4SF1 transmembrane 4 L six family member 1 -0.0346726
MT1X metallothionein 1X -0.0328185
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0326935
NDRG1 N-myc downstream regulated 1 -0.0322824
RASAL2 RAS protein activator like 2 -0.030506
SOX6 SRY (sex determining region Y)-box 6 -0.0299272
WWTR1 WW domain containing transcription regulator 1 -0.0294906
HDAC9 histone deacetylase 9 -0.0279082
RPL32 ribosomal protein L32 -0.0277802
RPL35A ribosomal protein L35a -0.0272226
TPT1 tumor protein, translationally-controlled 1 -0.0270803
MELTF melanotransferrin -0.0259158
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0256604
COMMD10 COMM domain containing 10 -0.0253699
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0251139
RRBP1 ribosome binding protein 1 -0.0246008
WNT2B wingless-type MMTV integration site family, member 2B -0.0245991
SLC38A2 solute carrier family 38, member 2 -0.024492
BPTF bromodomain PHD finger transcription factor -0.0244067
RACK1 receptor for activated C kinase 1 -0.0237035
TPI1 triosephosphate isomerase 1 -0.0228008
LINC02798 long intergenic non-protein coding RNA 2798 -0.0224191
ANXA2 annexin A2 -0.0223617
RPLP2 ribosomal protein, large, P2 -0.0221179
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0217791
VDAC1 voltage-dependent anion channel 1 -0.0214601
SP100 SP100 nuclear antigen -0.0214109
RPL34 ribosomal protein L34 -0.0213331
LOC112694756 uncharaterized LOC112694756 -0.021246
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 -0.0209874
RPS8 ribosomal protein S8 -0.0207341
PLSCR1 phospholipid scramblase 1 -0.0206243
OPHN1 oligophrenin 1 -0.020395
KLF6 Kruppel-like factor 6 -0.0202684
RPL28 ribosomal protein L28 -0.0198926
RPS24 ribosomal protein S24 -0.0198368
BICD1 bicaudal D homolog 1 (Drosophila) -0.0195255
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like -0.0193566
RPS23 ribosomal protein S23 -0.0191508
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) -0.0191172
RPL12 ribosomal protein L12 -0.0190826
TBCA tubulin folding cofactor A -0.0190462
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0189083
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0188881
ICAM1 intercellular adhesion molecule 1 -0.0183842
CDK6 cyclin-dependent kinase 6 -0.0179845
ZBTB20 zinc finger and BTB domain containing 20 -0.0179207
ANKRD28 ankyrin repeat domain 28 -0.0173142
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0172299
TENM1 teneurin transmembrane protein 1 -0.0171739
ACTN4 actinin, alpha 4 -0.0170788
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0170673
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0170028
IFI6 interferon, alpha-inducible protein 6 -0.0169969
FAM222B family with sequence similarity 222, member B -0.016904
HMGA1 high mobility group AT-hook 1 -0.016772
PRKN parkin RBR E3 ubiquitin protein ligase -0.0167353
EMP1 epithelial membrane protein 1 -0.0166492
H3-3B H3.3 histone B -0.0166478
EGR1 early growth response 1 -0.0165378
RPS13 ribosomal protein S13 -0.0163551
ASTN2 astrotactin 2 -0.0162665
CEMIP2 cell migration inducing hyaluronidase 2 -0.0162218
RPL38 ribosomal protein L38 -0.0161992
RPS29 ribosomal protein S29 -0.016045
TUBB tubulin, beta class I -0.0159374
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 -0.0158223
EHBP1 EH domain binding protein 1 -0.0157861
RPS5 ribosomal protein S5 -0.0157826
RPS6 ribosomal protein S6 -0.015532
CMTM7 CKLF-like MARVEL transmembrane domain containing 7 -0.0154122
OSBPL3 oxysterol binding protein-like 3 -0.0149896
RPL8 ribosomal protein L8 -0.0149599
FBXL17 F-box and leucine-rich repeat protein 17 -0.0149548
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0148133
PCNX4 pecanex 4 -0.0146795
RPS19 ribosomal protein S19 -0.0146019
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0144986
BLZF1 basic leucine zipper nuclear factor 1 -0.0144796
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0144584
RPS27A ribosomal protein S27a -0.014319