Cytarabine (hydrochloride)_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cytarabine (hydrochloride) perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cytarabine (hydrochloride)_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.13553
GOLGA4 golgin A4 0.106038
SOX6 SRY (sex determining region Y)-box 6 0.104467
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0998983
ZNF292 zinc finger protein 292 0.0986604
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.096953
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0954535
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0920236
PDGFC platelet derived growth factor C 0.0915078
EIF4A2 eukaryotic translation initiation factor 4A2 0.0858887
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0831021
MSI2 musashi RNA-binding protein 2 0.0809676
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0803319
ADAM10 ADAM metallopeptidase domain 10 0.0794844
DSCAM Down syndrome cell adhesion molecule 0.076887
PICALM phosphatidylinositol binding clathrin assembly protein 0.0764268
CAMTA1 calmodulin binding transcription activator 1 0.0730588
FLNB filamin B, beta 0.0693157
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0689428
EML4 echinoderm microtubule associated protein like 4 0.067571
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0673314
SSBP2 single-stranded DNA binding protein 2 0.0656879
EVI5 ecotropic viral integration site 5 0.0648328
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0631817
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.062779
PCBP2 poly(rC) binding protein 2 0.0612583
ZEB1 zinc finger E-box binding homeobox 1 0.0587363
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0576539
NUP58 nucleoporin 58 0.0573548
DLG1 discs, large homolog 1 (Drosophila) 0.0557622
OGA O-GlcNAcase 0.055518
KDM6A lysine (K)-specific demethylase 6A 0.0546166
NBAS neuroblastoma amplified sequence 0.0539781
ANKRD12 ankyrin repeat domain 12 0.0531425
ADAM9 ADAM metallopeptidase domain 9 0.0518994
CCNL1 cyclin L1 0.0517862
NAMPT nicotinamide phosphoribosyltransferase 0.0516833
UBA6 ubiquitin-like modifier activating enzyme 6 0.0516041
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0515349
BIRC6 baculoviral IAP repeat containing 6 0.0511063
PGK1 phosphoglycerate kinase 1 0.0508694
GLS2 glutaminase 2 (liver, mitochondrial) 0.0493235
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0491825
SBF2 SET binding factor 2 0.0488567
AKAP9 A kinase (PRKA) anchor protein 9 0.0480035
ENO1 enolase 1, (alpha) 0.0479663
KDM3A lysine (K)-specific demethylase 3A 0.047308
CD47 CD47 molecule 0.0471854
ENO2 enolase 2 (gamma, neuronal) 0.047175
KDM4C lysine (K)-specific demethylase 4C 0.0470088
HELZ helicase with zinc finger 0.0467887
EZR ezrin 0.0461908
TGFBR3 transforming growth factor, beta receptor III 0.0458903
TMSB4X thymosin beta 4, X-linked 0.0453089
ACTG1 actin gamma 1 0.0448854
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0448272
CDC73 cell division cycle 73 0.0447756
ELOVL5 ELOVL fatty acid elongase 5 0.044757
QKI QKI, KH domain containing, RNA binding 0.0447223
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.0446933
YAP1 Yes-associated protein 1 0.0445722
KMT2E lysine (K)-specific methyltransferase 2E 0.043884
WSB1 WD repeat and SOCS box containing 1 0.0438459
ZMYM2 zinc finger, MYM-type 2 0.0436937
MON2 MON2 homolog (S. cerevisiae) 0.0434184
PUM2 pumilio RNA-binding family member 2 0.0426005
CNOT6L CCR4-NOT transcription complex, subunit 6-like 0.0425003
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0423479
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0421841
PTBP2 polypyrimidine tract binding protein 2 0.0420501
PRELID2 PRELI domain containing 2 0.0420057
FAT1 FAT atypical cadherin 1 0.0416154
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0415416
ZFAND3 zinc finger, AN1-type domain 3 0.0410499
DDB2 damage-specific DNA binding protein 2, 48kDa 0.0406677
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0406628
EEF2 eukaryotic translation elongation factor 2 0.040575
EIF4B eukaryotic translation initiation factor 4B 0.0403497
FAM13A family with sequence similarity 13, member A 0.0403239
RBM39 RNA binding motif protein 39 0.0402301
TJP1 tight junction protein 1 0.0401798
ECT2 epithelial cell transforming 2 0.0401218
LPP LIM domain containing preferred translocation partner in lipoma 0.0401042
GPHN gephyrin 0.0400067
COG5 component of oligomeric golgi complex 5 0.0392247
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0390509
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0389759
TXNIP thioredoxin interacting protein 0.0388598
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0387022
SREBF2 sterol regulatory element binding transcription factor 2 0.0382748
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.038205
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0379876
SEC23A Sec23 homolog A (S. cerevisiae) 0.0379036
RNMT RNA (guanine-7-) methyltransferase 0.0378109
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0375821
PTK2 protein tyrosine kinase 2 0.0370147
FXR1 fragile X mental retardation, autosomal homolog 1 0.0369311
WDR43 WD repeat domain 43 0.0368902
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.036404
YTHDC1 YTH domain containing 1 0.0362978

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.119509
FOXP1 forkhead box P1 -0.100522
EGFR epidermal growth factor receptor -0.0811087
PKM pyruvate kinase, muscle -0.0595139
GLI3 GLI family zinc finger 3 -0.0516709
PDE4D phosphodiesterase 4D, cAMP-specific -0.0466223
NFE2L2 nuclear factor, erythroid 2-like 2 -0.040051
CCND1 cyclin D1 -0.036563
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0363439
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -0.0355541
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b -0.0349234
MKI67 marker of proliferation Ki-67 -0.0343756
BMP10 bone morphogenetic protein 10 -0.0308565
CENPF centromere protein F, 350/400kDa -0.03047
ZMYND8 zinc finger, MYND-type containing 8 -0.0293962
SLC38A2 solute carrier family 38, member 2 -0.0292832
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0289516
ZBTB20 zinc finger and BTB domain containing 20 -0.0287952
NPAS2 neuronal PAS domain protein 2 -0.0269943
OSMR oncostatin M receptor -0.0266241
NAV2 neuron navigator 2 -0.025693
MTAP methylthioadenosine phosphorylase -0.0256412
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0249691
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -0.0243904
RPS24 ribosomal protein S24 -0.0238548
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) -0.0237265
PDE7B phosphodiesterase 7B -0.0230783
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.0223459
CENPE centromere protein E, 312kDa -0.0219981
SPRY4 sprouty homolog 4 (Drosophila) -0.0219598
STAU2 staufen double-stranded RNA binding protein 2 -0.0208264
TBCA tubulin folding cofactor A -0.0207551
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 -0.020638
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.020426
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0199878
RPS23 ribosomal protein S23 -0.0199021
VCL vinculin -0.0197591
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0194974
SCLT1 sodium channel and clathrin linker 1 -0.0189565
ZNF438 zinc finger protein 438 -0.0187934
GLI2 GLI family zinc finger 2 -0.0187203
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0186873
PKP4 plakophilin 4 -0.0186159
ONECUT2 one cut homeobox 2 -0.0184216
TACC2 transforming, acidic coiled-coil containing protein 2 -0.0182786
RPL32 ribosomal protein L32 -0.0181826
TPT1 tumor protein, translationally-controlled 1 -0.0178585
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0178134
PARD3B par-3 family cell polarity regulator beta -0.0175757
TPX2 TPX2, microtubule-associated -0.0175687
S100A4 S100 calcium binding protein A4 -0.0175376
COMMD10 COMM domain containing 10 -0.0175138
PRH1 proline-rich protein HaeIII subfamily 1 -0.0174797
HJURP Holliday junction recognition protein -0.0173494
TAS2R14 taste receptor, type 2, member 14 -0.0173007
TMSB10 thymosin beta 10 -0.0170734
WARS1 tryptophanyl-tRNA synthetase 1 -0.0170572
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 -0.0170073
RIGI RNA sensor RIG-I -0.0168157
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.0165782
BPTF bromodomain PHD finger transcription factor -0.0161644
S100A6 S100 calcium binding protein A6 -0.0160312
LOC102724023 ES1 protein homolog, mitochondrial -0.0157298
MYO5C myosin VC -0.0157007
DOCK3 dedicator of cytokinesis 3 -0.015651
ADNP activity-dependent neuroprotector homeobox -0.0155365
CKAP2 cytoskeleton associated protein 2 -0.0155327
RPL12 ribosomal protein L12 -0.0154426
RPLP1 ribosomal protein, large, P1 -0.015418
HMGB1 high mobility group box 1 -0.0151731
KIF18B kinesin family member 18B -0.0150926
ARL2BP ADP-ribosylation factor-like 2 binding protein -0.0150901
RPS5 ribosomal protein S5 -0.0149393
EHBP1 EH domain binding protein 1 -0.014905
RPL31 ribosomal protein L31 -0.0148082
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0147158
FTL ferritin, light polypeptide -0.0146174
RPL8 ribosomal protein L8 -0.014344
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0140455
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0139721
NOP56 NOP56 ribonucleoprotein -0.0138255
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) -0.0137667
LRRC7 leucine rich repeat containing 7 -0.0136588
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 -0.0136118
BICD1 bicaudal D homolog 1 (Drosophila) -0.0135747
SCMH1 sex comb on midleg homolog 1 (Drosophila) -0.0135414
PRDX2 peroxiredoxin 2 -0.0135156
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0134568
R3HDM1 R3H domain containing 1 -0.0133293
BCAS3 breast carcinoma amplified sequence 3 -0.0132503
KLF3 Kruppel-like factor 3 (basic) -0.0131115
ENOSF1 enolase superfamily member 1 -0.0130219
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0129966
SMC4 structural maintenance of chromosomes 4 -0.0129371
CUX1 cut-like homeobox 1 -0.0128257
TBL1X transducin (beta)-like 1X-linked -0.0126903
BBS9 Bardet-Biedl syndrome 9 -0.0125
EXOC4 exocyst complex component 4 -0.0124241
TUBB tubulin, beta class I -0.0123934
IFITM1 interferon induced transmembrane protein 1 -0.01236