Cytarabine (hydrochloride)_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cytarabine (hydrochloride) perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cytarabine (hydrochloride)_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SOD2 superoxide dismutase 2, mitochondrial 0.125871
TRIO trio Rho guanine nucleotide exchange factor 0.116452
DST dystonin 0.11354
MYH9 myosin, heavy chain 9, non-muscle 0.109357
FN1 fibronectin 1 0.0752448
CADM1 cell adhesion molecule 1 0.0701651
ATP13A3 ATPase type 13A3 0.0662056
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0612745
SDK1 sidekick cell adhesion molecule 1 0.0588039
FNDC3B fibronectin type III domain containing 3B 0.0587837
TNIP1 TNFAIP3 interacting protein 1 0.0579038
AKAP12 A kinase (PRKA) anchor protein 12 0.0558064
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0553678
SDC4 syndecan 4 0.0517689
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0516267
NAMPT nicotinamide phosphoribosyltransferase 0.0510026
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.050713
WTAP Wilms tumor 1 associated protein 0.0505977
ZNF292 zinc finger protein 292 0.0499373
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.049047
BIRC3 baculoviral IAP repeat containing 3 0.0469191
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0465967
SPAG9 sperm associated antigen 9 0.0462306
DIAPH3 diaphanous-related formin 3 0.0457567
ACTG1 actin gamma 1 0.0438598
ELL2 elongation factor, RNA polymerase II, 2 0.0435192
CXCL8 chemokine (C-X-C motif) ligand 8 0.0429756
USP9X ubiquitin specific peptidase 9, X-linked 0.0428911
DENND5A DENN/MADD domain containing 5A 0.0428628
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0428609
EPS8 epidermal growth factor receptor pathway substrate 8 0.0425506
PCBP2 poly(rC) binding protein 2 0.041741
HELLS helicase, lymphoid-specific 0.0405788
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0402399
DEK DEK proto-oncogene 0.0401792
AMPD3 adenosine monophosphate deaminase 3 0.0390689
MACF1 microtubule-actin crosslinking factor 1 0.0385581
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0381286
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0376957
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0373843
OGFRL1 opioid growth factor receptor-like 1 0.0372079
CEP250 centrosomal protein 250kDa 0.0370248
ATAD2 ATPase family, AAA domain containing 2 0.0368711
MSN moesin 0.0367789
SPTBN1 spectrin, beta, non-erythrocytic 1 0.036373
ARID5B AT rich interactive domain 5B (MRF1-like) 0.0361383
UGCG UDP-glucose ceramide glucosyltransferase 0.0360955
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0351756
FRMD4A FERM domain containing 4A 0.0349002
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0347733
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0334543
RTN4 reticulon 4 0.0334094
COL8A1 collagen, type VIII, alpha 1 0.0329914
UBA6 ubiquitin-like modifier activating enzyme 6 0.0328588
JMJD1C jumonji domain containing 1C 0.0327481
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0327066
HDAC9 histone deacetylase 9 0.0325768
PARP14 poly (ADP-ribose) polymerase family, member 14 0.032536
APP amyloid beta (A4) precursor protein 0.0324993
ERBIN erbb2 interacting protein 0.0311605
PRELID2 PRELI domain containing 2 0.0310335
RRM2 ribonucleotide reductase M2 0.0310018
IRAK2 interleukin-1 receptor-associated kinase 2 0.030912
RUNX1 runt-related transcription factor 1 0.0299244
SRGN serglycin 0.0297941
OGA O-GlcNAcase 0.0297894
ZFAND3 zinc finger, AN1-type domain 3 0.0296907
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0296828
NUP153 nucleoporin 153kDa 0.0296425
PICALM phosphatidylinositol binding clathrin assembly protein 0.0294596
PPP4R4 protein phosphatase 4, regulatory subunit 4 0.0291486
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0287917
CALD1 caldesmon 1 0.0287345
CLIC4 chloride intracellular channel 4 0.0286835
C3 complement component 3 0.0284722
BASP1 brain abundant, membrane attached signal protein 1 0.0282034
TBK1 TANK-binding kinase 1 0.0281871
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0280934
BCLAF1 BCL2-associated transcription factor 1 0.0278552
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0277439
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit 0.027666
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0276276
RBM39 RNA binding motif protein 39 0.0275625
USP47 ubiquitin specific peptidase 47 0.0275345
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0275312
EIF4B eukaryotic translation initiation factor 4B 0.0274876
MYOF myoferlin 0.0274056
ANLN anillin, actin binding protein 0.0273636
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0272976
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0271473
TPM3 tropomyosin 3 0.0268279
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0263044
CCNL1 cyclin L1 0.0262263
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0258792
CCDC14 coiled-coil domain containing 14 0.025594
KIAA1217 KIAA1217 0.0255169
SFTPA2 surfactant protein A2 0.0253073
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0252121
TJP2 tight junction protein 2 0.0250344
HLA-B major histocompatibility complex, class I, B 0.0249617

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.166894
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.1578
BICC1 BicC family RNA binding protein 1 -0.0926908
NDRG1 N-myc downstream regulated 1 -0.0882241
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0624701
HMGA2 high mobility group AT-hook 2 -0.062015
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0610894
SLC38A2 solute carrier family 38, member 2 -0.059706
FTL ferritin, light polypeptide -0.0566456
IGFBP3 insulin-like growth factor binding protein 3 -0.0543432
GLIS3 GLIS family zinc finger 3 -0.0457593
TMSB10 thymosin beta 10 -0.0445432
EGR1 early growth response 1 -0.0442173
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0408055
VEGFA vascular endothelial growth factor A -0.0398603
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0377623
MT2A metallothionein 2A -0.0370993
IER3 immediate early response 3 -0.0363019
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0356924
INTS6 integrator complex subunit 6 -0.0349558
VCL vinculin -0.0324265
KYNU kynureninase -0.0323128
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0317588
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.03041
SQSTM1 sequestosome 1 -0.0299207
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0289317
BTG1 B-cell translocation gene 1, anti-proliferative -0.0285612
RPS2 ribosomal protein S2 -0.0284643
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0281267
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0275073
RPS24 ribosomal protein S24 -0.0275031
LDHA lactate dehydrogenase A -0.027423
CENPF centromere protein F, 350/400kDa -0.0270097
EIF1 eukaryotic translation initiation factor 1 -0.0269894
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0269285
TUBB tubulin, beta class I -0.026137
EPAS1 endothelial PAS domain protein 1 -0.0260834
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0258882
GPC6 glypican 6 -0.0258473
MORF4L2 mortality factor 4 like 2 -0.0252699
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.024766
TPM1 tropomyosin 1 (alpha) -0.0243818
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0231876
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0228567
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -0.0226326
KLHL24 kelch-like family member 24 -0.0218218
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0217567
MKI67 marker of proliferation Ki-67 -0.0214488
RPS23 ribosomal protein S23 -0.0211888
FTH1 ferritin, heavy polypeptide 1 -0.0206058
DEPP1 DEPP autophagy regulator 1 -0.0205905
RPS6 ribosomal protein S6 -0.0201396
UBC ubiquitin C -0.0200117
IFITM3 interferon induced transmembrane protein 3 -0.0194086
GOLGB1 golgin B1 -0.0191139
TPT1 tumor protein, translationally-controlled 1 -0.018839
RRBP1 ribosome binding protein 1 -0.0187726
EHBP1 EH domain binding protein 1 -0.0184844
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0184275
BPTF bromodomain PHD finger transcription factor -0.0183598
VCAN versican -0.0183459
PCLO piccolo presynaptic cytomatrix protein -0.0182938
RPL32 ribosomal protein L32 -0.0179063
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0174794
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0174386
BACE2 beta-site APP-cleaving enzyme 2 -0.017031
RPL6 ribosomal protein L6 -0.0169647
ANXA2 annexin A2 -0.01679
PLPP6 phospholipid phosphatase 6 -0.0167758
FBXO32 F-box protein 32 -0.0167532
STC1 stanniocalcin 1 -0.0164482
CTSD cathepsin D -0.0160853
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0157367
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0157046
KLF12 Kruppel-like factor 12 -0.0155634
CTSB cathepsin B -0.0153394
TXNIP thioredoxin interacting protein -0.0153021
RPL12 ribosomal protein L12 -0.0152352
RPLP2 ribosomal protein, large, P2 -0.0150246
STXBP5 syntaxin binding protein 5 (tomosyn) -0.014721
RPL28 ribosomal protein L28 -0.014584
FBXL20 F-box and leucine-rich repeat protein 20 -0.0145195
SBF2 SET binding factor 2 -0.014496
CNTN6 contactin 6 -0.0144709
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.014361
RAB31 RAB31, member RAS oncogene family -0.0141119
RPL31 ribosomal protein L31 -0.014095
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0140578
RPL9 ribosomal protein L9 -0.0140241
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0139613
PKM pyruvate kinase, muscle -0.013923
SFRP1 secreted frizzled-related protein 1 -0.0136992
THBS1 thrombospondin 1 -0.0136863
SMAD2 SMAD family member 2 -0.013667
PTMA prothymosin, alpha -0.0136214
CDK13 cyclin-dependent kinase 13 -0.0135939
RPL38 ribosomal protein L38 -0.0135694
MBD5 methyl-CpG binding domain protein 5 -0.0134977
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0134896
IGFBP7 insulin-like growth factor binding protein 7 -0.0134167