Cytarabine (hydrochloride)_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cytarabine (hydrochloride) perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cytarabine (hydrochloride)_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.230249
SDC4 syndecan 4 0.0973337
MACF1 microtubule-actin crosslinking factor 1 0.090351
CD44 CD44 molecule (Indian blood group) 0.0656806
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.064038
SOD2 superoxide dismutase 2, mitochondrial 0.0635715
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.058053
MATR3 matrin 3 0.0556884
TRA2A transformer 2 alpha homolog (Drosophila) 0.0490901
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0485059
ESYT2 extended synaptotagmin-like protein 2 0.0458181
UBA6 ubiquitin-like modifier activating enzyme 6 0.0457822
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0436817
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0435151
NAMPT nicotinamide phosphoribosyltransferase 0.042605
TOP1 topoisomerase (DNA) I 0.0425035
TFG TRK-fused gene 0.041878
FAM20C family with sequence similarity 20, member C 0.0415785
MYH9 myosin, heavy chain 9, non-muscle 0.0405105
SUCO SUN domain containing ossification factor 0.0404397
RIGI RNA sensor RIG-I 0.040379
ATP13A3 ATPase type 13A3 0.0401552
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.0397999
CADM1 cell adhesion molecule 1 0.0380466
ARRDC3 arrestin domain containing 3 0.0378534
MBD5 methyl-CpG binding domain protein 5 0.0377288
FNDC3B fibronectin type III domain containing 3B 0.037647
PGK1 phosphoglycerate kinase 1 0.0372858
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.0369282
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0367147
VCAM1 vascular cell adhesion molecule 1 0.0358907
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.035644
MYO1E myosin IE 0.0354875
FRMD6 FERM domain containing 6 0.0354636
TRIP12 thyroid hormone receptor interactor 12 0.0354071
GLIS3 GLIS family zinc finger 3 0.0353471
ELL2 elongation factor, RNA polymerase II, 2 0.0351274
ATXN1 ataxin 1 0.0346772
UGCG UDP-glucose ceramide glucosyltransferase 0.0338629
PCBP2 poly(rC) binding protein 2 0.033475
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0331577
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0329379
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0323583
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0321551
OGA O-GlcNAcase 0.0320994
TNIP1 TNFAIP3 interacting protein 1 0.0318626
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0317832
ARID5B AT rich interactive domain 5B (MRF1-like) 0.0316887
RPRD1B regulation of nuclear pre-mRNA domain containing 1B 0.0311113
TRIO trio Rho guanine nucleotide exchange factor 0.0309321
SRP54 signal recognition particle 54kDa 0.0305193
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0300378
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0298834
SMAD3 SMAD family member 3 0.0298034
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 0.0297265
AVL9 AVL9 homolog (S. cerevisiase) 0.029687
CLINT1 clathrin interactor 1 0.029453
KDM2A lysine (K)-specific demethylase 2A 0.0293436
APOL2 apolipoprotein L, 2 0.0292686
GLS2 glutaminase 2 (liver, mitochondrial) 0.0291783
GBP1 guanylate binding protein 1, interferon-inducible 0.0290263
SLC35F5 solute carrier family 35, member F5 0.0288099
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.028808
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0284587
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 0.0284418
MTREX Mtr4 exosome RNA helicase 0.0282342
KDM6A lysine (K)-specific demethylase 6A 0.0281893
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 0.0280578
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0279772
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0277593
RSAD2 radical S-adenosyl methionine domain containing 2 0.0277215
OSER1 oxidative stress responsive serine-rich 1 0.0275886
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 0.0274272
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.027404
BIRC3 baculoviral IAP repeat containing 3 0.0273614
CDC73 cell division cycle 73 0.0271473
CTSB cathepsin B 0.0269852
COG5 component of oligomeric golgi complex 5 0.026895
RAB1A RAB1A, member RAS oncogene family 0.0268026
USP33 ubiquitin specific peptidase 33 0.0267951
NRXN3 neurexin 3 0.0266774
ARHGAP24 Rho GTPase activating protein 24 0.0265934
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0264188
LDHA lactate dehydrogenase A 0.0260997
TVP23C-CDRT4 TVP23C-CDRT4 readthrough 0.0260028
ZDHHC20 zinc finger, DHHC-type containing 20 0.0260001
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme 0.0259653
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa 0.0257439
FERMT2 fermitin family member 2 0.025255
BCLAF1 BCL2-associated transcription factor 1 0.024496
PRELID2 PRELI domain containing 2 0.0244042
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0243446
NUP205 nucleoporin 205kDa 0.0242831
MED4 mediator complex subunit 4 0.0242398
CD47 CD47 molecule 0.0239893
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 0.0239624
CXXC5 CXXC finger protein 5 0.0239215
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0239149
LIMS1 LIM and senescent cell antigen-like domains 1 0.0237602
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0237163

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.188814
VIM vimentin -0.153348
IGFBP3 insulin-like growth factor binding protein 3 -0.150502
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.138835
MT2A metallothionein 2A -0.138572
FTL ferritin, light polypeptide -0.121213
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.113815
F3 coagulation factor III (thromboplastin, tissue factor) -0.105806
TGFBI transforming growth factor, beta-induced, 68kDa -0.102007
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0958496
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0773443
MT1X metallothionein 1X -0.0697635
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0679065
CALD1 caldesmon 1 -0.06575
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0624873
PKM pyruvate kinase, muscle -0.0612052
STC1 stanniocalcin 1 -0.0598159
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0590181
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.058249
PRSS23 protease, serine, 23 -0.0575792
EGFR epidermal growth factor receptor -0.0571663
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0568577
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0566413
ZMYND8 zinc finger, MYND-type containing 8 -0.055237
TMEM165 transmembrane protein 165 -0.0480711
MAP1B microtubule-associated protein 1B -0.047858
CAV1 caveolin 1, caveolae protein, 22kDa -0.0459214
S100A10 S100 calcium binding protein A10 -0.0451644
NDRG1 N-myc downstream regulated 1 -0.0425536
WSB1 WD repeat and SOCS box containing 1 -0.0423611
MAP4 microtubule-associated protein 4 -0.0423108
RRBP1 ribosome binding protein 1 -0.041514
FTH1 ferritin, heavy polypeptide 1 -0.0412478
RAI14 retinoic acid induced 14 -0.0410512
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0399215
HLA-B major histocompatibility complex, class I, B -0.0398288
INHBA inhibin, beta A -0.0395013
CDH13 cadherin 13 -0.0386934
COL1A1 collagen, type I, alpha 1 -0.0380502
PSD3 pleckstrin and Sec7 domain containing 3 -0.036821
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0365459
KTN1 kinectin 1 (kinesin receptor) -0.0358054
EIF1 eukaryotic translation initiation factor 1 -0.0355909
FBN1 fibrillin 1 -0.035353
USP34 ubiquitin specific peptidase 34 -0.0352155
RAB5A RAB5A, member RAS oncogene family -0.034916
PTPRF protein tyrosine phosphatase, receptor type, F -0.0345191
PDLIM5 PDZ and LIM domain 5 -0.0342191
RPL34 ribosomal protein L34 -0.0340063
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0338857
FN1 fibronectin 1 -0.0338133
NAV1 neuron navigator 1 -0.0337537
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0337276
MORF4L2 mortality factor 4 like 2 -0.0337162
ERRFI1 ERBB receptor feedback inhibitor 1 -0.033507
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0334976
MTDH metadherin -0.0334164
IL6 interleukin 6 -0.0333237
TFPI2 tissue factor pathway inhibitor 2 -0.033113
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0330652
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0324382
TPT1 tumor protein, translationally-controlled 1 -0.0319553
TNS3 tensin 3 -0.0315205
MYADM myeloid-associated differentiation marker -0.0312343
GNAS GNAS complex locus -0.0311648
FBXO11 F-box protein 11 -0.031123
DLG1 discs, large homolog 1 (Drosophila) -0.0309557
ECE1 endothelin converting enzyme 1 -0.0308881
LMNA lamin A/C -0.0303748
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0302667
ZBTB38 zinc finger and BTB domain containing 38 -0.0291129
JAZF1 JAZF zinc finger 1 -0.0289237
ANTXR2 anthrax toxin receptor 2 -0.0285865
HIPK2 homeodomain interacting protein kinase 2 -0.0285221
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0283686
ACTG1 actin gamma 1 -0.0283608
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0280974
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0276159
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0275965
PRRC1 proline-rich coiled-coil 1 -0.0275902
LARP1 La ribonucleoprotein domain family, member 1 -0.027478
S100A9 S100 calcium binding protein A9 -0.0273763
TOMM7 translocase of outer mitochondrial membrane 7 homolog (yeast) -0.0272386
SCAMP1 secretory carrier membrane protein 1 -0.0270311
FUS FUS RNA binding protein -0.0266562
SH3PXD2B SH3 and PX domains 2B -0.0264735
RAB10 RAB10, member RAS oncogene family -0.0261151
HLA-C major histocompatibility complex, class I, C -0.0259461
TMEM131 transmembrane protein 131 -0.0256653
NAP1L4 nucleosome assembly protein 1-like 4 -0.0255724
CD63 CD63 molecule -0.0254613
RPS14 ribosomal protein S14 -0.0250882
H3-3B H3.3 histone B -0.0250512
STK17A serine/threonine kinase 17a -0.0249523
LOX lysyl oxidase -0.0247908
THY1 Thy-1 cell surface antigen -0.0247433
FLNA filamin A, alpha -0.0247178
TAS2R14 taste receptor, type 2, member 14 -0.0245831
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0245731
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) -0.0244311