Cytarabine (hydrochloride)_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cytarabine (hydrochloride) perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cytarabine (hydrochloride)_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RBM39 RNA binding motif protein 39 0.0910268
BIRC3 baculoviral IAP repeat containing 3 0.0877658
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0828599
SET SET nuclear proto-oncogene 0.0797378
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0751286
NUP58 nucleoporin 58 0.0675928
WAC WW domain containing adaptor with coiled-coil 0.0655578
GOLGA4 golgin A4 0.0645695
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0639384
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.06379
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0600153
PUM2 pumilio RNA-binding family member 2 0.0596922
DEK DEK proto-oncogene 0.0595913
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.05716
DERA deoxyribose-phosphate aldolase (putative) 0.0560194
RSRC2 arginine/serine-rich coiled-coil 2 0.0521808
TFG TRK-fused gene 0.0508077
TENT2 terminal nucleotidyltransferase 2 0.0501063
SETD5 SET domain containing 5 0.0497149
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.048788
NAMPT nicotinamide phosphoribosyltransferase 0.048365
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0463639
PCBP2 poly(rC) binding protein 2 0.0458313
B2M beta-2-microglobulin 0.0456996
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0454573
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0451609
TBK1 TANK-binding kinase 1 0.0447172
HELZ helicase with zinc finger 0.0444587
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0441396
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0427667
RPL12 ribosomal protein L12 0.0426065
FXR1 fragile X mental retardation, autosomal homolog 1 0.042487
BIRC2 baculoviral IAP repeat containing 2 0.0422641
RPL4 ribosomal protein L4 0.0422504
MATR3 matrin 3 0.0419857
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0416093
RAB7A RAB7A, member RAS oncogene family 0.0410837
RPS12 ribosomal protein S12 0.0408951
ZNF292 zinc finger protein 292 0.0403933
SPAG9 sperm associated antigen 9 0.0402153
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0401998
NAP1L1 nucleosome assembly protein 1-like 1 0.0400067
PDS5B PDS5 cohesin associated factor B 0.0398971
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0396148
RBM33 RNA binding motif protein 33 0.039453
BCLAF1 BCL2-associated transcription factor 1 0.0393226
CXCL8 chemokine (C-X-C motif) ligand 8 0.0391236
CCNL1 cyclin L1 0.0386798
AHCTF1 AT hook containing transcription factor 1 0.0385216
PHIP pleckstrin homology domain interacting protein 0.0381868
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.0380565
ITCH itchy E3 ubiquitin protein ligase 0.0379057
DENND4A DENN/MADD domain containing 4A 0.0377171
USP3 ubiquitin specific peptidase 3 0.0367464
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0363806
RPL23 ribosomal protein L23 0.0356838
ANXA1 annexin A1 0.0350374
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0350264
UGCG UDP-glucose ceramide glucosyltransferase 0.0344031
RTN4 reticulon 4 0.0342873
EEF2 eukaryotic translation elongation factor 2 0.033968
ECT2 epithelial cell transforming 2 0.0338411
RPLP1 ribosomal protein, large, P1 0.0338275
OLA1 Obg-like ATPase 1 0.0334778
RAB6A RAB6A, member RAS oncogene family 0.033414
SRPK2 SRSF protein kinase 2 0.0332766
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0326962
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0325774
XPO1 exportin 1 0.0324023
DIAPH3 diaphanous-related formin 3 0.0322534
CDC5L cell division cycle 5-like 0.0322088
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 0.0319661
MEF2A myocyte enhancer factor 2A 0.0316709
IPO7 importin 7 0.0311474
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0308111
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0306005
KIF5B kinesin family member 5B 0.0305118
PRRC2C proline-rich coiled-coil 2C 0.0303408
KDM6A lysine (K)-specific demethylase 6A 0.030303
TMEM123 transmembrane protein 123 0.030214
GLS2 glutaminase 2 (liver, mitochondrial) 0.0299986
DSCAM Down syndrome cell adhesion molecule 0.0299239
CANX calnexin 0.029895
PNISR PNN-interacting serine/arginine-rich protein 0.0297687
HSPA4 heat shock 70kDa protein 4 0.0296956
UBA6 ubiquitin-like modifier activating enzyme 6 0.0296943
PRPF8 pre-mRNA processing factor 8 0.029618
PAWR PRKC, apoptosis, WT1, regulator 0.0296019
SDC4 syndecan 4 0.0293197
ATP11B ATPase, class VI, type 11B 0.0292959
WDR36 WD repeat domain 36 0.0291611
SFPQ splicing factor proline/glutamine-rich 0.0291413
MAPRE1 microtubule-associated protein, RP/EB family, member 1 0.028992
MAP2K1 mitogen-activated protein kinase kinase 1 0.0287645
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 0.0284421
CHD1 chromodomain helicase DNA binding protein 1 0.0283722
GARS1 glycyl-tRNA synthetase 1 0.0282789
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.028224
HLA-B major histocompatibility complex, class I, B 0.0281006
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0279553

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.226276
IGFBP3 insulin-like growth factor binding protein 3 -0.117412
FNDC3B fibronectin type III domain containing 3B -0.103139
HMGA2 high mobility group AT-hook 2 -0.0991977
VIM vimentin -0.0929392
PRKCA protein kinase C, alpha -0.0886671
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0878458
TMSB10 thymosin beta 10 -0.0817135
DST dystonin -0.0794875
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0739027
NAV2 neuron navigator 2 -0.0710242
FLNB filamin B, beta -0.0700944
ATXN1 ataxin 1 -0.0698586
ATM ATM serine/threonine kinase -0.0683705
DNER delta/notch-like EGF repeat containing -0.0647618
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0611045
GPC6 glypican 6 -0.060965
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0603874
ZBTB20 zinc finger and BTB domain containing 20 -0.060348
NDRG1 N-myc downstream regulated 1 -0.0588907
PYGL phosphorylase, glycogen, liver -0.0575126
INTS6 integrator complex subunit 6 -0.056592
NT5E 5'-nucleotidase, ecto (CD73) -0.0519082
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0516094
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0505179
ANGPTL4 angiopoietin-like 4 -0.0504793
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0503779
THSD4 thrombospondin, type I, domain containing 4 -0.0503056
MACF1 microtubule-actin crosslinking factor 1 -0.0501857
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0488407
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0477386
EFNA5 ephrin-A5 -0.0474855
FMN1 formin 1 -0.0459232
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0455241
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0426929
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0425602
SLC38A2 solute carrier family 38, member 2 -0.0423119
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0422579
CD44 CD44 molecule (Indian blood group) -0.0419629
PRSS23 protease, serine, 23 -0.0401021
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0384553
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0380272
LDHA lactate dehydrogenase A -0.0375281
TM4SF1 transmembrane 4 L six family member 1 -0.0364549
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0358072
PCED1B PC-esterase domain containing 1B -0.0351206
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0351164
PRR16 proline rich 16 -0.0348323
IGF2 insulin-like growth factor 2 -0.0347141
ZMYND8 zinc finger, MYND-type containing 8 -0.0339874
BABAM2 BRISC and BRCA1 A complex member 2 -0.0339306
RAI14 retinoic acid induced 14 -0.0337939
BICD1 bicaudal D homolog 1 (Drosophila) -0.0332785
PRH1 proline-rich protein HaeIII subfamily 1 -0.0332691
PBX3 pre-B-cell leukemia homeobox 3 -0.0331519
UTRN utrophin -0.0328585
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.032386
MAPKAP1 mitogen-activated protein kinase associated protein 1 -0.0319793
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.031733
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0313739
LMO7 LIM domain 7 -0.0309374
NPAS2 neuronal PAS domain protein 2 -0.0306512
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0303872
CAPRIN2 caprin family member 2 -0.0303688
PKM pyruvate kinase, muscle -0.0303089
SCLT1 sodium channel and clathrin linker 1 -0.0298305
TCF12 transcription factor 12 -0.0298224
HILPDA hypoxia inducible lipid droplet-associated -0.0287871
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -0.0282979
MYO9A myosin IXA -0.0281799
EXOC4 exocyst complex component 4 -0.0280426
AEBP2 AE binding protein 2 -0.0279359
CDH4 cadherin 4, type 1, R-cadherin (retinal) -0.0278986
ABR active BCR-related -0.02779
ACER3 alkaline ceramidase 3 -0.0277566
ZNF609 zinc finger protein 609 -0.0274438
FTH1 ferritin, heavy polypeptide 1 -0.0273156
BASP1 brain abundant, membrane attached signal protein 1 -0.0272088
BBS9 Bardet-Biedl syndrome 9 -0.027143
IL1RAP interleukin 1 receptor accessory protein -0.0259806
SYNJ2 synaptojanin 2 -0.025915
RGS17 regulator of G-protein signaling 17 -0.0256607
PTK2 protein tyrosine kinase 2 -0.0255987
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0255193
EPAS1 endothelial PAS domain protein 1 -0.0254589
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0254056
EGFR epidermal growth factor receptor -0.0253003
MAML3 mastermind-like 3 (Drosophila) -0.0252972
MBD5 methyl-CpG binding domain protein 5 -0.0251874
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0251872
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 -0.0251543
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0250847
RNF213 ring finger protein 213 -0.0247074
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 -0.0246907
DPYD dihydropyrimidine dehydrogenase -0.0246336
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.024632
NALCN sodium leak channel, non selective -0.0244671
RAD51B RAD51 paralog B -0.0244489
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0242852
ANKRD28 ankyrin repeat domain 28 -0.0242091