Cytarabine (hydrochloride)_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cytarabine (hydrochloride) perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cytarabine (hydrochloride)_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase 0.138644
CXCL8 chemokine (C-X-C motif) ligand 8 0.138038
TMEM156 transmembrane protein 156 0.110856
CD109 CD109 molecule 0.0805413
FNDC3B fibronectin type III domain containing 3B 0.0794503
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.072374
FAM13A family with sequence similarity 13, member A 0.068341
GOLGA4 golgin A4 0.0663264
AHR aryl hydrocarbon receptor 0.0629111
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0624923
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0615016
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0600586
SUCO SUN domain containing ossification factor 0.0581551
SEC23A Sec23 homolog A (S. cerevisiae) 0.0547291
ZNF292 zinc finger protein 292 0.053638
PCBP2 poly(rC) binding protein 2 0.0507404
TRIO trio Rho guanine nucleotide exchange factor 0.0467397
UGCG UDP-glucose ceramide glucosyltransferase 0.0463162
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0458326
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0453398
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0453201
DOCK5 dedicator of cytokinesis 5 0.043475
IRAK3 interleukin-1 receptor-associated kinase 3 0.0422484
OGA O-GlcNAcase 0.0417415
EREG epiregulin 0.0415108
SOD2 superoxide dismutase 2, mitochondrial 0.0412267
ETNK1 ethanolamine kinase 1 0.0411111
RNF145 ring finger protein 145 0.0406719
ITGA1 integrin, alpha 1 0.0399527
DST dystonin 0.0393435
TM9SF3 transmembrane 9 superfamily member 3 0.0391851
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0389748
BIRC3 baculoviral IAP repeat containing 3 0.038791
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.038373
ZC3H12C zinc finger CCCH-type containing 12C 0.0379239
UBA6 ubiquitin-like modifier activating enzyme 6 0.0378111
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0378007
RICTOR RPTOR independent companion of MTOR, complex 2 0.0371384
TENT2 terminal nucleotidyltransferase 2 0.0369009
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0368052
WDR26 WD repeat domain 26 0.0363465
COPA coatomer protein complex, subunit alpha 0.0359635
TPR translocated promoter region, nuclear basket protein 0.0356624
DENND5B DENN/MADD domain containing 5B 0.0356617
ARRDC3 arrestin domain containing 3 0.0354611
HELZ helicase with zinc finger 0.0354537
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.0354254
TFG TRK-fused gene 0.035135
ETV6 ets variant 6 0.0351282
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0348457
FBXL5 F-box and leucine-rich repeat protein 5 0.0343111
CAB39 calcium binding protein 39 0.0342881
FAT1 FAT atypical cadherin 1 0.0339904
PTBP3 polypyrimidine tract binding protein 3 0.0339567
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0334058
APP amyloid beta (A4) precursor protein 0.0326661
CCNL1 cyclin L1 0.0324425
MNAT1 MNAT CDK-activating kinase assembly factor 1 0.0323773
RAB8B RAB8B, member RAS oncogene family 0.0319604
FNBP1 formin binding protein 1 0.0319499
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.031558
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0310722
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0310585
NEK7 NIMA-related kinase 7 0.0309654
PRELID2 PRELI domain containing 2 0.0307825
MARCHF6 membrane associated ring-CH-type finger 6 0.0306476
NBAS neuroblastoma amplified sequence 0.0304725
EPS8 epidermal growth factor receptor pathway substrate 8 0.0303608
ERBIN erbb2 interacting protein 0.0303295
CDCP1 CUB domain containing protein 1 0.0301238
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0300032
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0299605
CDC73 cell division cycle 73 0.029731
PICALM phosphatidylinositol binding clathrin assembly protein 0.0296651
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0293372
RUNX2 runt-related transcription factor 2 0.0293298
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0289245
SLTM SAFB-like, transcription modulator 0.0289147
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0287434
SFTPA2 surfactant protein A2 0.028713
ZC3H11A zinc finger CCCH-type containing 11A 0.0285789
TPM3 tropomyosin 3 0.0284983
FBXO32 F-box protein 32 0.0283452
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0283425
ADAM17 ADAM metallopeptidase domain 17 0.0283274
MYO6 myosin VI 0.0281264
RB1CC1 RB1-inducible coiled-coil 1 0.0280873
FXR1 fragile X mental retardation, autosomal homolog 1 0.0280583
RAB18 RAB18, member RAS oncogene family 0.0276708
ATAD2 ATPase family, AAA domain containing 2 0.0275871
DSCAM Down syndrome cell adhesion molecule 0.0275175
SMAD3 SMAD family member 3 0.0274851
NUP58 nucleoporin 58 0.0274197
MCTP2 multiple C2 domains, transmembrane 2 0.0273014
MYH9 myosin, heavy chain 9, non-muscle 0.0268653
ADAM9 ADAM metallopeptidase domain 9 0.0268412
PUM2 pumilio RNA-binding family member 2 0.0266923
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0266487
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0266242
ZFR zinc finger RNA binding protein 0.0264935

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.271379
FN1 fibronectin 1 -0.230358
NRG1 neuregulin 1 -0.200618
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.169123
HMGA2 high mobility group AT-hook 2 -0.12384
VCL vinculin -0.0914253
EXT1 exostosin glycosyltransferase 1 -0.0909121
TMSB10 thymosin beta 10 -0.088404
MT2A metallothionein 2A -0.0874166
SQSTM1 sequestosome 1 -0.0868402
SYT1 synaptotagmin I -0.0741263
FTL ferritin, light polypeptide -0.0648265
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0635885
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0624979
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0621666
INTS6 integrator complex subunit 6 -0.0595401
PTMA prothymosin, alpha -0.0591189
NTN4 netrin 4 -0.0578349
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.055243
AEBP2 AE binding protein 2 -0.053033
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0510054
ASPH aspartate beta-hydroxylase -0.0507062
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0501735
IFI27 interferon, alpha-inducible protein 27 -0.0497322
LOC102724023 ES1 protein homolog, mitochondrial -0.0495193
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0471186
PALLD palladin, cytoskeletal associated protein -0.0468319
TPT1 tumor protein, translationally-controlled 1 -0.0465124
S100A10 S100 calcium binding protein A10 -0.0439425
VIM vimentin -0.043873
WSB1 WD repeat and SOCS box containing 1 -0.0433499
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0423366
GRB10 growth factor receptor-bound protein 10 -0.0422737
HLA-B major histocompatibility complex, class I, B -0.0400458
EGR1 early growth response 1 -0.0395805
SOX4 SRY (sex determining region Y)-box 4 -0.0382213
NDRG1 N-myc downstream regulated 1 -0.0376485
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.037463
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0364113
H1-0 H1.0 linker histone -0.0360737
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0359656
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0359528
TGFB1 transforming growth factor, beta 1 -0.0358497
AHRR aryl-hydrocarbon receptor repressor -0.0345876
RAI14 retinoic acid induced 14 -0.0332725
SLC38A2 solute carrier family 38, member 2 -0.0331102
GNAS GNAS complex locus -0.0329547
RAB10 RAB10, member RAS oncogene family -0.0329511
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0322171
S100A6 S100 calcium binding protein A6 -0.0317489
GLIS3 GLIS family zinc finger 3 -0.0304542
LRRC23 leucine rich repeat containing 23 -0.0299028
LMNA lamin A/C -0.029286
RASAL2 RAS protein activator like 2 -0.0292785
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0291531
SLC35F3 solute carrier family 35, member F3 -0.0291356
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0285005
CLIP2 CAP-GLY domain containing linker protein 2 -0.028092
AKAP12 A kinase (PRKA) anchor protein 12 -0.0264856
CRK v-crk avian sarcoma virus CT10 oncogene homolog -0.0264614
TNNC1 troponin C type 1 (slow) -0.0264087
MAP1B microtubule-associated protein 1B -0.0262265
FTH1 ferritin, heavy polypeptide 1 -0.0260196
DNAH5 dynein, axonemal, heavy chain 5 -0.0255185
RPS24 ribosomal protein S24 -0.0250447
FBXO11 F-box protein 11 -0.02492
NXN nucleoredoxin -0.0245988
RAB31 RAB31, member RAS oncogene family -0.0245443
HMGA1 high mobility group AT-hook 1 -0.024458
RPL35A ribosomal protein L35a -0.0239135
ACTG1 actin gamma 1 -0.0238145
SFRP1 secreted frizzled-related protein 1 -0.023227
EIF1 eukaryotic translation initiation factor 1 -0.023123
RPL31 ribosomal protein L31 -0.0231006
TENM4 teneurin transmembrane protein 4 -0.0226314
UBASH3B ubiquitin associated and SH3 domain containing B -0.0225772
UGDH UDP-glucose 6-dehydrogenase -0.0222554
CCDC138 coiled-coil domain containing 138 -0.0221543
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0217848
LOX lysyl oxidase -0.0217626
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A -0.0216799
IFI6 interferon, alpha-inducible protein 6 -0.0214332
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0213783
SP100 SP100 nuclear antigen -0.0211473
CUX1 cut-like homeobox 1 -0.021071
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0209688
PRH1 proline-rich protein HaeIII subfamily 1 -0.0209274
TBCA tubulin folding cofactor A -0.0209107
MX2 MX dynamin-like GTPase 2 -0.0206133
NCOA7 nuclear receptor coactivator 7 -0.0204395
IGFBP3 insulin-like growth factor binding protein 3 -0.0203984
TM4SF1 transmembrane 4 L six family member 1 -0.0203375
NBEA neurobeachin -0.0199724
FHL2 four and a half LIM domains 2 -0.0198177
ADAM8 ADAM metallopeptidase domain 8 -0.0195872
BPTF bromodomain PHD finger transcription factor -0.0195769
TOP1 topoisomerase (DNA) I -0.0195605
AHNAK2 AHNAK nucleoprotein 2 -0.0191793
MCL1 myeloid cell leukemia 1 -0.0191587
RRBP1 ribosome binding protein 1 -0.0191431