Cytarabine (hydrochloride)_SW1417 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cytarabine (hydrochloride) perturbation in SW1417 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cytarabine (hydrochloride)_SW1417 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
KRT8 keratin 8, type II 0.103401
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0742874
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0724028
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0711216
EPS8 epidermal growth factor receptor pathway substrate 8 0.0682748
ZNF292 zinc finger protein 292 0.0661938
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0635382
ACTG1 actin gamma 1 0.0601135
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0596262
NCKAP1 NCK-associated protein 1 0.0577137
SDC4 syndecan 4 0.0558179
FXR1 fragile X mental retardation, autosomal homolog 1 0.0554765
MED13L mediator complex subunit 13-like 0.0542684
ANKRD11 ankyrin repeat domain 11 0.053114
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0526438
HSPA8 heat shock 70kDa protein 8 0.0525945
MATR3 matrin 3 0.0503958
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0477662
RAD21 RAD21 homolog (S. pombe) 0.0473057
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0472706
RBM39 RNA binding motif protein 39 0.0471849
UBQLN1 ubiquilin 1 0.0471086
EIF4A2 eukaryotic translation initiation factor 4A2 0.0469775
KDM6A lysine (K)-specific demethylase 6A 0.0469461
CCNL1 cyclin L1 0.0468683
PUM2 pumilio RNA-binding family member 2 0.0462012
DSPP dentin sialophosphoprotein 0.0451333
PICALM phosphatidylinositol binding clathrin assembly protein 0.0451212
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0450898
NAMPT nicotinamide phosphoribosyltransferase 0.0449585
PLEC plectin 0.0442951
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0442604
RBM33 RNA binding motif protein 33 0.04412
MYH9 myosin, heavy chain 9, non-muscle 0.0437614
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0433559
MEF2A myocyte enhancer factor 2A 0.0431333
PCBP2 poly(rC) binding protein 2 0.0422566
MTMR3 myotubularin related protein 3 0.0413569
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0413427
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0405169
KMT2E lysine (K)-specific methyltransferase 2E 0.0395192
SUCO SUN domain containing ossification factor 0.0393661
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0390113
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0389771
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 0.0387317
TFG TRK-fused gene 0.0383231
YAP1 Yes-associated protein 1 0.0382601
TUFT1 tuftelin 1 0.0375595
TRA2A transformer 2 alpha homolog (Drosophila) 0.0374178
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.037295
LMTK2 lemur tyrosine kinase 2 0.0372824
USP3 ubiquitin specific peptidase 3 0.0371397
RAB1A RAB1A, member RAS oncogene family 0.0369273
SET SET nuclear proto-oncogene 0.0365417
PTK2 protein tyrosine kinase 2 0.0362764
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0352737
OLA1 Obg-like ATPase 1 0.0349028
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0345915
AKAP13 A kinase (PRKA) anchor protein 13 0.0344924
TPM3 tropomyosin 3 0.034483
ARHGAP26 Rho GTPase activating protein 26 0.033835
RAD23B RAD23 homolog B (S. cerevisiae) 0.0338183
OGA O-GlcNAcase 0.0336613
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0336515
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0334209
RHEB Ras homolog enriched in brain 0.0333232
RPS6 ribosomal protein S6 0.0332126
SPAG9 sperm associated antigen 9 0.0326252
FAR1 fatty acyl CoA reductase 1 0.0324414
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0321532
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit 0.0316926
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0316652
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0316209
DIAPH1 diaphanous-related formin 1 0.0314456
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0312635
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0311478
RPL4 ribosomal protein L4 0.0303954
GOLGA4 golgin A4 0.0303604
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.029812
WAC WW domain containing adaptor with coiled-coil 0.0295959
HELLS helicase, lymphoid-specific 0.0295428
HMGB2 high mobility group box 2 0.0289699
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0287086
DIDO1 death inducer-obliterator 1 0.0286392
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0285122
CRY1 cryptochrome circadian clock 1 0.0284881
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0283698
AFDN afadin, adherens junction formation factor 0.0283025
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.0282386
GLS2 glutaminase 2 (liver, mitochondrial) 0.0281259
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0281043
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0278697
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0277478
CTNND1 catenin (cadherin-associated protein), delta 1 0.0276242
MAPRE1 microtubule-associated protein, RP/EB family, member 1 0.0275999
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0274
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit 0.0273187
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0272977
CNOT4 CCR4-NOT transcription complex, subunit 4 0.0271231
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0271085

decreased expression

Symbol Name Standardized Value
MAML2 mastermind-like 2 (Drosophila) -0.134159
EGR1 early growth response 1 -0.0938814
EZR ezrin -0.0852246
LOC102724023 ES1 protein homolog, mitochondrial -0.0845341
TMSB10 thymosin beta 10 -0.079842
MACC1 metastasis associated in colon cancer 1 -0.0773574
ZMYND8 zinc finger, MYND-type containing 8 -0.0725077
PTMA prothymosin, alpha -0.0712014
EHBP1 EH domain binding protein 1 -0.0697131
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.067073
FTL ferritin, light polypeptide -0.0641717
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0629948
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0624221
FTH1 ferritin, heavy polypeptide 1 -0.0585887
SLC38A1 solute carrier family 38, member 1 -0.056808
H1-0 H1.0 linker histone -0.0559005
DLG1 discs, large homolog 1 (Drosophila) -0.0542983
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide -0.050818
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.048373
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0481196
ZBTB20 zinc finger and BTB domain containing 20 -0.0467081
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0465925
CLDN4 claudin 4 -0.0444744
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0438715
CUX1 cut-like homeobox 1 -0.0412626
SVIL supervillin -0.0411947
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.041135
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0408451
NEBL nebulette -0.0402458
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0400219
LDHA lactate dehydrogenase A -0.038874
NDRG1 N-myc downstream regulated 1 -0.0383782
RPL18 ribosomal protein L18 -0.0380814
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0375044
S100A6 S100 calcium binding protein A6 -0.0351577
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0351207
NFIA nuclear factor I/A -0.0348494
IFITM1 interferon induced transmembrane protein 1 -0.0346798
KRT19 keratin 19, type I -0.0344247
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.033868
SOX4 SRY (sex determining region Y)-box 4 -0.0333266
GCC2 GRIP and coiled-coil domain containing 2 -0.0332366
TMEM123 transmembrane protein 123 -0.0330975
PLSCR1 phospholipid scramblase 1 -0.032622
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0323934
PATJ PATJ crumbs cell polarity complex component -0.0320463
CENPF centromere protein F, 350/400kDa -0.0313904
ZFP36L2 ZFP36 ring finger protein-like 2 -0.030796
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.030788
ESYT2 extended synaptotagmin-like protein 2 -0.0307526
KRT18 keratin 18, type I -0.0304535
LOC112694756 uncharaterized LOC112694756 -0.0300842
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.0297399
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0296479
ADNP activity-dependent neuroprotector homeobox -0.029551
RNF43 ring finger protein 43 -0.0294336
CADPS Ca++-dependent secretion activator -0.0287414
RPS24 ribosomal protein S24 -0.0277438
EDN1 endothelin 1 -0.0275991
FAT1 FAT atypical cadherin 1 -0.0275425
IER3 immediate early response 3 -0.027506
PERP PERP, TP53 apoptosis effector -0.0273326
EPB41L1 erythrocyte membrane protein band 4.1-like 1 -0.0271191
RSF1 remodeling and spacing factor 1 -0.026829
UBE2C ubiquitin-conjugating enzyme E2C -0.0267411
MIDN midnolin -0.0266268
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0264493
TUBB tubulin, beta class I -0.0262412
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0261886
ETV6 ets variant 6 -0.0260833
KDM7A lysine (K)-specific demethylase 7A -0.0259561
BCL2L1 BCL2-like 1 -0.0257929
FRMD5 FERM domain containing 5 -0.0257709
PHF14 PHD finger protein 14 -0.0254881
SLC38A2 solute carrier family 38, member 2 -0.0254709
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0253554
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like -0.025124
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0249168
TRIM56 tripartite motif containing 56 -0.0248356
SON SON DNA binding protein -0.0247619
BTG1 B-cell translocation gene 1, anti-proliferative -0.02475
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0247319
NF1 neurofibromin 1 -0.0244881
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0243057
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0241875
MYOF myoferlin -0.0239522
GTF2IRD1 GTF2I repeat domain containing 1 -0.0238822
CTSD cathepsin D -0.0238769
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0237518
PCSK5 proprotein convertase subtilisin/kexin type 5 -0.0234809
ATXN2 ataxin 2 -0.0233026
FNBP4 formin binding protein 4 -0.023265
LARS1 leucyl-tRNA synthetase 1 -0.0232104
ZBTB7A zinc finger and BTB domain containing 7A -0.0230796
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.0229876
THOC2 THO complex 2 -0.0229092
CMTM7 CKLF-like MARVEL transmembrane domain containing 7 -0.0228633
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0228579
ST14 suppression of tumorigenicity 14 (colon carcinoma) -0.0227046
EPCAM epithelial cell adhesion molecule -0.0226503