Cytarabine (hydrochloride)_SW48 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cytarabine (hydrochloride) perturbation in SW48 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cytarabine (hydrochloride)_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.130864
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0983852
DSCAM Down syndrome cell adhesion molecule 0.0581551
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.058012
GOLGA4 golgin A4 0.0568844
PDE4B phosphodiesterase 4B, cAMP-specific 0.0565812
KDM6A lysine (K)-specific demethylase 6A 0.045747
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0448535
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0435902
GDF15 growth differentiation factor 15 0.0419825
DDB2 damage-specific DNA binding protein 2, 48kDa 0.0416005
NUP58 nucleoporin 58 0.0398958
LMO7 LIM domain 7 0.0398707
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0395164
CDPF1 cysteine-rich, DPF motif domain containing 1 0.0391253
KMT2C lysine (K)-specific methyltransferase 2C 0.0383996
WAC WW domain containing adaptor with coiled-coil 0.0381075
TSC22D2 TSC22 domain family, member 2 0.0374256
COG5 component of oligomeric golgi complex 5 0.0366087
ZFAND3 zinc finger, AN1-type domain 3 0.0345256
USP3 ubiquitin specific peptidase 3 0.0337648
PUM2 pumilio RNA-binding family member 2 0.0325966
ZNF292 zinc finger protein 292 0.0325827
RNF145 ring finger protein 145 0.032082
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0317612
STRN3 striatin, calmodulin binding protein 3 0.0313337
DSPP dentin sialophosphoprotein 0.0302771
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0302498
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0301712
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0300665
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.0298733
RLF rearranged L-myc fusion 0.0295601
GARS1 glycyl-tRNA synthetase 1 0.029305
BIRC3 baculoviral IAP repeat containing 3 0.029213
OSBPL3 oxysterol binding protein-like 3 0.0292086
RAB1A RAB1A, member RAS oncogene family 0.0291478
HILPDA hypoxia inducible lipid droplet-associated 0.028716
SLMAP sarcolemma associated protein 0.0285557
RBM39 RNA binding motif protein 39 0.0285022
COPA coatomer protein complex, subunit alpha 0.0283048
UBA6 ubiquitin-like modifier activating enzyme 6 0.0281586
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0279776
CDC73 cell division cycle 73 0.0279083
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0277981
CCNL1 cyclin L1 0.0277639
OGA O-GlcNAcase 0.0273734
ESYT2 extended synaptotagmin-like protein 2 0.0268674
PPP4R3A protein phosphatase 4 regulatory subunit 3A 0.0261019
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0260383
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0252885
RAB6A RAB6A, member RAS oncogene family 0.0250134
ZMYM2 zinc finger, MYM-type 2 0.0247563
TFRC transferrin receptor 0.0246275
TXNRD1 thioredoxin reductase 1 0.0245029
RAB10 RAB10, member RAS oncogene family 0.0244185
NAMPT nicotinamide phosphoribosyltransferase 0.0243874
EIF4A2 eukaryotic translation initiation factor 4A2 0.0240894
PCBP2 poly(rC) binding protein 2 0.0237804
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0231633
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0231449
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0230309
WDR43 WD repeat domain 43 0.022905
KDM3A lysine (K)-specific demethylase 3A 0.0227974
NPEPPS aminopeptidase puromycin sensitive 0.0227543
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0226487
MARCHF6 membrane associated ring-CH-type finger 6 0.0224613
ANXA1 annexin A1 0.0222953
TOP1 topoisomerase (DNA) I 0.0222006
YBX3 Y box binding protein 3 0.0216395
WDR45B WD repeat domain 45B 0.0215261
ARRDC3 arrestin domain containing 3 0.0215172
FXR1 fragile X mental retardation, autosomal homolog 1 0.0214171
NBAS neuroblastoma amplified sequence 0.0214134
PTBP2 polypyrimidine tract binding protein 2 0.0213722
NCKAP1 NCK-associated protein 1 0.0213671
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0211442
SDC4 syndecan 4 0.0210087
ATP11B ATPase, class VI, type 11B 0.0209158
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0206734
BRWD1 bromodomain and WD repeat domain containing 1 0.0205251
SEC24D SEC24 family member D 0.0204531
PLK2 polo-like kinase 2 0.0201704
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.020067
YTHDC1 YTH domain containing 1 0.0196705
DIAPH1 diaphanous-related formin 1 0.0196628
TRA2A transformer 2 alpha homolog (Drosophila) 0.0196279
TFG TRK-fused gene 0.0196085
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.019486
NDRG1 N-myc downstream regulated 1 0.0194531
MED13L mediator complex subunit 13-like 0.0194034
SRP54 signal recognition particle 54kDa 0.0191386
ZNF654 zinc finger protein 654 0.0188765
DDIT4 DNA-damage-inducible transcript 4 0.0187659
TMOD3 tropomodulin 3 (ubiquitous) 0.0185408
SEC23A Sec23 homolog A (S. cerevisiae) 0.0185093
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0184449
RREB1 ras responsive element binding protein 1 0.0183301
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 0.018116
MON2 MON2 homolog (S. cerevisiae) 0.0181114
SPAG9 sperm associated antigen 9 0.0180862

decreased expression

Symbol Name Standardized Value
HMGA2 high mobility group AT-hook 2 -0.152557
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.127698
PTMA prothymosin, alpha -0.119958
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.114106
ACTG1 actin gamma 1 -0.0945195
RAD51B RAD51 paralog B -0.0942764
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0935147
EGR1 early growth response 1 -0.0926604
FHIT fragile histidine triad -0.0809006
FRAS1 Fraser extracellular matrix complex subunit 1 -0.0595725
CD36 CD36 molecule (thrombospondin receptor) -0.0571496
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0551656
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0545534
EGFR epidermal growth factor receptor -0.0525582
EZR ezrin -0.0510416
LAMA4 laminin, alpha 4 -0.050968
LOC102724023 ES1 protein homolog, mitochondrial -0.0506529
CCSER1 coiled-coil serine-rich protein 1 -0.048743
TMSB10 thymosin beta 10 -0.0484046
ATXN1 ataxin 1 -0.0479115
RPS6 ribosomal protein S6 -0.0477072
EHBP1 EH domain binding protein 1 -0.047542
FERMT1 fermitin family member 1 -0.0469647
MKI67 marker of proliferation Ki-67 -0.0467279
CUX1 cut-like homeobox 1 -0.0453408
RPS24 ribosomal protein S24 -0.0415983
RPL35A ribosomal protein L35a -0.0388752
EXOC4 exocyst complex component 4 -0.0380528
RPS8 ribosomal protein S8 -0.0376267
CENPF centromere protein F, 350/400kDa -0.0375828
DOCK5 dedicator of cytokinesis 5 -0.036691
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0362439
HDAC2 histone deacetylase 2 -0.0356581
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0346068
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0340162
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0335029
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0331405
CD9 CD9 molecule -0.0326281
RPL31 ribosomal protein L31 -0.0316345
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0315459
RPLP1 ribosomal protein, large, P1 -0.0296599
RPL34 ribosomal protein L34 -0.0295441
AKAP12 A kinase (PRKA) anchor protein 12 -0.0294827
GPHN gephyrin -0.0292328
BMP4 bone morphogenetic protein 4 -0.0291051
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0286657
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0272898
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor -0.0267621
FOS FBJ murine osteosarcoma viral oncogene homolog -0.026102
MAML3 mastermind-like 3 (Drosophila) -0.0257802
HMGA1 high mobility group AT-hook 1 -0.0257322
MTAP methylthioadenosine phosphorylase -0.0256658
PARD3B par-3 family cell polarity regulator beta -0.0255245
SMYD3 SET and MYND domain containing 3 -0.0253847
RPL12 ribosomal protein L12 -0.0253085
ANXA2 annexin A2 -0.0252774
RPS25 ribosomal protein S25 -0.0252769
RPS29 ribosomal protein S29 -0.0250797
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0245321
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0241324
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0240896
NTSR1 neurotensin receptor 1 (high affinity) -0.0240198
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0240196
DIAPH2 diaphanous-related formin 2 -0.0238539
FLOT1 flotillin 1 -0.0235506
ITPKC inositol-trisphosphate 3-kinase C -0.0234899
SKAP1 src kinase associated phosphoprotein 1 -0.0234531
RPL37A ribosomal protein L37a -0.0233033
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.023283
RCOR1 REST corepressor 1 -0.0226815
CCND1 cyclin D1 -0.022623
EFNB2 ephrin-B2 -0.0223058
VCL vinculin -0.0221501
TPT1 tumor protein, translationally-controlled 1 -0.0219239
RPS12 ribosomal protein S12 -0.0219231
ZBTB20 zinc finger and BTB domain containing 20 -0.0218855
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like -0.0218614
PHF14 PHD finger protein 14 -0.0214913
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0214888
ITGB4 integrin, beta 4 -0.0214559
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0211551
RPLP2 ribosomal protein, large, P2 -0.0211125
RPS19 ribosomal protein S19 -0.0210893
TUBB tubulin, beta class I -0.0208225
FOXP1 forkhead box P1 -0.0206396
TENM3 teneurin transmembrane protein 3 -0.0205001
CMIP c-Maf inducing protein -0.020459
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0203454
RPS23 ribosomal protein S23 -0.02032
RABGAP1L RAB GTPase activating protein 1-like -0.0202816
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0201575
S100A6 S100 calcium binding protein A6 -0.0200812
RPS3 ribosomal protein S3 -0.0200188
ARID1B AT rich interactive domain 1B (SWI1-like) -0.0199917
MPRIP myosin phosphatase Rho interacting protein -0.0199402
RPL7A ribosomal protein L7a -0.0197838
SGPP2 sphingosine-1-phosphate phosphatase 2 -0.0197804
RPS13 ribosomal protein S13 -0.0197362
RPL9 ribosomal protein L9 -0.019562
PATJ PATJ crumbs cell polarity complex component -0.0195363