Cytarabine (hydrochloride)_hTERT-HPNE Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cytarabine (hydrochloride) perturbation in hTERT-HPNE cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cytarabine (hydrochloride)_hTERT-HPNE drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.195559
MYH9 myosin, heavy chain 9, non-muscle 0.101582
FAM13A family with sequence similarity 13, member A 0.0816777
GOLGA4 golgin A4 0.081204
B2M beta-2-microglobulin 0.0743392
SOD2 superoxide dismutase 2, mitochondrial 0.0667153
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0661551
DSCAM Down syndrome cell adhesion molecule 0.0641088
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0638016
PCBP2 poly(rC) binding protein 2 0.0606165
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0588364
ZNF292 zinc finger protein 292 0.0582599
TRIO trio Rho guanine nucleotide exchange factor 0.0575865
DST dystonin 0.0565986
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0540782
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.053622
HELZ helicase with zinc finger 0.0514482
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0488399
MEIS1 Meis homeobox 1 0.0480134
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.047502
SPAG9 sperm associated antigen 9 0.046491
NBAS neuroblastoma amplified sequence 0.0460847
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0454125
GPHN gephyrin 0.0446736
ENO1 enolase 1, (alpha) 0.0442696
ADAM9 ADAM metallopeptidase domain 9 0.0430002
MED13L mediator complex subunit 13-like 0.0429489
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 0.0429416
COPA coatomer protein complex, subunit alpha 0.0420701
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0420414
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.0415996
MSN moesin 0.0413616
PTEN phosphatase and tensin homolog 0.0409964
OGA O-GlcNAcase 0.0404643
ARHGAP21 Rho GTPase activating protein 21 0.0404134
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0399114
PICALM phosphatidylinositol binding clathrin assembly protein 0.0398757
MMP1 matrix metallopeptidase 1 0.0393765
CDPF1 cysteine-rich, DPF motif domain containing 1 0.0393139
ADM adrenomedullin 0.0392678
DDB2 damage-specific DNA binding protein 2, 48kDa 0.038272
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0380442
CCNL1 cyclin L1 0.0365298
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 0.0360469
FNIP1 folliculin interacting protein 1 0.0356443
FDXR ferredoxin reductase 0.0354143
ETNK1 ethanolamine kinase 1 0.0344177
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0343
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0339593
KIAA1217 KIAA1217 0.0337721
AKAP9 A kinase (PRKA) anchor protein 9 0.033656
POTEF POTE ankyrin domain family, member F 0.033318
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0332284
TRPC4 transient receptor potential cation channel, subfamily C, member 4 0.0329957
KDM6A lysine (K)-specific demethylase 6A 0.0327211
CXCL8 chemokine (C-X-C motif) ligand 8 0.0319921
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0318039
UBA6 ubiquitin-like modifier activating enzyme 6 0.0317244
AXL AXL receptor tyrosine kinase 0.0316462
CALD1 caldesmon 1 0.0314742
PRRC2C proline-rich coiled-coil 2C 0.0312516
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0310312
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0307989
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0306301
RPS12 ribosomal protein S12 0.0303072
BIRC6 baculoviral IAP repeat containing 6 0.0302494
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0300795
ESYT2 extended synaptotagmin-like protein 2 0.0300058
FAT1 FAT atypical cadherin 1 0.0296445
HIPK2 homeodomain interacting protein kinase 2 0.0292435
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0286171
BHLHE40 basic helix-loop-helix family, member e40 0.0284342
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0282314
RARS1 arginyl-tRNA synthetase 1 0.0279859
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0279715
CSDE1 cold shock domain containing E1, RNA-binding 0.027944
EPS8 epidermal growth factor receptor pathway substrate 8 0.0278048
TMF1 TATA element modulatory factor 1 0.0275371
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0275187
GLS2 glutaminase 2 (liver, mitochondrial) 0.0274939
LIMS1 LIM and senescent cell antigen-like domains 1 0.0273328
ATP13A3 ATPase type 13A3 0.027314
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D 0.0268158
SETD5 SET domain containing 5 0.0266501
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0266225
YTHDC1 YTH domain containing 1 0.0265926
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0264885
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0264484
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0264333
XPC xeroderma pigmentosum, complementation group C 0.0264226
NUP58 nucleoporin 58 0.0259322
ENO2 enolase 2 (gamma, neuronal) 0.0258424
HDAC9 histone deacetylase 9 0.025787
MON2 MON2 homolog (S. cerevisiae) 0.024785
SRPK2 SRSF protein kinase 2 0.0247425
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0245796
ARRDC3 arrestin domain containing 3 0.0245486
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0243326
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0242773
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0240559

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.216546
FN1 fibronectin 1 -0.204039
VIM vimentin -0.174795
HMGA2 high mobility group AT-hook 2 -0.168556
AKAP12 A kinase (PRKA) anchor protein 12 -0.14355
TMSB10 thymosin beta 10 -0.13019
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.116365
STC1 stanniocalcin 1 -0.08308
EMP1 epithelial membrane protein 1 -0.0769034
COL1A1 collagen, type I, alpha 1 -0.0735511
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0703413
INHBA inhibin, beta A -0.0677208
LOXL2 lysyl oxidase-like 2 -0.0674454
CAVIN1 caveolae associated protein 1 -0.0664607
NDRG1 N-myc downstream regulated 1 -0.0624449
RAI14 retinoic acid induced 14 -0.0616443
ADGRB3 adhesion G protein-coupled receptor B3 -0.0576309
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0571935
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0559281
ANKRD28 ankyrin repeat domain 28 -0.0552828
EXT1 exostosin glycosyltransferase 1 -0.0543646
TPT1 tumor protein, translationally-controlled 1 -0.0534304
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0525915
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0500281
NALF1 NALCN channel auxiliary factor 1 -0.0495677
OSMR oncostatin M receptor -0.0487797
GREM1 gremlin 1, DAN family BMP antagonist -0.0470481
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 -0.0464312
ASPH aspartate beta-hydroxylase -0.044801
LOC112694756 uncharaterized LOC112694756 -0.0426898
CD44 CD44 molecule (Indian blood group) -0.041375
OXR1 oxidation resistance 1 -0.0401304
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0371003
TM4SF1 transmembrane 4 L six family member 1 -0.0364581
SLC38A2 solute carrier family 38, member 2 -0.0363062
CCND1 cyclin D1 -0.0360674
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.034173
FBN1 fibrillin 1 -0.0340799
IER3 immediate early response 3 -0.0333479
RRBP1 ribosome binding protein 1 -0.0332358
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0320996
PRKG1 protein kinase, cGMP-dependent, type I -0.030931
FNDC3B fibronectin type III domain containing 3B -0.0305611
NAA16 N(alpha)-acetyltransferase 16, NatA auxiliary subunit -0.0304989
FTL ferritin, light polypeptide -0.0304214
COL6A2 collagen, type VI, alpha 2 -0.029825
DIAPH2 diaphanous-related formin 2 -0.0296364
NT5E 5'-nucleotidase, ecto (CD73) -0.0296276
VCL vinculin -0.0293139
CCDC102B coiled-coil domain containing 102B -0.0292423
EIF1 eukaryotic translation initiation factor 1 -0.0291345
LOX lysyl oxidase -0.0287907
SLIT2 slit homolog 2 (Drosophila) -0.0279147
EGFR epidermal growth factor receptor -0.0267981
EGR1 early growth response 1 -0.0267966
GNAS GNAS complex locus -0.0263415
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0251873
H1-0 H1.0 linker histone -0.0251636
RPS24 ribosomal protein S24 -0.0251503
FBXL17 F-box and leucine-rich repeat protein 17 -0.025112
COL8A1 collagen, type VIII, alpha 1 -0.0249218
CAV1 caveolin 1, caveolae protein, 22kDa -0.0248208
TSHZ3 teashirt zinc finger homeobox 3 -0.0243853
COL1A2 collagen, type I, alpha 2 -0.0234548
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0227432
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0224909
PLPP3 phospholipid phosphatase 3 -0.0224094
RPL35A ribosomal protein L35a -0.0221996
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0221211
BBS9 Bardet-Biedl syndrome 9 -0.0215384
FKBP10 FK506 binding protein 10, 65 kDa -0.0213812
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0213244
WNT2B wingless-type MMTV integration site family, member 2B -0.0213161
TPM4 tropomyosin 4 -0.0211584
EPAS1 endothelial PAS domain protein 1 -0.0207404
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0206777
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0206562
FRMD4A FERM domain containing 4A -0.0205476
ANXA2 annexin A2 -0.0202095
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0200267
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0199012
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0198359
ARHGAP24 Rho GTPase activating protein 24 -0.0197181
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0194999
MAP1B microtubule-associated protein 1B -0.0193136
TUBB tubulin, beta class I -0.0192471
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0187424
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0187218
RPL34 ribosomal protein L34 -0.018637
FOXP1 forkhead box P1 -0.0184931
ARF1 ADP-ribosylation factor 1 -0.018425
KLF6 Kruppel-like factor 6 -0.0182027
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0180912
ITPRIPL2 inositol 1,4,5-trisphosphate receptor interacting protein-like 2 -0.0180472
CLMP CXADR-like membrane protein -0.0178781
FTH1 ferritin, heavy polypeptide 1 -0.0178235
CDH13 cadherin 13 -0.0177353
LAMA4 laminin, alpha 4 -0.0177339
NAV2 neuron navigator 2 -0.0175377
IGF2 insulin-like growth factor 2 -0.0174587