Cytarabine_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cytarabine perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cytarabine_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.139553
PLAT plasminogen activator, tissue 0.138508
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.131892
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.128493
PODXL podocalyxin-like 0.126678
DLG1 discs, large homolog 1 (Drosophila) 0.0813845
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0803486
FLNB filamin B, beta 0.0784521
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0735663
OGA O-GlcNAcase 0.0698871
SBF2 SET binding factor 2 0.0656648
AKAP12 A kinase (PRKA) anchor protein 12 0.0647753
CDH13 cadherin 13 0.064568
ZEB1 zinc finger E-box binding homeobox 1 0.0644284
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0635917
TRIO trio Rho guanine nucleotide exchange factor 0.0603522
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0601285
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0600747
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0593609
ATP13A3 ATPase type 13A3 0.0574332
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0559644
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0555151
SLC39A11 solute carrier family 39, member 11 0.0542235
PGK1 phosphoglycerate kinase 1 0.0527518
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0522303
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 0.0508616
CYLD cylindromatosis (turban tumor syndrome) 0.0497049
FNDC3B fibronectin type III domain containing 3B 0.0480844
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0478163
NAV2 neuron navigator 2 0.0464997
ZNF292 zinc finger protein 292 0.0461851
CEP170 centrosomal protein 170kDa 0.0455595
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.044846
RPL37A ribosomal protein L37a 0.041053
DTNA dystrobrevin, alpha 0.0409011
PTMA prothymosin, alpha 0.0406411
NDRG1 N-myc downstream regulated 1 0.0397382
YEATS2 YEATS domain containing 2 0.039313
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0390651
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0390108
MYOF myoferlin 0.038888
HELZ helicase with zinc finger 0.0386013
DST dystonin 0.0385094
ELL2 elongation factor, RNA polymerase II, 2 0.0380096
COL3A1 collagen, type III, alpha 1 0.0378384
GOLGA4 golgin A4 0.0373863
SETD5 SET domain containing 5 0.0366053
ANKRD12 ankyrin repeat domain 12 0.0365938
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0349561
NT5C2 5'-nucleotidase, cytosolic II 0.0347038
MXI1 MAX interactor 1, dimerization protein 0.0346428
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0346085
NAP1L1 nucleosome assembly protein 1-like 1 0.0344932
GPC6 glypican 6 0.0342972
SPIRE1 spire-type actin nucleation factor 1 0.0341331
ANO6 anoctamin 6 0.0340794
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.0337538
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0337457
ARRDC3 arrestin domain containing 3 0.0336407
NFE2L1 nuclear factor, erythroid 2-like 1 0.0334472
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.033244
RICTOR RPTOR independent companion of MTOR, complex 2 0.032527
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0324352
FNIP1 folliculin interacting protein 1 0.0323985
USP34 ubiquitin specific peptidase 34 0.0318479
TPT1 tumor protein, translationally-controlled 1 0.0315817
NCKAP1 NCK-associated protein 1 0.031395
XPO1 exportin 1 0.0313408
SDK1 sidekick cell adhesion molecule 1 0.0312941
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase 0.0308969
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 0.0306621
STC1 stanniocalcin 1 0.0305534
SP3 Sp3 transcription factor 0.0301302
GNB4 guanine nucleotide binding protein (G protein), beta polypeptide 4 0.03012
UBA6 ubiquitin-like modifier activating enzyme 6 0.0299938
NGLY1 N-glycanase 1 0.0298921
SNX9 sorting nexin 9 0.0298063
RNF24 ring finger protein 24 0.0294309
PRKD3 protein kinase D3 0.0293961
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0293723
HIP1 huntingtin interacting protein 1 0.0291951
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0291159
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.029112
PCGF5 polycomb group ring finger 5 0.0290589
FAM162A family with sequence similarity 162, member A 0.0288737
ANKRD10 ankyrin repeat domain 10 0.0288699
PBX3 pre-B-cell leukemia homeobox 3 0.0287477
INSIG2 insulin induced gene 2 0.027972
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.0278001
RPS6 ribosomal protein S6 0.0277928
ANKRD11 ankyrin repeat domain 11 0.0276229
ARFGEF3 ARFGEF family member 3 0.0272325
DDIT4 DNA-damage-inducible transcript 4 0.0270903
ESYT2 extended synaptotagmin-like protein 2 0.0268082
ASPH aspartate beta-hydroxylase 0.0267133
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0266694
LPP LIM domain containing preferred translocation partner in lipoma 0.0265288
FCHSD2 FCH and double SH3 domains 2 0.0264854
UBA2 ubiquitin-like modifier activating enzyme 2 0.0261742
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0260794

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.301452
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.210274
LOX lysyl oxidase -0.183255
TMSB10 thymosin beta 10 -0.163839
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.144165
MAP1B microtubule-associated protein 1B -0.115136
LOC112694756 uncharaterized LOC112694756 -0.085638
FTH1 ferritin, heavy polypeptide 1 -0.0821701
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0713779
BSG basigin (Ok blood group) -0.0650671
AHNAK AHNAK nucleoprotein -0.0631106
UBC ubiquitin C -0.0611182
COL5A2 collagen, type V, alpha 2 -0.0610358
LDHA lactate dehydrogenase A -0.0556115
COL5A1 collagen, type V, alpha 1 -0.0553079
THBS2 thrombospondin 2 -0.0530987
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0530868
FBN1 fibrillin 1 -0.0523806
MEIS2 Meis homeobox 2 -0.0523656
ANXA2 annexin A2 -0.0514559
MARCKS myristoylated alanine-rich protein kinase C substrate -0.04956
GLIS3 GLIS family zinc finger 3 -0.0494431
HDLBP high density lipoprotein binding protein -0.0485045
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0483952
FTL ferritin, light polypeptide -0.0448732
CANX calnexin -0.04438
VCL vinculin -0.0433886
RIGI RNA sensor RIG-I -0.0425
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0415872
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 -0.0404734
PKM pyruvate kinase, muscle -0.0397393
TIMP2 TIMP metallopeptidase inhibitor 2 -0.039123
IFITM1 interferon induced transmembrane protein 1 -0.0388856
CD44 CD44 molecule (Indian blood group) -0.0380871
CALR calreticulin -0.0377352
TXNIP thioredoxin interacting protein -0.0373473
HLA-C major histocompatibility complex, class I, C -0.0368474
IFITM3 interferon induced transmembrane protein 3 -0.036436
HLA-B major histocompatibility complex, class I, B -0.036189
RRBP1 ribosome binding protein 1 -0.0337827
SP100 SP100 nuclear antigen -0.0329514
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.031251
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0311576
COPA coatomer protein complex, subunit alpha -0.0308252
FSTL1 follistatin-like 1 -0.0307697
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0304269
LHFPL2 lipoma HMGIC fusion partner-like 2 -0.0303539
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0301076
HILPDA hypoxia inducible lipid droplet-associated -0.0289399
RAB7A RAB7A, member RAS oncogene family -0.0286964
HLA-A major histocompatibility complex, class I, A -0.0285261
FBXO11 F-box protein 11 -0.0284763
AKAP9 A kinase (PRKA) anchor protein 9 -0.0284423
IARS1 isoleucyl-tRNA synthetase 1 -0.0284345
HLA-E major histocompatibility complex, class I, E -0.0281046
S100A6 S100 calcium binding protein A6 -0.0280056
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0271629
DKK3 dickkopf WNT signaling pathway inhibitor 3 -0.0262352
INTS6 integrator complex subunit 6 -0.0258918
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0257696
TAPBP TAP binding protein (tapasin) -0.0255705
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0253897
COL4A2 collagen, type IV, alpha 2 -0.0252607
TUFT1 tuftelin 1 -0.0247144
APP amyloid beta (A4) precursor protein -0.0239152
KDM5B lysine (K)-specific demethylase 5B -0.0232083
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0230759
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0230353
EGR1 early growth response 1 -0.0225336
TNS3 tensin 3 -0.0224126
TRABD2B TraB domain containing 2B -0.0220575
RABGAP1L RAB GTPase activating protein 1-like -0.0220305
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein -0.0219939
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.0219353
AFF4 AF4/FMR2 family, member 4 -0.0212767
RASAL2 RAS protein activator like 2 -0.0211954
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0211042
GOLGB1 golgin B1 -0.021102
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0210356
TMCO3 transmembrane and coiled-coil domains 3 -0.0210054
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0208797
TAGLN2 transgelin 2 -0.020838
TSC22D2 TSC22 domain family, member 2 -0.0207009
MNT MAX network transcriptional repressor -0.0204908
SEC16A SEC16 homolog A (S. cerevisiae) -0.0201159
EGFR epidermal growth factor receptor -0.0201032
MMP14 matrix metallopeptidase 14 (membrane-inserted) -0.020085
ACTN4 actinin, alpha 4 -0.0199706
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0199154
BLZF1 basic leucine zipper nuclear factor 1 -0.0198985
COL1A2 collagen, type I, alpha 2 -0.0198826
HSPB1 heat shock 27kDa protein 1 -0.0196494
H1-10 H1.10 linker histone -0.019642
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0196385
RNF213 ring finger protein 213 -0.0195296
VMP1 vacuole membrane protein 1 -0.0194821
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0194237
GOLGA2 golgin A2 -0.0192576
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0191996
EPAS1 endothelial PAS domain protein 1 -0.0191734