Cytarabine_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cytarabine perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cytarabine_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VCL vinculin 0.116967
FAM13A family with sequence similarity 13, member A 0.0986226
RPS6 ribosomal protein S6 0.0803017
SOX9 SRY (sex determining region Y)-box 9 0.0704166
TIMP3 TIMP metallopeptidase inhibitor 3 0.0675244
LPIN1 lipin 1 0.0672422
HELZ helicase with zinc finger 0.0642404
TLE4 transducin-like enhancer of split 4 0.0642331
AKAP12 A kinase (PRKA) anchor protein 12 0.063545
DTNA dystrobrevin, alpha 0.0576154
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0572352
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0571689
FNDC3B fibronectin type III domain containing 3B 0.0571555
KMT2E lysine (K)-specific methyltransferase 2E 0.0568888
MARCHF6 membrane associated ring-CH-type finger 6 0.0566893
MED13 mediator complex subunit 13 0.0562337
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0550996
WAC WW domain containing adaptor with coiled-coil 0.0540522
UBA6 ubiquitin-like modifier activating enzyme 6 0.0536578
MEF2A myocyte enhancer factor 2A 0.0524623
NPEPPS aminopeptidase puromycin sensitive 0.0513915
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0497681
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.0480032
SQSTM1 sequestosome 1 0.0476576
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0471316
ZSWIM6 zinc finger, SWIM-type containing 6 0.0460752
CCND1 cyclin D1 0.0450287
DDIT4 DNA-damage-inducible transcript 4 0.043471
CDC73 cell division cycle 73 0.0417804
PTMA prothymosin, alpha 0.0407263
BIRC2 baculoviral IAP repeat containing 2 0.0406042
XPO1 exportin 1 0.0405753
OGA O-GlcNAcase 0.0401845
KIAA1217 KIAA1217 0.0398839
DPH6 diphthamine biosynthesis 6 0.0396765
ANXA2 annexin A2 0.0396553
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.0391674
NCKAP1 NCK-associated protein 1 0.0382762
RAP1B RAP1B, member of RAS oncogene family 0.0379504
PARD3 par-3 family cell polarity regulator 0.037815
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0377629
EPS8 epidermal growth factor receptor pathway substrate 8 0.0375809
PTPRD protein tyrosine phosphatase, receptor type, D 0.0375648
MBNL1 muscleblind-like splicing regulator 1 0.0372116
NCOR1 nuclear receptor corepressor 1 0.0368691
KMT2C lysine (K)-specific methyltransferase 2C 0.0365982
GPBP1 GC-rich promoter binding protein 1 0.0364192
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.0359321
WDR43 WD repeat domain 43 0.0357724
HSPA8 heat shock 70kDa protein 8 0.0356936
MORF4L1 mortality factor 4 like 1 0.0356775
KDM3A lysine (K)-specific demethylase 3A 0.0346133
ACTG1 actin gamma 1 0.0346031
NUP58 nucleoporin 58 0.0344547
GPHN gephyrin 0.0342046
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0338504
ERBIN erbb2 interacting protein 0.0338235
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0337883
PHIP pleckstrin homology domain interacting protein 0.0331617
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0331549
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0328501
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0323181
RYBP RING1 and YY1 binding protein 0.0323122
WDR45B WD repeat domain 45B 0.0320352
NAMPT nicotinamide phosphoribosyltransferase 0.031892
RAB1A RAB1A, member RAS oncogene family 0.0317281
SBNO1 strawberry notch homolog 1 (Drosophila) 0.0313161
SLMAP sarcolemma associated protein 0.0312194
PEAK1 pseudopodium-enriched atypical kinase 1 0.0311549
ENAH enabled homolog (Drosophila) 0.0309271
TXNL1 thioredoxin-like 1 0.0309083
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.030753
RPS2 ribosomal protein S2 0.0307098
SSBP2 single-stranded DNA binding protein 2 0.0306747
KDM6A lysine (K)-specific demethylase 6A 0.0306057
PNISR PNN-interacting serine/arginine-rich protein 0.030508
RPL38 ribosomal protein L38 0.030506
EIF3E eukaryotic translation initiation factor 3, subunit E 0.030409
FNDC3A fibronectin type III domain containing 3A 0.0301863
OSBPL8 oxysterol binding protein-like 8 0.0301722
PIAS1 protein inhibitor of activated STAT, 1 0.029821
ZMYM2 zinc finger, MYM-type 2 0.029772
ITPRID2 ITPR interacting domain containing 2 0.0296137
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0295989
NRIP1 nuclear receptor interacting protein 1 0.0295589
PPP4R2 protein phosphatase 4, regulatory subunit 2 0.029334
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0293208
RPS20 ribosomal protein S20 0.0291799
AFF4 AF4/FMR2 family, member 4 0.0291797
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0287187
SBF2 SET binding factor 2 0.0282782
LRRC58 leucine rich repeat containing 58 0.0278964
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2 0.0275286
TOP1 topoisomerase (DNA) I 0.0271574
ANKRD17 ankyrin repeat domain 17 0.0270585
FXR1 fragile X mental retardation, autosomal homolog 1 0.026856
CSNK1G1 casein kinase 1, gamma 1 0.0266691
CAMKMT calmodulin-lysine N-methyltransferase 0.0265995
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A 0.0265724
MRTFA myocardin related transcription factor A 0.0265649

decreased expression

Symbol Name Standardized Value
NRG1 neuregulin 1 -0.1175
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.109658
NALF1 NALCN channel auxiliary factor 1 -0.10909
CENPF centromere protein F, 350/400kDa -0.106739
SYT1 synaptotagmin I -0.100247
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0788085
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0761065
IGF2 insulin-like growth factor 2 -0.0735918
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0733091
COL4A5 collagen, type IV, alpha 5 -0.0716862
ZBTB20 zinc finger and BTB domain containing 20 -0.0704342
MAP1B microtubule-associated protein 1B -0.0701872
CEMIP cell migration inducing protein, hyaluronan binding -0.0694298
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0688398
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0688161
VIM vimentin -0.0677826
COL1A1 collagen, type I, alpha 1 -0.0635096
PCBP2 poly(rC) binding protein 2 -0.0624091
NCAM2 neural cell adhesion molecule 2 -0.0579863
PDE4D phosphodiesterase 4D, cAMP-specific -0.0571951
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0560489
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.0545479
EXOC4 exocyst complex component 4 -0.0532647
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0502695
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0495275
PACS1 phosphofurin acidic cluster sorting protein 1 -0.0492507
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog -0.047412
TMSB10 thymosin beta 10 -0.0471797
ANTXR1 anthrax toxin receptor 1 -0.0457694
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0449619
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 -0.0449049
GDF15 growth differentiation factor 15 -0.0442099
PRRC2C proline-rich coiled-coil 2C -0.0439797
FTH1 ferritin, heavy polypeptide 1 -0.0430448
FN1 fibronectin 1 -0.0410827
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0408615
BPTF bromodomain PHD finger transcription factor -0.0401144
FRMD4A FERM domain containing 4A -0.0396666
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0395259
BCAS3 breast carcinoma amplified sequence 3 -0.0393467
RAB7A RAB7A, member RAS oncogene family -0.0392534
NRP1 neuropilin 1 -0.0384059
EPAS1 endothelial PAS domain protein 1 -0.0379336
CALD1 caldesmon 1 -0.0379157
SLC38A2 solute carrier family 38, member 2 -0.0377856
CALR calreticulin -0.0374567
COL4A6 collagen, type IV, alpha 6 -0.037333
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0372279
MAML2 mastermind-like 2 (Drosophila) -0.0358525
EEF1G eukaryotic translation elongation factor 1 gamma -0.0354893
AHNAK AHNAK nucleoprotein -0.035483
CENPE centromere protein E, 312kDa -0.035296
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0349889
DCAF7 DDB1 and CUL4 associated factor 7 -0.0347943
TXNRD1 thioredoxin reductase 1 -0.0346097
ZNF638 zinc finger protein 638 -0.0345624
LOC112694756 uncharaterized LOC112694756 -0.034412
LDHA lactate dehydrogenase A -0.0343547
STC1 stanniocalcin 1 -0.0343313
NCOA7 nuclear receptor coactivator 7 -0.0342067
B2M beta-2-microglobulin -0.0341771
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0339632
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0337727
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0335576
KDM2A lysine (K)-specific demethylase 2A -0.0333772
PTPRK protein tyrosine phosphatase, receptor type, K -0.0332813
PDZRN3 PDZ domain containing ring finger 3 -0.0330722
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.0324102
MCL1 myeloid cell leukemia 1 -0.0324084
ZNF609 zinc finger protein 609 -0.0323091
SRRM2 serine/arginine repetitive matrix 2 -0.0319411
CSNK1D casein kinase 1, delta -0.031582
MKI67 marker of proliferation Ki-67 -0.0314109
IGFBP4 insulin-like growth factor binding protein 4 -0.03138
KDM5B lysine (K)-specific demethylase 5B -0.0312322
TOR1AIP2 torsin A interacting protein 2 -0.0312307
HMGB2 high mobility group box 2 -0.0312041
HDLBP high density lipoprotein binding protein -0.0311758
NFIB nuclear factor I/B -0.0310772
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0306866
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 -0.0303092
MMP2 matrix metallopeptidase 2 -0.0301553
LIMCH1 LIM and calponin homology domains 1 -0.0301137
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0296877
COL6A1 collagen, type VI, alpha 1 -0.0296182
DDX18 DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 -0.0294904
CACNB2 calcium channel, voltage-dependent, beta 2 subunit -0.0294203
TBCK TBC1 domain containing kinase -0.0293134
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2 -0.0292257
ZNF652 zinc finger protein 652 -0.02912
IFI16 interferon, gamma-inducible protein 16 -0.0290649
MEF2D myocyte enhancer factor 2D -0.0290318
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 -0.0289896
SCARB1 scavenger receptor class B, member 1 -0.0289124
SEC63 SEC63 homolog (S. cerevisiae) -0.028898
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0283851
NEK1 NIMA-related kinase 1 -0.0282303
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0281074
RPS27A ribosomal protein S27a -0.0278373
RPTOR regulatory associated protein of MTOR, complex 1 -0.0277751