Cytarabine_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cytarabine perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cytarabine_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.10159
FNDC3B fibronectin type III domain containing 3B 0.0874965
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.074438
ERRFI1 ERBB receptor feedback inhibitor 1 0.0710923
ARGLU1 arginine and glutamate rich 1 0.0688313
RNF149 ring finger protein 149 0.0614268
FNIP1 folliculin interacting protein 1 0.0602007
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 0.0597864
FNDC3A fibronectin type III domain containing 3A 0.057753
TPT1 tumor protein, translationally-controlled 1 0.0558754
DIAPH3 diaphanous-related formin 3 0.0538302
NDRG1 N-myc downstream regulated 1 0.0509734
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0483028
MBNL2 muscleblind-like splicing regulator 2 0.047604
TMPRSS4 transmembrane protease, serine 4 0.0463827
BTBD9 BTB (POZ) domain containing 9 0.0457905
ZMYM2 zinc finger, MYM-type 2 0.0442298
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0439517
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0437357
TM9SF2 transmembrane 9 superfamily member 2 0.0425422
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0412378
ESYT2 extended synaptotagmin-like protein 2 0.0410324
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0403499
NPEPPS aminopeptidase puromycin sensitive 0.0399175
NT5C3A 5'-nucleotidase, cytosolic IIIA 0.0397741
DENND4C DENN/MADD domain containing 4C 0.0390872
APOL1 apolipoprotein L, 1 0.038455
XAF1 XIAP associated factor 1 0.0383547
SMAD3 SMAD family member 3 0.0377174
GOLGA4 golgin A4 0.0375332
YEATS2 YEATS domain containing 2 0.0373926
ZDHHC20 zinc finger, DHHC-type containing 20 0.0372008
EREG epiregulin 0.0369381
EGLN3 egl-9 family hypoxia-inducible factor 3 0.036847
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0368247
USP3 ubiquitin specific peptidase 3 0.0366452
ARRDC3 arrestin domain containing 3 0.0361969
EFNB2 ephrin-B2 0.0359257
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.0356862
PTBP3 polypyrimidine tract binding protein 3 0.0352006
RPS6 ribosomal protein S6 0.0348065
SFXN1 sideroflexin 1 0.0344596
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 0.033723
FANCI Fanconi anemia, complementation group I 0.0336772
KLF5 Kruppel-like factor 5 (intestinal) 0.0336138
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0335673
SBF2 SET binding factor 2 0.033449
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.033326
USP34 ubiquitin specific peptidase 34 0.0332765
WAC WW domain containing adaptor with coiled-coil 0.03292
EHF ets homologous factor 0.032815
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0328133
KDM3A lysine (K)-specific demethylase 3A 0.0327829
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.0325825
HELZ helicase with zinc finger 0.0317762
NCOR1 nuclear receptor corepressor 1 0.0316743
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.0316474
MXD1 MAX dimerization protein 1 0.0311517
BIRC6 baculoviral IAP repeat containing 6 0.0308137
NAMPT nicotinamide phosphoribosyltransferase 0.0305177
ABLIM1 actin binding LIM protein 1 0.0304512
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 0.0303466
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.0302266
OGA O-GlcNAcase 0.030169
RAB1A RAB1A, member RAS oncogene family 0.0296546
NIPBL Nipped-B homolog (Drosophila) 0.029589
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0294144
ANKRD10 ankyrin repeat domain 10 0.028946
USPL1 ubiquitin specific peptidase like 1 0.0288278
NCOA3 nuclear receptor coactivator 3 0.0286155
TSC22D2 TSC22 domain family, member 2 0.0285487
SORBS1 sorbin and SH3 domain containing 1 0.0284033
SEC24D SEC24 family member D 0.0282147
ZNF292 zinc finger protein 292 0.0279594
KDM6A lysine (K)-specific demethylase 6A 0.0278597
KMT2C lysine (K)-specific methyltransferase 2C 0.0277398
NEBL nebulette 0.0276972
STARD4 StAR-related lipid transfer (START) domain containing 4 0.0276268
NEK7 NIMA-related kinase 7 0.0275748
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0274082
GRK3 G protein-coupled receptor kinase 3 0.0271676
KMT2E lysine (K)-specific methyltransferase 2E 0.0271385
MT2A metallothionein 2A 0.0271127
BRWD3 bromodomain and WD repeat domain containing 3 0.0269646
RAD51B RAD51 paralog B 0.0269155
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.026736
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0266682
PRELID2 PRELI domain containing 2 0.026446
CCDC146 coiled-coil domain containing 146 0.0262841
RNF145 ring finger protein 145 0.0260847
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0260571
AREG amphiregulin 0.0258968
SUCO SUN domain containing ossification factor 0.0257169
SREBF2 sterol regulatory element binding transcription factor 2 0.0256785
MEF2A myocyte enhancer factor 2A 0.0256302
KLF6 Kruppel-like factor 6 0.0252855
AFF1 AF4/FMR2 family, member 1 0.0248087
IL6ST interleukin 6 signal transducer 0.0247685
TNRC6A trinucleotide repeat containing 6A 0.0247391
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.0245774

decreased expression

Symbol Name Standardized Value
EPSTI1 epithelial stromal interaction 1 (breast) -0.190251
UBC ubiquitin C -0.127796
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0995068
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -0.0976272
VMP1 vacuole membrane protein 1 -0.0929996
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0923266
MX1 MX dynamin-like GTPase 1 -0.090616
LMO7 LIM domain 7 -0.0902454
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0837688
PKM pyruvate kinase, muscle -0.0836699
EPHB2 EPH receptor B2 -0.0827865
TSC22D1 TSC22 domain family, member 1 -0.0781948
EGR1 early growth response 1 -0.0779223
LYZ lysozyme -0.0725572
PERP PERP, TP53 apoptosis effector -0.0708655
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.068908
RNF213 ring finger protein 213 -0.0677834
JUN jun proto-oncogene -0.0637847
RIGI RNA sensor RIG-I -0.0628448
ITGA6 integrin, alpha 6 -0.0617491
MX2 MX dynamin-like GTPase 2 -0.0609834
PLSCR1 phospholipid scramblase 1 -0.0600665
INTS6 integrator complex subunit 6 -0.0577826
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0566537
ENO1 enolase 1, (alpha) -0.0517859
C6ORF132 chromosome 6 open reading frame 132 -0.0513251
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0491914
AHNAK AHNAK nucleoprotein -0.048941
IGFBP3 insulin-like growth factor binding protein 3 -0.0485722
TMC5 transmembrane channel-like 5 -0.048354
NPSR1 neuropeptide S receptor 1 -0.0483399
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0474224
ALCAM activated leukocyte cell adhesion molecule -0.0471776
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0466382
STS steroid sulfatase (microsomal), isozyme S -0.0463984
SPATA13 spermatogenesis associated 13 -0.0445694
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0427614
PCBP2 poly(rC) binding protein 2 -0.0424128
SP100 SP100 nuclear antigen -0.0422265
LOC112694756 uncharaterized LOC112694756 -0.0420892
POTEF POTE ankyrin domain family, member F -0.0405836
PARP9 poly (ADP-ribose) polymerase family, member 9 -0.0394298
B2M beta-2-microglobulin -0.0391302
ACTN4 actinin, alpha 4 -0.0389848
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0388054
SETX senataxin -0.0373273
ETV6 ets variant 6 -0.0371577
CDHR2 cadherin-related family member 2 -0.0367223
CALR calreticulin -0.0367086
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.034734
ATP11A ATPase, class VI, type 11A -0.0344523
IRS2 insulin receptor substrate 2 -0.0341784
MAP2K6 mitogen-activated protein kinase kinase 6 -0.033939
EZR ezrin -0.033637
GMDS GDP-mannose 4,6-dehydratase -0.0333218
FAT1 FAT atypical cadherin 1 -0.0332318
MLPH melanophilin -0.0326624
MCL1 myeloid cell leukemia 1 -0.0325059
ARHGAP26 Rho GTPase activating protein 26 -0.0316149
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0309348
TNRC18 trinucleotide repeat containing 18 -0.0304688
CANX calnexin -0.0300938
HLA-E major histocompatibility complex, class I, E -0.0296392
ANXA2 annexin A2 -0.0295207
BRD2 bromodomain containing 2 -0.0294321
TSHZ2 teashirt zinc finger homeobox 2 -0.0293695
PMP22 peripheral myelin protein 22 -0.0292927
KRT8 keratin 8, type II -0.0292761
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0290194
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.028883
VCL vinculin -0.0285971
BICRAL BICRA like chromatin remodeling complex associated protein -0.0282729
MYH9 myosin, heavy chain 9, non-muscle -0.0281357
APP amyloid beta (A4) precursor protein -0.0281302
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0278607
FTH1 ferritin, heavy polypeptide 1 -0.0277289
TNS3 tensin 3 -0.0273296
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0272176
GK glycerol kinase -0.027125
ENO2 enolase 2 (gamma, neuronal) -0.0268723
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like -0.0267112
TAPBP TAP binding protein (tapasin) -0.026452
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle -0.0262171
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0259369
GOSR2 golgi SNAP receptor complex member 2 -0.0256995
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0256523
RAB7A RAB7A, member RAS oncogene family -0.0256029
CLDN7 claudin 7 -0.0254597
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0251862
HDAC4 histone deacetylase 4 -0.0248698
MLXIP MLX interacting protein -0.0248343
LRP5 low density lipoprotein receptor-related protein 5 -0.0241886
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0240467
C6ORF62 chromosome 6 open reading frame 62 -0.0240105
SAMHD1 SAM domain and HD domain 1 -0.0239236
LCN2 lipocalin 2 -0.0236332
MCU mitochondrial calcium uniporter -0.0236252
CFAP44 cilia and flagella associated protein 44 -0.0233582
CATSPERB catsper channel auxiliary subunit beta -0.0233403
TOX3 TOX high mobility group box family member 3 -0.0232637