Cytarabine_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cytarabine perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cytarabine_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FLNB filamin B, beta 0.177968
TRIO trio Rho guanine nucleotide exchange factor 0.128877
MEF2A myocyte enhancer factor 2A 0.100879
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0874322
ITGA6 integrin, alpha 6 0.0834407
IGF2 insulin-like growth factor 2 0.0689416
OGA O-GlcNAcase 0.0647056
PODXL podocalyxin-like 0.0642438
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0631668
CLU clusterin 0.0601571
ANKRD33B ankyrin repeat domain 33B 0.0596137
ITCH itchy E3 ubiquitin protein ligase 0.058685
FOXO1 forkhead box O1 0.0519125
MYOF myoferlin 0.051478
PLAT plasminogen activator, tissue 0.0507123
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 0.0505018
RICTOR RPTOR independent companion of MTOR, complex 2 0.0492758
KIAA1217 KIAA1217 0.0489141
BZW1 basic leucine zipper and W2 domains 1 0.0479425
ANLN anillin, actin binding protein 0.0477399
KRT6A keratin 6A, type II 0.0476362
PGK1 phosphoglycerate kinase 1 0.045188
SPAG9 sperm associated antigen 9 0.0450849
BCL2L1 BCL2-like 1 0.0449807
RIN2 Ras and Rab interactor 2 0.0449134
PRELID2 PRELI domain containing 2 0.0437883
NAMPT nicotinamide phosphoribosyltransferase 0.0429672
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0423586
CUL4B cullin 4B 0.0415699
NEK7 NIMA-related kinase 7 0.0401785
STC1 stanniocalcin 1 0.0400154
NRG1 neuregulin 1 0.0387669
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0381359
ZNF292 zinc finger protein 292 0.0374824
PTMA prothymosin, alpha 0.0374613
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0374275
KDM6A lysine (K)-specific demethylase 6A 0.0365521
RBM39 RNA binding motif protein 39 0.0364447
VCL vinculin 0.0363084
ARHGAP29 Rho GTPase activating protein 29 0.0362269
NCOA3 nuclear receptor coactivator 3 0.0361101
HELZ helicase with zinc finger 0.0359113
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0358477
LNPEP leucyl/cystinyl aminopeptidase 0.0357034
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.0351851
ARGLU1 arginine and glutamate rich 1 0.0338917
MYO10 myosin X 0.0330963
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 0.0327866
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0327862
KLF7 Kruppel-like factor 7 (ubiquitous) 0.032312
EHF ets homologous factor 0.0318627
GOLGA4 golgin A4 0.0317609
KMT2E lysine (K)-specific methyltransferase 2E 0.0309453
SAMD9 sterile alpha motif domain containing 9 0.0308421
FN1 fibronectin 1 0.030252
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0298632
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0297983
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0297152
PNISR PNN-interacting serine/arginine-rich protein 0.0295041
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0288449
NAP1L1 nucleosome assembly protein 1-like 1 0.0287671
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0284145
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0279592
SLMAP sarcolemma associated protein 0.0269169
EMP1 epithelial membrane protein 1 0.0268373
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0268173
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0265872
RAB6A RAB6A, member RAS oncogene family 0.0264565
KDM3A lysine (K)-specific demethylase 3A 0.0262808
PDGFB platelet-derived growth factor beta polypeptide 0.026218
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.025975
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0258991
ARRDC3 arrestin domain containing 3 0.0258184
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0252124
TM9SF2 transmembrane 9 superfamily member 2 0.0250685
SKIC3 SKI3 subunit of superkiller complex 0.024928
RAP1B RAP1B, member of RAS oncogene family 0.0247872
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0247464
BIRC2 baculoviral IAP repeat containing 2 0.0246408
NUP58 nucleoporin 58 0.0246238
ZEB1 zinc finger E-box binding homeobox 1 0.0246084
BHLHE40 basic helix-loop-helix family, member e40 0.0245802
YEATS2 YEATS domain containing 2 0.0244909
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0242767
SLK STE20-like kinase 0.0242534
SBF2 SET binding factor 2 0.0242265
DOCK5 dedicator of cytokinesis 5 0.0241547
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 0.0240619
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0238813
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) 0.0238394
CAVIN1 caveolae associated protein 1 0.0237051
LIMA1 LIM domain and actin binding 1 0.0236636
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 0.0236254
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.02349
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0234721
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0232067
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0231712
C4BPB complement component 4 binding protein, beta 0.0230655
PHF21A PHD finger protein 21A 0.0228838
PDGFA platelet-derived growth factor alpha polypeptide 0.022602

decreased expression

Symbol Name Standardized Value
POTEF POTE ankyrin domain family, member F -0.102831
LMO7 LIM domain 7 -0.0948356
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0893138
FTH1 ferritin, heavy polypeptide 1 -0.0795375
NDRG1 N-myc downstream regulated 1 -0.0640318
LOC112694756 uncharaterized LOC112694756 -0.0600149
LDHA lactate dehydrogenase A -0.0577664
HLA-B major histocompatibility complex, class I, B -0.057135
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0564868
PDE4D phosphodiesterase 4D, cAMP-specific -0.0544386
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0515528
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0492148
MT2A metallothionein 2A -0.0486696
TMSB10 thymosin beta 10 -0.047409
INTS6 integrator complex subunit 6 -0.0466154
FTL ferritin, light polypeptide -0.0455949
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0438997
TXNIP thioredoxin interacting protein -0.0423685
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0423648
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0418896
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0411306
HLA-A major histocompatibility complex, class I, A -0.039267
UBC ubiquitin C -0.0392569
CD44 CD44 molecule (Indian blood group) -0.0385963
B2M beta-2-microglobulin -0.0385836
RPLP1 ribosomal protein, large, P1 -0.0379146
TGM2 transglutaminase 2 -0.0373273
YBX1 Y box binding protein 1 -0.0368528
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0357001
GRB10 growth factor receptor-bound protein 10 -0.0355176
HSPG2 heparan sulfate proteoglycan 2 -0.0348788
DPYD dihydropyrimidine dehydrogenase -0.0346036
EGFR epidermal growth factor receptor -0.0344933
SLC35F3 solute carrier family 35, member F3 -0.0330864
ANO1 anoctamin 1, calcium activated chloride channel -0.0316673
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0316623
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 -0.0314797
HM13 histocompatibility (minor) 13 -0.0305198
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0302196
SULF2 sulfatase 2 -0.0301318
PCDH1 protocadherin 1 -0.0299439
RAI14 retinoic acid induced 14 -0.0297878
TAPBP TAP binding protein (tapasin) -0.0297861
NAV2 neuron navigator 2 -0.0296277
IFITM3 interferon induced transmembrane protein 3 -0.0296186
PLEC plectin -0.0290255
IARS1 isoleucyl-tRNA synthetase 1 -0.0290099
RPS13 ribosomal protein S13 -0.0286418
WARS1 tryptophanyl-tRNA synthetase 1 -0.028612
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0285459
VEGFA vascular endothelial growth factor A -0.028209
HLA-E major histocompatibility complex, class I, E -0.0279535
CANX calnexin -0.0267094
IFITM1 interferon induced transmembrane protein 1 -0.026602
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0264666
CDK6 cyclin-dependent kinase 6 -0.0263861
MCL1 myeloid cell leukemia 1 -0.0262293
IFI6 interferon, alpha-inducible protein 6 -0.0260008
OSMR oncostatin M receptor -0.0258896
ENO2 enolase 2 (gamma, neuronal) -0.0258049
SLCO4A1 solute carrier organic anion transporter family, member 4A1 -0.0257193
DIAPH1 diaphanous-related formin 1 -0.0254557
RABGAP1L RAB GTPase activating protein 1-like -0.0251718
SETX senataxin -0.0250738
LAMA5 laminin, alpha 5 -0.025041
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0250062
LRP1B low density lipoprotein receptor-related protein 1B -0.0247949
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) -0.0246104
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0242982
S100A9 S100 calcium binding protein A9 -0.0242561
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0240878
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0238234
EXT1 exostosin glycosyltransferase 1 -0.023797
RPL5 ribosomal protein L5 -0.02375
EGR1 early growth response 1 -0.0237263
CALB1 calbindin 1, 28kDa -0.0234035
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0233003
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0231039
PDLIM5 PDZ and LIM domain 5 -0.022832
ALCAM activated leukocyte cell adhesion molecule -0.0226039
KRT14 keratin 14, type I -0.0224774
IFI44L interferon-induced protein 44-like -0.0224367
RPL23 ribosomal protein L23 -0.0220893
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0219999
TPM3 tropomyosin 3 -0.0219908
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0219161
CALR calreticulin -0.0217863
PYGL phosphorylase, glycogen, liver -0.021744
PKM pyruvate kinase, muscle -0.0217191
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.0215962
RPL36 ribosomal protein L36 -0.0215958
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0213927
RPL35A ribosomal protein L35a -0.0212303
EFNA5 ephrin-A5 -0.0209111
MSN moesin -0.0208796
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 -0.0205692
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0205443
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0203364
RPS19 ribosomal protein S19 -0.0202779
TINAGL1 tubulointerstitial nephritis antigen-like 1 -0.0201663