Cytarabine_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cytarabine perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cytarabine_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.133183
PTMA prothymosin, alpha 0.124801
RPS6 ribosomal protein S6 0.117165
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.11493
NDRG1 N-myc downstream regulated 1 0.111858
EREG epiregulin 0.107194
FAM13A family with sequence similarity 13, member A 0.105523
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0981841
RPS12 ribosomal protein S12 0.0814344
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0724533
TPT1 tumor protein, translationally-controlled 1 0.0687316
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0666691
ZNF292 zinc finger protein 292 0.0652431
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0636211
RPL37A ribosomal protein L37a 0.0617662
TXNIP thioredoxin interacting protein 0.0582303
WAC WW domain containing adaptor with coiled-coil 0.0543693
RPS8 ribosomal protein S8 0.0541458
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0533832
CCNY cyclin Y 0.0526795
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0523308
RSRC2 arginine/serine-rich coiled-coil 2 0.0514589
UBA6 ubiquitin-like modifier activating enzyme 6 0.0494599
RPL9 ribosomal protein L9 0.0488935
NCKAP1 NCK-associated protein 1 0.0486407
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0477076
RPL23 ribosomal protein L23 0.0455021
DDIT4 DNA-damage-inducible transcript 4 0.0453765
RPL26 ribosomal protein L26 0.0452755
PDIA6 protein disulfide isomerase family A, member 6 0.0452046
RBM39 RNA binding motif protein 39 0.0451443
MXI1 MAX interactor 1, dimerization protein 0.0450171
KMT2E lysine (K)-specific methyltransferase 2E 0.0439738
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.043563
HELZ helicase with zinc finger 0.0432541
TRA2A transformer 2 alpha homolog (Drosophila) 0.0422821
ANKRD11 ankyrin repeat domain 11 0.0421384
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0417492
ESYT2 extended synaptotagmin-like protein 2 0.0410576
GOLGA4 golgin A4 0.0390427
RPS17 ribosomal protein S17 0.0389521
ERRFI1 ERBB receptor feedback inhibitor 1 0.0389089
DIAPH3 diaphanous-related formin 3 0.038642
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0378033
MXD1 MAX dimerization protein 1 0.0368161
KDM6A lysine (K)-specific demethylase 6A 0.0367954
RAB1A RAB1A, member RAS oncogene family 0.0362994
DSPP dentin sialophosphoprotein 0.0357913
TES testin LIM domain protein 0.0355585
KITLG KIT ligand 0.034733
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0342038
PARD3 par-3 family cell polarity regulator 0.0338309
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0329503
PDIA3 protein disulfide isomerase family A, member 3 0.0326848
NUP58 nucleoporin 58 0.0322172
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0315377
ZFC3H1 zinc finger, C3H1-type containing 0.0314427
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0313868
TFG TRK-fused gene 0.031335
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0313105
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.0312862
B2M beta-2-microglobulin 0.031117
VEGFA vascular endothelial growth factor A 0.0307939
ZFAND3 zinc finger, AN1-type domain 3 0.0301078
SYNE2 spectrin repeat containing, nuclear envelope 2 0.030089
RPS2 ribosomal protein S2 0.0299081
RPS19 ribosomal protein S19 0.0298731
TPD52 tumor protein D52 0.0296298
ANXA1 annexin A1 0.0295061
MUC6 mucin 6, oligomeric mucus/gel-forming 0.0293243
FNBP1L formin binding protein 1-like 0.0288553
TM9SF2 transmembrane 9 superfamily member 2 0.0286791
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0286652
NAP1L1 nucleosome assembly protein 1-like 1 0.0285883
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0284034
LPP LIM domain containing preferred translocation partner in lipoma 0.0281313
EGFR epidermal growth factor receptor 0.0278406
FNDC3B fibronectin type III domain containing 3B 0.0276459
PNN pinin, desmosome associated protein 0.0275116
ADAM17 ADAM metallopeptidase domain 17 0.0274609
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 0.0272431
RPL34 ribosomal protein L34 0.0271286
CBX3 chromobox homolog 3 0.0270667
SET SET nuclear proto-oncogene 0.0269527
NAMPT nicotinamide phosphoribosyltransferase 0.0266437
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.026555
HMGA1 high mobility group AT-hook 1 0.0265271
RPL35A ribosomal protein L35a 0.026417
MIER1 mesoderm induction early response 1, transcriptional regulator 0.0262881
DDB2 damage-specific DNA binding protein 2, 48kDa 0.0262506
WSB1 WD repeat and SOCS box containing 1 0.0260203
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0259752
CCNL1 cyclin L1 0.0259736
GRB10 growth factor receptor-bound protein 10 0.0254029
ACBD3 acyl-CoA binding domain containing 3 0.0253457
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0252162
GARS1 glycyl-tRNA synthetase 1 0.0249641
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0249626
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0249623
YME1L1 YME1-like 1 ATPase 0.0247879

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.22457
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.208631
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.135721
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.12205
FTH1 ferritin, heavy polypeptide 1 -0.113526
FAT1 FAT atypical cadherin 1 -0.102985
NALF1 NALCN channel auxiliary factor 1 -0.097755
MYO1E myosin IE -0.0878431
CEMIP cell migration inducing protein, hyaluronan binding -0.0858392
KRT8 keratin 8, type II -0.0845798
LOC112694756 uncharaterized LOC112694756 -0.0805284
H1-0 H1.0 linker histone -0.0789207
CADPS Ca++-dependent secretion activator -0.0756821
LDHA lactate dehydrogenase A -0.0755899
LMO7 LIM domain 7 -0.0681432
TMSB10 thymosin beta 10 -0.0636587
AHNAK AHNAK nucleoprotein -0.0610747
PIGR polymeric immunoglobulin receptor -0.0555702
TNS4 tensin 4 -0.0544838
PRSS3 protease, serine, 3 -0.0533981
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0531089
CD44 CD44 molecule (Indian blood group) -0.0526691
ACTN4 actinin, alpha 4 -0.0524381
EGR1 early growth response 1 -0.0471665
LOC102724023 ES1 protein homolog, mitochondrial -0.0466055
PKP2 plakophilin 2 -0.0465053
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0457725
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0452671
RNF43 ring finger protein 43 -0.0437931
HDLBP high density lipoprotein binding protein -0.0431978
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -0.0421877
POF1B premature ovarian failure, 1B -0.0419327
PTPRK protein tyrosine phosphatase, receptor type, K -0.0414255
EPCAM epithelial cell adhesion molecule -0.0405763
NOSTRIN nitric oxide synthase trafficking -0.0405218
TRIM2 tripartite motif containing 2 -0.0400278
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -0.0399751
SH3D19 SH3 domain containing 19 -0.0391679
ASPH aspartate beta-hydroxylase -0.0388792
ABLIM1 actin binding LIM protein 1 -0.0377486
FOXO1 forkhead box O1 -0.0369701
SOX9 SRY (sex determining region Y)-box 9 -0.0366546
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 -0.0365704
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0365022
GPHN gephyrin -0.0359245
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.0354383
VCL vinculin -0.0348115
ARHGAP5 Rho GTPase activating protein 5 -0.0335732
UBE2H ubiquitin-conjugating enzyme E2H -0.0334189
AHCYL2 adenosylhomocysteinase-like 2 -0.0333726
GMDS GDP-mannose 4,6-dehydratase -0.0331742
SPON1 spondin 1, extracellular matrix protein -0.0331638
TACC2 transforming, acidic coiled-coil containing protein 2 -0.0330662
CACNB2 calcium channel, voltage-dependent, beta 2 subunit -0.0328155
CANX calnexin -0.0326187
GREB1L growth regulation by estrogen in breast cancer-like -0.0321269
WWC1 WW and C2 domain containing 1 -0.0314287
TSC22D1 TSC22 domain family, member 1 -0.0310719
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0308296
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0302659
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0300496
CDK6 cyclin-dependent kinase 6 -0.0298093
NCEH1 neutral cholesterol ester hydrolase 1 -0.0293172
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0291443
NR4A1 nuclear receptor subfamily 4, group A, member 1 -0.0289261
CDH17 cadherin 17, LI cadherin (liver-intestine) -0.028231
LRRK1 leucine-rich repeat kinase 1 -0.0281744
EXPH5 exophilin 5 -0.0278368
DGKD diacylglycerol kinase, delta 130kDa -0.0272961
KLF3 Kruppel-like factor 3 (basic) -0.0272418
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0267115
EXT1 exostosin glycosyltransferase 1 -0.0259763
RAB10 RAB10, member RAS oncogene family -0.025957
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.025948
PDLIM5 PDZ and LIM domain 5 -0.0259193
ATP5F1B ATP synthase F1 subunit beta -0.0259059
CLDN7 claudin 7 -0.0257789
VDAC1 voltage-dependent anion channel 1 -0.0257265
GAK cyclin G associated kinase -0.0256239
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0255772
PRRC2B proline-rich coiled-coil 2B -0.0250277
COBL cordon-bleu WH2 repeat protein -0.024832
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0245471
RESF1 retroelement silencing factor 1 -0.0243924
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0243878
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta -0.0243168
NF1 neurofibromin 1 -0.0241191
POTEF POTE ankyrin domain family, member F -0.0240337
ABHD17C abhydrolase domain containing 17C -0.023904
ITGA6 integrin, alpha 6 -0.0238639
PCDHB16 protocadherin beta 16 -0.0238198
RRBP1 ribosome binding protein 1 -0.0237185
ABHD2 abhydrolase domain containing 2 -0.0236556
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 -0.0236214
HEPH hephaestin -0.0235354
BSG basigin (Ok blood group) -0.0233232
ITPRID2 ITPR interacting domain containing 2 -0.0231761
TC2N tandem C2 domains, nuclear -0.0231394
UBE3C ubiquitin protein ligase E3C -0.0230859
SMAD2 SMAD family member 2 -0.0229904