Cytarabine_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cytarabine perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Cytarabine_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase 0.0928955
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.081124
LAMC2 laminin, gamma 2 0.0663005
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0612279
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0541973
ADAM17 ADAM metallopeptidase domain 17 0.0489782
EGFR epidermal growth factor receptor 0.0469929
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B 0.0457117
NGLY1 N-glycanase 1 0.0450662
LRP1B low density lipoprotein receptor-related protein 1B 0.0433731
LAMB3 laminin, beta 3 0.0413906
ARGLU1 arginine and glutamate rich 1 0.0405272
ATP13A3 ATPase type 13A3 0.0389474
PGK1 phosphoglycerate kinase 1 0.0385499
TBC1D22A TBC1 domain family, member 22A 0.0376499
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0372978
CAMTA1 calmodulin binding transcription activator 1 0.0348472
ELL2 elongation factor, RNA polymerase II, 2 0.0325367
RICTOR RPTOR independent companion of MTOR, complex 2 0.032167
ZFAND3 zinc finger, AN1-type domain 3 0.0310121
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0308433
BZW1 basic leucine zipper and W2 domains 1 0.0299524
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0296513
ANKRD10 ankyrin repeat domain 10 0.0293284
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0293018
CXCL8 chemokine (C-X-C motif) ligand 8 0.0280114
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0266996
SOD2 superoxide dismutase 2, mitochondrial 0.0265872
UBA6 ubiquitin-like modifier activating enzyme 6 0.0258903
ANKRD12 ankyrin repeat domain 12 0.0256819
USP9X ubiquitin specific peptidase 9, X-linked 0.0251189
RNF145 ring finger protein 145 0.0250445
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) 0.0250144
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 0.0246216
BRWD3 bromodomain and WD repeat domain containing 3 0.0241617
FAM13A family with sequence similarity 13, member A 0.0240202
YEATS2 YEATS domain containing 2 0.0235197
DENND4A DENN/MADD domain containing 4A 0.0233771
ZNF292 zinc finger protein 292 0.0233192
TPD52 tumor protein D52 0.0229302
NRIP1 nuclear receptor interacting protein 1 0.022526
SAMD4A sterile alpha motif domain containing 4A 0.02231
ARRDC3 arrestin domain containing 3 0.0220866
TES testin LIM domain protein 0.0219654
LAMA4 laminin, alpha 4 0.0219477
MARK3 MAP/microtubule affinity-regulating kinase 3 0.021651
RAB27B RAB27B, member RAS oncogene family 0.0215365
GCLC glutamate-cysteine ligase, catalytic subunit 0.021261
ZFAND6 zinc finger, AN1-type domain 6 0.0206583
KCMF1 potassium channel modulatory factor 1 0.0205675
ITSN2 intersectin 2 0.0204477
TMEM165 transmembrane protein 165 0.0202804
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0202603
RNF24 ring finger protein 24 0.0200528
IFNAR2 interferon (alpha, beta and omega) receptor 2 0.0196573
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1) 0.0193829
FGD6 FYVE, RhoGEF and PH domain containing 6 0.0191747
SLMAP sarcolemma associated protein 0.019075
DTNA dystrobrevin, alpha 0.0190455
OGA O-GlcNAcase 0.0189802
UVRAG UV radiation resistance associated 0.0189484
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0189414
CDKN2A cyclin-dependent kinase inhibitor 2A 0.018878
BIRC3 baculoviral IAP repeat containing 3 0.0188342
GSK3B glycogen synthase kinase 3 beta 0.0187996
MAP3K4 mitogen-activated protein kinase kinase kinase 4 0.0184746
ZMYND8 zinc finger, MYND-type containing 8 0.01841
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0183942
HELZ helicase with zinc finger 0.018252
VEZT vezatin, adherens junctions transmembrane protein 0.0181627
KIAA1217 KIAA1217 0.0181566
RAP1B RAP1B, member of RAS oncogene family 0.0180563
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0179146
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0178787
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0178555
PRRC2C proline-rich coiled-coil 2C 0.0178512
TMEM41B transmembrane protein 41B 0.0178065
NCKAP1 NCK-associated protein 1 0.0177055
FOXJ3 forkhead box J3 0.0174188
ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 0.0172491
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 0.017247
KMT2E lysine (K)-specific methyltransferase 2E 0.0172314
BMAL2 basic helix-loop-helix ARNT like 2 0.0172129
TMEM45B transmembrane protein 45B 0.0169193
KDM6A lysine (K)-specific demethylase 6A 0.0169112
SRRM2 serine/arginine repetitive matrix 2 0.0165789
UBE2O ubiquitin-conjugating enzyme E2O 0.0164337
SBF2 SET binding factor 2 0.0164063
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0163786
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0163308
WDR26 WD repeat domain 26 0.0161693
MXD1 MAX dimerization protein 1 0.0160853
OFD1 oral-facial-digital syndrome 1 0.0159918
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0158408
NPC1 Niemann-Pick disease, type C1 0.0157735
FBXL5 F-box and leucine-rich repeat protein 5 0.015721
TBK1 TANK-binding kinase 1 0.0157088
CAB39 calcium binding protein 39 0.0156682
OTUD7B OTU deubiquitinase 7B 0.0154937
TM9SF2 transmembrane 9 superfamily member 2 0.015464

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.412368
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.206513
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.187197
ASPH aspartate beta-hydroxylase -0.149586
LOC112694756 uncharaterized LOC112694756 -0.100323
PKM pyruvate kinase, muscle -0.0963895
MCL1 myeloid cell leukemia 1 -0.0854432
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0747573
TXNRD1 thioredoxin reductase 1 -0.0716616
TMSB10 thymosin beta 10 -0.0711438
INTS6 integrator complex subunit 6 -0.0681954
MKI67 marker of proliferation Ki-67 -0.0667115
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0647221
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0645125
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0609233
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.057824
DSCAM Down syndrome cell adhesion molecule -0.0542504
LMO7 LIM domain 7 -0.0533423
MYOF myoferlin -0.0528864
BRD2 bromodomain containing 2 -0.0526264
LDHA lactate dehydrogenase A -0.052548
CANX calnexin -0.0516714
HDLBP high density lipoprotein binding protein -0.050199
PDLIM5 PDZ and LIM domain 5 -0.0476841
FTL ferritin, light polypeptide -0.0474544
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0473345
RPLP1 ribosomal protein, large, P1 -0.0470677
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0456537
ENO1 enolase 1, (alpha) -0.0445355
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0442316
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0422379
PTMA prothymosin, alpha -0.0402145
NDRG1 N-myc downstream regulated 1 -0.0398742
GRAMD1B GRAM domain containing 1B -0.0393358
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0390495
FTH1 ferritin, heavy polypeptide 1 -0.0382816
ACTG1 actin gamma 1 -0.0379791
THSD4 thrombospondin, type I, domain containing 4 -0.0378887
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0372057
MT2A metallothionein 2A -0.0369285
PRKCA protein kinase C, alpha -0.0367018
MAML3 mastermind-like 3 (Drosophila) -0.0358931
PDE4D phosphodiesterase 4D, cAMP-specific -0.0358307
KRT8 keratin 8, type II -0.0357637
SEC61G Sec61 gamma subunit -0.0347623
CAV1 caveolin 1, caveolae protein, 22kDa -0.0345916
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0341508
POTEF POTE ankyrin domain family, member F -0.0337494
DOCK5 dedicator of cytokinesis 5 -0.0332553
TPT1 tumor protein, translationally-controlled 1 -0.0328774
PCBP2 poly(rC) binding protein 2 -0.0328525
H1-0 H1.0 linker histone -0.0325648
UBC ubiquitin C -0.0316768
EGR1 early growth response 1 -0.0316527
AGO2 argonaute RISC catalytic component 2 -0.031382
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0313368
HYOU1 hypoxia up-regulated 1 -0.0306714
UGDH UDP-glucose 6-dehydrogenase -0.0300675
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0299262
NR4A1 nuclear receptor subfamily 4, group A, member 1 -0.0298456
USP53 ubiquitin specific peptidase 53 -0.0297615
JMJD1C jumonji domain containing 1C -0.0292789
RPS3 ribosomal protein S3 -0.0287185
RIMS2 regulating synaptic membrane exocytosis 2 -0.0286651
S100A10 S100 calcium binding protein A10 -0.0285101
RPS24 ribosomal protein S24 -0.0278321
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0278086
MORF4L2 mortality factor 4 like 2 -0.0274921
TMCO3 transmembrane and coiled-coil domains 3 -0.027325
EXT1 exostosin glycosyltransferase 1 -0.0271712
PAPOLA poly(A) polymerase alpha -0.0268781
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0267346
RPL35A ribosomal protein L35a -0.0266176
GOLGB1 golgin B1 -0.0265683
CPE carboxypeptidase E -0.0264079
HOMER1 homer scaffolding protein 1 -0.026216
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0261404
CST3 cystatin C -0.0260929
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0259038
AREG amphiregulin -0.0258397
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0257054
KRT7 keratin 7, type II -0.0255961
NABP1 nucleic acid binding protein 1 -0.0253434
VCL vinculin -0.0251026
MAP7 microtubule-associated protein 7 -0.0250251
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0247264
CCND1 cyclin D1 -0.0247136
MKNK2 MAP kinase interacting serine/threonine kinase 2 -0.0245712
RPL19 ribosomal protein L19 -0.0245692
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.0244583
NR4A2 nuclear receptor subfamily 4, group A, member 2 -0.0244356
NTSR1 neurotensin receptor 1 (high affinity) -0.0243828
AHNAK AHNAK nucleoprotein -0.0243128
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0242506
RPS8 ribosomal protein S8 -0.0239785
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0239264
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0238953
IGF1R insulin-like growth factor 1 receptor -0.0238808
CAV2 caveolin 2 -0.0238385
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0237598