Cytarabine_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cytarabine perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cytarabine_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RICTOR RPTOR independent companion of MTOR, complex 2 0.151089
CXCL8 chemokine (C-X-C motif) ligand 8 0.107315
ATP13A3 ATPase type 13A3 0.0974676
FAM13A family with sequence similarity 13, member A 0.0804666
MEF2A myocyte enhancer factor 2A 0.0679239
OGA O-GlcNAcase 0.0655612
NGLY1 N-glycanase 1 0.0650828
UBA6 ubiquitin-like modifier activating enzyme 6 0.0642115
PARP8 poly (ADP-ribose) polymerase family, member 8 0.0620155
SPAG9 sperm associated antigen 9 0.0617005
AKAP12 A kinase (PRKA) anchor protein 12 0.0580668
WAC WW domain containing adaptor with coiled-coil 0.0569764
CNOT2 CCR4-NOT transcription complex, subunit 2 0.055361
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0528304
HELZ helicase with zinc finger 0.0524394
RAB8B RAB8B, member RAS oncogene family 0.0513454
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0512204
TRIO trio Rho guanine nucleotide exchange factor 0.0509707
GOLGA4 golgin A4 0.0507764
USP3 ubiquitin specific peptidase 3 0.050203
FN1 fibronectin 1 0.048852
KMT2C lysine (K)-specific methyltransferase 2C 0.0488457
ITCH itchy E3 ubiquitin protein ligase 0.0474225
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.047093
PIAS2 protein inhibitor of activated STAT, 2 0.0470796
ANKRD11 ankyrin repeat domain 11 0.0461041
PARD3 par-3 family cell polarity regulator 0.0457404
USP34 ubiquitin specific peptidase 34 0.0451892
MYO1B myosin IB 0.0451389
YEATS2 YEATS domain containing 2 0.0450379
KDM3A lysine (K)-specific demethylase 3A 0.0446812
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0444384
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0440487
KDM2A lysine (K)-specific demethylase 2A 0.0433839
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0433036
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.042467
SDK1 sidekick cell adhesion molecule 1 0.0417455
ZNF292 zinc finger protein 292 0.040472
ESYT2 extended synaptotagmin-like protein 2 0.0401861
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0385602
RAP1B RAP1B, member of RAS oncogene family 0.0384318
FMNL2 formin-like 2 0.0382338
RUNX1 runt-related transcription factor 1 0.0381998
WSB1 WD repeat and SOCS box containing 1 0.0381273
EEF2 eukaryotic translation elongation factor 2 0.0365646
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0363713
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0363298
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0361556
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0353593
SRP54 signal recognition particle 54kDa 0.0353057
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0352865
ZEB2 zinc finger E-box binding homeobox 2 0.0350643
GRB10 growth factor receptor-bound protein 10 0.0349819
ADAM17 ADAM metallopeptidase domain 17 0.0349594
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0349083
FLNB filamin B, beta 0.034577
ZFAND3 zinc finger, AN1-type domain 3 0.0344634
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0342957
RAB1A RAB1A, member RAS oncogene family 0.0338977
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.0337522
UBE2O ubiquitin-conjugating enzyme E2O 0.0337093
SMAD4 SMAD family member 4 0.0315404
CDC73 cell division cycle 73 0.0302573
BHLHE40 basic helix-loop-helix family, member e40 0.0300899
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0292307
CTNNBL1 catenin, beta like 1 0.0291498
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0290084
DENND4A DENN/MADD domain containing 4A 0.0289048
AMPD3 adenosine monophosphate deaminase 3 0.028898
NPC1 Niemann-Pick disease, type C1 0.028818
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0286379
PICALM phosphatidylinositol binding clathrin assembly protein 0.0284816
KTN1 kinectin 1 (kinesin receptor) 0.0284408
CERT1 ceramide transporter 1 0.0283563
INSIG2 insulin induced gene 2 0.0282216
RAB6A RAB6A, member RAS oncogene family 0.0282112
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 0.0281401
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 0.0280186
FBXL13 F-box and leucine-rich repeat protein 13 0.0279667
CD109 CD109 molecule 0.0276056
ARHGAP12 Rho GTPase activating protein 12 0.0274748
ADD3 adducin 3 (gamma) 0.0274466
MAP2K1 mitogen-activated protein kinase kinase 1 0.0270079
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0270074
EPS8 epidermal growth factor receptor pathway substrate 8 0.026891
MARCHF6 membrane associated ring-CH-type finger 6 0.0268219
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0266238
TBC1D15 TBC1 domain family, member 15 0.026476
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0264279
WDR45B WD repeat domain 45B 0.0263905
SETD5 SET domain containing 5 0.0262019
YME1L1 YME1-like 1 ATPase 0.026028
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.0258128
RNF149 ring finger protein 149 0.0257076
RNF145 ring finger protein 145 0.0255513
CCNY cyclin Y 0.0253708
STRN3 striatin, calmodulin binding protein 3 0.0252777
FOXJ3 forkhead box J3 0.0251762
RAI14 retinoic acid induced 14 0.0248182
PNISR PNN-interacting serine/arginine-rich protein 0.0247965

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.174669
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.158929
PDE4D phosphodiesterase 4D, cAMP-specific -0.15168
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.124507
FTL ferritin, light polypeptide -0.106638
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0979679
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0833977
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0804075
PCBP2 poly(rC) binding protein 2 -0.0735075
ASPH aspartate beta-hydroxylase -0.066038
MT2A metallothionein 2A -0.0637242
PTMA prothymosin, alpha -0.060234
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0588504
GLCCI1 glucocorticoid induced 1 -0.0578902
VIM vimentin -0.0567377
HDLBP high density lipoprotein binding protein -0.056224
NAMPT nicotinamide phosphoribosyltransferase -0.0553162
NRG1 neuregulin 1 -0.0527248
TMSB10 thymosin beta 10 -0.0512209
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0477532
SOD2 superoxide dismutase 2, mitochondrial -0.0449253
RPS19 ribosomal protein S19 -0.0437934
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0436355
LDHA lactate dehydrogenase A -0.0435999
YBX1 Y box binding protein 1 -0.0414286
GFPT2 glutamine-fructose-6-phosphate transaminase 2 -0.0413772
RPS24 ribosomal protein S24 -0.0409826
EFNA5 ephrin-A5 -0.0408692
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.040773
RPLP1 ribosomal protein, large, P1 -0.0402922
CANX calnexin -0.0387643
RAD51B RAD51 paralog B -0.037526
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0373685
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0360799
FTH1 ferritin, heavy polypeptide 1 -0.0354933
HMGA1 high mobility group AT-hook 1 -0.0351107
EGR1 early growth response 1 -0.0350846
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0347826
RPLP0 ribosomal protein, large, P0 -0.0342889
STC1 stanniocalcin 1 -0.0340422
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0335636
LRMDA leucine rich melanocyte differentiation associated -0.0331101
BASP1 brain abundant, membrane attached signal protein 1 -0.0324505
GRAMD1B GRAM domain containing 1B -0.0318406
DDIT3 DNA-damage-inducible transcript 3 -0.0314469
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0312388
FAM20C family with sequence similarity 20, member C -0.0310489
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0307862
LOC112694756 uncharaterized LOC112694756 -0.0301125
FBN1 fibrillin 1 -0.0300541
RPS6 ribosomal protein S6 -0.0296639
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0290324
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0287073
NTN4 netrin 4 -0.0283514
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0280439
H1-0 H1.0 linker histone -0.0277612
LRP1B low density lipoprotein receptor-related protein 1B -0.0276604
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.027205
YBX3 Y box binding protein 3 -0.0270492
B2M beta-2-microglobulin -0.0268856
NDRG1 N-myc downstream regulated 1 -0.0267865
IGFBP3 insulin-like growth factor binding protein 3 -0.0266594
C15ORF48 chromosome 15 open reading frame 48 -0.0265977
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0265399
PSD3 pleckstrin and Sec7 domain containing 3 -0.0265348
R3HDM2 R3H domain containing 2 -0.0265146
KYNU kynureninase -0.0264722
INTS6 integrator complex subunit 6 -0.026268
ATXN1 ataxin 1 -0.0260362
RPL11 ribosomal protein L11 -0.0259511
TM4SF1 transmembrane 4 L six family member 1 -0.0258732
MAML3 mastermind-like 3 (Drosophila) -0.0249221
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0247815
EXT1 exostosin glycosyltransferase 1 -0.024764
VEGFA vascular endothelial growth factor A -0.0246137
RPL19 ribosomal protein L19 -0.0245107
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin -0.0244734
UBC ubiquitin C -0.0244555
WDPCP WD repeat containing planar cell polarity effector -0.0242658
SYAP1 synapse associated protein 1 -0.024225
ETV6 ets variant 6 -0.0239948
RPL7 ribosomal protein L7 -0.0239902
HDAC4 histone deacetylase 4 -0.0239824
RPL23 ribosomal protein L23 -0.0239738
TXNRD1 thioredoxin reductase 1 -0.0239001
NCOA7 nuclear receptor coactivator 7 -0.0237502
LOXL2 lysyl oxidase-like 2 -0.0236767
TOP2A topoisomerase (DNA) II alpha 170kDa -0.023618
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0236065
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 -0.02332
RPS21 ribosomal protein S21 -0.0230789
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0230688
RPL35A ribosomal protein L35a -0.0229057
PMEPA1 prostate transmembrane protein, androgen induced 1 -0.0227491
RPL9 ribosomal protein L9 -0.0227482
DPYD dihydropyrimidine dehydrogenase -0.0227151
ZNF385D zinc finger protein 385D -0.0226781
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0225991
TMEM263 transmembrane protein 263 -0.0225302
H3-3B H3.3 histone B -0.0223705