Cytarabine_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cytarabine perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cytarabine_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 0.143969
ELL2 elongation factor, RNA polymerase II, 2 0.0997739
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0908042
ZNF292 zinc finger protein 292 0.0832774
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0805857
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0788437
RNF145 ring finger protein 145 0.0734481
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0697246
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0684408
HELZ helicase with zinc finger 0.0655003
VCL vinculin 0.065081
OXR1 oxidation resistance 1 0.0641834
PRRC2C proline-rich coiled-coil 2C 0.0641074
TOP1 topoisomerase (DNA) I 0.0616325
GSK3B glycogen synthase kinase 3 beta 0.0614759
RTN4 reticulon 4 0.0614195
EREG epiregulin 0.0592341
AKAP12 A kinase (PRKA) anchor protein 12 0.0590858
GPHN gephyrin 0.0586751
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0585056
RAD51B RAD51 paralog B 0.0577152
FAM13A family with sequence similarity 13, member A 0.0575481
GPC6 glypican 6 0.0565555
LAMA4 laminin, alpha 4 0.0524955
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0516134
PDE10A phosphodiesterase 10A 0.0500579
HOOK2 hook microtubule-tethering protein 2 0.0489279
RFX7 regulatory factor X, 7 0.0489134
MNAT1 MNAT CDK-activating kinase assembly factor 1 0.0485434
SCAF11 SR-related CTD-associated factor 11 0.0482893
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0474861
ADM adrenomedullin 0.0472069
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.046854
TPD52 tumor protein D52 0.0466395
ATRN attractin 0.0465683
SEC23A Sec23 homolog A (S. cerevisiae) 0.0465414
DENND5B DENN/MADD domain containing 5B 0.0457672
MBNL2 muscleblind-like splicing regulator 2 0.0456725
AAK1 AP2 associated kinase 1 0.0446435
ERRFI1 ERBB receptor feedback inhibitor 1 0.0439758
TM9SF3 transmembrane 9 superfamily member 3 0.04389
LSAMP limbic system-associated membrane protein 0.0436207
LRP1B low density lipoprotein receptor-related protein 1B 0.0434944
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.0433903
ABI1 abl-interactor 1 0.0432943
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0432671
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.043103
CHD1L chromodomain helicase DNA binding protein 1-like 0.0430393
AGO3 argonaute RISC catalytic component 3 0.0430383
PRKCA protein kinase C, alpha 0.0429369
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.042468
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.0424274
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0420891
COG5 component of oligomeric golgi complex 5 0.0414583
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0414544
PIAS1 protein inhibitor of activated STAT, 1 0.0407167
ATP13A3 ATPase type 13A3 0.0406272
PHIP pleckstrin homology domain interacting protein 0.0405018
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0399258
NLGN1 neuroligin 1 0.0396549
NGLY1 N-glycanase 1 0.0396218
SYNGAP1 synaptic Ras GTPase activating protein 1 0.0394942
FNBP1L formin binding protein 1-like 0.0394453
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0394182
DOCK4 dedicator of cytokinesis 4 0.039386
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0390714
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0389463
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 0.0388947
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 0.038738
PCNX1 pecanex 1 0.0386775
WDR43 WD repeat domain 43 0.0385635
CORO1C coronin, actin binding protein, 1C 0.038517
RBM25 RNA binding motif protein 25 0.0385122
FAT1 FAT atypical cadherin 1 0.0384935
MARK3 MAP/microtubule affinity-regulating kinase 3 0.0378506
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0378206
BCLAF1 BCL2-associated transcription factor 1 0.0377964
SSBP2 single-stranded DNA binding protein 2 0.037711
ZZZ3 zinc finger, ZZ-type containing 3 0.0376934
DTNA dystrobrevin, alpha 0.0376535
SLC35F5 solute carrier family 35, member F5 0.03748
CREBBP CREB binding protein 0.0374385
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0370749
CSNK1A1 casein kinase 1, alpha 1 0.0369813
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0369417
PHF21A PHD finger protein 21A 0.036908
APOB apolipoprotein B 0.0368127
SPAG9 sperm associated antigen 9 0.0366821
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0366204
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0366008
FAM168A family with sequence similarity 168, member A 0.0364589
NCKAP1 NCK-associated protein 1 0.0361322
GMDS GDP-mannose 4,6-dehydratase 0.0359872
HMGA2 high mobility group AT-hook 2 0.0358505
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.035755
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0353559
SERINC1 serine incorporator 1 0.0353381
ADAM9 ADAM metallopeptidase domain 9 0.0352729
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0352497
BTBD9 BTB (POZ) domain containing 9 0.0352109

decreased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide -0.160407
GRB10 growth factor receptor-bound protein 10 -0.140611
TMSB10 thymosin beta 10 -0.132981
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 -0.12903
LAMB3 laminin, beta 3 -0.119896
CEMIP cell migration inducing protein, hyaluronan binding -0.119369
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.118222
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.116932
MYO1E myosin IE -0.108672
KRT17 keratin 17, type I -0.105074
TPT1 tumor protein, translationally-controlled 1 -0.104468
SAMD4A sterile alpha motif domain containing 4A -0.0883309
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0863006
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0838876
SVIL supervillin -0.0765858
ANXA2 annexin A2 -0.0749595
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0730743
SRPK2 SRSF protein kinase 2 -0.071126
PKM pyruvate kinase, muscle -0.0703466
PDE4D phosphodiesterase 4D, cAMP-specific -0.0700601
AHNAK AHNAK nucleoprotein -0.0678939
IGFBP3 insulin-like growth factor binding protein 3 -0.0671733
BACE2 beta-site APP-cleaving enzyme 2 -0.0669053
LMO7 LIM domain 7 -0.0668206
FTH1 ferritin, heavy polypeptide 1 -0.0667901
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.066262
ACTG1 actin gamma 1 -0.0651203
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0633286
RPS19 ribosomal protein S19 -0.062914
FNDC3B fibronectin type III domain containing 3B -0.0627928
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0624458
MXD1 MAX dimerization protein 1 -0.0603533
DLG1 discs, large homolog 1 (Drosophila) -0.0598301
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0593109
ATOSA atos homolog A -0.058986
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0589833
MUC16 mucin 16, cell surface associated -0.0588266
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0585187
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0583375
VIM vimentin -0.0575393
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0551878
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0542628
ASPH aspartate beta-hydroxylase -0.0540959
FBXO11 F-box protein 11 -0.0533755
FLNB filamin B, beta -0.0527511
MAST4 microtubule associated serine/threonine kinase family member 4 -0.0522452
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0521888
PTMA prothymosin, alpha -0.0510965
SLC38A1 solute carrier family 38, member 1 -0.0507116
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0502382
LPP LIM domain containing preferred translocation partner in lipoma -0.0497725
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0493031
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0490519
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0483759
RPL35A ribosomal protein L35a -0.0482881
NCOR2 nuclear receptor corepressor 2 -0.0474378
RBM39 RNA binding motif protein 39 -0.0465421
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1 -0.046214
RAB1A RAB1A, member RAS oncogene family -0.045877
F3 coagulation factor III (thromboplastin, tissue factor) -0.0457043
KTN1 kinectin 1 (kinesin receptor) -0.0453681
MAML2 mastermind-like 2 (Drosophila) -0.0452441
RPL19 ribosomal protein L19 -0.0450449
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0437662
CMIP c-Maf inducing protein -0.0435252
DICER1 dicer 1, ribonuclease type III -0.0431884
TRIO trio Rho guanine nucleotide exchange factor -0.043066
WASF2 WAS protein family, member 2 -0.0419998
MT2A metallothionein 2A -0.0415566
SHB Src homology 2 domain containing adaptor protein B -0.0412147
ABHD17C abhydrolase domain containing 17C -0.0407881
RBM47 RNA binding motif protein 47 -0.0407689
RPLP1 ribosomal protein, large, P1 -0.0407109
DSPP dentin sialophosphoprotein -0.040574
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0403105
PAIP2 poly(A) binding protein interacting protein 2 -0.0396915
LOC112694756 uncharaterized LOC112694756 -0.0394448
INTS6 integrator complex subunit 6 -0.0392345
NUP98 nucleoporin 98kDa -0.0388847
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0387987
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0387683
BZW1 basic leucine zipper and W2 domains 1 -0.0384814
HLA-B major histocompatibility complex, class I, B -0.0379871
CDH13 cadherin 13 -0.0373997
S100A10 S100 calcium binding protein A10 -0.0371931
TM4SF1 transmembrane 4 L six family member 1 -0.0370597
AFDN afadin, adherens junction formation factor -0.0364999
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.036271
KPNB1 karyopherin (importin) beta 1 -0.0360682
RPL9 ribosomal protein L9 -0.0356313
AFAP1 actin filament associated protein 1 -0.0354205
RPL11 ribosomal protein L11 -0.0351374
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0346078
RPL12 ribosomal protein L12 -0.0345662
UBC ubiquitin C -0.0344326
EXOC6B exocyst complex component 6B -0.0340546
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0339373
OGA O-GlcNAcase -0.0339326
ZBTB20 zinc finger and BTB domain containing 20 -0.0339282
RBM15 RNA binding motif protein 15 -0.0337525