Cytarabine_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cytarabine perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cytarabine_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.0907604
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.071721
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0513615
OGA O-GlcNAcase 0.0486357
BIRC2 baculoviral IAP repeat containing 2 0.0465833
EEF2 eukaryotic translation elongation factor 2 0.045851
KPNB1 karyopherin (importin) beta 1 0.0449498
ANKRD36 ankyrin repeat domain 36 0.0448221
ERRFI1 ERBB receptor feedback inhibitor 1 0.0398803
DIAPH3 diaphanous-related formin 3 0.0397593
EIF1 eukaryotic translation initiation factor 1 0.0367653
ANKRD36C ankyrin repeat domain 36C 0.0360241
SET SET nuclear proto-oncogene 0.0344425
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0331987
PHF20 PHD finger protein 20 0.0320331
VIM vimentin 0.031933
AHNAK AHNAK nucleoprotein 0.0315842
WSB1 WD repeat and SOCS box containing 1 0.0313968
AFF3 AF4/FMR2 family, member 3 0.0307167
NAP1L1 nucleosome assembly protein 1-like 1 0.0301486
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0298996
NCKAP1 NCK-associated protein 1 0.0297902
XPOT exportin, tRNA 0.0285772
NUP58 nucleoporin 58 0.0284608
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0277875
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0275928
SMAD3 SMAD family member 3 0.027476
RAP1A RAP1A, member of RAS oncogene family 0.0271266
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0269251
SYNE2 spectrin repeat containing, nuclear envelope 2 0.026255
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0262001
PNISR PNN-interacting serine/arginine-rich protein 0.0257661
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.0257469
PA2G4 proliferation-associated 2G4, 38kDa 0.0256319
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0246679
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 0.0246213
SINHCAF SIN3-HDAC complex associated factor 0.0245254
MELK maternal embryonic leucine zipper kinase 0.0244635
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0240434
RPL4 ribosomal protein L4 0.0239445
RABGAP1L RAB GTPase activating protein 1-like 0.023769
AFTPH aftiphilin 0.02365
FAM199X family with sequence similarity 199, X-linked 0.0234818
TFG TRK-fused gene 0.0234297
TAS2R14 taste receptor, type 2, member 14 0.023401
BAIAP2L1 BAI1-associated protein 2-like 1 0.0231459
TMEM165 transmembrane protein 165 0.0229444
FAM168A family with sequence similarity 168, member A 0.0228712
AKAP10 A kinase (PRKA) anchor protein 10 0.0228627
PRKD3 protein kinase D3 0.0226198
KIF13A kinesin family member 13A 0.0224667
PGK1 phosphoglycerate kinase 1 0.0223403
PTBP3 polypyrimidine tract binding protein 3 0.0222692
RPRD2 regulation of nuclear pre-mRNA domain containing 2 0.0222521
USP37 ubiquitin specific peptidase 37 0.0222114
SPATS2 spermatogenesis associated, serine-rich 2 0.0221963
CGAS cyclic GMP-AMP synthase 0.0220016
UBE2H ubiquitin-conjugating enzyme E2H 0.0219831
GOLPH3 golgi phosphoprotein 3 (coat-protein) 0.0218797
UBA6 ubiquitin-like modifier activating enzyme 6 0.021757
IPO5 importin 5 0.0217537
TMEM41B transmembrane protein 41B 0.0215174
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.02133
ARGLU1 arginine and glutamate rich 1 0.0212492
USP34 ubiquitin specific peptidase 34 0.0207816
PRELID2 PRELI domain containing 2 0.0207255
PHF21A PHD finger protein 21A 0.0207224
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0205277
CSE1L CSE1 chromosome segregation 1-like (yeast) 0.0204745
CPNE8 copine VIII 0.020382
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.0203218
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0201981
KRT8 keratin 8, type II 0.0201734
CPSF6 cleavage and polyadenylation specific factor 6, 68kDa 0.0200927
WRN Werner syndrome, RecQ helicase-like 0.0200361
TOP6BL TOP6B like initiator of meiotic double strand breaks 0.020026
MNAT1 MNAT CDK-activating kinase assembly factor 1 0.0198495
PDIA6 protein disulfide isomerase family A, member 6 0.0197493
TPM2 tropomyosin 2 (beta) 0.019703
PALS2 protein associated with LIN7 2, MAGUK p55 family member 0.0196872
HDGF hepatoma-derived growth factor 0.0196407
SSH2 slingshot protein phosphatase 2 0.0196316
NUP153 nucleoporin 153kDa 0.0194694
PREPL prolyl endopeptidase-like 0.0194165
ADAM17 ADAM metallopeptidase domain 17 0.0193194
ANKRD10 ankyrin repeat domain 10 0.0192239
RPL37A ribosomal protein L37a 0.0192093
RSL1D1 ribosomal L1 domain containing 1 0.0191697
DAPK3 death-associated protein kinase 3 0.0189717
TMEM123 transmembrane protein 123 0.0188716
CTTN cortactin 0.0188658
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.0188138
PHIP pleckstrin homology domain interacting protein 0.0186649
NFE2L1 nuclear factor, erythroid 2-like 1 0.0185576
ATP13A3 ATPase type 13A3 0.0185169
UGCG UDP-glucose ceramide glucosyltransferase 0.0184948
ARB2A ARB2 cotranscriptional regulator A 0.0184321
PTPN2 protein tyrosine phosphatase, non-receptor type 2 0.0184312
FGD6 FYVE, RhoGEF and PH domain containing 6 0.0184139
MED14 mediator complex subunit 14 0.0184086

decreased expression

Symbol Name Standardized Value
EGR1 early growth response 1 -0.166768
YBX3 Y box binding protein 3 -0.127517
TFPI2 tissue factor pathway inhibitor 2 -0.121518
MCL1 myeloid cell leukemia 1 -0.0902174
PDE4D phosphodiesterase 4D, cAMP-specific -0.0850816
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0847425
BRD2 bromodomain containing 2 -0.0803145
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0802743
TPI1 triosephosphate isomerase 1 -0.0765825
YBX1 Y box binding protein 1 -0.0745577
TMSB10 thymosin beta 10 -0.0738176
NABP1 nucleic acid binding protein 1 -0.0667471
TXNRD1 thioredoxin reductase 1 -0.0644054
GRAMD1B GRAM domain containing 1B -0.062289
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0621248
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0593646
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0580047
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0558661
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 -0.0533606
ELL2 elongation factor, RNA polymerase II, 2 -0.0530695
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0519963
KTN1 kinectin 1 (kinesin receptor) -0.0514847
WNK1 WNK lysine deficient protein kinase 1 -0.0503248
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0500884
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0496807
LOC112694756 uncharaterized LOC112694756 -0.0477036
CENPF centromere protein F, 350/400kDa -0.047571
ATP5F1B ATP synthase F1 subunit beta -0.0461429
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0452388
ADAR adenosine deaminase, RNA-specific -0.0451058
BSG basigin (Ok blood group) -0.0450493
CLTC clathrin, heavy chain (Hc) -0.0450024
CSNK1A1 casein kinase 1, alpha 1 -0.0448649
POTEF POTE ankyrin domain family, member F -0.0447961
PRRC2B proline-rich coiled-coil 2B -0.0436019
SRRM2 serine/arginine repetitive matrix 2 -0.0422517
PCBP2 poly(rC) binding protein 2 -0.0422439
PFN1 profilin 1 -0.0420934
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0419988
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0412275
TMBIM6 transmembrane BAX inhibitor motif containing 6 -0.0409637
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0408384
NIPBL Nipped-B homolog (Drosophila) -0.0402398
HSPA8 heat shock 70kDa protein 8 -0.0399968
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0393244
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 -0.0388941
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0386593
EEF1G eukaryotic translation elongation factor 1 gamma -0.0385917
RAB7A RAB7A, member RAS oncogene family -0.0381955
GOLGB1 golgin B1 -0.0375624
PHF3 PHD finger protein 3 -0.0374465
NLGN1 neuroligin 1 -0.0371077
HDLBP high density lipoprotein binding protein -0.0366599
BPTF bromodomain PHD finger transcription factor -0.0365141
ATP11A ATPase, class VI, type 11A -0.036278
WNT2B wingless-type MMTV integration site family, member 2B -0.0357492
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0356535
PRRC2A proline-rich coiled-coil 2A -0.0354855
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0349008
SFPQ splicing factor proline/glutamine-rich -0.0346173
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0344645
IGF1R insulin-like growth factor 1 receptor -0.0342521
CMIP c-Maf inducing protein -0.0340928
MYH9 myosin, heavy chain 9, non-muscle -0.0340151
TAOK1 TAO kinase 1 -0.0333339
INTS6 integrator complex subunit 6 -0.0331817
EP400 E1A binding protein p400 -0.0326346
MEF2D myocyte enhancer factor 2D -0.0325332
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0323808
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0323392
ZNF644 zinc finger protein 644 -0.0319993
PYGL phosphorylase, glycogen, liver -0.0319873
GPHN gephyrin -0.031838
RPS2 ribosomal protein S2 -0.0318155
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0317209
PER1 period circadian clock 1 -0.0314652
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0310524
RBM39 RNA binding motif protein 39 -0.0307262
TAPBP TAP binding protein (tapasin) -0.0295642
RPLP1 ribosomal protein, large, P1 -0.0295298
ACTG1 actin gamma 1 -0.0286803
ASXL2 additional sex combs like transcriptional regulator 2 -0.0286068
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0285298
ACTN1 actinin, alpha 1 -0.0282879
CDK17 cyclin-dependent kinase 17 -0.0282435
KRT18 keratin 18, type I -0.0277426
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0277302
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0271261
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0270782
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.027027
RPL38 ribosomal protein L38 -0.0269809
PKM pyruvate kinase, muscle -0.0269699
RPL3 ribosomal protein L3 -0.0268713
JMJD1C jumonji domain containing 1C -0.0267982
RTN4 reticulon 4 -0.0267967
GSE1 Gse1 coiled-coil protein -0.0266779
DCAF8 DDB1 and CUL4 associated factor 8 -0.026406
NR4A1 nuclear receptor subfamily 4, group A, member 1 -0.0260827
LRRC23 leucine rich repeat containing 23 -0.025856
KDM6B lysine (K)-specific demethylase 6B -0.0258135