Cytarabine_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cytarabine perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cytarabine_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase 0.0817414
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0744273
LAMB3 laminin, beta 3 0.0672211
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.066534
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0662741
SQSTM1 sequestosome 1 0.0623471
RPS6 ribosomal protein S6 0.0589088
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0552577
UBA6 ubiquitin-like modifier activating enzyme 6 0.0541179
LAMC2 laminin, gamma 2 0.0526426
NCKAP1 NCK-associated protein 1 0.052492
BZW1 basic leucine zipper and W2 domains 1 0.0514193
SET SET nuclear proto-oncogene 0.0465235
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0463458
BHLHE40 basic helix-loop-helix family, member e40 0.0444839
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.042507
GARS1 glycyl-tRNA synthetase 1 0.0424127
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0422768
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0421815
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0416158
PDIA6 protein disulfide isomerase family A, member 6 0.0403244
RPS12 ribosomal protein S12 0.0397127
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0385989
DSPP dentin sialophosphoprotein 0.0384228
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0372359
RPS2 ribosomal protein S2 0.0353429
ASPH aspartate beta-hydroxylase 0.0346741
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0339767
PEG10 paternally expressed 10 0.0337851
CCND1 cyclin D1 0.0337206
PGK1 phosphoglycerate kinase 1 0.0335366
RACK1 receptor for activated C kinase 1 0.033298
FXR1 fragile X mental retardation, autosomal homolog 1 0.0323748
ZNF292 zinc finger protein 292 0.0307957
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0306711
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0306079
EREG epiregulin 0.0299014
NAP1L1 nucleosome assembly protein 1-like 1 0.0298286
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0297449
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0286812
LPP LIM domain containing preferred translocation partner in lipoma 0.0283968
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0281489
RPS3 ribosomal protein S3 0.0281331
SLMAP sarcolemma associated protein 0.0276955
MATR3 matrin 3 0.027428
MIER1 mesoderm induction early response 1, transcriptional regulator 0.0271186
ANXA1 annexin A1 0.026761
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.026733
KPNA1 karyopherin alpha 1 (importin alpha 5) 0.0266659
SACK1A scaffolding CK1 anchoring protein A 0.0266363
RPS8 ribosomal protein S8 0.0265965
NUP58 nucleoporin 58 0.0265759
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0263166
RAD23B RAD23 homolog B (S. cerevisiae) 0.0256901
TRIO trio Rho guanine nucleotide exchange factor 0.0248745
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0248187
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0247293
RSRC2 arginine/serine-rich coiled-coil 2 0.0242818
YME1L1 YME1-like 1 ATPase 0.0237204
FAM13A family with sequence similarity 13, member A 0.0231471
CXCL3 chemokine (C-X-C motif) ligand 3 0.0228473
SMG7 SMG7 nonsense mediated mRNA decay factor 0.0227182
MSMO1 methylsterol monooxygenase 1 0.0224275
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.022419
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1 0.0222503
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0222009
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0218379
MKI67 marker of proliferation Ki-67 0.0218019
ARRDC3 arrestin domain containing 3 0.0217848
BIRC3 baculoviral IAP repeat containing 3 0.02175
IRF6 interferon regulatory factor 6 0.021518
RPL26 ribosomal protein L26 0.021324
TM9SF2 transmembrane 9 superfamily member 2 0.0211778
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.021143
SCEL sciellin 0.0208709
STAG2 stromal antigen 2 0.0208516
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0207515
RPS17 ribosomal protein S17 0.0206058
CAPN2 calpain 2, (m/II) large subunit 0.0204952
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.0204747
CBX3 chromobox homolog 3 0.0204515
LDHB lactate dehydrogenase B 0.0203543
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.020334
ITGAV integrin, alpha V 0.0202956
WDR36 WD repeat domain 36 0.0202156
PA2G4 proliferation-associated 2G4, 38kDa 0.0196956
EEF2 eukaryotic translation elongation factor 2 0.0196018
OGA O-GlcNAcase 0.0194575
HNRNPK heterogeneous nuclear ribonucleoprotein K 0.0194334
FHIT fragile histidine triad 0.0193953
WDR43 WD repeat domain 43 0.0193913
NFE2L1 nuclear factor, erythroid 2-like 1 0.0193173
SERINC1 serine incorporator 1 0.0192337
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.0192317
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 0.0191783
RPL7 ribosomal protein L7 0.0190327
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0189945
TNIP1 TNFAIP3 interacting protein 1 0.0188886
KIF5B kinesin family member 5B 0.0188416
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0186558

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.265576
FTL ferritin, light polypeptide -0.22413
TMSB10 thymosin beta 10 -0.148287
NDRG1 N-myc downstream regulated 1 -0.141191
SAMD4A sterile alpha motif domain containing 4A -0.111448
POTEF POTE ankyrin domain family, member F -0.10817
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0999946
IGFBP3 insulin-like growth factor binding protein 3 -0.0855162
TSC22D2 TSC22 domain family, member 2 -0.081231
LOC112694756 uncharaterized LOC112694756 -0.0753471
LIMCH1 LIM and calponin homology domains 1 -0.0748509
FTH1 ferritin, heavy polypeptide 1 -0.0725258
EXT1 exostosin glycosyltransferase 1 -0.0714306
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0695857
LDHA lactate dehydrogenase A -0.0678203
LMO7 LIM domain 7 -0.0619317
EFNA5 ephrin-A5 -0.0614394
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0602313
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0599411
BRD2 bromodomain containing 2 -0.0563767
HLA-A major histocompatibility complex, class I, A -0.0561103
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0545431
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0536755
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0527524
RPLP1 ribosomal protein, large, P1 -0.0497088
KDM5B lysine (K)-specific demethylase 5B -0.0488483
ENO2 enolase 2 (gamma, neuronal) -0.0483617
TMEM263 transmembrane protein 263 -0.0482132
TAPBP TAP binding protein (tapasin) -0.0459063
FNIP1 folliculin interacting protein 1 -0.0455643
RAB7A RAB7A, member RAS oncogene family -0.0447524
FAM3C family with sequence similarity 3, member C -0.0444115
VEGFA vascular endothelial growth factor A -0.0436001
PCBP2 poly(rC) binding protein 2 -0.0429419
IFI27 interferon, alpha-inducible protein 27 -0.0427887
HLA-B major histocompatibility complex, class I, B -0.0423183
ARF4 ADP-ribosylation factor 4 -0.0414424
MYO1E myosin IE -0.0410062
QSOX1 quiescin Q6 sulfhydryl oxidase 1 -0.0407794
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0405974
WASF2 WAS protein family, member 2 -0.040263
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 -0.0401381
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0399986
ALCAM activated leukocyte cell adhesion molecule -0.0393918
HDLBP high density lipoprotein binding protein -0.039135
MCL1 myeloid cell leukemia 1 -0.0390306
EGR1 early growth response 1 -0.0387604
RPS19 ribosomal protein S19 -0.0386744
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0386602
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0380642
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0376543
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 -0.0376445
KDM2A lysine (K)-specific demethylase 2A -0.0374736
SDC4 syndecan 4 -0.0373527
GOLGB1 golgin B1 -0.0372227
TMEM165 transmembrane protein 165 -0.0369732
IFI6 interferon, alpha-inducible protein 6 -0.0362546
MCU mitochondrial calcium uniporter -0.0358736
MT2A metallothionein 2A -0.0358353
TUBB4B tubulin, beta 4B class IVb -0.0353661
RCOR1 REST corepressor 1 -0.0352228
RPL35A ribosomal protein L35a -0.0344429
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0341729
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0338587
SOX4 SRY (sex determining region Y)-box 4 -0.0336657
BLZF1 basic leucine zipper nuclear factor 1 -0.0336195
TXNIP thioredoxin interacting protein -0.0335135
ATP5F1B ATP synthase F1 subunit beta -0.0333968
COPA coatomer protein complex, subunit alpha -0.0331291
TJP1 tight junction protein 1 -0.0330448
SLC38A1 solute carrier family 38, member 1 -0.0330389
CDCP1 CUB domain containing protein 1 -0.0325328
CLDN4 claudin 4 -0.0322904
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0322564
LMNA lamin A/C -0.0319696
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0317217
KLHL24 kelch-like family member 24 -0.031389
UGDH UDP-glucose 6-dehydrogenase -0.0312049
SH3RF1 SH3 domain containing ring finger 1 -0.0308934
IFITM1 interferon induced transmembrane protein 1 -0.0308791
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.030855
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0301939
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0300959
PPP1R13B protein phosphatase 1, regulatory subunit 13B -0.0300875
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0299197
PKM pyruvate kinase, muscle -0.0298311
PTK2 protein tyrosine kinase 2 -0.0295017
PALLD palladin, cytoskeletal associated protein -0.0292924
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0292542
OCLN occludin -0.0291811
F11R F11 receptor -0.0291473
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0288437
ATOSA atos homolog A -0.0287535
TPM4 tropomyosin 4 -0.0287019
AKAP13 A kinase (PRKA) anchor protein 13 -0.0282076
AGO2 argonaute RISC catalytic component 2 -0.0281979
VMP1 vacuole membrane protein 1 -0.028128
DLG1 discs, large homolog 1 (Drosophila) -0.0281264
AFF4 AF4/FMR2 family, member 4 -0.0280796
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0277764