Cytarabine_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cytarabine perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cytarabine_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ZNF292 zinc finger protein 292 0.0765096
MKI67 marker of proliferation Ki-67 0.0727061
NCKAP1 NCK-associated protein 1 0.0523677
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0468315
H1-4 H1.4 linker histone, cluster member 0.0459277
KMT2E lysine (K)-specific methyltransferase 2E 0.0446352
NPAS3 neuronal PAS domain protein 3 0.0434599
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0414586
WDR43 WD repeat domain 43 0.0413435
ZFAND3 zinc finger, AN1-type domain 3 0.0401957
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0378131
MARCHF6 membrane associated ring-CH-type finger 6 0.035738
LUZP2 leucine zipper protein 2 0.0351202
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0350685
SRSF11 serine/arginine-rich splicing factor 11 0.0334818
OLA1 Obg-like ATPase 1 0.0334145
SET SET nuclear proto-oncogene 0.0323093
ANXA1 annexin A1 0.0318122
RHEB Ras homolog enriched in brain 0.0311223
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 0.0302008
PLPP1 phospholipid phosphatase 1 0.0288728
MSRB3 methionine sulfoxide reductase B3 0.0282693
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0278606
PDGFC platelet derived growth factor C 0.0278169
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0274788
OSBPL9 oxysterol binding protein-like 9 0.0271189
ARGLU1 arginine and glutamate rich 1 0.0263847
MEF2A myocyte enhancer factor 2A 0.0263249
KIF11 kinesin family member 11 0.0258551
WRN Werner syndrome, RecQ helicase-like 0.0256084
XPR1 xenotropic and polytropic retrovirus receptor 1 0.025467
RTF1 Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) 0.025372
FUBP1 far upstream element (FUSE) binding protein 1 0.0250666
ANKRD11 ankyrin repeat domain 11 0.0247705
PGAP1 post-GPI attachment to proteins 1 0.0244989
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0244838
RPS2 ribosomal protein S2 0.0243195
SP3 Sp3 transcription factor 0.0240216
COL1A2 collagen, type I, alpha 2 0.0240138
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 0.0232432
CLSPN claspin 0.0227977
DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1 0.0225148
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.0225143
RAD23B RAD23 homolog B (S. cerevisiae) 0.0225127
USP3 ubiquitin specific peptidase 3 0.02236
ERBIN erbb2 interacting protein 0.0221573
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0220806
FXR1 fragile X mental retardation, autosomal homolog 1 0.0219673
RPS12 ribosomal protein S12 0.0217384
SH3RF2 SH3 domain containing ring finger 2 0.021703
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.0216969
CLINT1 clathrin interactor 1 0.0216636
NIPBL Nipped-B homolog (Drosophila) 0.0214412
PTBP2 polypyrimidine tract binding protein 2 0.0213809
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0212943
LCA5 Leber congenital amaurosis 5 0.021117
PDE8A phosphodiesterase 8A 0.0210543
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0206025
MBIP MAP3K12 binding inhibitory protein 1 0.0206009
BCLAF1 BCL2-associated transcription factor 1 0.0205952
USP33 ubiquitin specific peptidase 33 0.0204996
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0204831
TNPO1 transportin 1 0.0203779
RYBP RING1 and YY1 binding protein 0.0202762
PDS5B PDS5 cohesin associated factor B 0.0202491
GIGYF2 GRB10 interacting GYF protein 2 0.0201825
DPYD dihydropyrimidine dehydrogenase 0.0200836
PARD3B par-3 family cell polarity regulator beta 0.020054
ZNF451 zinc finger protein 451 0.0200459
FOXP2 forkhead box P2 0.019918
TSPAN12 tetraspanin 12 0.0198278
PUM1 pumilio RNA-binding family member 1 0.0197014
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0195706
MEMO1 mediator of cell motility 1 0.0194574
SARNP SAP domain containing ribonucleoprotein 0.0194358
DDX18 DEAD (Asp-Glu-Ala-Asp) box polypeptide 18 0.0193673
CDC42 cell division cycle 42 0.0193414
TBC1D12 TBC1 domain family, member 12 0.01934
SPOPL speckle-type POZ protein-like 0.0192178
DIAPH3 diaphanous-related formin 3 0.0191323
RBMX RNA binding motif protein, X-linked 0.018911
SELENOI selenoprotein I 0.0188578
RAB8B RAB8B, member RAS oncogene family 0.0187506
H2AZ2 H2A.Z variant histone 2 0.0187113
HMGN3 high mobility group nucleosomal binding domain 3 0.0186906
KIF1B kinesin family member 1B 0.0185884
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.018535
RBM33 RNA binding motif protein 33 0.0185081
WARS1 tryptophanyl-tRNA synthetase 1 0.018291
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 0.0182352
NCOR1 nuclear receptor corepressor 1 0.018197
BTG3 BTG family, member 3 0.018015
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0180036
ZBTB35 zinc finger and BTB domain containing 35 0.0177488
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 0.0176671
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1 0.0175635
MTF2 metal response element binding transcription factor 2 0.0175277
NFE2L1 nuclear factor, erythroid 2-like 1 0.0175007
UPP1 uridine phosphorylase 1 0.0173267
RBM26 RNA binding motif protein 26 0.0172883

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.245661
COL11A1 collagen, type XI, alpha 1 -0.168123
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.157819
CDH10 cadherin 10, type 2 (T2-cadherin) -0.110833
GPC3 glypican 3 -0.110613
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0989661
PEG10 paternally expressed 10 -0.0984731
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0982714
PCLO piccolo presynaptic cytomatrix protein -0.0953109
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) -0.086809
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0695433
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.0662737
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0643926
RPS16 ribosomal protein S16 -0.0629628
RPL35A ribosomal protein L35a -0.0596206
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0593154
FN1 fibronectin 1 -0.05825
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0575804
PFN1 profilin 1 -0.0574304
CADM2 cell adhesion molecule 2 -0.0555387
RPLP0 ribosomal protein, large, P0 -0.0555177
COTL1 coactosin-like F-actin binding protein 1 -0.054218
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0538554
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0538443
ADNP activity-dependent neuroprotector homeobox -0.0538328
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0534955
TMSB4X thymosin beta 4, X-linked -0.0532997
ENO1 enolase 1, (alpha) -0.0527821
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0513762
RPS6 ribosomal protein S6 -0.0505277
ZBTB20 zinc finger and BTB domain containing 20 -0.0501274
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 -0.0480737
CALR calreticulin -0.0479817
TRIO trio Rho guanine nucleotide exchange factor -0.047896
THBS1 thrombospondin 1 -0.0474812
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0465923
RPL23 ribosomal protein L23 -0.0463988
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0461142
RASAL2 RAS protein activator like 2 -0.0457093
PPP1R12A protein phosphatase 1, regulatory subunit 12A -0.0455356
APLP2 amyloid beta (A4) precursor-like protein 2 -0.044688
KPNB1 karyopherin (importin) beta 1 -0.0435702
LMAN1 lectin, mannose-binding, 1 -0.0434443
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 -0.0434247
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0433075
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.043161
CBX3 chromobox homolog 3 -0.0428372
SOX5 SRY (sex determining region Y)-box 5 -0.0427563
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0426696
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0424781
SYT1 synaptotagmin I -0.0424563
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 -0.0419366
MAP4 microtubule-associated protein 4 -0.0418191
EMP1 epithelial membrane protein 1 -0.0417835
PCDH9 protocadherin 9 -0.0411857
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0409648
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0405579
ZNF217 zinc finger protein 217 -0.0402865
FTL ferritin, light polypeptide -0.040101
PDE4D phosphodiesterase 4D, cAMP-specific -0.0398702
PCBP2 poly(rC) binding protein 2 -0.0396701
LRRC4C leucine rich repeat containing 4C -0.0394784
TCF12 transcription factor 12 -0.0394217
POTEF POTE ankyrin domain family, member F -0.0394013
TUBA1B tubulin, alpha 1b -0.0393026
ADGRL3 adhesion G protein-coupled receptor L3 -0.0392215
UBC ubiquitin C -0.0391366
SETD5 SET domain containing 5 -0.0389285
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0388958
YBX1 Y box binding protein 1 -0.0388137
CAVIN1 caveolae associated protein 1 -0.0385891
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0384277
DST dystonin -0.0383371
BBX bobby sox homolog (Drosophila) -0.0382937
ACTG1 actin gamma 1 -0.0378518
BPTF bromodomain PHD finger transcription factor -0.0378158
MRPS6 mitochondrial ribosomal protein S6 -0.0373459
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0373219
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0371775
RAB31 RAB31, member RAS oncogene family -0.0371486
MDK midkine (neurite growth-promoting factor 2) -0.0369524
HDAC9 histone deacetylase 9 -0.0369427
TMSB10 thymosin beta 10 -0.036722
SAMD4A sterile alpha motif domain containing 4A -0.0365281
FBL fibrillarin -0.0361481
PHIP pleckstrin homology domain interacting protein -0.0359282
CALU calumenin -0.0355589
IGF1R insulin-like growth factor 1 receptor -0.0354707
GLG1 golgi glycoprotein 1 -0.0354592
ADGRV1 adhesion G protein-coupled receptor V1 -0.035307
COPB1 coatomer protein complex, subunit beta 1 -0.0351801
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0351619
FAM177A1 family with sequence similarity 177, member A1 -0.0351165
SEPTIN7 septin 7 -0.0350231
PDIA3 protein disulfide isomerase family A, member 3 -0.0348641
H1-0 H1.0 linker histone -0.0348552
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0345934
RFPL4B ret finger protein-like 4B -0.0343706
APP amyloid beta (A4) precursor protein -0.0340695
WASF2 WAS protein family, member 2 -0.0338856