Cytarabine_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cytarabine perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cytarabine_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.104441
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0977352
ADAM10 ADAM metallopeptidase domain 10 0.0834594
PNISR PNN-interacting serine/arginine-rich protein 0.0729781
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0686854
FLNB filamin B, beta 0.0659042
NCKAP1 NCK-associated protein 1 0.0636037
GOLGA4 golgin A4 0.063233
ARL4C ADP-ribosylation factor-like 4C 0.0611269
EEF2 eukaryotic translation elongation factor 2 0.0597771
ZNF292 zinc finger protein 292 0.05206
SMNDC1 survival motor neuron domain containing 1 0.0508228
RPS6 ribosomal protein S6 0.0504108
HDAC9 histone deacetylase 9 0.0497371
RPS12 ribosomal protein S12 0.0489821
PRELID2 PRELI domain containing 2 0.0487875
SBF2 SET binding factor 2 0.0471525
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0467096
OGA O-GlcNAcase 0.0462489
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 0.0460529
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0460417
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0450035
SET SET nuclear proto-oncogene 0.0448016
ZEB1 zinc finger E-box binding homeobox 1 0.0440214
EIF4A2 eukaryotic translation initiation factor 4A2 0.0433956
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0426009
NAP1L1 nucleosome assembly protein 1-like 1 0.0409001
TXNIP thioredoxin interacting protein 0.0405639
RPS2 ribosomal protein S2 0.0399111
ZMYM2 zinc finger, MYM-type 2 0.0398264
MXI1 MAX interactor 1, dimerization protein 0.0396587
RPL26 ribosomal protein L26 0.0394732
PYGB phosphorylase, glycogen; brain 0.0388137
UBA6 ubiquitin-like modifier activating enzyme 6 0.0383966
TPD52 tumor protein D52 0.0380544
YEATS2 YEATS domain containing 2 0.0371731
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.036678
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0357003
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0356668
TMEM41B transmembrane protein 41B 0.0355015
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0345679
ANKRD36 ankyrin repeat domain 36 0.0342755
COG5 component of oligomeric golgi complex 5 0.0339466
SQSTM1 sequestosome 1 0.0337556
SLMAP sarcolemma associated protein 0.0334633
NAMPT nicotinamide phosphoribosyltransferase 0.0333204
PGK1 phosphoglycerate kinase 1 0.0333091
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0328807
EML4 echinoderm microtubule associated protein like 4 0.0328171
EIF1 eukaryotic translation initiation factor 1 0.0327297
CNOT6L CCR4-NOT transcription complex, subunit 6-like 0.0322516
PUM2 pumilio RNA-binding family member 2 0.031276
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 0.0309224
ANKRD12 ankyrin repeat domain 12 0.0306112
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.030438
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.030353
DENND4A DENN/MADD domain containing 4A 0.0303337
TPR translocated promoter region, nuclear basket protein 0.0301013
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0300115
SCAF8 SR-related CTD-associated factor 8 0.029418
DAPK3 death-associated protein kinase 3 0.0284803
ADAM17 ADAM metallopeptidase domain 17 0.0281758
FAM13A family with sequence similarity 13, member A 0.0280853
SPAG9 sperm associated antigen 9 0.0279989
PTBP2 polypyrimidine tract binding protein 2 0.0279709
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0278585
NFE2L1 nuclear factor, erythroid 2-like 1 0.0277883
RBM25 RNA binding motif protein 25 0.0276696
RPS8 ribosomal protein S8 0.0276058
USP34 ubiquitin specific peptidase 34 0.0274897
ARGLU1 arginine and glutamate rich 1 0.0273046
PTMA prothymosin, alpha 0.0272008
PHIP pleckstrin homology domain interacting protein 0.0271667
KIF5B kinesin family member 5B 0.0269738
CAMTA1 calmodulin binding transcription activator 1 0.0268721
ABHD12 abhydrolase domain containing 12 0.0267509
PHF3 PHD finger protein 3 0.0265777
HELZ helicase with zinc finger 0.0264
TMEM65 transmembrane protein 65 0.0263287
RPL7 ribosomal protein L7 0.0258197
NCOR1 nuclear receptor corepressor 1 0.0256907
PICALM phosphatidylinositol binding clathrin assembly protein 0.0254307
NUP58 nucleoporin 58 0.0252346
RO60 Ro60, Y RNA binding protein 0.0251275
ZFAND3 zinc finger, AN1-type domain 3 0.0249297
TGFBR3 transforming growth factor, beta receptor III 0.024671
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1 0.0246661
EZH1 enhancer of zeste 1 polycomb repressive complex 2 subunit 0.0246313
MAP3K14 mitogen-activated protein kinase kinase kinase 14 0.024119
BIRC2 baculoviral IAP repeat containing 2 0.0239298
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0239006
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.023887
MBD5 methyl-CpG binding domain protein 5 0.0238093
SERINC1 serine incorporator 1 0.0236438
ELP2 elongator acetyltransferase complex subunit 2 0.023156
NBAS neuroblastoma amplified sequence 0.0231049
STAG2 stromal antigen 2 0.0231004
ANKRD36C ankyrin repeat domain 36C 0.0229037
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0228594
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0228583

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.274248
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.198309
PKM pyruvate kinase, muscle -0.132077
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.126009
BMP10 bone morphogenetic protein 10 -0.092653
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0912926
FOXP1 forkhead box P1 -0.0822288
CPED1 cadherin-like and PC-esterase domain containing 1 -0.072143
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 -0.0657965
ENO2 enolase 2 (gamma, neuronal) -0.0605298
LOC112694756 uncharaterized LOC112694756 -0.0587907
POTEF POTE ankyrin domain family, member F -0.0563681
IARS1 isoleucyl-tRNA synthetase 1 -0.0523597
HDLBP high density lipoprotein binding protein -0.0515888
PFN1 profilin 1 -0.0505199
GLI3 GLI family zinc finger 3 -0.04832
RPLP0 ribosomal protein, large, P0 -0.0474303
SSBP2 single-stranded DNA binding protein 2 -0.0455965
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0451595
CALR calreticulin -0.0432938
TMSB10 thymosin beta 10 -0.0425781
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -0.042387
GLI2 GLI family zinc finger 2 -0.0423719
LDHA lactate dehydrogenase A -0.0397718
CAMKMT calmodulin-lysine N-methyltransferase -0.0393486
ZMYND8 zinc finger, MYND-type containing 8 -0.0390525
ZNF438 zinc finger protein 438 -0.0389939
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0386228
TJP1 tight junction protein 1 -0.0386092
FTL ferritin, light polypeptide -0.037304
RPLP1 ribosomal protein, large, P1 -0.0369093
S100A4 S100 calcium binding protein A4 -0.0360972
TXNRD1 thioredoxin reductase 1 -0.0359163
RPL13A ribosomal protein L13a -0.0358882
HSPB1 heat shock 27kDa protein 1 -0.0352064
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0349475
LOC102724023 ES1 protein homolog, mitochondrial -0.0329173
TACC2 transforming, acidic coiled-coil containing protein 2 -0.03212
PKP4 plakophilin 4 -0.0318836
STAT1 signal transducer and activator of transcription 1, 91kDa -0.031454
SPRY4 sprouty homolog 4 (Drosophila) -0.030786
SP100 SP100 nuclear antigen -0.03068
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.0306121
PRUNE2 prune homolog 2 (Drosophila) -0.0304833
RPS11 ribosomal protein S11 -0.0304422
ANKRD17 ankyrin repeat domain 17 -0.0301938
ANKRD11 ankyrin repeat domain 11 -0.0301896
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) -0.0301105
FBLN2 fibulin 2 -0.0298278
PDE7B phosphodiesterase 7B -0.0297899
HEG1 heart development protein with EGF-like domains 1 -0.0296398
ZNFX1 zinc finger, NFX1-type containing 1 -0.02931
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0287663
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.028747
RPL35A ribosomal protein L35a -0.0286741
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0283326
CANX calnexin -0.0282432
RPL28 ribosomal protein L28 -0.0281701
DOCK3 dedicator of cytokinesis 3 -0.028145
PRDX2 peroxiredoxin 2 -0.0279595
FER1L6 fer-1-like family member 6 -0.0279554
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0277892
YBX1 Y box binding protein 1 -0.0276141
RAB7A RAB7A, member RAS oncogene family -0.0273858
CTIF CBP80/20-dependent translation initiation factor -0.0272592
RPL31 ribosomal protein L31 -0.0271532
RRBP1 ribosome binding protein 1 -0.0267832
RPS24 ribosomal protein S24 -0.0267691
EGFR epidermal growth factor receptor -0.026476
CRPPA CDP-L-ribitol pyrophosphorylase A -0.0263547
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0260336
SLC41A1 solute carrier family 41 (magnesium transporter), member 1 -0.0258413
RPS19 ribosomal protein S19 -0.025549
TAPBP TAP binding protein (tapasin) -0.0254808
DOCK1 dedicator of cytokinesis 1 -0.0254218
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 -0.0250631
RPL8 ribosomal protein L8 -0.0250282
NT5C2 5'-nucleotidase, cytosolic II -0.0247147
EIF3H eukaryotic translation initiation factor 3, subunit H -0.024455
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0244336
RPS5 ribosomal protein S5 -0.0243327
RPL27A ribosomal protein L27a -0.0242514
EEF1G eukaryotic translation elongation factor 1 gamma -0.024239
RPS4Y1 ribosomal protein S4, Y-linked 1 -0.024211
ACTG1 actin gamma 1 -0.0241772
RHOA ras homolog family member A -0.0240989
EZR ezrin -0.02398
IFITM3 interferon induced transmembrane protein 3 -0.023871
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0237612
AFF4 AF4/FMR2 family, member 4 -0.0236355
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0236046
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0235495
BSG basigin (Ok blood group) -0.0234642
MLIP muscular LMNA-interacting protein -0.0232826
ZBTB38 zinc finger and BTB domain containing 38 -0.0232433
TTC3 tetratricopeptide repeat domain 3 -0.023025
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0230103
GCLM glutamate-cysteine ligase, modifier subunit -0.0229847
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b -0.0229678
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0228157