Cytarabine_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cytarabine perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cytarabine_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TRIO trio Rho guanine nucleotide exchange factor 0.194173
OGA O-GlcNAcase 0.106047
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0889536
FRMD4A FERM domain containing 4A 0.0809508
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0809385
FLOT1 flotillin 1 0.0748555
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0748125
ZNF292 zinc finger protein 292 0.0740571
RPS6 ribosomal protein S6 0.0738374
RPS12 ribosomal protein S12 0.0729665
MXI1 MAX interactor 1, dimerization protein 0.071253
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0691573
HDAC9 histone deacetylase 9 0.0663483
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0655442
UBA6 ubiquitin-like modifier activating enzyme 6 0.0647161
TPT1 tumor protein, translationally-controlled 1 0.0604725
CDK19 cyclin-dependent kinase 19 0.0574576
PRELID2 PRELI domain containing 2 0.057331
ATP13A3 ATPase type 13A3 0.0572381
AKAP12 A kinase (PRKA) anchor protein 12 0.0554713
UGCG UDP-glucose ceramide glucosyltransferase 0.053628
WDFY1 WD repeat and FYVE domain containing 1 0.0525466
RB1CC1 RB1-inducible coiled-coil 1 0.0508342
BIRC3 baculoviral IAP repeat containing 3 0.0488869
NAV2 neuron navigator 2 0.0487426
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0463435
PDE10A phosphodiesterase 10A 0.0449683
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0445489
GPC6 glypican 6 0.0444611
PTBP3 polypyrimidine tract binding protein 3 0.0444583
SLC41A2 solute carrier family 41 (magnesium transporter), member 2 0.0442208
AMPD3 adenosine monophosphate deaminase 3 0.0420654
TRPM7 transient receptor potential cation channel, subfamily M, member 7 0.0411533
TENT5A terminal nucleotidyltransferase 5A 0.0402958
PNISR PNN-interacting serine/arginine-rich protein 0.0397323
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0395561
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0391706
WTAP Wilms tumor 1 associated protein 0.0389337
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0385779
NAP1L1 nucleosome assembly protein 1-like 1 0.0382301
RPS8 ribosomal protein S8 0.0381334
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0380237
ERBIN erbb2 interacting protein 0.0379101
NPEPPS aminopeptidase puromycin sensitive 0.0378499
NT5C2 5'-nucleotidase, cytosolic II 0.0375804
HELZ helicase with zinc finger 0.0371981
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.036949
RICTOR RPTOR independent companion of MTOR, complex 2 0.0368599
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 0.0368596
YEATS2 YEATS domain containing 2 0.0365797
RPS2 ribosomal protein S2 0.0356416
FMNL2 formin-like 2 0.0354934
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 0.0350375
LCORL ligand dependent nuclear receptor corepressor-like 0.0344281
STAG2 stromal antigen 2 0.0342456
ANKRD12 ankyrin repeat domain 12 0.034141
IL6ST interleukin 6 signal transducer 0.0339714
JMJD1C jumonji domain containing 1C 0.0336588
MYOF myoferlin 0.0334717
SBF2 SET binding factor 2 0.0331186
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 0.0331026
NGLY1 N-glycanase 1 0.0330582
IGFBP7 insulin-like growth factor binding protein 7 0.0330457
NCKAP1 NCK-associated protein 1 0.0329726
ARFGEF3 ARFGEF family member 3 0.0327515
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.0327425
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0327258
KLF6 Kruppel-like factor 6 0.0326273
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0322881
ARL4C ADP-ribosylation factor-like 4C 0.0319891
GOLGA4 golgin A4 0.03172
SNX9 sorting nexin 9 0.0316318
RPL37A ribosomal protein L37a 0.0315018
FNIP1 folliculin interacting protein 1 0.0314189
RAB6A RAB6A, member RAS oncogene family 0.0307583
ARRDC3 arrestin domain containing 3 0.0299491
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0298867
RPS17 ribosomal protein S17 0.029879
SMYD3 SET and MYND domain containing 3 0.0293184
IRAK2 interleukin-1 receptor-associated kinase 2 0.0290729
ZNF638 zinc finger protein 638 0.0279525
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0275863
GPBP1 GC-rich promoter binding protein 1 0.0275642
RPL26 ribosomal protein L26 0.0275578
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 0.0275209
SLC39A11 solute carrier family 39, member 11 0.0274914
PGK1 phosphoglycerate kinase 1 0.0274365
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0274145
MKI67 marker of proliferation Ki-67 0.0273392
COL8A1 collagen, type VIII, alpha 1 0.0272604
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 0.0272321
CTSB cathepsin B 0.027172
KIF13A kinesin family member 13A 0.0271474
TPD52 tumor protein D52 0.0269418
PPP4R4 protein phosphatase 4, regulatory subunit 4 0.026908
KTN1 kinectin 1 (kinesin receptor) 0.0268808
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.0268288
AFF3 AF4/FMR2 family, member 3 0.0263942
SYNJ2 synaptojanin 2 0.0263039
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0260918

decreased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 -0.162586
SOD2 superoxide dismutase 2, mitochondrial -0.14392
FN1 fibronectin 1 -0.139671
LDHA lactate dehydrogenase A -0.111943
EXT1 exostosin glycosyltransferase 1 -0.111075
EGR1 early growth response 1 -0.101554
GLIS3 GLIS family zinc finger 3 -0.0994697
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0977778
BICC1 BicC family RNA binding protein 1 -0.0967337
VEGFA vascular endothelial growth factor A -0.0885763
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.088094
TMSB10 thymosin beta 10 -0.0861972
CD44 CD44 molecule (Indian blood group) -0.0804828
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0743032
COL6A3 collagen, type VI, alpha 3 -0.0691893
MYH9 myosin, heavy chain 9, non-muscle -0.0688275
NAMPT nicotinamide phosphoribosyltransferase -0.0681154
LOC112694756 uncharaterized LOC112694756 -0.0680868
IGFBP3 insulin-like growth factor binding protein 3 -0.0662968
TAPBP TAP binding protein (tapasin) -0.0649663
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0649434
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0625962
EEF1G eukaryotic translation elongation factor 1 gamma -0.0586429
FTL ferritin, light polypeptide -0.0547785
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0544489
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0530125
HLA-A major histocompatibility complex, class I, A -0.0512788
YBX1 Y box binding protein 1 -0.0507965
PCBP2 poly(rC) binding protein 2 -0.0506977
VCL vinculin -0.0501363
CALR calreticulin -0.0490382
CTSD cathepsin D -0.048926
CANX calnexin -0.047608
TNS3 tensin 3 -0.0469457
HDLBP high density lipoprotein binding protein -0.0441352
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0441208
EPAS1 endothelial PAS domain protein 1 -0.043578
SMAD3 SMAD family member 3 -0.0418346
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0413006
UBC ubiquitin C -0.040207
VMP1 vacuole membrane protein 1 -0.0396591
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0392744
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.039131
ARF4 ADP-ribosylation factor 4 -0.0380625
APP amyloid beta (A4) precursor protein -0.0379317
AHNAK AHNAK nucleoprotein -0.037722
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0368351
RAB7A RAB7A, member RAS oncogene family -0.0367488
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0356815
ZBTB38 zinc finger and BTB domain containing 38 -0.0352303
NABP1 nucleic acid binding protein 1 -0.03479
PPARD peroxisome proliferator-activated receptor delta -0.0346556
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0342088
HLA-E major histocompatibility complex, class I, E -0.0338822
BRD2 bromodomain containing 2 -0.0336761
HMGA2 high mobility group AT-hook 2 -0.033301
FLNA filamin A, alpha -0.0331972
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0325938
VIM vimentin -0.0316927
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0313852
SRRM2 serine/arginine repetitive matrix 2 -0.0311464
KYNU kynureninase -0.0309526
GOLGB1 golgin B1 -0.0308303
PKM pyruvate kinase, muscle -0.03038
SDC4 syndecan 4 -0.0301982
SMAD2 SMAD family member 2 -0.0297383
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0297249
MAP1B microtubule-associated protein 1B -0.0297238
TMEM263 transmembrane protein 263 -0.029664
PTPRK protein tyrosine phosphatase, receptor type, K -0.0295666
NONO non-POU domain containing, octamer-binding -0.02951
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein -0.0295056
SETX senataxin -0.0287756
ENO2 enolase 2 (gamma, neuronal) -0.028646
JUN jun proto-oncogene -0.0286296
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0283989
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -0.0276408
PTMA prothymosin, alpha -0.0269405
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0269036
ZMIZ1 zinc finger, MIZ-type containing 1 -0.0262386
TOP1 topoisomerase (DNA) I -0.0259957
RNF213 ring finger protein 213 -0.0257195
CCNL1 cyclin L1 -0.0256099
HLA-C major histocompatibility complex, class I, C -0.0254043
NCOA7 nuclear receptor coactivator 7 -0.0250301
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.024884
BSG basigin (Ok blood group) -0.0248492
INTS6 integrator complex subunit 6 -0.0248274
CDK17 cyclin-dependent kinase 17 -0.0247159
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.024653
TSC22D2 TSC22 domain family, member 2 -0.0244549
MORF4L2 mortality factor 4 like 2 -0.0243886
IL6 interleukin 6 -0.0243332
WBP2 WW domain binding protein 2 -0.0243124
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0242953
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0241521
FAM20C family with sequence similarity 20, member C -0.0240727
CALU calumenin -0.0239575
SYAP1 synapse associated protein 1 -0.0238114
COL6A1 collagen, type VI, alpha 1 -0.0237351