Cytarabine_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cytarabine perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cytarabine_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ERRFI1 ERBB receptor feedback inhibitor 1 0.116677
TGFBI transforming growth factor, beta-induced, 68kDa 0.108401
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0948801
TENT5A terminal nucleotidyltransferase 5A 0.0892233
AVL9 AVL9 homolog (S. cerevisiase) 0.0760343
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0722733
NAMPT nicotinamide phosphoribosyltransferase 0.0679698
TRIO trio Rho guanine nucleotide exchange factor 0.0673921
LIMS1 LIM and senescent cell antigen-like domains 1 0.0635227
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 0.0616744
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0584637
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0578542
ATP13A3 ATPase type 13A3 0.0541134
COG5 component of oligomeric golgi complex 5 0.0537989
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0489289
FAM13A family with sequence similarity 13, member A 0.0487487
AUTS2 autism susceptibility candidate 2 0.0481958
OGA O-GlcNAcase 0.0471595
GOLGA4 golgin A4 0.0469166
ANKRD17 ankyrin repeat domain 17 0.0460698
LOXL2 lysyl oxidase-like 2 0.0459826
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0459372
PRELID2 PRELI domain containing 2 0.0454448
LAMB1 laminin, beta 1 0.045015
PDIA6 protein disulfide isomerase family A, member 6 0.0449005
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0447248
EIF1 eukaryotic translation initiation factor 1 0.0444624
MARCHF6 membrane associated ring-CH-type finger 6 0.0442793
YEATS2 YEATS domain containing 2 0.0431619
UBA6 ubiquitin-like modifier activating enzyme 6 0.0426786
SETD5 SET domain containing 5 0.0410928
ELL2 elongation factor, RNA polymerase II, 2 0.0407754
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0401284
AKAP9 A kinase (PRKA) anchor protein 9 0.0400576
LGALS3 lectin, galactoside-binding, soluble, 3 0.039851
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0395241
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0392328
CNOT8 CCR4-NOT transcription complex, subunit 8 0.0385626
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.038276
FMNL2 formin-like 2 0.0381374
HOOK2 hook microtubule-tethering protein 2 0.0381354
CADM1 cell adhesion molecule 1 0.0375091
RASA2 RAS p21 protein activator 2 0.0372739
SLMAP sarcolemma associated protein 0.0370684
CA12 carbonic anhydrase XII 0.0362165
CELF1 CUGBP, Elav-like family member 1 0.0348424
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0345084
MT2A metallothionein 2A 0.0344727
CDC25C cell division cycle 25C 0.034217
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0337405
SBF2 SET binding factor 2 0.0336682
ARRDC3 arrestin domain containing 3 0.0336182
HELZ helicase with zinc finger 0.0333281
RAB6A RAB6A, member RAS oncogene family 0.0322451
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0321954
SND1 staphylococcal nuclease and tudor domain containing 1 0.0314675
ZZZ3 zinc finger, ZZ-type containing 3 0.0314073
SEC24D SEC24 family member D 0.0312095
GOLT1B golgi transport 1B 0.0309286
SECISBP2L SECIS binding protein 2-like 0.030926
NAP1L1 nucleosome assembly protein 1-like 1 0.0303526
PRSS23 protease, serine, 23 0.0303012
SEC24A SEC24 family member A 0.0301837
RBM25 RNA binding motif protein 25 0.0301405
MKI67 marker of proliferation Ki-67 0.0301084
RPL37 ribosomal protein L37 0.0300559
PUM2 pumilio RNA-binding family member 2 0.02993
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0299099
UGCG UDP-glucose ceramide glucosyltransferase 0.0299017
CDC73 cell division cycle 73 0.0297126
RNF24 ring finger protein 24 0.0295787
IGFBP6 insulin-like growth factor binding protein 6 0.0292784
CDH13 cadherin 13 0.0291971
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1 0.0291797
SFTPA2 surfactant protein A2 0.0291236
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0290035
COL6A2 collagen, type VI, alpha 2 0.0285768
FNIP1 folliculin interacting protein 1 0.0285304
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase 0.0285147
MT1X metallothionein 1X 0.0283878
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0283172
BACE2 beta-site APP-cleaving enzyme 2 0.0281524
CENPC centromere protein C 0.0281307
ANTXR2 anthrax toxin receptor 2 0.0279707
RARS1 arginyl-tRNA synthetase 1 0.0278966
MRPL1 mitochondrial ribosomal protein L1 0.0277522
TMF1 TATA element modulatory factor 1 0.027677
MMP12 matrix metallopeptidase 12 0.0276353
WSB1 WD repeat and SOCS box containing 1 0.0274492
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.0274446
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0272714
TTK TTK protein kinase 0.0271931
ZNF654 zinc finger protein 654 0.0268406
SBNO1 strawberry notch homolog 1 (Drosophila) 0.0268379
BHLHE40 basic helix-loop-helix family, member e40 0.0268281
PLAUR plasminogen activator, urokinase receptor 0.0267689
FAR1 fatty acyl CoA reductase 1 0.0264258
EXOC1 exocyst complex component 1 0.0262666
BRAF B-Raf proto-oncogene, serine/threonine kinase 0.0262068
HP1BP3 heterochromatin protein 1, binding protein 3 0.0261715

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.27582
IGFBP3 insulin-like growth factor binding protein 3 -0.184719
FTH1 ferritin, heavy polypeptide 1 -0.113949
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.103425
ENO1 enolase 1, (alpha) -0.101973
COL6A1 collagen, type VI, alpha 1 -0.100598
VEGFA vascular endothelial growth factor A -0.0960396
LDHA lactate dehydrogenase A -0.0900609
FN1 fibronectin 1 -0.0822485
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0777008
FNDC3B fibronectin type III domain containing 3B -0.074998
IL6 interleukin 6 -0.0729158
COL1A1 collagen, type I, alpha 1 -0.0699245
UBC ubiquitin C -0.0667772
POTEF POTE ankyrin domain family, member F -0.0650183
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0633509
TPT1 tumor protein, translationally-controlled 1 -0.0633387
PTMA prothymosin, alpha -0.062546
LOX lysyl oxidase -0.0604929
EXT1 exostosin glycosyltransferase 1 -0.0597519
NDRG1 N-myc downstream regulated 1 -0.0593559
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0592374
EGR1 early growth response 1 -0.0588577
PKM pyruvate kinase, muscle -0.0588502
VIM vimentin -0.0567411
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0540328
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0514875
AKAP12 A kinase (PRKA) anchor protein 12 -0.0510008
HLA-C major histocompatibility complex, class I, C -0.0486424
NCOR2 nuclear receptor corepressor 2 -0.0481769
COL1A2 collagen, type I, alpha 2 -0.0458187
SDC4 syndecan 4 -0.0444678
FTL ferritin, light polypeptide -0.0443534
HLA-B major histocompatibility complex, class I, B -0.0442258
MYH9 myosin, heavy chain 9, non-muscle -0.0442094
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0439048
SRRM2 serine/arginine repetitive matrix 2 -0.0421145
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0411222
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0411124
TAGLN2 transgelin 2 -0.040967
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0406604
ZNF395 zinc finger protein 395 -0.0406136
TMSB10 thymosin beta 10 -0.0406071
ALCAM activated leukocyte cell adhesion molecule -0.0403813
HM13 histocompatibility (minor) 13 -0.0400352
HLA-A major histocompatibility complex, class I, A -0.0393848
F3 coagulation factor III (thromboplastin, tissue factor) -0.0391971
EPAS1 endothelial PAS domain protein 1 -0.0389734
RPLP1 ribosomal protein, large, P1 -0.0386458
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.038103
RNF213 ring finger protein 213 -0.0378461
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.037188
MAP1B microtubule-associated protein 1B -0.0371688
TXNIP thioredoxin interacting protein -0.0371544
SLC39A14 solute carrier family 39 (zinc transporter), member 14 -0.0371494
GLIS3 GLIS family zinc finger 3 -0.0371277
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.036824
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0367282
LMNA lamin A/C -0.0365672
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0364915
BRD2 bromodomain containing 2 -0.0363349
NABP1 nucleic acid binding protein 1 -0.0361787
TXNRD1 thioredoxin reductase 1 -0.0353723
PGK1 phosphoglycerate kinase 1 -0.0353095
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.035201
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0346375
ECE1 endothelin converting enzyme 1 -0.0345271
VDAC1 voltage-dependent anion channel 1 -0.0340388
CBX3 chromobox homolog 3 -0.0336299
RPS11 ribosomal protein S11 -0.0335235
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0333698
PSD3 pleckstrin and Sec7 domain containing 3 -0.0333494
CDK6 cyclin-dependent kinase 6 -0.0331843
HILPDA hypoxia inducible lipid droplet-associated -0.0330859
SIK3 SIK family kinase 3 -0.0329651
RIGI RNA sensor RIG-I -0.0329397
FAM20C family with sequence similarity 20, member C -0.0325332
MTDH metadherin -0.0323099
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0321638
RUNX1 runt-related transcription factor 1 -0.0320652
H3-3B H3.3 histone B -0.0320322
WDR45B WD repeat domain 45B -0.031683
FBXO11 F-box protein 11 -0.0314812
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0313116
HIPK2 homeodomain interacting protein kinase 2 -0.0306883
CSDE1 cold shock domain containing E1, RNA-binding -0.0305801
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0304939
IARS1 isoleucyl-tRNA synthetase 1 -0.0302899
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0302047
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0301463
ACTG1 actin gamma 1 -0.0300597
PDE10A phosphodiesterase 10A -0.0300345
COL7A1 collagen, type VII, alpha 1 -0.0299361
AZIN1 antizyme inhibitor 1 -0.0298203
SRP72 signal recognition particle 72kDa -0.0295522
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 -0.0292927
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0290434
MYADM myeloid-associated differentiation marker -0.0285918
QKI QKI, KH domain containing, RNA binding -0.0284503
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0283512