Cytarabine_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cytarabine perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cytarabine_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
WAC WW domain containing adaptor with coiled-coil 0.136933
NUP58 nucleoporin 58 0.0977458
HILPDA hypoxia inducible lipid droplet-associated 0.0858059
PTMA prothymosin, alpha 0.0850567
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0845862
SETD5 SET domain containing 5 0.0812883
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0781837
PNISR PNN-interacting serine/arginine-rich protein 0.0768541
SPAG9 sperm associated antigen 9 0.0747799
NAP1L1 nucleosome assembly protein 1-like 1 0.0737349
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0718946
SNX14 sorting nexin 14 0.0715284
ITCH itchy E3 ubiquitin protein ligase 0.0675913
MATR3 matrin 3 0.0659516
TRA2A transformer 2 alpha homolog (Drosophila) 0.0658562
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0629456
SET SET nuclear proto-oncogene 0.0626162
KIF5B kinesin family member 5B 0.0620739
RICTOR RPTOR independent companion of MTOR, complex 2 0.0600004
SEPTIN7 septin 7 0.0585354
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0569781
RSRC2 arginine/serine-rich coiled-coil 2 0.0562904
ZNF292 zinc finger protein 292 0.0562458
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0557338
HELZ helicase with zinc finger 0.0546144
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0531177
RPS12 ribosomal protein S12 0.0523695
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0523032
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.052274
TRIO trio Rho guanine nucleotide exchange factor 0.0521898
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0520855
RAB6A RAB6A, member RAS oncogene family 0.0518165
SRPK2 SRSF protein kinase 2 0.0498831
PARD3 par-3 family cell polarity regulator 0.0492449
RPS3 ribosomal protein S3 0.0489376
PUM2 pumilio RNA-binding family member 2 0.0486887
CXCL8 chemokine (C-X-C motif) ligand 8 0.048632
FNDC3B fibronectin type III domain containing 3B 0.0483206
WSB1 WD repeat and SOCS box containing 1 0.048226
IER3 immediate early response 3 0.0473831
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0471183
RNF145 ring finger protein 145 0.0461765
TFG TRK-fused gene 0.0459915
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0446273
VIM vimentin 0.044482
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0441517
MIS18BP1 MIS18 binding protein 1 0.0429087
FAM13A family with sequence similarity 13, member A 0.0428451
DGKD diacylglycerol kinase, delta 130kDa 0.042645
MEF2A myocyte enhancer factor 2A 0.0425185
XPO1 exportin 1 0.0422822
GPBP1 GC-rich promoter binding protein 1 0.0422529
ANLN anillin, actin binding protein 0.0420928
RAB1A RAB1A, member RAS oncogene family 0.041716
MIER1 mesoderm induction early response 1, transcriptional regulator 0.041345
PRELID2 PRELI domain containing 2 0.041295
ANXA2 annexin A2 0.0409593
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0408709
RBM39 RNA binding motif protein 39 0.0408522
AKAP10 A kinase (PRKA) anchor protein 10 0.0407829
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0402002
UBA6 ubiquitin-like modifier activating enzyme 6 0.0398474
CHD1 chromodomain helicase DNA binding protein 1 0.0391147
RLF rearranged L-myc fusion 0.0391044
SEPTIN2 septin 2 0.0391002
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0384744
NUP153 nucleoporin 153kDa 0.03839
RBM25 RNA binding motif protein 25 0.0381802
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.037709
BHLHE40 basic helix-loop-helix family, member e40 0.0375726
SCAF11 SR-related CTD-associated factor 11 0.037507
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0373771
TM9SF2 transmembrane 9 superfamily member 2 0.0371015
TENT2 terminal nucleotidyltransferase 2 0.0363069
RPS17 ribosomal protein S17 0.0360282
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0359226
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0357851
WDR43 WD repeat domain 43 0.0356161
NGLY1 N-glycanase 1 0.0354665
BIRC2 baculoviral IAP repeat containing 2 0.0351928
TTK TTK protein kinase 0.0350358
CNOT2 CCR4-NOT transcription complex, subunit 2 0.034723
NPEPPS aminopeptidase puromycin sensitive 0.0347156
NBAS neuroblastoma amplified sequence 0.0346708
DTNA dystrobrevin, alpha 0.0341803
RPL37A ribosomal protein L37a 0.0340187
UBQLN1 ubiquilin 1 0.0338505
KMT2E lysine (K)-specific methyltransferase 2E 0.033803
RBM27 RNA binding motif protein 27 0.0337974
POTEF POTE ankyrin domain family, member F 0.0337773
ZMYM2 zinc finger, MYM-type 2 0.0335657
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0332892
BIRC3 baculoviral IAP repeat containing 3 0.0332152
MT2A metallothionein 2A 0.0331619
FXR1 fragile X mental retardation, autosomal homolog 1 0.0330995
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0330834
ECT2 epithelial cell transforming 2 0.0329324
ZFAND3 zinc finger, AN1-type domain 3 0.0325848
BCLAF1 BCL2-associated transcription factor 1 0.0324628
CUL3 cullin 3 0.0324173

decreased expression

Symbol Name Standardized Value
OSMR oncostatin M receptor -0.0832955
LOC112694756 uncharaterized LOC112694756 -0.0777341
INTS6 integrator complex subunit 6 -0.0746242
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0687976
ATM ATM serine/threonine kinase -0.055066
HMGA2 high mobility group AT-hook 2 -0.0504172
DPYD dihydropyrimidine dehydrogenase -0.0482527
IGFBP3 insulin-like growth factor binding protein 3 -0.0479406
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0469511
PCNX4 pecanex 4 -0.0464966
THSD4 thrombospondin, type I, domain containing 4 -0.0457759
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0457433
ATF7IP activating transcription factor 7 interacting protein -0.0450292
ZBTB20 zinc finger and BTB domain containing 20 -0.044478
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0443468
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0425527
GPC6 glypican 6 -0.0425308
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0409238
TUBB4B tubulin, beta 4B class IVb -0.0407068
BICD1 bicaudal D homolog 1 (Drosophila) -0.0401476
SLC38A2 solute carrier family 38, member 2 -0.0396457
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0393544
FMN1 formin 1 -0.0390741
MACF1 microtubule-actin crosslinking factor 1 -0.0377289
DSCAM Down syndrome cell adhesion molecule -0.037342
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0367566
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0367117
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0366417
BCAR3 breast cancer anti-estrogen resistance 3 -0.0363095
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0360555
MAP1B microtubule-associated protein 1B -0.0354876
FNIP1 folliculin interacting protein 1 -0.0342799
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0341522
ELL2 elongation factor, RNA polymerase II, 2 -0.0340292
PRH1 proline-rich protein HaeIII subfamily 1 -0.0339574
NABP1 nucleic acid binding protein 1 -0.0336894
DST dystonin -0.0333932
IL1RAP interleukin 1 receptor accessory protein -0.0333828
ANKRD28 ankyrin repeat domain 28 -0.0332566
EPAS1 endothelial PAS domain protein 1 -0.0316136
SEPTIN10 septin 10 -0.0314377
EXOC6B exocyst complex component 6B -0.0313885
WWTR1 WW domain containing transcription regulator 1 -0.0311005
RANBP17 RAN binding protein 17 -0.0309409
SLC36A4 solute carrier family 36 (proton/amino acid symporter), member 4 -0.0296689
PRSS23 protease, serine, 23 -0.0293054
VCL vinculin -0.0292387
STARD13 StAR-related lipid transfer (START) domain containing 13 -0.0291554
PHF14 PHD finger protein 14 -0.0287534
FAM114A1 family with sequence similarity 114, member A1 -0.0286525
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0283423
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0283131
EP400 E1A binding protein p400 -0.0280517
SMYD3 SET and MYND domain containing 3 -0.0279077
MBD5 methyl-CpG binding domain protein 5 -0.0272096
ZC3H12C zinc finger CCCH-type containing 12C -0.027094
EXT1 exostosin glycosyltransferase 1 -0.026962
ZBTB38 zinc finger and BTB domain containing 38 -0.0269542
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0267736
WDR70 WD repeat domain 70 -0.0265876
ZNF655 zinc finger protein 655 -0.0262929
SPTAN1 spectrin, alpha, non-erythrocytic 1 -0.0252311
TAS2R14 taste receptor, type 2, member 14 -0.0250388
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0248916
RAD51B RAD51 paralog B -0.0247196
GOLGB1 golgin B1 -0.0246405
STAU2 staufen double-stranded RNA binding protein 2 -0.0245728
SIK2 salt-inducible kinase 2 -0.0245311
EXOC4 exocyst complex component 4 -0.0244317
ATP9B ATPase, class II, type 9B -0.0239684
BASP1 brain abundant, membrane attached signal protein 1 -0.0239005
CPEB4 cytoplasmic polyadenylation element binding protein 4 -0.0238755
EFNA5 ephrin-A5 -0.0233095
TBCA tubulin folding cofactor A -0.0231764
ZC3H12B zinc finger CCCH-type containing 12B -0.0230405
CAB39 calcium binding protein 39 -0.0230285
COPB1 coatomer protein complex, subunit beta 1 -0.0230068
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0229821
PCNX2 pecanex 2 -0.0226163
MBNL2 muscleblind-like splicing regulator 2 -0.0225252
RASAL2 RAS protein activator like 2 -0.022342
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.022157
MSRB3 methionine sulfoxide reductase B3 -0.0217836
MBTD1 mbt domain containing 1 -0.021701
SDCCAG8 serologically defined colon cancer antigen 8 -0.0215735
DNER delta/notch-like EGF repeat containing -0.0211784
RIGI RNA sensor RIG-I -0.0211426
RPL19 ribosomal protein L19 -0.0210184
CENPF centromere protein F, 350/400kDa -0.0209333
SAMD4A sterile alpha motif domain containing 4A -0.0208902
BBX bobby sox homolog (Drosophila) -0.0207789
ACTG1 actin gamma 1 -0.0207349
BPTF bromodomain PHD finger transcription factor -0.0207167
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0206007
TSC22D1 TSC22 domain family, member 1 -0.020537
NINL ninein-like -0.0204791
RSU1 Ras suppressor protein 1 -0.0204772
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0204379
EPC2 enhancer of polycomb homolog 2 (Drosophila) -0.0204372
SETX senataxin -0.020427