Cytarabine_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Cytarabine perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Cytarabine_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.181276
CXCL8 chemokine (C-X-C motif) ligand 8 0.143569
NAMPT nicotinamide phosphoribosyltransferase 0.134973
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.104096
ITGA1 integrin, alpha 1 0.0960968
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0924932
NDRG1 N-myc downstream regulated 1 0.0818121
CD109 CD109 molecule 0.0801604
FAM13A family with sequence similarity 13, member A 0.0766191
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0754442
TRIO trio Rho guanine nucleotide exchange factor 0.0750505
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0721422
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0710182
OGA O-GlcNAcase 0.069857
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.068579
GRB10 growth factor receptor-bound protein 10 0.0619455
ZNF292 zinc finger protein 292 0.06136
PRELID2 PRELI domain containing 2 0.0610548
AHR aryl hydrocarbon receptor 0.0597756
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0515422
RPS12 ribosomal protein S12 0.0494681
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0488904
BIRC3 baculoviral IAP repeat containing 3 0.0486926
PRRC2C proline-rich coiled-coil 2C 0.0484403
PLIN2 perilipin 2 0.048161
UBA6 ubiquitin-like modifier activating enzyme 6 0.0471449
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0453307
PTK2 protein tyrosine kinase 2 0.0449747
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0445065
EPS8 epidermal growth factor receptor pathway substrate 8 0.0434854
PELO pelota homolog (Drosophila) 0.0430256
HMGA2 high mobility group AT-hook 2 0.0409957
RAB8B RAB8B, member RAS oncogene family 0.0403877
TPR translocated promoter region, nuclear basket protein 0.0395119
WAC WW domain containing adaptor with coiled-coil 0.0376529
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0375897
EREG epiregulin 0.0373813
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0373796
ADAM17 ADAM metallopeptidase domain 17 0.0364444
RAD51B RAD51 paralog B 0.036274
RPS6 ribosomal protein S6 0.0362296
UGCG UDP-glucose ceramide glucosyltransferase 0.0360534
CDC73 cell division cycle 73 0.0354131
AKAP12 A kinase (PRKA) anchor protein 12 0.0352561
XPO1 exportin 1 0.0351732
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0345482
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0338359
CAB39 calcium binding protein 39 0.0337493
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.0330402
B2M beta-2-microglobulin 0.0324082
ENO1 enolase 1, (alpha) 0.0323643
ITGAV integrin, alpha V 0.0323314
FBXL5 F-box and leucine-rich repeat protein 5 0.0320209
SEPTIN7 septin 7 0.0312553
FNDC3B fibronectin type III domain containing 3B 0.0309159
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.030678
FHIT fragile histidine triad 0.0306167
YEATS2 YEATS domain containing 2 0.0305974
SPAG9 sperm associated antigen 9 0.0304177
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0303107
MYOF myoferlin 0.0300656
PNISR PNN-interacting serine/arginine-rich protein 0.0299111
AKAP10 A kinase (PRKA) anchor protein 10 0.0296055
SFXN1 sideroflexin 1 0.0295954
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0293097
RICTOR RPTOR independent companion of MTOR, complex 2 0.0292906
VIM vimentin 0.0292748
KMT2E lysine (K)-specific methyltransferase 2E 0.0291711
ACTR2 ARP2 actin-related protein 2 homolog (yeast) 0.0291481
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0289916
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.028991
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0289406
ARRDC3 arrestin domain containing 3 0.0286189
SDK1 sidekick cell adhesion molecule 1 0.0282638
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0275373
TPD52 tumor protein D52 0.0272006
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0265619
NCKAP1 NCK-associated protein 1 0.0265003
MT2A metallothionein 2A 0.0262582
NUP58 nucleoporin 58 0.0261962
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0261297
RIOK3 RIO kinase 3 0.0260031
DOCK5 dedicator of cytokinesis 5 0.0258268
FUT11 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) 0.0257172
HELZ helicase with zinc finger 0.0254462
GCC2 GRIP and coiled-coil domain containing 2 0.0252467
HDGF hepatoma-derived growth factor 0.0252372
SLTM SAFB-like, transcription modulator 0.0250829
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0250624
KMT2C lysine (K)-specific methyltransferase 2C 0.024996
PTBP3 polypyrimidine tract binding protein 3 0.0249938
CAPN2 calpain 2, (m/II) large subunit 0.0247817
MYO1B myosin IB 0.0247436
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0246946
STC2 stanniocalcin 2 0.0246767
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0246047
GOLPH3 golgi phosphoprotein 3 (coat-protein) 0.0243689
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 0.0241578
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0237884
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.023737

decreased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 -0.202395
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.184708
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.160584
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.12966
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.100752
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0888748
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0824792
EXT1 exostosin glycosyltransferase 1 -0.0802745
TMSB10 thymosin beta 10 -0.0767337
GLIS3 GLIS family zinc finger 3 -0.0717027
FTL ferritin, light polypeptide -0.0716768
CANX calnexin -0.0672843
FN1 fibronectin 1 -0.0656993
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.063576
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0632911
NRG1 neuregulin 1 -0.0616262
SYT1 synaptotagmin I -0.0609744
LMNA lamin A/C -0.058133
EFNA5 ephrin-A5 -0.0545995
HDLBP high density lipoprotein binding protein -0.0473338
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0455172
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0452685
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0447988
CALR calreticulin -0.0447643
LOC112694756 uncharaterized LOC112694756 -0.0440897
UGDH UDP-glucose 6-dehydrogenase -0.0402986
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0392435
H1-0 H1.0 linker histone -0.0372094
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0355702
TXNRD1 thioredoxin reductase 1 -0.0352017
EZR ezrin -0.0344802
PTMA prothymosin, alpha -0.0339463
PDE4D phosphodiesterase 4D, cAMP-specific -0.0337305
RRBP1 ribosome binding protein 1 -0.0334278
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0330549
VEGFA vascular endothelial growth factor A -0.0329479
CALU calumenin -0.0328103
RAB7A RAB7A, member RAS oncogene family -0.0325713
BLZF1 basic leucine zipper nuclear factor 1 -0.0324924
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0318686
APP amyloid beta (A4) precursor protein -0.0313773
TMEM263 transmembrane protein 263 -0.0305431
GOLGB1 golgin B1 -0.0304558
ARF1 ADP-ribosylation factor 1 -0.0302711
BICD1 bicaudal D homolog 1 (Drosophila) -0.0300876
EGR1 early growth response 1 -0.0299994
RPLP1 ribosomal protein, large, P1 -0.029248
AEBP2 AE binding protein 2 -0.0289707
ANKRD28 ankyrin repeat domain 28 -0.0288159
KDM5B lysine (K)-specific demethylase 5B -0.0282655
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0278286
NRP1 neuropilin 1 -0.0271851
RPS24 ribosomal protein S24 -0.0271365
AHRR aryl-hydrocarbon receptor repressor -0.0261029
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0256903
ATF3 activating transcription factor 3 -0.0254731
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0253183
TNS3 tensin 3 -0.0247437
MBNL1 muscleblind-like splicing regulator 1 -0.0244501
TAS2R14 taste receptor, type 2, member 14 -0.0237879
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0237611
STAU1 staufen double-stranded RNA binding protein 1 -0.0233253
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0232224
YBX1 Y box binding protein 1 -0.0230419
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0229259
TMBIM6 transmembrane BAX inhibitor motif containing 6 -0.0227483
DDB1 damage-specific DNA binding protein 1, 127kDa -0.0227259
ANKHD1 ankyrin repeat and KH domain containing 1 -0.022601
ADIPOR2 adiponectin receptor 2 -0.0225017
SLC38A2 solute carrier family 38, member 2 -0.0221724
INTS6 integrator complex subunit 6 -0.0217654
AOPEP aminopeptidase O (putative) -0.021753
PALLD palladin, cytoskeletal associated protein -0.0216866
MAP1B microtubule-associated protein 1B -0.0216384
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.021445
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) -0.0214084
CDK13 cyclin-dependent kinase 13 -0.021382
LOC102724023 ES1 protein homolog, mitochondrial -0.0213084
PCBP2 poly(rC) binding protein 2 -0.0212801
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0212236
RASAL2 RAS protein activator like 2 -0.0211741
RPS21 ribosomal protein S21 -0.0209992
ATP5F1B ATP synthase F1 subunit beta -0.0209046
BRD2 bromodomain containing 2 -0.0208934
DSTN destrin (actin depolymerizing factor) -0.0208532
HMGB1 high mobility group box 1 -0.0207541
BAIAP2 BAI1-associated protein 2 -0.020544
ATF6 activating transcription factor 6 -0.0205405
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0204515
TPI1 triosephosphate isomerase 1 -0.0203957
ABLIM1 actin binding LIM protein 1 -0.0203442
IFRD1 interferon-related developmental regulator 1 -0.0203002
RPS19 ribosomal protein S19 -0.0202159
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0200886
LMAN2 lectin, mannose-binding 2 -0.0199992
LARP4B La ribonucleoprotein domain family, member 4B -0.0199701
SFPQ splicing factor proline/glutamine-rich -0.0199493
TMED9 transmembrane emp24 protein transport domain containing 9 -0.0198984
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0198065
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0197184