Cytosolic DNA-sensing pathway Gene Set

Dataset KEGG Pathways 2026
Category structural or functional annotations
Type pathway
Description Specific families of pattern recognition receptors are responsible for detecting foreign DNA from invading microbes or host cells and generating innate immune responses. DAI is the first identified sensor of cytosolic DNA which activates the IRF and NF-{kappa}B transcription factors, leading to production of type I interferon and other cytokines. The second type of cytoplasmic DNA sensor is AIM2. Upon sensing DNA, AIM2 triggers the assembly of the inflammasome, culminating in interleukin maturation. In addition to these receptors, there is a mechanism to sense foreign DNA, with the host RNA polymerase III converting the DNA into RNA for recognition by the RNA sensor RIG-I. These pathways provide various means to alert the cell. (Kyoto Encyclopedia of Genes and Genomes, hsa04623)
External Link https://www.kegg.jp/entry/hsa04623
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Genes

82 proteins participating in the Cytosolic DNA-sensing pathway pathway from the KEGG Pathways 2026 dataset.

Symbol Name
ADAR adenosine deaminase, RNA-specific
AIM2 absent in melanoma 2
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CCL4 chemokine (C-C motif) ligand 4
CCL4L1 chemokine (C-C motif) ligand 4-like 1
CCL4L2 chemokine (C-C motif) ligand 4-like 2
CCL5 chemokine (C-C motif) ligand 5
CGAS cyclic GMP-AMP synthase
CHUK conserved helix-loop-helix ubiquitous kinase
CXCL10 chemokine (C-X-C motif) ligand 10
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41
DNASE2 deoxyribonuclease II, lysosomal
DNASE2B deoxyribonuclease II beta
FADD Fas (TNFRSF6)-associated via death domain
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GSDMD gasdermin D
GSDME gasdermin E
IFI16 interferon, gamma-inducible protein 16
IFNA1 interferon, alpha 1
IFNA10 interferon, alpha 10
IFNA13 interferon, alpha 13
IFNA14 interferon, alpha 14
IFNA16 interferon, alpha 16
IFNA17 interferon, alpha 17
IFNA2 interferon, alpha 2
IFNA21 interferon, alpha 21
IFNA4 interferon, alpha 4
IFNA5 interferon, alpha 5
IFNA6 interferon, alpha 6
IFNA7 interferon, alpha 7
IFNA8 interferon, alpha 8
IFNB1 interferon, beta 1, fibroblast
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IL18 interleukin 18
IL1B interleukin 1, beta
IL33 interleukin 33
IL6 interleukin 6
IRF3 interferon regulatory factor 3
IRF7 interferon regulatory factor 7
MAVS mitochondrial antiviral signaling protein
MEFV Mediterranean fever
MLKL mixed lineage kinase domain-like
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NLRP3 NLR family, pyrin domain containing 3
PCBP1 poly(rC) binding protein 1
POLR1D polymerase (RNA) I polypeptide D, 16kDa
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
POLR2F polymerase (RNA) II (DNA directed) polypeptide F
POLR2H polymerase (RNA) II (DNA directed) polypeptide H
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
POLR3A polymerase (RNA) III (DNA directed) polypeptide A, 155kDa
POLR3B polymerase (RNA) III (DNA directed) polypeptide B
POLR3C polymerase (RNA) III (DNA directed) polypeptide C (62kD)
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD)
POLR3F polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa
POLR3G polymerase (RNA) III (DNA directed) polypeptide G (32kD)
POLR3GL polymerase (RNA) III (DNA directed) polypeptide G (32kD)-like
POLR3H polymerase (RNA) III (DNA directed) polypeptide H (22.9kD)
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PYCARD PYD and CARD domain containing
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RIGI RNA sensor RIG-I
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RIPK3 receptor-interacting serine-threonine kinase 3
SAMHD1 SAM domain and HD domain 1
STING1 stimulator of interferon response cGAMP interactor 1
TBK1 TANK-binding kinase 1
TREX1 three prime repair exonuclease 1
ZBP1 Z-DNA binding protein 1
ZCCHC3 zinc finger, CCHC domain containing 3
ZDHHC1 zinc finger, DHHC-type containing 1
ZDHHC11 zinc finger, DHHC-type containing 11
ZDHHC11B zinc finger, DHHC-type containing 11B