D-(+)-Glucose Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/79025
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Genes

198 proteins with high or low expression in D-(+)-Glucose relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
KIAA0825 KIAA0825 0.86
KMT2B lysine (K)-specific methyltransferase 2B 0.61
TM7SF3 transmembrane 7 superfamily member 3 0.6
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.58
ZCCHC14 zinc finger, CCHC domain containing 14 0.55
ADCY10 adenylate cyclase 10 (soluble) 0.54
MSX2 msh homeobox 2 0.53
SLC41A3 solute carrier family 41, member 3 0.5
SMAD1 SMAD family member 1 0.49
ZNF776 zinc finger protein 776 0.48
BMPR1A bone morphogenetic protein receptor, type IA 0.46
FAM117A family with sequence similarity 117, member A 0.46
ZNF263 zinc finger protein 263 0.46
ATXN1L ataxin 1-like 0.43
KLHL29 kelch-like family member 29 0.42
SDR16C5 short chain dehydrogenase/reductase family 16C, member 5 0.38
GSTZ1 glutathione S-transferase zeta 1 0.38
CPE carboxypeptidase E 0.35
PLK4 polo-like kinase 4 0.34
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 0.34
ACTL8 actin-like 8 0.34
ADGRF1 adhesion G protein-coupled receptor F1 0.33
UNC13C unc-13 homolog C (C. elegans) 0.33
HSH2D hematopoietic SH2 domain containing 0.33
VIM vimentin 0.32
PLXNB1 plexin B1 0.31
DIXDC1 DIX domain containing 1 0.31
GAS2L1 growth arrest-specific 2 like 1 0.31
METRN meteorin, glial cell differentiation regulator 0.31
CTNND2 catenin (cadherin-associated protein), delta 2 0.3
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit 0.3
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2 0.3
PCSK9 proprotein convertase subtilisin/kexin type 9 0.3
SHROOM1 shroom family member 1 0.3
DST dystonin 0.29
VCPKMT valosin containing protein lysine (K) methyltransferase 0.29
RGPD8 RANBP2-like and GRIP domain containing 8 0.29
ALG13 ALG13, UDP-N-acetylglucosaminyltransferase subunit 0.28
RNF6 ring finger protein (C3H2C3 type) 6 0.28
ENTR1 endosome associated trafficking regulator 1 0.28
YDJC YdjC homolog (bacterial) 0.27
TM7SF2 transmembrane 7 superfamily member 2 0.27
ZGRF1 zinc finger, GRF-type containing 1 0.27
CUL9 cullin 9 0.27
ZG16B zymogen granule protein 16B 0.27
ETV6 ets variant 6 0.26
PDE4DIP phosphodiesterase 4D interacting protein 0.26
DENND5A DENN/MADD domain containing 5A 0.26
C6ORF136 chromosome 6 open reading frame 136 0.26
RILPL2 Rab interacting lysosomal protein-like 2 0.25
PEMT phosphatidylethanolamine N-methyltransferase 0.25
CCSER1 coiled-coil serine-rich protein 1 0.25
RTL6 retrotransposon Gag like 6 0.24
TMEM175 transmembrane protein 175 0.24
GKAP1 G kinase anchoring protein 1 0.24
RCBTB1 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1 0.24
RFTN1 raftlin, lipid raft linker 1 0.24
TCEA3 transcription elongation factor A (SII), 3 0.24
ANKRD39 ankyrin repeat domain 39 0.24
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11 0.24
LTO1 LTO1 maturation factor of ABCE1 0.24
CHST7 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7 0.24
PEX16 peroxisomal biogenesis factor 16 0.23
COMMD2 COMM domain containing 2 0.22
ZNF200 zinc finger protein 200 0.22
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae) 0.22
MITD1 MIT, microtubule interacting and transport, domain containing 1 0.22
ATAD5 ATPase family, AAA domain containing 5 0.22
MSL3 male-specific lethal 3 homolog (Drosophila) 0.22
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial) 0.22
ELK1 ELK1, member of ETS oncogene family 0.22
GRB14 growth factor receptor-bound protein 14 0.21
AMMECR1L AMMECR1-like 0.21
TCEA2 transcription elongation factor A (SII), 2 0.21
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 0.21
GRK6 G protein-coupled receptor kinase 6 0.21
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa 0.21
IFT22 intraflagellar transport 22 0.21
FABP6 fatty acid binding protein 6, ileal 0.21
ZNF92 zinc finger protein 92 0.21
STARD13 StAR-related lipid transfer (START) domain containing 13 0.21
RIPK4 receptor-interacting serine-threonine kinase 4 0.21
ZNF799 zinc finger protein 799 0.21
PDGFC platelet derived growth factor C 0.2
MYH2 myosin, heavy chain 2, skeletal muscle, adult 0.2
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae) 0.2
ZNF511 zinc finger protein 511 0.2
VAMP8 vesicle-associated membrane protein 8 0.2
COX10 COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor 0.2
CYP2U1 cytochrome P450, family 2, subfamily U, polypeptide 1 0.2
GPR108 G protein-coupled receptor 108 0.2
ANK2 ankyrin 2, neuronal 0.2
E2F7 E2F transcription factor 7 0.2
ENC1 ectodermal-neural cortex 1 (with BTB domain) 0.2
CROCC2 ciliary rootlet coiled-coil, rootletin family member 2 0.2
FBXO31 F-box protein 31 0.2
MSL2 male-specific lethal 2 homolog (Drosophila) 0.2
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 0.19
CCDC150 coiled-coil domain containing 150 0.19

low expression

Symbol Name Standardized Value
SLC19A2 solute carrier family 19 (thiamine transporter), member 2 -0.66
OASL 2'-5'-oligoadenylate synthetase-like -0.57
CLN8 ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation) -0.57
FAM171A2 family with sequence similarity 171, member A2 -0.55
HLA-F major histocompatibility complex, class I, F -0.51
B3GNT3 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 -0.5
SLC38A7 solute carrier family 38, member 7 -0.49
SLC38A9 solute carrier family 38, member 9 -0.45
TBC1D31 TBC1 domain family, member 31 -0.44
ITGA1 integrin, alpha 1 -0.43
NF1 neurofibromin 1 -0.41
MRC2 mannose receptor, C type 2 -0.4
ZSCAN26 zinc finger and SCAN domain containing 26 -0.4
CD82 CD82 molecule -0.4
PRRG1 proline rich Gla (G-carboxyglutamic acid) 1 -0.4
KLF4 Kruppel-like factor 4 (gut) -0.38
ALPK1 alpha-kinase 1 -0.38
FAM219B family with sequence similarity 219, member B -0.38
NIPSNAP3A nipsnap homolog 3A (C. elegans) -0.37
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1 -0.37
TMSB10 thymosin beta 10 -0.35
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.34
ATP6V0A1 ATPase, H+ transporting, lysosomal V0 subunit a1 -0.34
LRRC58 leucine rich repeat containing 58 -0.34
KATNBL1 katanin p80 subunit B-like 1 -0.33
ABCD1 ATP-binding cassette, sub-family D (ALD), member 1 -0.33
MAP3K12 mitogen-activated protein kinase kinase kinase 12 -0.32
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B -0.32
PIP prolactin-induced protein -0.32
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.32
ZNF189 zinc finger protein 189 -0.32
ZBTB8A zinc finger and BTB domain containing 8A -0.31
CTHRC1 collagen triple helix repeat containing 1 -0.31
GUCD1 guanylyl cyclase domain containing 1 -0.31
CDC42EP2 CDC42 effector protein (Rho GTPase binding) 2 -0.31
DUSP5 dual specificity phosphatase 5 -0.3
ATE1 arginyltransferase 1 -0.3
UCHL5 ubiquitin carboxyl-terminal hydrolase L5 -0.29
SGSH N-sulfoglucosamine sulfohydrolase -0.29
S100A14 S100 calcium binding protein A14 -0.29
MAP2 microtubule-associated protein 2 -0.29
EIF2B4 eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa -0.29
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8 -0.28
GRID1 glutamate receptor, ionotropic, delta 1 -0.27
CCNI cyclin I -0.27
KLHDC8B kelch domain containing 8B -0.27
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4 -0.27
UBL7 ubiquitin-like 7 -0.27
C4BPA complement component 4 binding protein, alpha -0.27
CCDC9B coiled-coil domain containing 9B -0.26
ATXN7L1 ataxin 7-like 1 -0.26
RPP21 ribonuclease P/MRP 21kDa subunit -0.26
CDCA3 cell division cycle associated 3 -0.25
ZFP36 ZFP36 ring finger protein -0.25
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 -0.25
MPV17 MpV17 mitochondrial inner membrane protein -0.25
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain -0.25
SERF2 small EDRK-rich factor 2 -0.25
CEP112 centrosomal protein 112kDa -0.25
ZBTB14 zinc finger and BTB domain containing 14 -0.25
HBA1 hemoglobin, alpha 1 -0.25
C19ORF25 chromosome 19 open reading frame 25 -0.24
TMEM160 transmembrane protein 160 -0.24
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.24
NPTXR neuronal pentraxin receptor -0.24
DMXL2 Dmx-like 2 -0.24
WSB1 WD repeat and SOCS box containing 1 -0.24
ADCK5 aarF domain containing kinase 5 -0.24
NFE2L2 nuclear factor, erythroid 2-like 2 -0.24
TPM1 tropomyosin 1 (alpha) -0.24
MED8 mediator complex subunit 8 -0.24
BLOC1S5 biogenesis of lysosomal organelles complex-1, subunit 5, muted -0.24
ICOSLG inducible T-cell co-stimulator ligand -0.23
NMNAT3 nicotinamide nucleotide adenylyltransferase 3 -0.23
RPAIN RPA interacting protein -0.23
IGFBP6 insulin-like growth factor binding protein 6 -0.23
ISCA2 iron-sulfur cluster assembly 2 -0.23
ATG2A autophagy related 2A -0.23
PDK1 pyruvate dehydrogenase kinase, isozyme 1 -0.23
KCTD6 potassium channel tetramerization domain containing 6 -0.23
LTN1 listerin E3 ubiquitin protein ligase 1 -0.23
DCLRE1C DNA cross-link repair 1C -0.23
RTN1 reticulon 1 -0.22
METTL26 methyltransferase like 26 -0.22
PCNX1 pecanex 1 -0.22
MCRIP1 MAPK regulated corepressor interacting protein 1 -0.22
FBXO41 F-box protein 41 -0.22
WDR20 WD repeat domain 20 -0.22
PSEN1 presenilin 1 -0.22
ADIRF adipogenesis regulatory factor -0.22
METTL25 methyltransferase like 25 -0.22
ATP6V1F ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F -0.22
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.22
BTBD11 BTB (POZ) domain containing 11 -0.22
ZNF428 zinc finger protein 428 -0.21
DENND4B DENN/MADD domain containing 4B -0.21
ATG10 autophagy related 10 -0.21
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -0.21
B4GALT4 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4 -0.21