DA-29-ZD04_10uM Gene Set

Dataset NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles
Category transcriptomics
Type drug perturbation
Description Dose=10uM, Losartan, AGTR1 gene inhibitor targeting AGTR1 (Novartis, 3961)
External Link https://pubchem.ncbi.nlm.nih.gov/compound/3961
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Genes

127 genes differentially expressed following the DA-29-ZD04_10uM drug perturbation from the NIBR DRUG-seq U2OS MoA Box dataset.

increased expression

Symbol Name Standardized Value
MMP9 matrix metallopeptidase 9 2.92664
TIMP1 TIMP metallopeptidase inhibitor 1 2.78121
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b 2.39761
KISS1 KiSS-1 metastasis-suppressor 2.19368
TGM2 transglutaminase 2 1.76899
CD59 CD59 molecule, complement regulatory protein 1.20821
ITGB5 integrin, beta 5 1.00048
FKBP1A FK506 binding protein 1A, 12kDa 0.860506
SAA2 serum amyloid A2 0.818711
SCG5 secretogranin V 0.691832
NNMT nicotinamide N-methyltransferase 0.66071
HRNR hornerin 0.659251
HMGA1 high mobility group AT-hook 1 0.658305
HDAC5 histone deacetylase 5 0.553886
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa 0.528018
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed 0.522658
RPL31 ribosomal protein L31 0.485761
MRPL13 mitochondrial ribosomal protein L13 0.479369
RPS5 ribosomal protein S5 0.432512
RPLP2 ribosomal protein, large, P2 0.427522
CLEC11A C-type lectin domain family 11, member A 0.419957
MVP major vault protein 0.399441
RPL28 ribosomal protein L28 0.393233
MDH2 malate dehydrogenase 2, NAD (mitochondrial) 0.385777
MT2A metallothionein 2A 0.383128
TNIP1 TNFAIP3 interacting protein 1 0.380374
PSMG3 proteasome (prosome, macropain) assembly chaperone 3 0.373291
ALPL alkaline phosphatase, liver/bone/kidney 0.367286
RPS13 ribosomal protein S13 0.366462
RPL18A ribosomal protein L18a 0.366462
SSR4 signal sequence receptor, delta 0.362953
CTSB cathepsin B 0.35439
PFN1 profilin 1 0.343996
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 0.340771
ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase) 0.330944
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.316002
RPS9 ribosomal protein S9 0.306916
ZNHIT1 zinc finger, HIT-type containing 1 0.306916
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 0.304031
SPHK1 sphingosine kinase 1 0.299433
LTB lymphotoxin beta (TNF superfamily, member 3) 0.298272
GSTO1 glutathione S-transferase omega 1 0.29056
KRT18 keratin 18, type I 0.282623
ATP5MC1 ATP synthase membrane subunit c locus 1 0.281955
NOP10 NOP10 ribonucleoprotein 0.279536
BIK BCL2-interacting killer (apoptosis-inducing) 0.279536
SELENOM selenoprotein M 0.279536
RPS17 ribosomal protein S17 0.276145
MYDGF myeloid-derived growth factor 0.274731
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 0.272085
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B 0.265851
ETNK2 ethanolamine kinase 2 0.265052
TM4SF1 transmembrane 4 L six family member 1 0.261341
RHOG ras homolog family member G 0.261341
BEX2 brain expressed X-linked 2 0.257745
LINC02762 long intergenic non-protein coding RNA 2762 0.253589
YPEL3 yippee-like 3 (Drosophila) 0.249109
LAMC2 laminin, gamma 2 0.247849
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B 0.247849
RPS27A ribosomal protein S27a 0.244202
RANGAP1 Ran GTPase activating protein 1 0.243852
SLAMF9 SLAM family member 9 0.238688
RPS16 ribosomal protein S16 0.2375
TMEM205 transmembrane protein 205 0.2375
RPL35 ribosomal protein L35 0.236951
RPL23 ribosomal protein L23 0.233179
TMEM208 transmembrane protein 208 0.224863
DUS1L dihydrouridine synthase 1-like (S. cerevisiae) 0.22369
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.223456
CIB1 calcium and integrin binding 1 (calmyrin) 0.219416
MT1H metallothionein 1H 0.219416
TSPAN4 tetraspanin 4 0.218201
UBC ubiquitin C 0.218109
RPL26 ribosomal protein L26 0.214673
RACK1 receptor for activated C kinase 1 0.210783
RPL15 ribosomal protein L15 0.203871
IFITM3 interferon induced transmembrane protein 3 0.203329
PTPRR protein tyrosine phosphatase, receptor type, R 0.20153
NME1 NME/NM23 nucleoside diphosphate kinase 1 0.200118

decreased expression

Symbol Name Standardized Value
TMSB4X thymosin beta 4, X-linked -1.73506
TPM1 tropomyosin 1 (alpha) -1.66523
MDK midkine (neurite growth-promoting factor 2) -1.0822
MARCKSL1 MARCKS-like 1 -1.05086
KRT17 keratin 17, type I -0.968344
KRT80 keratin 80, type II -0.806679
HSPB1 heat shock 27kDa protein 1 -0.720072
CLU clusterin -0.673003
KRT75 keratin 75, type II -0.673003
PDLIM1 PDZ and LIM domain 1 -0.65428
CPA4 carboxypeptidase A4 -0.582995
TAGLN transgelin -0.528269
S100A10 S100 calcium binding protein A10 -0.503002
PFDN1 prefoldin subunit 1 -0.479369
COL1A1 collagen, type I, alpha 1 -0.43175
MAGED1 melanoma antigen family D1 -0.43175
RAB7B RAB7B, member RAS oncogene family -0.428434
CRABP2 cellular retinoic acid binding protein 2 -0.398145
MYL9 myosin, light chain 9, regulatory -0.391554
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.343996
FSCN1 fascin actin-bundling protein 1 -0.325747
CALB2 calbindin 2 -0.325553
NPPB natriuretic peptide B -0.324148
EDN2 endothelin 2 -0.316002
GLIPR2 GLI pathogenesis-related 2 -0.310035
KRT81 keratin 81, type II -0.309944
GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2 -0.307651
CNN1 calponin 1, basic, smooth muscle -0.301112
DUSP12 dual specificity phosphatase 12 -0.293101
METRNL meteorin, glial cell differentiation regulator-like -0.293101
CLCN3 chloride channel, voltage-sensitive 3 -0.292814
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.284295
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.282623
TUBB2A tubulin, beta 2A class IIa -0.259073
PCLO piccolo presynaptic cytomatrix protein -0.25858
LOXL1 lysyl oxidase-like 1 -0.248581
AMMECR1L AMMECR1-like -0.239751
REXO2 RNA exonuclease 2 -0.218575
MN1 meningioma (disrupted in balanced translocation) 1 -0.218154
SCX scleraxis basic helix-loop-helix transcription factor -0.21639
SUMO2 small ubiquitin-like modifier 2 -0.210617
NANOS1 nanos homolog 1 (Drosophila) -0.209322
CXCL14 chemokine (C-X-C motif) ligand 14 -0.207192
LMCD1 LIM and cysteine-rich domains 1 -0.205237
ADGRG1 adhesion G protein-coupled receptor G1 -0.205147
ACVR2B activin A receptor, type IIB -0.201716
IGFBPL1 insulin-like growth factor binding protein-like 1 -0.200118
GLS2 glutaminase 2 (liver, mitochondrial) -0.200118