DA-29-ZD04_1uM Gene Set

Dataset NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles
Category transcriptomics
Type drug perturbation
Description Dose=1uM, Losartan, AGTR1 gene inhibitor targeting AGTR1 (Novartis, 3961)
External Link https://pubchem.ncbi.nlm.nih.gov/compound/3961
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Genes

27 genes differentially expressed following the DA-29-ZD04_1uM drug perturbation from the NIBR DRUG-seq U2OS MoA Box dataset.

increased expression

Symbol Name Standardized Value
MYL2 myosin, light chain 2, regulatory, cardiac, slow 0.955064
PHPT1 phosphohistidine phosphatase 1 0.670735
RPL31 ribosomal protein L31 0.541213
C19ORF33 chromosome 19 open reading frame 33 0.455596
RPL35 ribosomal protein L35 0.451993
RPS29 ribosomal protein S29 0.446989
CRYAB crystallin, alpha B 0.385648
SCAND1 SCAN domain containing 1 0.346891
TNNI3 troponin I type 3 (cardiac) 0.273081
MVP major vault protein 0.269583
RPS19 ribosomal protein S19 0.262812
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa 0.262812
RPL28 ribosomal protein L28 0.249583
RPL37 ribosomal protein L37 0.249583
TMEM258 transmembrane protein 258 0.249583
RHOG ras homolog family member G 0.249583
MRPL13 mitochondrial ribosomal protein L13 0.249583
RPL18A ribosomal protein L18a 0.24873
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.241266
RPS13 ribosomal protein S13 0.232412
KRT18 keratin 18, type I 0.230324
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed 0.22564
LSM7 LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae) 0.222879
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous) 0.220687
SH3D19 SH3 domain containing 19 0.209832

decreased expression

Symbol Name Standardized Value
CBX1 chromobox homolog 1 -0.249583
LRRC37B leucine rich repeat containing 37B -0.20009