DA-32-QL71_0.1uM Gene Set

Dataset NIBR DRUG-seq U2OS MoA Box Gene Expression Profiles
Category transcriptomics
Type drug perturbation
Description Dose=0.1uM, Namodenoson, Adenosine A3 Agonists targeting ADORA3 (Novartis, 3035850)
External Link https://pubchem.ncbi.nlm.nih.gov/compound/3035850
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Genes

31 genes differentially expressed following the DA-32-QL71_0.1uM drug perturbation from the NIBR DRUG-seq U2OS MoA Box dataset.

increased expression

Symbol Name Standardized Value
RPS13 ribosomal protein S13 0.33334
RPL31 ribosomal protein L31 0.302566
RNF181 ring finger protein 181 0.302566
RPL26 ribosomal protein L26 0.265737
MYL12B myosin, light chain 12B, regulatory 0.265737
CCNB1 cyclin B1 0.265737
RPS27A ribosomal protein S27a 0.265737
FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed 0.265737
NDUFB11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa 0.241441
RPL9 ribosomal protein L9 0.23166
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 0.231319

decreased expression

Symbol Name Standardized Value
ATP6V0C ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c -0.546458
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.331133
ARF1 ADP-ribosylation factor 1 -0.331133
CCNI cyclin I -0.265737
TPTEP2-CSNK1E TPTEP2-CSNK1E readthrough -0.265737
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) -0.265737
MRPS2 mitochondrial ribosomal protein S2 -0.265737
BCAP31 B-cell receptor-associated protein 31 -0.265732
UBE2C ubiquitin-conjugating enzyme E2C -0.259364
MARCKSL1 MARCKS-like 1 -0.255756
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) -0.244823
MBOAT7 membrane bound O-acyltransferase domain containing 7 -0.233025
LZTS2 leucine zipper, putative tumor suppressor 2 -0.227341
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G -0.224304
CFAP20 cilia and flagella associated protein 20 -0.214194
MFSD10 major facilitator superfamily domain containing 10 -0.214194
DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 -0.210419
EML3 echinoderm microtubule associated protein like 3 -0.208392
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.20212
ENO1 enolase 1, (alpha) -0.20212